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Entry version 165 (13 Nov 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Trio, isoform A

Gene

trio

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-416476 G alpha (q) signalling events
R-DME-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Trio, isoform AImported
Submitted name:
Trio, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trioImported
Synonyms:03Imported, 0368Imported, 06Imported, 06]Imported, 0959Imported, 10Imported, 1372Imported, 1386Imported, 14Imported, 3]Imported, BEST:LD36950Imported, CG9208Imported, Dmel\CG18214Imported, DTrioImported, dTrioImported, l(3)036810Imported, l(3)6D104Imported, l(3)S036810Imported, l(3)S095914Imported, l(3)S137203Imported, l(3)S138606Imported, l(3)S[1372Imported, l(3)S[1386Imported, l(3)trioImported, M89Imported, TRIOImported, TrioImported, UNC-73Imported
ORF Names:CG18214Imported, Dmel_CG18214Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0024277 trio

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7KVD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0024277 Expressed in 35 organ(s), highest expression level in antenna

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7KVD1 differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7KVD1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072539

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7KVD1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 156CRAL-TRIOInterPro annotationAdd BLAST151
Domaini1283 – 1457DHInterPro annotationAdd BLAST175
Domaini1469 – 1581PHInterPro annotationAdd BLAST113
Domaini1640 – 1710SH3InterPro annotationAdd BLAST71
Domaini1941 – 2123DHInterPro annotationAdd BLAST183
Domaini2136 – 2245PHInterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni235 – 277DisorderedSequence analysisAdd BLAST43
Regioni494 – 518DisorderedSequence analysisAdd BLAST25
Regioni1240 – 1279DisorderedSequence analysisAdd BLAST40
Regioni1591 – 1638DisorderedSequence analysisAdd BLAST48
Regioni1702 – 1931DisorderedSequence analysisAdd BLAST230

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili742 – 769Sequence analysisAdd BLAST28
Coiled coili813 – 833Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi246 – 275PolarSequence analysisAdd BLAST30
Compositional biasi1240 – 1254PolarSequence analysisAdd BLAST15
Compositional biasi1255 – 1279PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1604 – 1619PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1620 – 1638PolarSequence analysisAdd BLAST19
Compositional biasi1717 – 1754PolarSequence analysisAdd BLAST38
Compositional biasi1772 – 1794PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1795 – 1823PolarSequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0689 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170624

KEGG Orthology (KO)

More...
KOi
K08810

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDWIENH

Database of Orthologous Groups

More...
OrthoDBi
5761at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 2 hits
2.30.29.30, 2 hits
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO

