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Entry version 146 (11 Dec 2019)
Sequence version 2 (18 Mar 2008)
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Protein

Centriolin

Gene

CNTRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants [Q7Z7A1-3]
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5655302 Signaling by FGFR1 in disease [Q7Z7A1-3]
R-HSA-8854518 AURKA Activation by TPX2

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q7Z7A1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centriolin
Alternative name(s):
Centrosomal protein 1
Centrosomal protein of 110 kDa
Short name:
Cep110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNTRL
Synonyms:CEP1, CEP110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119397.16

Human Gene Nomenclature Database

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HGNCi
HGNC:1858 CNTRL

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605496 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z7A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2139 – 2140Breakpoint for translocation to form CEP110-FGFR12

Organism-specific databases

DisGeNET

More...
DisGeNETi
11064

Open Targets

More...
OpenTargetsi
ENSG00000119397

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26414

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z7A1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CNTRL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172045911

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003236751 – 2325CentriolinAdd BLAST2325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei831PhosphoserineCombined sources1
Modified residuei1475PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z7A1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z7A1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z7A1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7Z7A1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z7A1

PeptideAtlas

More...
PeptideAtlasi
Q7Z7A1

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z7A1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69493 [Q7Z7A1-1]
69494 [Q7Z7A1-2]
69495 [Q7Z7A1-3]
69496 [Q7Z7A1-4]
69497 [Q7Z7A1-5]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q7Z7A1

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z7A1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z7A1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in testis and trachea.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119397 Expressed in 202 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z7A1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z7A1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020468
HPA020480
HPA051583

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HOOK2.

Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116248, 162 interactors

Database of interacting proteins

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DIPi
DIP-47280N

Protein interaction database and analysis system

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IntActi
Q7Z7A1, 183 interactors

Molecular INTeraction database

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MINTi
Q7Z7A1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362962

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z7A1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z7A1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati126 – 147LRR 1Add BLAST22
Repeati148 – 169LRR 2Add BLAST22
Repeati170 – 191LRR 3Add BLAST22
Repeati194 – 215LRR 4Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 266LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1948 – 2118Required for centrosome localizationAdd BLAST171
Regioni1985 – 2325Sufficient for interaction with HOOK21 PublicationAdd BLAST341

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili267 – 343Sequence analysisAdd BLAST77
Coiled coili435 – 799Sequence analysisAdd BLAST365
Coiled coili851 – 1101Sequence analysisAdd BLAST251
Coiled coili1317 – 2255Sequence analysisAdd BLAST939

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi956 – 959Poly-Lys4
Compositional biasi1147 – 1150Poly-Pro4
Compositional biasi1236 – 1307Pro-richAdd BLAST72

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155434

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z7A1

KEGG Orthology (KO)

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KOi
K16770

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQMQHEY

Database of Orthologous Groups

More...
OrthoDBi
79816at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z7A1

