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Entry version 120 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Protein FAM83A

Gene

FAM83A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM83ACurated
Alternative name(s):
Tumor antigen BJ-TSA-91 Publication
Tumor-specific gene expressed in prostate protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM83AImported
Synonyms:TSGP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28210 FAM83A

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86UY5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
84985

Open Targets

More...
OpenTargetsi
ENSG00000147689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671851

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86UY5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM83A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74727505

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002868131 – 434Protein FAM83AAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei301PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon EGFR activation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86UY5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86UY5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86UY5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86UY5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86UY5

PeptideAtlas

More...
PeptideAtlasi
Q86UY5

PRoteomics IDEntifications database

More...
PRIDEi
Q86UY5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69935 [Q86UY5-1]
69936 [Q86UY5-2]
69937 [Q86UY5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86UY5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86UY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147689 Expressed in 124 organ(s), highest expression level in lower esophagus mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86UY5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052615

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the regulatory subunit p85 of PI3-kinase; increased by EGFR activation (PubMed:22886303).

Interacts with RAF1; increased by EGFR activation it activates RAF1 (PubMed:22886303, PubMed:24736947).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124411, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q86UY5, 27 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428876

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1434
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86UY5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi320 – 357Ser-richAdd BLAST38
Compositional biasi355 – 394Pro-richAdd BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM83 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGUW Eukaryota
ENOG410XSTH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160768

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112483

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86UY5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLCGQVH

Database of Orthologous Groups

More...
OrthoDBi
1566696at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86UY5

TreeFam database of animal gene trees

More...
TreeFami
TF330777

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012461 FAM83_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07894 FAM83, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86UY5-1) [UniParc]FASTAAdd to basket
Also known as: TSGP-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRSRHLGKI RKRLEDVKSQ WVRPARADFS DNESARLATD ALLDGGSEAY
60 70 80 90 100
WRVLSQEGEV DFLSSVEAQY IQAQAREPPC PPDTLGGAEA GPKGLDSSSL
110 120 130 140 150
QSGTYFPVAS EGSEPALLHS WASAEKPYLK EKSSATVYFQ TVKHNNIRDL
160 170 180 190 200
VRRCITRTSQ VLVILMDVFT DVEIFCDILE AANKRGVFVC VLLDQGGVKL
210 220 230 240 250
FQEMCDKVQI SDSHLKNISI RSVEGEIYCA KSGRKFAGQI REKFIISDWR
260 270 280 290 300
FVLSGSYSFT WLCGHVHRNI LSKFTGQAVE LFDEEFRHLY ASSKPVMGLK
310 320 330 340 350
SPRLVAPVPP GAAPANGRLS SSSGSASDRT SSNPFSGRSA GSHPGTRSVS
360 370 380 390 400
ASSGPCSPAA PHPPPPPRFQ PHQGPWGAPS PQAHLSPRPH DGPPAAVYSN
410 420 430
LGAYRPTRLQ LEQLGLVPRL TPTWRPFLQA SPHF
Length:434
Mass (Da):47,458
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63D09D927D452FCC
GO
Isoform 2 (identifier: Q86UY5-2) [UniParc]FASTAAdd to basket
Also known as: TSGP-S

The sequence of this isoform differs from the canonical sequence as follows:
     161-216: Missing.
     348-350: SVS → TDG
     351-434: Missing.

Show »
Length:294
Mass (Da):32,158
Checksum:i73D90BAEC4F5B8E3
GO
Isoform 3 (identifier: Q86UY5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-367: GTRSVSASSGPCSPAAPHPPPPP → VPESKQNKTKTKKQTTLWFLMAF
     368-434: Missing.

