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Entry version 105 (16 Jan 2019)
Sequence version 1 (01 Oct 2003)
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Protein
Submitted name:

Notch

Gene

N

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NotchImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NImported
ORF Names:CG3936Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004647 N

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1 ↔ 10PROSITE-ProRule annotation
Disulfide bondi42 ↔ 51PROSITE-ProRule annotation
Disulfide bondi82 ↔ 91PROSITE-ProRule annotation
Disulfide bondi102 ↔ 119PROSITE-ProRule annotation
Disulfide bondi121 ↔ 130PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7YSR5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004647 Expressed in 30 organ(s), highest expression level in embryo

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 11EGF-likeInterPro annotationAdd BLAST11
Domaini12 – 52EGF-likeInterPro annotationAdd BLAST41
Domaini55 – 92EGF-likeInterPro annotationAdd BLAST38
Domaini93 – 131EGF-likeInterPro annotationAdd BLAST39
Domaini133 – 155EGF-likeInterPro annotationAdd BLAST23

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q7YSR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CDSHYVGDYC EHRNPCNSMR CQNGGTCQVT FRNGRPGISC KCPLGFDESL
60 70 80 90 100
CEIAVPNACD HVTCLNGGTC QLKTLEEYTC ACANGYTGER CETKNLCASS
110 120 130 140 150
PCRNGATCTA LAGSSSFTCS CPPGFTGDTC SYDIEECQSN PCKYGGTCVN