The PANTHER Classification System

More...
PANTHERi
PTHR22826:SF104 PTHR22826:SF104, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 2 hits
PF00435 Spectrin, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00516 SEC14, 1 hit
SM00150 SPEC, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 2 hits
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 2 hits
PS50003 PH_DOMAIN, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q7KVD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGQRARDLL TLLQERVVFL TGGRDRRGGP LLCFPATPRR DRLKPEDLRR
60 70 80 90 100
LLSYLISIPS DAAKNLGFTV IIDMRGNGNC STNVKTILKV LQEHFSANIH
110 120 130 140 150
NVVIIKPDNF WQKQRASISS HKYKFETTTV SIESLNKIVE SHQLTGDFEG
160 170 180 190 200
QQLYDHQQWT DARLAIEDFF WQAGDMADRI DDLQEDLNRN DFAEDVPLAR
210 220 230 240 250
HAIDHHNEMR KKITKLPIED LDMQGKKLLA KINAMAPPGG QAPTNSGGPD
260 270 280 290 300
MDSGPSSAGQ QSQPSQQSRS VGGNPDMSAA VNKALRQIEL IHTGQEKLLM
310 320 330 340 350
LWQHKKVKLD QCFQWRLFEQ DCEKMFDWIL HNRDVFQMSY VEIGHNYSVA
360 370 380 390 400
KSLQDEHQKF AVASMNVSVN IDRILAVAAR LIESQHYAAQ HIKTLAQRLD
410 420 430 440 450
RTWKDFAAGL DERTAVLQLS VLFHHKAEQY CNSVASWAAA CQASQPLPSD
460 470 480 490 500
IQSLETAIRT HQSLYEAMCQ AYTEVHSTSK KLLYQLDHLV QVCNQPPPPG
510 520 530 540 550
VPDHRKNSNN GSFNKYERQN PAADYSEGAS HVLAVIHQIL SHHRTLEAKW
560 570 580 590 600
HQERLRLHQT LALRLFQEDV KQVLDWLKNH GEVFLRKNTG IGRNFHKARV
610 620 630 640 650
YQTSHDNFEN VAQNTYSNAQ KLLAAADELA RSGEADPNEI YSVARELELQ
660 670 680 690 700
VGSFAERVEQ RRRRLDMAVI FYTHEKDVTA WIDKLRTDVS TDETRLSQEN
710 720 730 740 750
LEGIERILQQ YQRDQQESSV NVCLTTISQG EALLQEMRSL EYADNTGSIA
760 770 780 790 800
ALEATLEKLN KQKVELEELW SARKFRADLI LRLRYFERDA RLLSVQMEMW
810 820 830 840 850
SEELQHADLS RDYQKAEQLI RMHNESVTEI QNATYEVVQQ GQDLLQLFEN
860 870 880 890 900
AGFISMADAT HTAQARIEYL LDFLREREID LEEMSEAKRA KLEQAVQLCQ
910 920 930 940 950
FQNDANQVIS WIRNGEAMLV ASFVTPNSLQ EAEQLRKGHE QFQIAIEKTH
960 970 980 990 1000
TSAVQVKYRA DALINANHYD PLSIDEISDD VTKKWQQLVT YAEERHKLVT
1010 1020 1030 1040 1050
ASINFYKTAE QVCSVLDSLE REYKREDDWC DGGGGSDKAQ AIVQLISKHQ
1060 1070 1080 1090 1100
EQKEAFLKAC TLARRTAETF LKYANRSQQC YQYKGNCEGH VKSKLDKLLT
1110 1120 1130 1140 1150
QENQVLDYWT LRKKSLDQCQ QFVLFERSAK QAIEWIHNTG EAYLSSRSNL
1160 1170 1180 1190 1200
VGISKEETEG LLKEHNEFRS TAKETRERVK LLIQLADSLV EKGHAHASDI
1210 1220 1230 1240 1250
KQWVASVDQR YKDFSNRMDS YCEQLEKSLG MSQQQLLLGS DGNSSISSSS
1260 1270 1280 1290 1300
GDRHSDPTLE AKLNSSNKEN KEINEEKRKS ARRKEFIMAE LMQTERAYVN
1310 1320 1330 1340 1350
DLATCIKCFL EEFRAGKSVP SALIGQEDVI FGNIKEIHHF HQKIFLRELE
1360 1370 1380 1390 1400
KYETMPEDVG HCFVTWASKF DMYVHYCKNK PTSNNLLVQH GGSFFEELQR
1410 1420 1430 1440 1450
RLEVDHPLPA YLIKPVQRIT KYQLLLKDLL SCCEESHGEI KEGLEVMLNV
1460 1470 1480 1490 1500
PKKANDAMHL SLLENCDVSV DKLGEVVLQD AFQAWDTKQI IRKGRERRVF
1510 1520 1530 1540 1550
LFELYLLFAK EVKESNVVKY QFKSKLMTTD MGITEHIEGD ETKFAVWTGR
1560 1570 1580 1590 1600
SPMLSDCRIV LKATSLETKQ IWVKKLREVM QETCFSGTSL TLPKSPAKHS
1610 1620 1630 1640 1650
GSSQRSSRDL DEQLTENDHD RCSLASFGSG NTTDSDNKLG NQEATWVVAD
1660 1670 1680 1690 1700
YIATSGSNEL SVSKGQQVEI VEPPTAGEPD FCLVRLNPQH DDAAVQEGLV
1710 1720 1730 1740 1750
PVSVLKPPPG SHKHGSGTAA NAASSAGSQK SDMQDQSNRS KADALSSSTK
1760 1770 1780 1790 1800
RRGFSGRNWL PLMNRKGTDK PPSSKPLVKK PSEKNLRTPQ KHAEELAEQQ
1810 1820 1830 1840 1850
NQQPGASPAT VLPSSQFPSS TQHPGGAGAG DYEPDEEVGL ELPPPMKPIQ
1860 1870 1880 1890 1900
EPHLIANGPP AFAKDAKESS GNMASPGKMD GNPLSEIEEI VKTTTEQHES
1910 1920 1930 1940 1950
NSRVDGGGGV ENASTNGHGR SHDNNDESHT AVSDKAAALK KRQCVFAELM
1960 1970 1980 1990 2000
STEEAYVQDL HEIVNGYMTE INNTNSDIPM PEDLKGGKMK LVFNNIKDIY
2010 2020 2030 2040 2050
EWHRDFFLRA LRNCQKSPAD LGPLIKRSAT KFALYYTYCS NKPLSEYIVS
2060 2070 2080 2090 2100
AHYQYFDSIR QKLGHRLDLS NLIIKPVQRI TKYELLIKEI IKATEGAGLY
2110 2120 2130 2140 2150
KEVPMLQEAY QQMKVVVKTV NDMMVVLRSL QDFDGEITAQ GSLLMQGPMN
2160 2170 2180 2190 2200
CVVDAAQKHR ELQVFLFQQI IIFADIEKTK NQYASPIFKY RSHIQLNHMQ
2210 2220 2230 2240 2250
MKELGDCRFQ IRSTDPKIPE MTIICQAASQ ENYAGWRDML NKILQQQNDL
2260
IFMLSNPLST KNK
Length:2,263
Mass (Da):256,976
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7884E9858A8439F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IRI5Q8IRI5_DROME
Trio, isoform D
trio 03, 0368, 06, 06], 0959
804Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7YZA0Q7YZA0_DROME
Trio, isoform B
trio 03, 0368, 06, 06], 0959
658Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IRI4Q8IRI4_DROME
FI18839p1
trio 03, 0368, 06, 06], 0959
398Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47436.3
AE014296 Genomic DNA Translation: AAN11455.1

