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Entry version 160 (16 Oct 2019)
Sequence version 2 (07 Mar 2006)
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Protein

Liprin-beta-1

Gene

PPFIBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-388844 Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Liprin-beta-1
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
Short name:
PTPRF-interacting protein-binding protein 1
hSGT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPFIBP1
Synonyms:KIAA1230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9249 PPFIBP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603141 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86W92

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8496

Open Targets

More...
OpenTargetsi
ENSG00000110841

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33570

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86W92

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPFIBP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90185247

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910341 – 1011Liprin-beta-1Add BLAST1011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineCombined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei322N6-acetyllysineCombined sources1
Modified residuei434PhosphoserineBy similarity1
Modified residuei466PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei540PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei636PhosphoserineBy similarity1
Modified residuei794PhosphoserineCombined sources1
Modified residuei999PhosphoserineCombined sources1
Modified residuei1001PhosphoserineCombined sources1
Modified residuei1003PhosphoserineCombined sources1
Modified residuei1005PhosphothreonineCombined sources1
Isoform 2 (identifier: Q86W92-2)
Modified residuei523PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86W92

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86W92

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86W92

MaxQB - The MaxQuant DataBase

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MaxQBi
Q86W92

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86W92

PeptideAtlas

More...
PeptideAtlasi
Q86W92

PRoteomics IDEntifications database

More...
PRIDEi
Q86W92

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70131 [Q86W92-1]
70132 [Q86W92-2]
70133 [Q86W92-3]
70134 [Q86W92-4]
70135 [Q86W92-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86W92

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86W92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Absent in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110841 Expressed in 234 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86W92 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86W92 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001924

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers.

Interacts with S100A4 in a calcium-dependent mode.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114068, 45 interactors

Database of interacting proteins

More...
DIPi
DIP-42195N

Protein interaction database and analysis system

More...
IntActi
Q86W92, 32 interactors

Molecular INTeraction database

More...
MINTi
Q86W92

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000314724

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86W92

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini647 – 711SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini719 – 782SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini804 – 876SAM 3PROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili156 – 405Sequence analysisAdd BLAST250

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1899 Eukaryota
ENOG410XSFF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082535

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86W92

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNWLQDQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86W92

TreeFam database of animal gene trees

More...
TreeFami
TF314207

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits
1.20.5.1160, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042180 IF_rod_dom_coil1B
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86W92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL DLMAEISNLK LKLTAVEKDR LDYEDKFRDT
210 220 230 240 250
EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS MKIKVGQMQY
260 270 280 290 300
EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD
310 320 330 340 350
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD
360 370 380 390 400
GEYEELLNSS SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF
410 420 430 440 450
HTTILQVSIP SLLPATVSME TSEKSKLTPK PETSFEENDG NIILGATVDT
460 470 480 490 500
QLCDKLLTSS LQKSSSLGNL KKETSDGEKE TIQKTSEDRA PAESRPFGTL
510 520 530 540 550
PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS APNLAETEKE
560 570 580 590 600
TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ
610 620 630 640 650
STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE
660 670 680 690 700
QVCNWLMEQG LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK
710 720 730 740 750
LQLALQALGS EEETNHGKLD FNWVTRWLDD IGLPQYKTQF DEGRVDGRML
760 770 780 790 800
HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR INNFEPNCLR RRPSDENTIA
810 820 830 840 850
PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL EPRFNVETMA
860 870 880 890 900
QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV
910 920 930 940 950
KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL
960 970 980 990 1000
YEEDDLDRLE QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP
1010
SASITDEDSN V
Note: No experimental confirmation available.
Length:1,011
Mass (Da):114,024
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20E30DD99ACD5A92
GO
Isoform 2 (identifier: Q86W92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-263: Missing.
     302-302: D → DENFKKKLKEKN
     349-349: K → KKGK
     544-544: L → LDRKRSASAPTL

Note: No experimental confirmation available.Combined sources
Show »
Length:1,005
Mass (Da):113,181
Checksum:iE399A3BB86F46BAE
GO
Isoform 3 (identifier: Q86W92-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Note: No experimental confirmation available.
Show »
Length:858
Mass (Da):96,965
Checksum:iD5BE6B7D1D47C76A
GO
Isoform 4 (identifier: Q86W92-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-263: Missing.

