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Entry version 174 (11 Dec 2019)
Sequence version 2 (22 Aug 2003)
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Protein

Serine/threonine-protein kinase tousled-like 2

Gene

TLK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Cell cycle-regulated, with maximal activity in the S-phase. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase, probably by CHEK1, possibly at Ser-750. This inhibition is cell cycle checkpoint- and ATM-dependent.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei491ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei592Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi468 – 476ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, DNA damage
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86UE8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase tousled-like 2 (EC:2.7.11.1)
Alternative name(s):
HsHPK
PKU-alpha
Tousled-like kinase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TLK2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146872.17

Human Gene Nomenclature Database

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HGNCi
HGNC:11842 TLK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608439 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UE8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 57 (MRD57)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD57 is characterized by delayed psychomotor development apparent in infancy or early childhood, and a variety of behavioral abnormalities. Affected individuals may have severe gastro-intestinal problems, and facial dysmorphism. MRD57 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08101713 – 772Missing in MRD57. 1 PublicationAdd BLAST760
Natural variantiVAR_08101861 – 772Missing in MRD57. 1 PublicationAdd BLAST712
Natural variantiVAR_08101968 – 772Missing in MRD57. 1 PublicationAdd BLAST705
Natural variantiVAR_081020259 – 772Missing in MRD57. 1 PublicationAdd BLAST514
Natural variantiVAR_081021262 – 772Missing in MRD57. 1 PublicationAdd BLAST511
Natural variantiVAR_081022297G → D in MRD57; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555639254EnsemblClinVar.1
Natural variantiVAR_081023303 – 772Missing in MRD57. 1 PublicationAdd BLAST470
Natural variantiVAR_081024330 – 772Missing in MRD57. 1 PublicationAdd BLAST443
Natural variantiVAR_081025339R → Q in MRD57; unknown pathological significance. 1 Publication1
Natural variantiVAR_081026339R → W in MRD57; unknown pathological significance. 1 Publication1
Natural variantiVAR_081027447E → K in MRD57; unknown pathological significance. 1 Publication1
Natural variantiVAR_081028493H → R in MRD57. 1 Publication1
Natural variantiVAR_081029518H → R in MRD57. 1 Publication1
Natural variantiVAR_081030568R → W in MRD57. 1 PublicationCorresponds to variant dbSNP:rs1283838287Ensembl.1
Natural variantiVAR_081031573 – 772Missing in MRD57. 1 PublicationAdd BLAST200
Natural variantiVAR_081032629D → N in MRD57. 1 Publication1
Natural variantiVAR_081033680P → R in MRD57. 1 Publication1
Natural variantiVAR_081034720 – 772Missing in MRD57; unknown pathological significance. 2 PublicationsAdd BLAST53
Natural variantiVAR_081035746 – 772Missing in MRD57; unknown pathological significance. 1 PublicationAdd BLAST27

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi613D → A: Loss of kinase activity. 2 Publications1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
11011

MalaCards human disease database

More...
MalaCardsi
TLK2
MIMi618050 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000146872

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36544

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UE8 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5404

Drug and drug target database

More...
DrugBanki
DB12010 Fostamatinib

DrugCentral

More...
DrugCentrali
Q86UE8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TLK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34222826

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000867541 – 772Serine/threonine-protein kinase tousled-like 2Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei73PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei750Phosphoserine; by CHEK11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-750, probably by CHEK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86UE8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86UE8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86UE8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UE8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86UE8

PeptideAtlas

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PeptideAtlasi
Q86UE8

PRoteomics IDEntifications database

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PRIDEi
Q86UE8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69811 [Q86UE8-1]
69812 [Q86UE8-2]
69813 [Q86UE8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UE8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UE8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146872 Expressed in 139 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86UE8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UE8 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and heterodimer with TLK1.

