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Entry version 144 (18 Sep 2019)
Sequence version 2 (24 May 2004)
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Protein

Peroxisome assembly protein 26

Gene

PEX26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9033241 Peroxisomal protein import
R-HSA-9603798 Class I peroxisomal membrane protein import

SIGNOR Signaling Network Open Resource

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SIGNORi
Q7Z412

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.20.1.1 the peroxisomal protein importer (ppi) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome assembly protein 26
Alternative name(s):
Peroxin-26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEX26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22965 PEX26

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608666 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z412

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 246CytoplasmicSequence analysisAdd BLAST246
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei247 – 267Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini268 – 305Peroxisomal matrixSequence analysisAdd BLAST38

Keywords - Cellular componenti

Membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Peroxisome biogenesis disorder complementation group 8 (PBD-CG8)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01864998R → W in PBD7B and PBD-CG8; neonatal adrenoleukodystrophy; affects the interaction with PEX6. 3 PublicationsCorresponds to variant dbSNP:rs62641228EnsemblClinVar.1
Peroxisome biogenesis disorder 7A (PBD7A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01864889G → R in PBD7A. 1 PublicationCorresponds to variant dbSNP:rs28940308EnsemblClinVar.1
Peroxisome biogenesis disorder 7B (PBD7B)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA peroxisome biogenesis disorder that includes neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD), two milder manifestations of the Zellweger disease spectrum. The clinical course of patients with the NALD and IRD presentation is variable and may include developmental delay, hypotonia, liver dysfunction, sensorineural hearing loss, retinal dystrophy and vision impairment. Children with the NALD presentation may reach their teens, while patients with the IRD presentation may reach adulthood. The clinical conditions are often slowly progressive in particular with respect to loss of hearing and vision. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01864745L → P in PBD7B; infantile Refsum disease. 1 PublicationCorresponds to variant dbSNP:rs61752132EnsemblClinVar.1
Natural variantiVAR_01864998R → W in PBD7B and PBD-CG8; neonatal adrenoleukodystrophy; affects the interaction with PEX6. 3 PublicationsCorresponds to variant dbSNP:rs62641228EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Peroxisome biogenesis disorder, Zellweger syndrome

Organism-specific databases

DisGeNET

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DisGeNETi
55670

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
PEX26

MalaCards human disease database

More...
MalaCardsi
PEX26
MIMi614872 phenotype
614873 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000215193

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
772 Infantile Refsum disease
44 Neonatal adrenoleukodystrophy
912 Zellweger syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134983458

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PEX26

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47606028

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000583401 – 305Peroxisome assembly protein 26Add BLAST305

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z412

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z412

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z412

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z412

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z412

PeptideAtlas

More...
PeptideAtlasi
Q7Z412

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z412

ProteomicsDB human proteome resource

More...
ProteomicsDBi
28013
69127 [Q7Z412-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z412

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z412

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in kidney, liver, brain and skeletal muscles. Expressed at intermediate level in pancreas, placenta and heart. Weakly expressed in lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000215193 Expressed in 203 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z412 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z412 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB070429

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with PEX6 via its cytoplasmic domain.

Interacts indirectly with PEX1, via its interaction with PEX6.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120802, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q7Z412

Protein interaction database and analysis system

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IntActi
Q7Z412, 6 interactors

Molecular INTeraction database

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MINTi
Q7Z412

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331106

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z412

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxin-26 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEAS Eukaryota
ENOG4111ZGY LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000049725

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z412

KEGG Orthology (KO)

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KOi
K13340

Identification of Orthologs from Complete Genome Data

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OMAi
LAEMNRW

Database of Orthologous Groups

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OrthoDBi
1053354at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z412

TreeFam database of animal gene trees

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TreeFami
TF332318

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR010797 Pex26

The PANTHER Classification System

More...
PANTHERi
PTHR16262 PTHR16262, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07163 Pex26, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z412-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSDSSTSAA PLRGLGGPLR SSEPVRAVPA RAPAVDLLEE AADLLVVHLD
60 70 80 90 100
FRAALETCER AWQSLANHAV AEEPAGTSLE VKCSLCVVGI QALAEMDRWQ
110 120 130 140 150
EVLSWVLQYY QVPEKLPPKV LELCILLYSK MQEPGAVLDV VGAWLQDPAN
160 170 180 190 200
QNLPEYGALA EFHVQRVLLP LGCLSEAEEL VVGSAAFGEE RRLDVLQAIH
210 220 230 240 250
TARQQQKQEH SGSEEAQKPN LEGSVSHKFL SLPMLVRQLW DSAVSHFFSL
260 270 280 290 300
PFKKSLLAAL ILCLLVVRFD PASPSSLHFL YKLAQLFRWI RKAAFSRLYQ

LRIRD
Length:305
Mass (Da):33,898
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B9FCF8E2B3178E1
GO
Isoform 2 (identifier: Q7Z412-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     223-271: Missing.