NCBI Reference Sequences

More...
RefSeqi
NP_651960.2, NM_143703.3
NP_728560.1, NM_167847.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072644; FBpp0072539; FBgn0024277
FBtr0072645; FBpp0072540; FBgn0024277

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43974

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG18214

UCSC genome browser

More...
UCSCi
CG18214-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47436.3
AE014296 Genomic DNA Translation: AAN11455.1
RefSeqiNP_651960.2, NM_143703.3
NP_728560.1, NM_167847.2

3D structure databases

SMRiQ7KVD1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ7KVD1, 6 interactors
STRINGi7227.FBpp0072539

Proteomic databases

PRIDEiQ7KVD1

Genome annotation databases

EnsemblMetazoaiFBtr0072644; FBpp0072539; FBgn0024277
FBtr0072645; FBpp0072540; FBgn0024277
GeneIDi43974
KEGGidme:Dmel_CG18214
UCSCiCG18214-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7204
FlyBaseiFBgn0024277 trio

Phylogenomic databases

eggNOGiKOG0689 Eukaryota
KOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00940000170624
KOiK08810
OMAiMDWIENH
OrthoDBi5761at2759

Enzyme and pathway databases

ReactomeiR-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-416476 G alpha (q) signalling events
R-DME-416482 G alpha (12/13) signalling events

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43974

Gene expression databases

BgeeiFBgn0024277 Expressed in 35 organ(s), highest expression level in antenna
ExpressionAtlasiQ7KVD1 differential

Family and domain databases

CDDicd00160 RhoGEF, 2 hits
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 2 hits
2.30.29.30, 2 hits
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR028570 TRIO
PANTHERiPTHR22826:SF104 PTHR22826:SF104, 3 hits
PfamiView protein in Pfam
PF00621 RhoGEF, 2 hits
PF00435 Spectrin, 3 hits
SMARTiView protein in SMART
SM00233 PH, 2 hits
SM00325 RhoGEF, 2 hits
SM00516 SEC14, 1 hit
SM00150 SPEC, 7 hits
SUPFAMiSSF48065 SSF48065, 2 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 2 hits
PS50003 PH_DOMAIN, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7KVD1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KVD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 13, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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