Interacts with ASF1A and ASF1B. Association with 14-3-3 proteins such as YWHAZ regulates subcellular location. May also interact with FEZ1/LZTS1 and FEZ2.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116201, 37 interactors

Protein interaction database and analysis system

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IntActi
Q86UE8, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316512

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q86UE8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86UE8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1772
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86UE8

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini462 – 741Protein kinasePROSITE-ProRule annotationAdd BLAST280

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili225 – 276Sequence analysisAdd BLAST52
Coiled coili317 – 347Sequence analysisAdd BLAST31
Coiled coili403 – 451Sequence analysisAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1151 Eukaryota
ENOG410Y3FX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182984

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000259522

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86UE8

KEGG Orthology (KO)

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KOi
K08864

Identification of Orthologs from Complete Genome Data

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OMAi
HKQSQSD

Database of Orthologous Groups

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OrthoDBi
363208at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86UE8

TreeFam database of animal gene trees

More...
TreeFami
TF315233

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR027086 TLK2

The PANTHER Classification System

More...
PANTHERi
PTHR22974:SF20 PTHR22974:SF20, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q86UE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV
60 70 80 90 100
ETPEKKQNDQ RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSAPGTSP
110 120 130 140 150
GRSVPPVARS SPQHSLSNPL PRRVEQPLYG LDGSAAKEAT EEQSALPTLM
160 170 180 190 200
SVMLAKPRLD TEQLAQRGAG LCFTFVSAQQ NSPSSTGSGN TEHSCSSQKQ
210 220 230 240 250
ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR ANCDLRRQID
260 270 280 290 300
EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT
310 320 330 340 350
TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM
360 370 380 390 400
GQAPPATNEQ KQRKSKTNGA ENETPSSGNT ELKDTAPALG AHSLLRLTLA
410 420 430 440 450
EYHEQEEIFK LRLGHLKKEE AEIQAELERL ERVRNLHIRE LKRIHNEDNS
460 470 480 490 500
QFKDHPTLND RYLLLHLLGR GGFSEVYKAF DLTEQRYVAV KIHQLNKNWR
510 520 530 540 550
DEKKENYHKH ACREYRIHKE LDHPRIVKLY DYFSLDTDSF CTVLEYCEGN
560 570 580 590 600
DLDFYLKQHK LMSEKEARSI IMQIVNALKY LNEIKPPIIH YDLKPGNILL
610 620 630 640 650
VNGTACGEIK ITDFGLSKIM DDDSYNSVDG MELTSQGAGT YWYLPPECFV
660 670 680 690 700
VGKEPPKISN KVDVWSVGVI FYQCLYGRKP FGHNQSQQDI LQENTILKAT
710 720 730 740 750
EVQFPPKPVV TPEAKAFIRR CLAYRKEDRI DVQQLACDPY LLPHIRKSVS
760 770
TSSPAGAAIA STSGASNNSS SN
Length:772
Mass (Da):87,661
Last modified:August 22, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i765EE37ED4A4ADEC
GO
Isoform 21 Publication (identifier: Q86UE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-396: Missing.

Show »
Length:750
Mass (Da):85,444
Checksum:iDECCDBF95115C286
GO
Isoform 31 Publication (identifier: Q86UE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-121: Missing.
     375-396: Missing.

