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Entry version 141 (13 Nov 2019)
Sequence version 1 (03 Oct 2006)
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Protein
Submitted name:

Diego, isoform A

Gene

dgo

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-350368 Activation of RHO1 by FZ:DSH complex
R-DME-350369 Negative feedback loop regulates asymmetric localisation
R-DME-350376 Activation of RAC1:GTP by FZ:DSH complex
R-DME-350411 Formation and asymmetric localisation of transmembrane complexes
R-DME-350480 Activation of non-muscle Myosin II
R-DME-450728 Inhibition of actin polymerisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Diego, isoform AImported
Submitted name:
Diego, isoform BImported
Submitted name:
LD08259pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dgoImported
Synonyms:DgoImported, Dmel\CG12342Imported, EP(2)2619Imported, EP2619Imported
ORF Names:CG12342Imported, Dmel_CG12342Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0086898 dgo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0086898 Expressed in 21 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P511405EBI-1158635,EBI-499383

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-36067N

Protein interaction database and analysis system

More...
IntActi
Q7JUF2, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0087345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7JUF2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 249ANK_REP_REGIONInterPro annotationAdd BLAST226
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati130 – 162ANKPROSITE-ProRule annotationAdd BLAST33
Repeati163 – 195ANKPROSITE-ProRule annotationAdd BLAST33
Repeati196 – 228ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni82 – 107DisorderedSequence analysisAdd BLAST26
Regioni256 – 278DisorderedSequence analysisAdd BLAST23
Regioni470 – 512DisorderedSequence analysisAdd BLAST43
Regioni541 – 620DisorderedSequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi478 – 502AcidicSequence analysisAdd BLAST25
Compositional biasi589 – 620PolarSequence analysisAdd BLAST32

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155887

KEGG Orthology (KO)

More...
KOi
K21435

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTTLIME

Database of Orthologous Groups

More...
OrthoDBi
146560at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7JUF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQHGSSRIPK QEALPNAISG PDSSNWTSLH EAVAAGDDRR VEGLLFSNAD
60 70 80 90 100
RLARESVQGN TPLHEAASRG FSRCVKLICT PPTPPASSGV GKAAKGQKDK
110 120 130 140 150
DKDKNKGRVK VAHQTIEALH NSALGIANNE GLSALHLAAQ NGHNQSSREL
160 170 180 190 200
LLAGADPDVR NNYGDTPLHT ACRYGHAGVS RILLSALCDP NKTNLNGDTA
210 220 230 240 250
LHITCAMGRR KLTRILLEAD ARLGIKNAQG DCPMHIAIRK NYREIIEILN
260 270 280 290 300
TPKKIRNRKE KPKEGGSRSD KDRDRERDVV DKGINWSPYG CHYFPDPRAF
310 320 330 340 350
PSPKLETLPK EPLKSGEQYF LDLAGHIHKG PVSVGNTCYC GPFFRHIENK
360 370 380 390 400
LNCNRKSLKK YVHKTKERLG HKVQALAIKT NDQIEQLTRT MIEDRLRCES
410 420 430 440 450
KRQHLSEFLR RGEPMRSTFD QQNKSSRIER TMSRCRSLEL LENNHEGGRL
460 470 480 490 500
TNSRSVDVLE DQAVEAIVHR SAEVQVDSDS DDDSNEARDE EEAEVGDKDQ
510 520 530 540 550
VQEEAEPEEH SKLDELKLDF LKVSERLGVL LEKTTLIMER DSEQESKRQL
560 570 580 590 600
SSLSPPYNPH PRAESAQLRE DKESVNSPNF DEYANVIRRY PNSSETSNPS
610 620 630 640 650
QNSNSWDWEA SPTGSNPHPD YNKYYQRIGR GENMLNSVIK ALRKDASFAD
660 670 680 690 700
LGKEETAVNE TAEGMGGDKL LYKEQASEAA GISNLMKRQP LCLEDNYPVM
710 720 730 740 750
SNLFYSNPIM EYAEETEVRQ NGNESMSKVE IRNSEIKCLK KPNAGQVRDM
760 770 780 790 800
VAQLQNTIDS NRQDSQTAHV IAARSHSRLN NNFHHLEGTS SNPSPTYSIP
810 820 830 840 850
HRSSAQFGLP ERHIPKDAYF HELPHRPPIP QTPQRRLHSG YVPNASLYRS
860 870 880 890 900
EDLYVGRIPH PNAPPRQVDY VDAVAYRPLQ SPTFQAIVPP HVNQRPRNWP
910 920
HPNLPSNEID LDELSAVGLY NNVSSLV
Length:927
Mass (Da):104,069
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7743AE0772753E27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58749.2
AE013599 Genomic DNA Translation: AAM68750.1
AY128436 mRNA Translation: AAM75029.1

NCBI Reference Sequences

More...
RefSeqi
NP_610614.1, NM_136770.2
NP_724973.1, NM_165800.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0088249; FBpp0087344; FBgn0086898
FBtr0088250; FBpp0087345; FBgn0086898

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG12342

UCSC genome browser

More...
UCSCi
CG12342-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF58749.2
AE013599 Genomic DNA Translation: AAM68750.1
AY128436 mRNA Translation: AAM75029.1
RefSeqiNP_610614.1, NM_136770.2
NP_724973.1, NM_165800.2

3D structure databases

SMRiQ7JUF2
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-36067N
IntActiQ7JUF2, 5 interactors
STRINGi7227.FBpp0087345

Genome annotation databases

EnsemblMetazoaiFBtr0088249; FBpp0087344; FBgn0086898
FBtr0088250; FBpp0087345; FBgn0086898
GeneIDi36139
KEGGidme:Dmel_CG12342
UCSCiCG12342-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36139
FlyBaseiFBgn0086898 dgo

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000155887
KOiK21435
OMAiKTTLIME
OrthoDBi146560at2759

Enzyme and pathway databases

ReactomeiR-DME-350368 Activation of RHO1 by FZ:DSH complex
R-DME-350369 Negative feedback loop regulates asymmetric localisation
R-DME-350376 Activation of RAC1:GTP by FZ:DSH complex
R-DME-350411 Formation and asymmetric localisation of transmembrane complexes
R-DME-350480 Activation of non-muscle Myosin II
R-DME-450728 Inhibition of actin polymerisation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Galphao fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36139

Gene expression databases

BgeeiFBgn0086898 Expressed in 21 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7JUF2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7JUF2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 13, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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