THGSY
Length:155
Mass (Da):16,462
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A4BBBACCD012675
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei155Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF361372 Genomic DNA Translation: AAL72219.1
AF361373 Genomic DNA Translation: AAL72220.1
AF361374 Genomic DNA Translation: AAL72221.1
AF361375 Genomic DNA Translation: AAL72222.1
AF361376 Genomic DNA Translation: AAL72223.1
AF361377 Genomic DNA Translation: AAL72224.1
AF361378 Genomic DNA Translation: AAL72225.1
AF361379 Genomic DNA Translation: AAL72226.1
AF361380 Genomic DNA Translation: AAL72227.1
AF361381 Genomic DNA Translation: AAL72228.1
AF361382 Genomic DNA Translation: AAL72229.1
AF361383 Genomic DNA Translation: AAL72230.1
AF361384 Genomic DNA Translation: AAL72231.1
AF361385 Genomic DNA Translation: AAL72232.1
AF361386 Genomic DNA Translation: AAL72233.1
AF361387 Genomic DNA Translation: AAL72234.1
AF361388 Genomic DNA Translation: AAL72235.1
AF361389 Genomic DNA Translation: AAL72236.1
AF361390 Genomic DNA Translation: AAL72237.1
AF361391 Genomic DNA Translation: AAL72238.1
AF361392 Genomic DNA Translation: AAL72239.1
AF361393 Genomic DNA Translation: AAL72240.1
AF361394 Genomic DNA Translation: AAL72241.1
AF361395 Genomic DNA Translation: AAL72242.1
AF361396 Genomic DNA Translation: AAL72243.1
AF361397 Genomic DNA Translation: AAL72244.1
AF361398 Genomic DNA Translation: AAL72245.1
AF361399 Genomic DNA Translation: AAL72246.1
AF361400 Genomic DNA Translation: AAL72247.1
AF361401 Genomic DNA Translation: AAL72248.1
AF361402 Genomic DNA Translation: AAL72249.1
AF361403 Genomic DNA Translation: AAL72250.1
AF361404 Genomic DNA Translation: AAL72251.1
AF361405 Genomic DNA Translation: AAL72252.1
AF361406 Genomic DNA Translation: AAL72253.1
AF361407 Genomic DNA Translation: AAL72254.1
AF361408 Genomic DNA Translation: AAL72255.1
AF361409 Genomic DNA Translation: AAL72256.1
AF361410 Genomic DNA Translation: AAL72257.1
AF361411 Genomic DNA Translation: AAL72258.1
AF361412 Genomic DNA Translation: AAL72259.1
AF361413 Genomic DNA Translation: AAL72260.1
AF361414 Genomic DNA Translation: AAL72261.1
AF361415 Genomic DNA Translation: AAL72262.1
AF361416 Genomic DNA Translation: AAL72263.1
AF361418 Genomic DNA Translation: AAL72265.1
AF361419 Genomic DNA Translation: AAL72266.1
AF361420 Genomic DNA Translation: AAL72267.1
AF361421 Genomic DNA Translation: AAL72268.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361372 Genomic DNA Translation: AAL72219.1
AF361373 Genomic DNA Translation: AAL72220.1
AF361374 Genomic DNA Translation: AAL72221.1
AF361375 Genomic DNA Translation: AAL72222.1
AF361376 Genomic DNA Translation: AAL72223.1
AF361377 Genomic DNA Translation: AAL72224.1
AF361378 Genomic DNA Translation: AAL72225.1
AF361379 Genomic DNA Translation: AAL72226.1
AF361380 Genomic DNA Translation: AAL72227.1
AF361381 Genomic DNA Translation: AAL72228.1
AF361382 Genomic DNA Translation: AAL72229.1
AF361383 Genomic DNA Translation: AAL72230.1
AF361384 Genomic DNA Translation: AAL72231.1
AF361385 Genomic DNA Translation: AAL72232.1
AF361386 Genomic DNA Translation: AAL72233.1
AF361387 Genomic DNA Translation: AAL72234.1
AF361388 Genomic DNA Translation: AAL72235.1
AF361389 Genomic DNA Translation: AAL72236.1
AF361390 Genomic DNA Translation: AAL72237.1
AF361391 Genomic DNA Translation: AAL72238.1
AF361392 Genomic DNA Translation: AAL72239.1
AF361393 Genomic DNA Translation: AAL72240.1
AF361394 Genomic DNA Translation: AAL72241.1
AF361395 Genomic DNA Translation: AAL72242.1
AF361396 Genomic DNA Translation: AAL72243.1
AF361397 Genomic DNA Translation: AAL72244.1
AF361398 Genomic DNA Translation: AAL72245.1
AF361399 Genomic DNA Translation: AAL72246.1
AF361400 Genomic DNA Translation: AAL72247.1
AF361401 Genomic DNA Translation: AAL72248.1
AF361402 Genomic DNA Translation: AAL72249.1
AF361403 Genomic DNA Translation: AAL72250.1
AF361404 Genomic DNA Translation: AAL72251.1
AF361405 Genomic DNA Translation: AAL72252.1
AF361406 Genomic DNA Translation: AAL72253.1
AF361407 Genomic DNA Translation: AAL72254.1
AF361408 Genomic DNA Translation: AAL72255.1
AF361409 Genomic DNA Translation: AAL72256.1
AF361410 Genomic DNA Translation: AAL72257.1
AF361411 Genomic DNA Translation: AAL72258.1
AF361412 Genomic DNA Translation: AAL72259.1
AF361413 Genomic DNA Translation: AAL72260.1
AF361414 Genomic DNA Translation: AAL72261.1
AF361415 Genomic DNA Translation: AAL72262.1
AF361416 Genomic DNA Translation: AAL72263.1
AF361418 Genomic DNA Translation: AAL72265.1
AF361419 Genomic DNA Translation: AAL72266.1
AF361420 Genomic DNA Translation: AAL72267.1
AF361421 Genomic DNA Translation: AAL72268.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ7YSR5

Organism-specific databases

FlyBaseiFBgn0004647 N

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
N fly

Gene expression databases

BgeeiFBgn0004647 Expressed in 30 organ(s), highest expression level in embryo

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PfamiView protein in Pfam
PF00008 EGF, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 4 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7YSR5_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7YSR5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: January 16, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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