Show »
Length:718
Mass (Da):82,348
Checksum:i60E703322E8F2D2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLK5J3QLK5_HUMAN
Serine/threonine-protein kinase tou...
TLK2
601Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRK0J3KRK0_HUMAN
Serine/threonine-protein kinase tou...
TLK2
593Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT82J3KT82_HUMAN
Serine/threonine-protein kinase tou...
TLK2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KST4J3KST4_HUMAN
Serine/threonine-protein kinase tou...
TLK2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS73J3QS73_HUMAN
Serine/threonine-protein kinase tou...
TLK2
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS44J3QS44_HUMAN
Serine/threonine-protein kinase tou...
TLK2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR10J3QR10_HUMAN
Serine/threonine-protein kinase tou...
TLK2
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQN4J3QQN4_HUMAN
Serine/threonine-protein kinase tou...
TLK2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF03095 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH44925 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA20561 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → I in BAA20561 (PubMed:9427565).Curated1
Sequence conflicti161T → P in BAA20561 (PubMed:9427565).Curated1
Sequence conflicti207Q → R in AAF03095 (PubMed:10523312).Curated1
Sequence conflicti562M → I in BAA20561 (PubMed:9427565).Curated1
Sequence conflicti727E → R in AAF03095 (PubMed:10523312).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0412166H → R2 PublicationsCorresponds to variant dbSNP:rs45550140Ensembl.1
Natural variantiVAR_08101713 – 772Missing in MRD57. 1 PublicationAdd BLAST760
Natural variantiVAR_04121754E → D1 Publication1
Natural variantiVAR_08101861 – 772Missing in MRD57. 1 PublicationAdd BLAST712
Natural variantiVAR_08101968 – 772Missing in MRD57. 1 PublicationAdd BLAST705
Natural variantiVAR_04121895A → G1 PublicationCorresponds to variant dbSNP:rs2598147Ensembl.1
Natural variantiVAR_041219108A → G1 Publication1
Natural variantiVAR_041220109R → L1 Publication1
Natural variantiVAR_041221173F → L in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1331331651Ensembl.1
Natural variantiVAR_081020259 – 772Missing in MRD57. 1 PublicationAdd BLAST514
Natural variantiVAR_081021262 – 772Missing in MRD57. 1 PublicationAdd BLAST511
Natural variantiVAR_041222262R → Q1 PublicationCorresponds to variant dbSNP:rs762409144Ensembl.1
Natural variantiVAR_081022297G → D in MRD57; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555639254EnsemblClinVar.1
Natural variantiVAR_081023303 – 772Missing in MRD57. 1 PublicationAdd BLAST470
Natural variantiVAR_081024330 – 772Missing in MRD57. 1 PublicationAdd BLAST443
Natural variantiVAR_081025339R → Q in MRD57; unknown pathological significance. 1 Publication1
Natural variantiVAR_081026339R → W in MRD57; unknown pathological significance. 1 Publication1
Natural variantiVAR_081027447E → K in MRD57; unknown pathological significance. 1 Publication1
Natural variantiVAR_081028493H → R in MRD57. 1 Publication1
Natural variantiVAR_081029518H → R in MRD57. 1 Publication1
Natural variantiVAR_081030568R → W in MRD57. 1 PublicationCorresponds to variant dbSNP:rs1283838287Ensembl.1
Natural variantiVAR_081031573 – 772Missing in MRD57. 1 PublicationAdd BLAST200
Natural variantiVAR_081032629D → N in MRD57. 1 Publication1
Natural variantiVAR_081033680P → R in MRD57. 1 Publication1
Natural variantiVAR_081034720 – 772Missing in MRD57; unknown pathological significance. 2 PublicationsAdd BLAST53
Natural variantiVAR_081035746 – 772Missing in MRD57; unknown pathological significance. 1 PublicationAdd BLAST27

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05057290 – 121Missing in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_050573375 – 396Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB004884 mRNA Translation: BAA20561.1 Different initiation.
AF162667 mRNA Translation: AAF03095.1 Different initiation.
CH471109 Genomic DNA Translation: EAW94346.1
CH471109 Genomic DNA Translation: EAW94348.1
BC044925 mRNA Translation: AAH44925.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11633.1 [Q86UE8-2]
CCDS45753.1 [Q86UE8-3]
CCDS62283.1 [Q86UE8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001271262.1, NM_001284333.1 [Q86UE8-1]
NP_001271292.1, NM_001284363.1 [Q86UE8-3]
NP_006843.2, NM_006852.3 [Q86UE8-2]
XP_011522518.1, XM_011524216.2 [Q86UE8-1]
XP_011522519.1, XM_011524217.2 [Q86UE8-1]
XP_011522524.1, XM_011524222.2 [Q86UE8-1]
XP_016879533.1, XM_017024044.1 [Q86UE8-2]
XP_016879535.1, XM_017024046.1 [Q86UE8-2]
XP_016879536.1, XM_017024047.1 [Q86UE8-2]
XP_016879540.1, XM_017024051.1 [Q86UE8-3]
XP_016879541.1, XM_017024052.1 [Q86UE8-3]
XP_016879542.1, XM_017024053.1 [Q86UE8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326270; ENSP00000316512; ENSG00000146872 [Q86UE8-1]
ENST00000343388; ENSP00000340800; ENSG00000146872 [Q86UE8-3]
ENST00000346027; ENSP00000275780; ENSG00000146872 [Q86UE8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11011

