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Entry version 121 (16 Oct 2019)
Sequence version 2 (02 Sep 2008)
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Protein

Trafficking protein particle complex subunit 11

Gene

TRAPPC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC11
Synonyms:C4orf41
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25751 TRAPPC11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614138 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z392

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Muscular dystrophy, limb-girdle, autosomal recessive 18 (LGMDR18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of limb-girdle muscular dystrophy characterized by proximal muscle weakness with childhood onset, resulting in gait abnormalities and scapular winging. Serum creatine kinase is increased. A subset of patients may show a hyperkinetic movement disorder with chorea, ataxia, or dystonia and global developmental delay.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070158980G → R in LGMDR18. 1 PublicationCorresponds to variant dbSNP:rs397509417EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
60684

MalaCards human disease database

More...
MalaCardsi
TRAPPC11
MIMi615356 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000168538

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
369840 Autosomal recessive limb-girdle muscular dystrophy type 2S
369847 Intellectual disability-hyperkinetic movement-truncal ataxia syndrome
869 Triple A syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379849

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z392

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAPPC11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205696378

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003480721 – 1133Trafficking protein particle complex subunit 11Add BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei245N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z392

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z392

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z392

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z392

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z392

PeptideAtlas

More...
PeptideAtlasi
Q7Z392

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z392

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69012 [Q7Z392-1]
69013 [Q7Z392-2]
69014 [Q7Z392-3]
69015 [Q7Z392-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z392

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z392

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168538 Expressed in 213 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z392 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z392 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045427

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121957, 55 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q7Z392

Database of interacting proteins

More...
DIPi
DIP-48282N

Protein interaction database and analysis system

More...
IntActi
Q7Z392, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000335371

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAPPC11 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4386 Eukaryota
ENOG410XSTE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006550

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z392

KEGG Orthology (KO)

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KOi
K20308

Identification of Orthologs from Complete Genome Data

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OMAi
FMLPFRR

Database of Orthologous Groups

More...
OrthoDBi
1065648at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z392

TreeFam database of animal gene trees

More...
TreeFami
TF314022

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021773 TPC11
IPR025876 TRAPPC11_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11817 Foie-gras_1, 1 hit
PF12742 Gryzun-like, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z392-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPTQWDFPV ELCCRPMAFV TLTGLDVVYN AVHRAVWDAF CANRRADRVP
60 70 80 90 100
ISFKVLPGDH EYPKCRPKRT SYEWYIPKGI LKTGWMNKHL NLVPALVVVF
110 120 130 140 150
YELDWDEPQW KEKQSECATR VEIVRQSLQG RNTKVAVVLI QKKTPLPPGE
160 170 180 190 200
DVIASERAAA LCNACELSGK SLFVLPHTDH LVGYIIRLEN AFYEHAQTYY
210 220 230 240 250
YTEIRRVKSH KEFLNKTTHQ LLFVRHQFKI AFFSELKQDT QNALKNYRTA
260 270 280 290 300
YNLVHELRAH ETNILEIKTM AGFINYKICR LCFQHNTPLD AIAQFRKHID
310 320 330 340 350
LCKKKIGSAE LSFEHDAWMS KQFQAFGDLF DEAIKLGLTA IQTQNPGFYY
360 370 380 390 400
QQAAYYAQER KQLAKTLCNH EASVMYPNPD PLETQTGVLD FYGQRSWRQG
410 420 430 440 450
ILSFDLSDPE KEKVGILAIQ LKERNVVHSE IIITLLSNAV AQFKKYKCPR
460 470 480 490 500
MKSHLMVQMG EEYYYAKDYT KALKLLDYVM CDYRSEGWWT LLTSVLTTAL
510 520 530 540 550
KCSYLMAQLK DYITYSLELL GRASTLKDDQ KSRIEKNLIN VLMNESPDPE
560 570 580 590 600
PDCDILAVKT AQKLWADRIS LAGSNIFTIG VQDFVPFVQC KAKFHAPSFH
610 620 630 640 650
VDVPVQFDIY LKADCPHPIR FSKLCVSFNN QEYNQFCVIE EASKANEVLE
660 670 680 690 700
NLTQGKMCLV PGKTRKLLFK FVAKTEDVGK KIEITSVDLA LGNETGRCVV
710 720 730 740 750
LNWQGGGGDA ASSQEALQAA RSFKRRPKLP DNEVHWDSII IQASTMIISR
760 770 780 790 800
VPNISVHLLH EPPALTNEMY CLVVTVQSHE KTQIRDVKLT AGLKPGQDAN
810 820 830 840 850
LTQKTHVTLH GTELCDESYP ALLTDIPVGD LHPGEQLEKM LYVRCGTVGS
860 870 880 890 900
RMFLVYVSYL INTTVEEKEI VCKCHKDETV TIETVFPFDV AVKFVSTKFE
910 920 930 940 950
HLERVYADIP FLLMTDLLSA SPWALTIVSS ELQLAPSMTT VDQLESQVDN
960 970 980 990 1000
VILQTGESAS ECFCLQCPSL GNIEGGVATG HYIISWKRTS AMENIPIITT
1010 1020 1030 1040 1050
VITLPHVIVE NIPLHVNADL PSFGRVRESL PVKYHLQNKT DLVQDVEISV
1060 1070 1080 1090 1100
EPSDAFMFSG LKQIRLRILP GTEQEMLYNF YPLMAGYQQL PSLNINLLRF
1110 1120 1130
PNFTNQLLRR FIPTSIFVKP QGRLMDDTSI AAA
Length:1,133
Mass (Da):128,881
Last modified:September 2, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6048FB396E946D4A
GO
Isoform 2 (identifier: Q7Z392-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-656: Missing.
     1067-1086: RILPGTEQEMLYNFYPLMAG → PAQAFYTYQYFCQATGSTHG
     1087-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):47,632
Checksum:i727C5FC79B7310A9
GO
Isoform 3 (identifier: Q7Z392-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1067-1086: RILPGTEQEMLYNFYPLMAG → PAQAFYTYQYFCQATGSTHG
     1087-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:1,086
Mass (Da):123,376
Checksum:i12B530B43141DEFE
GO
Isoform 4 (identifier: Q7Z392-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     962-1018: CFCLQCPSLG...VENIPLHVNA → LYYLLEKDLS...VVTCQVSPTE
     1019-1133: Missing.