TreeFam database of animal gene trees

More...
TreeFami
TF101135

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR34491:SF2 PTHR34491:SF2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51450 LRR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z7A1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKGSQQKIF SKAKIPSSSH SPIPSSMSNM RSRSLSPLIG SETLPFHSGG
60 70 80 90 100
QWCEQVEIAD ENNMLLDYQD HKGADSHAGV RYITEALIKK LTKQDNLALI
110 120 130 140 150
KSLNLSLSKD GGKKFKYIEN LEKCVKLEVL NLSYNLIGKI EKLDKLLKLR
160 170 180 190 200
ELNLSYNKIS KIEGIENMCN LQKLNLAGNE IEHIPVWLGK KLKSLRVLNL
210 220 230 240 250
KGNKISSLQD ISKLKPLQDL ISLILVENPV VTLPHYLQFT IFHLRSLESL
260 270 280 290 300
EGQPVTTQDR QEAFERFSLE EVERLERDLE KKMIETEELK SKQTRFLEEI
310 320 330 340 350
KNQDKLNKSL KEEAMLQKQS CEELKSDLNT KNELLKQKTI ELTRACQKQY
360 370 380 390 400
ELEQELAFYK IDAKFEPLNY YPSEYAEIDK APDESPYIGK SRYKRNMFAT
410 420 430 440 450
ESYIIDSAQA VQIKKMEPDE QLRNDHMNLR GHTPLDTQLE DKEKKISAAQ
460 470 480 490 500
TRLSELHDEI EKAEQQILRA TEEFKQLEEA IQLKKISEAG KDLLYKQLSG
510 520 530 540 550
RLQLVNKLRQ EALDLELQME KQKQEIAGKQ KEIKDLQIAI DSLDSKDPKH
560 570 580 590 600
SHMKAQKSGK EQQLDIMNKQ YQQLESRLDE ILSRIAKETE EIKDLEEQLT
610 620 630 640 650
EGQIAANEAL KKDLEGVISG LQEYLGTIKG QATQAQNECR KLRDEKETLL
660 670 680 690 700
QRLTEVEQER DQLEIVAMDA ENMRKELAEL ESALQEQHEV NASLQQTQGD
710 720 730 740 750
LSAYEAELEA RLNLRDAEAN QLKEELEKVT RLTQLEQSAL QAELEKERQA
760 770 780 790 800
LKNALGKAQF SEEKEQENSE LHAKLKHLQD DNNLLKQQLK DFQNHLNHVV
810 820 830 840 850
DGLVRPEEVA ARVDELRRKL KLGTGEMNIH SPSDVLGKSL ADLQKQFSEI
860 870 880 890 900
LARSKWERDE AQVRERKLQE EMALQQEKLA TGQEEFRQAC ERALEARMNF
910 920 930 940 950
DKRQHEARIQ QMENEIHYLQ ENLKSMEEIQ GLTDLQLQEA DEEKERILAQ
960 970 980 990 1000
LRELEKKKKL EDAKSQEQVF GLDKELKKLK KAVATSDKLA TAELTIAKDQ
1010 1020 1030 1040 1050
LKSLHGTVMK INQERAEELQ EAERFSRKAA QAARDLTRAE AEIELLQNLL
1060 1070 1080 1090 1100
RQKGEQFRLE MEKTGVGTGA NSQVLEIEKL NETMERQRTE IARLQNVLDL
1110 1120 1130 1140 1150
TGSDNKGGFE NVLEEIAELR REVSYQNDYI SSMADPFKRR GYWYFMPPPP
1160 1170 1180 1190 1200
SSKVSSHSSQ ATKDSGVGLK YSASTPVRKP RPGQQDGKEG SQPPPASGYW
1210 1220 1230 1240 1250
VYSPIRSGLH KLFPSRDADS GGDSQEESEL DDQEEPPFVP PPGYMMYTVL
1260 1270 1280 1290 1300
PDGSPVPQGM ALYAPPPPLP NNSRPLTPGT VVYGPPPAGA PMVYGPPPPN
1310 1320 1330 1340 1350
FSIPFIPMGV LHCNVPEHHN LENEVSRLED IMQHLKSKKR EERWMRASKR
1360 1370 1380 1390 1400
QSEKEMEELH HNIDDLLQEK KSLECEVEEL HRTVQKRQQQ KDFIDGNVES
1410 1420 1430 1440 1450
LMTELEIEKS LKHHEDIVDE IECIEKTLLK RRSELREADR LLAEAESELS
1460 1470 1480 1490 1500
CTKEKTKNAV EKFTDAKRSL LQTESDAEEL ERRAQETAVN LVKADQQLRS
1510 1520 1530 1540 1550
LQADAKDLEQ HKIKQEEILK EINKIVAAKD SDFQCLSKKK EKLTEELQKL
1560 1570 1580 1590 1600
QKDIEMAERN EDHHLQVLKE SEVLLQAKRA ELEKLKSQVT SQQQEMAVLD
1610 1620 1630 1640 1650
RQLGHKKEEL HLLQGSMVQA KADLQEALRL GETEVTEKCN HIREVKSLLE
1660 1670 1680 1690 1700
ELSFQKGELN VQISERKTQL TLIKQEIEKE EENLQVVLRQ MSKHKTELKN
1710 1720 1730 1740 1750
ILDMLQLENH ELQGLKLQHD QRVSELEKTQ VAVLEEKLEL ENLQQISQQQ
1760 1770 1780 1790 1800
KGEIEWQKQL LERDKREIER MTAESRALQS CVECLSKEKE DLQEKCDIWE
1810 1820 1830 1840 1850
KKLAQTKRVL AAAEENSKME QSNLEKLELN VRKLQQELDQ LNRDKLSLHN
1860 1870 1880 1890 1900
DISAMQQQLQ EKREAVNSLQ EELANVQDHL NLAKQDLLHT TKHQDVLLSE
1910 1920 1930 1940 1950
QTRLQKDISE WANRFEDCQK EEETKQQQLQ VLQNEIEENK LKLVQQEMMF
1960 1970 1980 1990 2000
QRLQKERESE ESKLETSKVT LKEQQHQLEK ELTDQKSKLD QVLSKVLAAE
2010 2020 2030 2040 2050
ERVRTLQEEE RWCESLEKTL SQTKRQLSER EQQLVEKSGE LLALQKEADS
2060 2070 2080 2090 2100
MRADFSLLRN QFLTERKKAE KQVASLKEAL KIQRSQLEKN LLEQKQENSC
2110 2120 2130 2140 2150
IQKEMATIEL VAQDNHERAR RLMKELNQMQ YEYTELKKQM ANQKDLERRQ
2160 2170 2180 2190 2200
MEISDAMRTL KSEVKDEIRT SLKNLNQFLP ELPADLEAIL ERNENLEGEL
2210 2220 2230 2240 2250
ESLKENLPFT MNEGPFEEKL NFSQVHIMDE HWRGEALREK LRHREDRLKA
2260 2270 2280 2290 2300
QLRHCMSKQA EVLIKGKRQT EGTLHSLRRQ VDALGELVTS TSADSASSPS
2310 2320
LSQLESSLTE DSQLGQNQEK NASAR
Length:2,325
Mass (Da):268,886
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93DD4CA08B5BD4AF
GO
Isoform 2 (identifier: Q7Z7A1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-552: Missing.

