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Entry version 166 (13 Nov 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Kinectin

Gene

KTN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q86UP2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinectin
Alternative name(s):
CG-1 antigen
Kinesin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KTN1
Synonyms:CG1, KIAA0004
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6467 KTN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600381 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 1357LumenalSequence analysisAdd BLAST1328

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3895

Open Targets

More...
OpenTargetsi
ENSG00000126777

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30256

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UP2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KTN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34098465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000843371 – 1357KinectinAdd BLAST1357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75Phosphoserine; by FAM20CCombined sources1 Publication1
Modified residuei77PhosphoserineCombined sources1
Modified residuei153PhosphothreonineCombined sources1
Modified residuei156PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi904N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1055N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1084PhosphoserineCombined sources1
Glycosylationi1088N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1263N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1313PhosphoserineCombined sources1
Glycosylationi1329N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UP2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UP2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UP2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UP2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UP2

PeptideAtlas

More...
PeptideAtlasi
Q86UP2

PRoteomics IDEntifications database

More...
PRIDEi
Q86UP2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69841 [Q86UP2-1]
69842 [Q86UP2-2]
69843 [Q86UP2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UP2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UP2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86UP2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126777 Expressed in 244 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86UP2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UP2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015331
HPA003178
HPA017876

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110092, 78 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q86UP2

Database of interacting proteins

More...
DIPi
DIP-27585N

Protein interaction database and analysis system

More...
IntActi
Q86UP2, 93 interactors

Molecular INTeraction database

More...
MINTi
Q86UP2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378725

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UP2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili330 – 1356Sequence analysisAdd BLAST1027

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the kinectin family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIAW Eukaryota
ENOG410YAE3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158237

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113267

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UP2

KEGG Orthology (KO)

More...
KOi
K17975

Identification of Orthologs from Complete Genome Data

More...
OMAi
LKQENCK

Database of Orthologous Groups

More...
OrthoDBi
327650at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UP2

TreeFam database of animal gene trees

More...
TreeFami
TF333579

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024854 Kinectin

The PANTHER Classification System

More...
PANTHERi
PTHR18864 PTHR18864, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86UP2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT
60 70 80 90 100
KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV
110 120 130 140 150
PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK
160 170 180 190 200
QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET
210 220 230 240 250
KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE
260 270 280 290 300
VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE
310 320 330 340 350
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA
360 370 380 390 400
TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE
410 420 430 440 450
TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK
460 470 480 490 500
LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV
510 520 530 540 550
QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL
560 570 580 590 600
MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV
610 620 630 640 650
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE
660 670 680 690 700
VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF
710 720 730 740 750
KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL
760 770 780 790 800
LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK
810 820 830 840 850
KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL
860 870 880 890 900
EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL
910 920 930 940 950
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK
960 970 980 990 1000
ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV
1010 1020 1030 1040 1050
ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML
1060 1070 1080 1090 1100
QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK
1110 1120 1130 1140 1150
KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL
1160 1170 1180 1190 1200
QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE
1210 1220 1230 1240 1250
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR
1260 1270 1280 1290 1300
QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA
1310 1320 1330 1340 1350
AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK

EHYQVLE
Length:1,357
Mass (Da):156,275
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i971FCDF8AA8FC88E
GO
Isoform 2 (identifier: Q86UP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1059: Missing.
     1232-1259: Missing.

Show »
Length:1,300
Mass (Da):149,611
Checksum:i5AE4CEBC926D079E
GO
Isoform 3 (identifier: Q86UP2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-854: Missing.
     1232-1259: Missing.

Show »
Length:1,306
Mass (Da):150,353
Checksum:iB972F3DD3C7B6960
GO
Isoform 4 (identifier: Q86UP2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1232-1259: Missing.

Show »
Length:1,329
Mass (Da):152,988
Checksum:i591E551B1658AB77
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4L8G3V4L8_HUMAN
Kinectin
KTN1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJZ8H0YJZ8_HUMAN
Kinectin
KTN1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5P0G3V5P0_HUMAN
Kinectin
KTN1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJV5H0YJV5_HUMAN
Kinectin
KTN1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V475G3V475_HUMAN
Kinectin
KTN1
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJP2H0YJP2_HUMAN
Kinectin
KTN1
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z6P3B7Z6P3_HUMAN
Kinectin
KTN1
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4Y7G3V4Y7_HUMAN
Kinectin
KTN1
595Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5G2G3V5G2_HUMAN
Kinectin
KTN1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5Q0G3V5Q0_HUMAN
Kinectin
KTN1
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50555 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA02794 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15S → P in BAA02794 (PubMed:7584026).Curated1
Sequence conflicti210Missing in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti373I → M in CAA80271 (PubMed:7787243).Curated1
Sequence conflicti939E → G in CAA80271 (PubMed:7787243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035931226P → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_016206282V → M. Corresponds to variant dbSNP:rs2274073Ensembl.1
Natural variantiVAR_0792661233L → M1 PublicationCorresponds to variant dbSNP:rs372815686Ensembl.1
Natural variantiVAR_0359321316T → P in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043207832 – 854Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0079811031 – 1059Missing in isoform 2. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_0079821232 – 1259Missing in isoform 2, isoform 3 and isoform 4. 4 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z22551 mRNA Translation: CAA80271.1
L25616 mRNA Translation: AAB65853.1
AY264265 mRNA Translation: AAP20418.1
D13629 mRNA Translation: BAA02794.2 Different initiation.
AK302797 mRNA Translation: BAG64000.1
AL138499 Genomic DNA No translation available.
AL355773 Genomic DNA No translation available.
BC050555 mRNA Translation: AAH50555.1 Sequence problems.
BC112337 mRNA Translation: AAI12338.1
BC117132 mRNA Translation: AAI17133.1
BC143720 mRNA Translation: AAI43721.1
AY536375 mRNA Translation: AAT66048.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41957.1 [Q86UP2-1]
CCDS41958.1 [Q86UP2-2]
CCDS41959.1 [Q86UP2-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
I53799
S32763