Note: No experimental confirmation available.
Show »
Length:1,018
Mass (Da):115,985
Checksum:i077A324FCE23D967
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHE5D6RHE5_HUMAN
Trafficking protein particle comple...
TRAPPC11
739Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9T9D6R9T9_HUMAN
Trafficking protein particle comple...
TRAPPC11
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14240 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14556 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15617 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAG37533 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB66686 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD91169 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAD97983 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70T → A in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti197Q → L in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti312S → F in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti397W → R in BAG37533 (PubMed:14702039).Curated1
Sequence conflicti467K → E in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti544N → K in BAB15617 (PubMed:14702039).Curated1
Sequence conflicti660V → L in AAH51724 (PubMed:15489334).Curated1
Sequence conflicti661P → L in BAB15617 (PubMed:14702039).Curated1
Sequence conflicti697R → K in CAG38584 (Ref. 4) Curated1
Sequence conflicti723 – 744Missing in BAB14556 (PubMed:14702039).CuratedAdd BLAST22
Sequence conflicti812T → P in CAD91169 (PubMed:17974005).Curated1
Sequence conflicti812T → P in CAG38584 (Ref. 4) Curated1
Sequence conflicti812T → P in CAB66686 (PubMed:11230166).Curated1
Sequence conflicti842Y → C in BAB15617 (PubMed:14702039).Curated1
Sequence conflicti865V → I in BAB14240 (PubMed:14702039).Curated1
Sequence conflicti869E → G in BAB14556 (PubMed:14702039).Curated1
Sequence conflicti1011N → S in BAB14240 (PubMed:14702039).Curated1
Sequence conflicti1030L → S in BAB14556 (PubMed:14702039).Curated1
Sequence conflicti1112I → L in CAD97983 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078126381P → A Found in a patient with congenital disorder of glycosylation; unknown pathological significance. 1 Publication1
Natural variantiVAR_070158980G → R in LGMDR18. 1 PublicationCorresponds to variant dbSNP:rs397509417EnsemblClinVar.1
Natural variantiVAR_0781271104T → A Found in a patient with congenital disorder of glycosylation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs78663235EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0350951 – 656Missing in isoform 2. 1 PublicationAdd BLAST656
Alternative sequenceiVSP_035096962 – 1018CFCLQ…LHVNA → LYYLLEKDLSNGEYPHHHNC HHSAARDCGEYPSPCECRSA VIWACQRVVTCQVSPTE in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_0350971019 – 1133Missing in isoform 4. 1 PublicationAdd BLAST115
Alternative sequenceiVSP_0350981067 – 1086RILPG…PLMAG → PAQAFYTYQYFCQATGSTHG in isoform 2 and isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0350991087 – 1133Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL833571 mRNA Translation: CAD91169.1 Different initiation.
BX538044 mRNA Translation: CAD97983.1 Different initiation.
BC051724 mRNA Translation: AAH51724.1
BC139745 mRNA Translation: AAI39746.1
AK022778 mRNA Translation: BAB14240.1 Different initiation.
AK023390 mRNA Translation: BAB14556.1 Different initiation.
AK026992 mRNA Translation: BAB15617.1 Sequence problems.
AK315057 mRNA Translation: BAG37533.1 Different initiation.
CR533553 mRNA Translation: CAG38584.1
AL136752 mRNA Translation: CAB66686.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34112.1 [Q7Z392-1]
CCDS47166.1 [Q7Z392-3]