Show »
Length:1,773
Mass (Da):205,172
Checksum:iF430B910E219D5E2
GO
Isoform 3 (identifier: Q7Z7A1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1331: Missing.

Show »
Length:994
Mass (Da):116,799
Checksum:iBFE7F893259BA73D
GO
Isoform 4 (identifier: Q7Z7A1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1818: Missing.
     1962-1986: Missing.

Show »
Length:482
Mass (Da):56,587
Checksum:i1B4867D4FEAFE023
GO
Isoform 5 (identifier: Q7Z7A1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1291-1296: Missing.

Show »
Length:2,319
Mass (Da):268,241
Checksum:i5C9924F8D58B852A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JVD3Q5JVD3_HUMAN
Centriolin
CNTRL
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JVD1Q5JVD1_HUMAN
Centriolin
CNTRL
994Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JVD6Q5JVD6_HUMAN
Centriolin
CNTRL
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JVD5Q5JVD5_HUMAN
Centriolin
CNTRL
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02932 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH02932 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH89415 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1389Q → R in AAC32373 (PubMed:10688839).Curated1
Sequence conflicti1699K → Q in AAC32373 (PubMed:10688839).Curated1
Sequence conflicti1828E → D in AAC32373 (PubMed:10688839).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03955956V → I1 PublicationCorresponds to variant dbSNP:rs10818503Ensembl.1
Natural variantiVAR_039560216P → L. Corresponds to variant dbSNP:rs10818504Ensembl.1
Natural variantiVAR_039561889A → T. Corresponds to variant dbSNP:rs17292952Ensembl.1
Natural variantiVAR_0616221146M → V. Corresponds to variant dbSNP:rs35342437Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0320461 – 1818Missing in isoform 4. 1 PublicationAdd BLAST1818
Alternative sequenceiVSP_0320471 – 1331Missing in isoform 3. 1 PublicationAdd BLAST1331
Alternative sequenceiVSP_0320481 – 552Missing in isoform 2. 1 PublicationAdd BLAST552
Alternative sequenceiVSP_0320491291 – 1296Missing in isoform 5. 1 Publication6
Alternative sequenceiVSP_0320501962 – 1986Missing in isoform 4. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF083322 mRNA Translation: AAC32373.1
AF513978 mRNA Translation: AAP43846.1
BX640927 mRNA Translation: CAE45965.1
AL137068 Genomic DNA No translation available.
BC002932 mRNA Translation: AAH02932.1 Sequence problems.
BC089415 mRNA Translation: AAH89415.1 Sequence problems.
BC137286 mRNA Translation: AAI37287.1
AY651261 mRNA Translation: AAX35689.1
AK074079 mRNA Translation: BAB84905.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35118.1 [Q7Z7A1-1]
CCDS83409.1 [Q7Z7A1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001317691.1, NM_001330762.1 [Q7Z7A1-2]
NP_008949.4, NM_007018.4 [Q7Z7A1-1]
XP_005251736.1, XM_005251679.3 [Q7Z7A1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238341; ENSP00000238341; ENSG00000119397 [Q7Z7A1-1]
ENST00000373850; ENSP00000362956; ENSG00000119397 [Q7Z7A1-2]
ENST00000373855; ENSP00000362962; ENSG00000119397 [Q7Z7A1-1]
ENST00000613863; ENSP00000481072; ENSG00000119397 [Q7Z7A1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11064