Show »
Length:367
Mass (Da):40,576
Checksum:i849DCF2B4F8A681C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05299 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032178237A → T3 PublicationsCorresponds to variant dbSNP:rs7813708Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025187161 – 216Missing in isoform 2. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_025188345 – 367GTRSV…PPPPP → VPESKQNKTKTKKQTTLWFL MAF in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_025190348 – 350SVS → TDG in isoform 2. 2 Publications3
Alternative sequenceiVSP_025191351 – 434Missing in isoform 2. 2 PublicationsAdd BLAST84
Alternative sequenceiVSP_025189368 – 434Missing in isoform 3. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ280322 mRNA Translation: ABB91800.1
DQ280323 mRNA Translation: ABB91801.1
AF497803 mRNA Translation: AAQ07260.1
BC007828 mRNA Translation: AAH07828.1
BC052300 mRNA Translation: AAH52300.1
AK098407 mRNA Translation: BAC05299.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6339.1 [Q86UY5-3]
CCDS6340.1 [Q86UY5-1]
CCDS75784.1 [Q86UY5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001275516.1, NM_001288587.2 [Q86UY5-2]
NP_116288.2, NM_032899.6 [Q86UY5-1]
NP_996889.1, NM_207006.2 [Q86UY5-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276699; ENSP00000276699; ENSG00000147689 [Q86UY5-3]
ENST00000518448; ENSP00000428876; ENSG00000147689 [Q86UY5-1]
ENST00000522648; ENSP00000427979; ENSG00000147689 [Q86UY5-2]
ENST00000536633; ENSP00000445218; ENSG00000147689 [Q86UY5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84985

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84985

UCSC genome browser

More...
UCSCi
uc003ypv.5 human [Q86UY5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ280322 mRNA Translation: ABB91800.1
DQ280323 mRNA Translation: ABB91801.1
AF497803 mRNA Translation: AAQ07260.1
BC007828 mRNA Translation: AAH07828.1
BC052300 mRNA Translation: AAH52300.1
AK098407 mRNA Translation: BAC05299.1 Different initiation.
CCDSiCCDS6339.1 [Q86UY5-3]
CCDS6340.1 [Q86UY5-1]
CCDS75784.1 [Q86UY5-2]
RefSeqiNP_001275516.1, NM_001288587.2 [Q86UY5-2]
NP_116288.2, NM_032899.6 [Q86UY5-1]
NP_996889.1, NM_207006.2 [Q86UY5-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4URJX-ray2.68A/B/C/D122-304[»]
SMRiQ86UY5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124411, 8 interactors
IntActiQ86UY5, 27 interactors
STRINGi9606.ENSP00000428876

PTM databases

iPTMnetiQ86UY5
PhosphoSitePlusiQ86UY5

Polymorphism and mutation databases

BioMutaiFAM83A
DMDMi74727505

Proteomic databases

EPDiQ86UY5
jPOSTiQ86UY5
MassIVEiQ86UY5
MaxQBiQ86UY5
PaxDbiQ86UY5
PeptideAtlasiQ86UY5
PRIDEiQ86UY5
ProteomicsDBi69935 [Q86UY5-1]
69936 [Q86UY5-2]
69937 [Q86UY5-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84985

Genome annotation databases

EnsembliENST00000276699; ENSP00000276699; ENSG00000147689 [Q86UY5-3]
ENST00000518448; ENSP00000428876; ENSG00000147689 [Q86UY5-1]
ENST00000522648; ENSP00000427979; ENSG00000147689 [Q86UY5-2]
ENST00000536633; ENSP00000445218; ENSG00000147689 [Q86UY5-3]
GeneIDi84985
KEGGihsa:84985
UCSCiuc003ypv.5 human [Q86UY5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84985
DisGeNETi84985

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM83A
HGNCiHGNC:28210 FAM83A
HPAiHPA052615
neXtProtiNX_Q86UY5
OpenTargetsiENSG00000147689
PharmGKBiPA142671851

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGUW Eukaryota
ENOG410XSTH LUCA
GeneTreeiENSGT00940000160768
HOGENOMiHOG000112483
InParanoidiQ86UY5
OMAiWLCGQVH
OrthoDBi1566696at2759
PhylomeDBiQ86UY5
TreeFamiTF330777

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM83A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FAM83A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84985
PharosiQ86UY5

Protein Ontology

More...
PROi
PR:Q86UY5

Gene expression databases

BgeeiENSG00000147689 Expressed in 124 organ(s), highest expression level in lower esophagus mucosa
GenevisibleiQ86UY5 HS

Family and domain databases

InterProiView protein in InterPro
IPR012461 FAM83_N
PfamiView protein in Pfam
PF07894 FAM83, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA83A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86UY5
Secondary accession number(s): Q71HL2, Q8N7I1, Q96I47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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