NCBI Reference Sequences

More...
RefSeqi
NP_001072989.1, NM_001079521.1 [Q86UP2-1]
NP_001072990.1, NM_001079522.1 [Q86UP2-3]
NP_001257943.1, NM_001271014.1 [Q86UP2-4]
NP_004977.2, NM_004986.3 [Q86UP2-2]
XP_006720201.1, XM_006720138.2 [Q86UP2-1]
XP_006720202.1, XM_006720139.2 [Q86UP2-4]
XP_011535053.1, XM_011536751.2 [Q86UP2-1]
XP_011535055.1, XM_011536753.1 [Q86UP2-3]
XP_016876767.1, XM_017021278.1 [Q86UP2-1]
XP_016876771.1, XM_017021282.1 [Q86UP2-2]
XP_016876772.1, XM_017021283.1 [Q86UP2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3895

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3895

UCSC genome browser

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UCSCi
uc001xcb.4 human [Q86UP2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22551 mRNA Translation: CAA80271.1
L25616 mRNA Translation: AAB65853.1
AY264265 mRNA Translation: AAP20418.1
D13629 mRNA Translation: BAA02794.2 Different initiation.
AK302797 mRNA Translation: BAG64000.1
AL138499 Genomic DNA No translation available.
AL355773 Genomic DNA No translation available.
BC050555 mRNA Translation: AAH50555.1 Sequence problems.
BC112337 mRNA Translation: AAI12338.1
BC117132 mRNA Translation: AAI17133.1
BC143720 mRNA Translation: AAI43721.1
AY536375 mRNA Translation: AAT66048.1
CCDSiCCDS41957.1 [Q86UP2-1]
CCDS41958.1 [Q86UP2-2]
CCDS41959.1 [Q86UP2-3]
PIRiI53799
S32763
RefSeqiNP_001072989.1, NM_001079521.1 [Q86UP2-1]
NP_001072990.1, NM_001079522.1 [Q86UP2-3]
NP_001257943.1, NM_001271014.1 [Q86UP2-4]
NP_004977.2, NM_004986.3 [Q86UP2-2]
XP_006720201.1, XM_006720138.2 [Q86UP2-1]
XP_006720202.1, XM_006720139.2 [Q86UP2-4]
XP_011535053.1, XM_011536751.2 [Q86UP2-1]
XP_011535055.1, XM_011536753.1 [Q86UP2-3]
XP_016876767.1, XM_017021278.1 [Q86UP2-1]
XP_016876771.1, XM_017021282.1 [Q86UP2-2]
XP_016876772.1, XM_017021283.1 [Q86UP2-2]

3D structure databases

SMRiQ86UP2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110092, 78 interactors
CORUMiQ86UP2
DIPiDIP-27585N
IntActiQ86UP2, 93 interactors
MINTiQ86UP2
STRINGi9606.ENSP00000378725

PTM databases

iPTMnetiQ86UP2
PhosphoSitePlusiQ86UP2
SwissPalmiQ86UP2

Polymorphism and mutation databases

BioMutaiKTN1
DMDMi34098465

Proteomic databases

EPDiQ86UP2
jPOSTiQ86UP2
MassIVEiQ86UP2
MaxQBiQ86UP2
PaxDbiQ86UP2
PeptideAtlasiQ86UP2
PRIDEiQ86UP2
ProteomicsDBi69841 [Q86UP2-1]
69842 [Q86UP2-2]
69843 [Q86UP2-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3895

Genome annotation databases

EnsembliENST00000395308; ENSP00000378719; ENSG00000126777 [Q86UP2-3]
ENST00000395309; ENSP00000378720; ENSG00000126777 [Q86UP2-3]
ENST00000395311; ENSP00000378722; ENSG00000126777 [Q86UP2-3]
ENST00000395314; ENSP00000378725; ENSG00000126777 [Q86UP2-1]
ENST00000413890; ENSP00000394992; ENSG00000126777 [Q86UP2-3]
ENST00000438792; ENSP00000391964; ENSG00000126777 [Q86UP2-2]
ENST00000459737; ENSP00000432149; ENSG00000126777 [Q86UP2-1]
GeneIDi3895
KEGGihsa:3895
UCSCiuc001xcb.4 human [Q86UP2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3895
DisGeNETi3895

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KTN1
HGNCiHGNC:6467 KTN1
HPAiCAB015331
HPA003178
HPA017876
MIMi600381 gene
neXtProtiNX_Q86UP2
OpenTargetsiENSG00000126777
PharmGKBiPA30256

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIAW Eukaryota
ENOG410YAE3 LUCA
GeneTreeiENSGT00940000158237
HOGENOMiHOG000113267
InParanoidiQ86UP2
KOiK17975
OMAiLKQENCK
OrthoDBi327650at2759
PhylomeDBiQ86UP2
TreeFamiTF333579

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5625970 RHO GTPases activate KTN1
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiQ86UP2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KTN1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KTN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3895
PharosiQ86UP2

Protein Ontology

More...
PROi
PR:Q86UP2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126777 Expressed in 244 organ(s), highest expression level in testis
ExpressionAtlasiQ86UP2 baseline and differential
GenevisibleiQ86UP2 HS

Family and domain databases

InterProiView protein in InterPro
IPR024854 Kinectin
PANTHERiPTHR18864 PTHR18864, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKTN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UP2
Secondary accession number(s): B4DZ88
, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86W57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: November 13, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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