Note: No experimental confirmation available.
Show »
Length:256
Mass (Da):28,388
Checksum:iD53D85F08A6DA5BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PRC5E9PRC5_HUMAN
Peroxisome assembly protein 26
PEX26
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90920 differs from that shown. Reason: Erroneous termination at position 253. Translated as Lys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti304R → H in AAH16280 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01864745L → P in PBD7B; infantile Refsum disease. 1 PublicationCorresponds to variant dbSNP:rs61752132EnsemblClinVar.1
Natural variantiVAR_01864889G → R in PBD7A. 1 PublicationCorresponds to variant dbSNP:rs28940308EnsemblClinVar.1
Natural variantiVAR_01864998R → W in PBD7B and PBD-CG8; neonatal adrenoleukodystrophy; affects the interaction with PEX6. 3 PublicationsCorresponds to variant dbSNP:rs62641228EnsemblClinVar.1
Natural variantiVAR_034146153L → V1 PublicationCorresponds to variant dbSNP:rs12484657EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053499223 – 271Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB089678 mRNA Translation: BAC66616.1
AB103106 mRNA Translation: BAC78804.1
AB103107 mRNA Translation: BAC78805.1
AB103108 mRNA Translation: BAC78806.1
AB103109 mRNA Translation: BAC78807.1
AB103110 mRNA Translation: BAC78808.1
AK000065 mRNA Translation: BAA90920.1 Sequence problems.
AK000702 mRNA Translation: BAA91329.1
CR456362 mRNA Translation: CAG30248.1
AC008079 Genomic DNA No translation available.
AC016027 Genomic DNA No translation available.
BC016280 mRNA Translation: AAH16280.1
BC047320 mRNA Translation: AAH47320.1
BF930319 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13750.1 [Q7Z412-1]
CCDS56221.1 [Q7Z412-2]

NCBI Reference Sequences

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RefSeqi
NP_001121121.1, NM_001127649.2 [Q7Z412-1]
NP_001186248.1, NM_001199319.1 [Q7Z412-2]
NP_060399.1, NM_017929.5 [Q7Z412-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329627; ENSP00000331106; ENSG00000215193 [Q7Z412-1]
ENST00000399744; ENSP00000382648; ENSG00000215193 [Q7Z412-1]
ENST00000428061; ENSP00000412441; ENSG00000215193 [Q7Z412-2]
ENST00000610387; ENSP00000482091; ENSG00000215193 [Q7Z412-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55670

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55670

UCSC genome browser

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UCSCi
uc002znp.5 human [Q7Z412-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbPEX, PEX Gene Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089678 mRNA Translation: BAC66616.1
AB103106 mRNA Translation: BAC78804.1
AB103107 mRNA Translation: BAC78805.1
AB103108 mRNA Translation: BAC78806.1
AB103109 mRNA Translation: BAC78807.1
AB103110 mRNA Translation: BAC78808.1
AK000065 mRNA Translation: BAA90920.1 Sequence problems.
AK000702 mRNA Translation: BAA91329.1
CR456362 mRNA Translation: CAG30248.1
AC008079 Genomic DNA No translation available.
AC016027 Genomic DNA No translation available.
BC016280 mRNA Translation: AAH16280.1
BC047320 mRNA Translation: AAH47320.1
BF930319 mRNA No translation available.
CCDSiCCDS13750.1 [Q7Z412-1]
CCDS56221.1 [Q7Z412-2]
RefSeqiNP_001121121.1, NM_001127649.2 [Q7Z412-1]
NP_001186248.1, NM_001199319.1 [Q7Z412-2]
NP_060399.1, NM_017929.5 [Q7Z412-1]

3D structure databases

SMRiQ7Z412
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120802, 6 interactors
CORUMiQ7Z412
IntActiQ7Z412, 6 interactors
MINTiQ7Z412
STRINGi9606.ENSP00000331106

Protein family/group databases

TCDBi3.A.20.1.1 the peroxisomal protein importer (ppi) family

PTM databases

iPTMnetiQ7Z412
PhosphoSitePlusiQ7Z412

Polymorphism and mutation databases

BioMutaiPEX26
DMDMi47606028

Proteomic databases

EPDiQ7Z412
jPOSTiQ7Z412
MassIVEiQ7Z412
MaxQBiQ7Z412
PaxDbiQ7Z412
PeptideAtlasiQ7Z412
PRIDEiQ7Z412
ProteomicsDBi28013
69127 [Q7Z412-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55670
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329627; ENSP00000331106; ENSG00000215193 [Q7Z412-1]
ENST00000399744; ENSP00000382648; ENSG00000215193 [Q7Z412-1]
ENST00000428061; ENSP00000412441; ENSG00000215193 [Q7Z412-2]
ENST00000610387; ENSP00000482091; ENSG00000215193 [Q7Z412-2]
GeneIDi55670
KEGGihsa:55670
UCSCiuc002znp.5 human [Q7Z412-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55670
DisGeNETi55670

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PEX26
GeneReviewsiPEX26
HGNCiHGNC:22965 PEX26
HPAiCAB070429
MalaCardsiPEX26
MIMi608666 gene
614872 phenotype
614873 phenotype
neXtProtiNX_Q7Z412
OpenTargetsiENSG00000215193
Orphaneti772 Infantile Refsum disease
44 Neonatal adrenoleukodystrophy
912 Zellweger syndrome
PharmGKBiPA134983458

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEAS Eukaryota
ENOG4111ZGY LUCA
GeneTreeiENSGT00510000049725
InParanoidiQ7Z412
KOiK13340
OMAiLAEMNRW
OrthoDBi1053354at2759
PhylomeDBiQ7Z412
TreeFamiTF332318

Enzyme and pathway databases

ReactomeiR-HSA-9033241 Peroxisomal protein import
R-HSA-9603798 Class I peroxisomal membrane protein import
SIGNORiQ7Z412

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PEX26 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PEX26

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55670

Pharos

More...
Pharosi
Q7Z412

Protein Ontology

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PROi
PR:Q7Z412

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000215193 Expressed in 203 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ7Z412 baseline and differential
GenevisibleiQ7Z412 HS

Family and domain databases

InterProiView protein in InterPro
IPR010797 Pex26
PANTHERiPTHR16262 PTHR16262, 1 hit
PfamiView protein in Pfam
PF07163 Pex26, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEX26_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z412
Secondary accession number(s): F6UBB5
, Q7Z413, Q7Z414, Q7Z415, Q7Z416, Q96B12, Q9NWQ0, Q9NXU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: September 18, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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