UCSC genome browser

More...
UCSCi
uc004bkx.1 human [Q7Z7A1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083322 mRNA Translation: AAC32373.1
AF513978 mRNA Translation: AAP43846.1
BX640927 mRNA Translation: CAE45965.1
AL137068 Genomic DNA No translation available.
BC002932 mRNA Translation: AAH02932.1 Sequence problems.
BC089415 mRNA Translation: AAH89415.1 Sequence problems.
BC137286 mRNA Translation: AAI37287.1
AY651261 mRNA Translation: AAX35689.1
AK074079 mRNA Translation: BAB84905.1
CCDSiCCDS35118.1 [Q7Z7A1-1]
CCDS83409.1 [Q7Z7A1-2]
RefSeqiNP_001317691.1, NM_001330762.1 [Q7Z7A1-2]
NP_008949.4, NM_007018.4 [Q7Z7A1-1]
XP_005251736.1, XM_005251679.3 [Q7Z7A1-1]

3D structure databases

SMRiQ7Z7A1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116248, 162 interactors
DIPiDIP-47280N
IntActiQ7Z7A1, 183 interactors
MINTiQ7Z7A1
STRINGi9606.ENSP00000362962

PTM databases

CarbonylDBiQ7Z7A1
iPTMnetiQ7Z7A1
PhosphoSitePlusiQ7Z7A1

Polymorphism and mutation databases

BioMutaiCNTRL
DMDMi172045911

Proteomic databases

EPDiQ7Z7A1
jPOSTiQ7Z7A1
MassIVEiQ7Z7A1
MaxQBiQ7Z7A1
PaxDbiQ7Z7A1
PeptideAtlasiQ7Z7A1
PRIDEiQ7Z7A1
ProteomicsDBi69493 [Q7Z7A1-1]
69494 [Q7Z7A1-2]
69495 [Q7Z7A1-3]
69496 [Q7Z7A1-4]
69497 [Q7Z7A1-5]

Genome annotation databases

EnsembliENST00000238341; ENSP00000238341; ENSG00000119397 [Q7Z7A1-1]
ENST00000373850; ENSP00000362956; ENSG00000119397 [Q7Z7A1-2]
ENST00000373855; ENSP00000362962; ENSG00000119397 [Q7Z7A1-1]
ENST00000613863; ENSP00000481072; ENSG00000119397 [Q7Z7A1-4]
GeneIDi11064
KEGGihsa:11064
UCSCiuc004bkx.1 human [Q7Z7A1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11064
DisGeNETi11064
EuPathDBiHostDB:ENSG00000119397.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CNTRL
HGNCiHGNC:1858 CNTRL
HPAiHPA020468
HPA020480
HPA051583
MIMi605496 gene
neXtProtiNX_Q7Z7A1
OpenTargetsiENSG00000119397
PharmGKBiPA26414

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA
GeneTreeiENSGT00940000155434
InParanoidiQ7Z7A1
KOiK16770
OMAiNQMQHEY
OrthoDBi79816at2759
PhylomeDBiQ7Z7A1
TreeFamiTF101135

Enzyme and pathway databases

ReactomeiR-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants [Q7Z7A1-3]
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5655302 Signaling by FGFR1 in disease [Q7Z7A1-3]
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiQ7Z7A1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CNTRL human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CNTRL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11064
PharosiQ7Z7A1 Tbio

Protein Ontology

More...
PROi
PR:Q7Z7A1
RNActiQ7Z7A1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119397 Expressed in 202 organ(s), highest expression level in testis
ExpressionAtlasiQ7Z7A1 baseline and differential
GenevisibleiQ7Z7A1 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR34491:SF2 PTHR34491:SF2, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNTRL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7A1
Secondary accession number(s): A2A2Y1
, B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q8TEP3, Q9Y489
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: December 11, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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