NCBI Reference Sequences

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RefSeqi
NP_068761.4, NM_021942.5 [Q7Z392-1]
NP_951008.1, NM_199053.2 [Q7Z392-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000334690; ENSP00000335371; ENSG00000168538 [Q7Z392-1]
ENST00000357207; ENSP00000349738; ENSG00000168538 [Q7Z392-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
60684

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:60684

UCSC genome browser

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UCSCi
uc003ivw.3 human [Q7Z392-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833571 mRNA Translation: CAD91169.1 Different initiation.
BX538044 mRNA Translation: CAD97983.1 Different initiation.
BC051724 mRNA Translation: AAH51724.1
BC139745 mRNA Translation: AAI39746.1
AK022778 mRNA Translation: BAB14240.1 Different initiation.
AK023390 mRNA Translation: BAB14556.1 Different initiation.
AK026992 mRNA Translation: BAB15617.1 Sequence problems.
AK315057 mRNA Translation: BAG37533.1 Different initiation.
CR533553 mRNA Translation: CAG38584.1
AL136752 mRNA Translation: CAB66686.1 Different initiation.
CCDSiCCDS34112.1 [Q7Z392-1]
CCDS47166.1 [Q7Z392-3]
RefSeqiNP_068761.4, NM_021942.5 [Q7Z392-1]
NP_951008.1, NM_199053.2 [Q7Z392-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121957, 55 interactors
CORUMiQ7Z392
DIPiDIP-48282N
IntActiQ7Z392, 12 interactors
STRINGi9606.ENSP00000335371

PTM databases

iPTMnetiQ7Z392
PhosphoSitePlusiQ7Z392

Polymorphism and mutation databases

BioMutaiTRAPPC11
DMDMi205696378

Proteomic databases

EPDiQ7Z392
jPOSTiQ7Z392
MassIVEiQ7Z392
MaxQBiQ7Z392
PaxDbiQ7Z392
PeptideAtlasiQ7Z392
PRIDEiQ7Z392
ProteomicsDBi69012 [Q7Z392-1]
69013 [Q7Z392-2]
69014 [Q7Z392-3]
69015 [Q7Z392-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
60684

Genome annotation databases

EnsembliENST00000334690; ENSP00000335371; ENSG00000168538 [Q7Z392-1]
ENST00000357207; ENSP00000349738; ENSG00000168538 [Q7Z392-3]
GeneIDi60684
KEGGihsa:60684
UCSCiuc003ivw.3 human [Q7Z392-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
60684
DisGeNETi60684

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAPPC11
HGNCiHGNC:25751 TRAPPC11
HPAiHPA045427
MalaCardsiTRAPPC11
MIMi614138 gene
615356 phenotype
neXtProtiNX_Q7Z392
OpenTargetsiENSG00000168538
Orphaneti369840 Autosomal recessive limb-girdle muscular dystrophy type 2S
369847 Intellectual disability-hyperkinetic movement-truncal ataxia syndrome
869 Triple A syndrome
PharmGKBiPA162379849

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4386 Eukaryota
ENOG410XSTE LUCA
GeneTreeiENSGT00390000006550
InParanoidiQ7Z392
KOiK20308
OMAiFMLPFRR
OrthoDBi1065648at2759
PhylomeDBiQ7Z392
TreeFamiTF314022

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRAPPC11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
60684
PharosiQ7Z392

Protein Ontology

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PROi
PR:Q7Z392

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168538 Expressed in 213 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ7Z392 baseline and differential
GenevisibleiQ7Z392 HS

Family and domain databases

InterProiView protein in InterPro
IPR021773 TPC11
IPR025876 TRAPPC11_C
PfamiView protein in Pfam
PF11817 Foie-gras_1, 1 hit
PF12742 Gryzun-like, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPC11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z392
Secondary accession number(s): A4QPB8
, B2RCD6, Q5U5I7, Q6FI73, Q86T25, Q9H0L1, Q9H5K9, Q9H8Q1, Q9H9I7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 16, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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