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11011

UCSC genome browser

More...
UCSCi
uc002izz.5 human [Q86UE8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004884 mRNA Translation: BAA20561.1 Different initiation.
AF162667 mRNA Translation: AAF03095.1 Different initiation.
CH471109 Genomic DNA Translation: EAW94346.1
CH471109 Genomic DNA Translation: EAW94348.1
BC044925 mRNA Translation: AAH44925.2 Different initiation.
CCDSiCCDS11633.1 [Q86UE8-2]
CCDS45753.1 [Q86UE8-3]
CCDS62283.1 [Q86UE8-1]
RefSeqiNP_001271262.1, NM_001284333.1 [Q86UE8-1]
NP_001271292.1, NM_001284363.1 [Q86UE8-3]
NP_006843.2, NM_006852.3 [Q86UE8-2]
XP_011522518.1, XM_011524216.2 [Q86UE8-1]
XP_011522519.1, XM_011524217.2 [Q86UE8-1]
XP_011522524.1, XM_011524222.2 [Q86UE8-1]
XP_016879533.1, XM_017024044.1 [Q86UE8-2]
XP_016879535.1, XM_017024046.1 [Q86UE8-2]
XP_016879536.1, XM_017024047.1 [Q86UE8-2]
XP_016879540.1, XM_017024051.1 [Q86UE8-3]
XP_016879541.1, XM_017024052.1 [Q86UE8-3]
XP_016879542.1, XM_017024053.1 [Q86UE8-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O0YX-ray2.86A191-755[»]
SMRiQ86UE8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116201, 37 interactors
IntActiQ86UE8, 21 interactors
STRINGi9606.ENSP00000316512

Chemistry databases

BindingDBiQ86UE8
ChEMBLiCHEMBL5404
DrugBankiDB12010 Fostamatinib
DrugCentraliQ86UE8

PTM databases

iPTMnetiQ86UE8
PhosphoSitePlusiQ86UE8

Polymorphism and mutation databases

BioMutaiTLK2
DMDMi34222826

Proteomic databases

EPDiQ86UE8
jPOSTiQ86UE8
MassIVEiQ86UE8
MaxQBiQ86UE8
PaxDbiQ86UE8
PeptideAtlasiQ86UE8
PRIDEiQ86UE8
ProteomicsDBi69811 [Q86UE8-1]
69812 [Q86UE8-2]
69813 [Q86UE8-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
11011

Genome annotation databases

EnsembliENST00000326270; ENSP00000316512; ENSG00000146872 [Q86UE8-1]
ENST00000343388; ENSP00000340800; ENSG00000146872 [Q86UE8-3]
ENST00000346027; ENSP00000275780; ENSG00000146872 [Q86UE8-2]
GeneIDi11011
KEGGihsa:11011
UCSCiuc002izz.5 human [Q86UE8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11011
DisGeNETi11011
EuPathDBiHostDB:ENSG00000146872.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TLK2
HGNCiHGNC:11842 TLK2
MalaCardsiTLK2
MIMi608439 gene
618050 phenotype
neXtProtiNX_Q86UE8
OpenTargetsiENSG00000146872
PharmGKBiPA36544

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1151 Eukaryota
ENOG410Y3FX LUCA
GeneTreeiENSGT00950000182984
HOGENOMiHOG000259522
InParanoidiQ86UE8
KOiK08864
OMAiHKQSQSD
OrthoDBi363208at2759
PhylomeDBiQ86UE8
TreeFamiTF315233

Enzyme and pathway databases

SignaLinkiQ86UE8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TLK2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TLK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11011
PharosiQ86UE8 Tchem

Protein Ontology

More...
PROi
PR:Q86UE8
RNActiQ86UE8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146872 Expressed in 139 organ(s), highest expression level in testis
ExpressionAtlasiQ86UE8 baseline and differential
GenevisibleiQ86UE8 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR027086 TLK2
PANTHERiPTHR22974:SF20 PTHR22974:SF20, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UE8
Secondary accession number(s): D3DU07, Q9UKI7, Q9Y4F7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: December 11, 2019
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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