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):110,297
Checksum:iA521EFCC0589E24B
GO
Isoform 5 (identifier: Q86W92-5) [UniParc]FASTAAdd to basket
Also known as: L2

The sequence of this isoform differs from the canonical sequence as follows:
     158-170: ELLSRTSLETQKL → VCAEARTKMGFPC
     171-1011: Missing.

Note: Due to intron retention.
Show »
Length:170
Mass (Da):18,972
Checksum:iC281D0F4E7896A7B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZP6F5GZP6_HUMAN
Liprin-beta-1
PPFIBP1
744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGH8H0YGH8_HUMAN
Liprin-beta-1
PPFIBP1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H495F5H495_HUMAN
Liprin-beta-1
PPFIBP1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTP2A0A0A0MTP2_HUMAN
Liprin-beta-1
PPFIBP1
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVX8A0A087WVX8_HUMAN
Liprin-beta-1
PPFIBP1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFE4H0YFE4_HUMAN
Liprin-beta-1
PPFIBP1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0E0F5H0E0_HUMAN
Liprin-beta-1
PPFIBP1
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6Q7F5H6Q7_HUMAN
Liprin-beta-1
PPFIBP1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7K5F5H7K5_HUMAN
Liprin-beta-1
PPFIBP1
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH46159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA86544 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti308M → K in AAH46159 (PubMed:15489334).Curated1
Sequence conflicti453C → R in AAC26103 (PubMed:9624153).Curated1
Sequence conflicti553E → A in AAC26103 (PubMed:9624153).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017758148V → L5 PublicationsCorresponds to variant dbSNP:rs2194816Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0093941 – 153Missing in isoform 3. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_009395158 – 170ELLSR…ETQKL → VCAEARTKMGFPC in isoform 5. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_009396171 – 1011Missing in isoform 5. 2 PublicationsAdd BLAST841
Alternative sequenceiVSP_009397233 – 263Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_009398302D → DENFKKKLKEKN in isoform 2. 1 Publication1
Alternative sequenceiVSP_009399349K → KKGK in isoform 2. 1 Publication1
Alternative sequenceiVSP_009400544L → LDRKRSASAPTL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF034802 mRNA Translation: AAC26103.1
AB033056 mRNA Translation: BAA86544.2 Different initiation.
AJ276680 mRNA Translation: CAB77544.1
AB049149 mRNA Translation: BAB39690.1
BC046159 mRNA Translation: AAH46159.1 Different initiation.
BC050281 mRNA Translation: AAH50281.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55812.1 [Q86W92-1]
CCDS55813.1 [Q86W92-4]
CCDS55814.1 [Q86W92-3]
CCDS8713.1 [Q86W92-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001185844.1, NM_001198915.1 [Q86W92-3]
NP_001185845.1, NM_001198916.1 [Q86W92-4]
NP_003613.3, NM_003622.3 [Q86W92-2]
NP_803193.2, NM_177444.2 [Q86W92-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228425; ENSP00000228425; ENSG00000110841 [Q86W92-2]
ENST00000318304; ENSP00000314724; ENSG00000110841 [Q86W92-1]
ENST00000535047; ENSP00000444046; ENSG00000110841 [Q86W92-5]
ENST00000537927; ENSP00000445425; ENSG00000110841 [Q86W92-3]
ENST00000542629; ENSP00000443442; ENSG00000110841 [Q86W92-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8496

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8496

UCSC genome browser

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UCSCi
uc001rhz.3 human [Q86W92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034802 mRNA Translation: AAC26103.1
AB033056 mRNA Translation: BAA86544.2 Different initiation.
AJ276680 mRNA Translation: CAB77544.1
AB049149 mRNA Translation: BAB39690.1
BC046159 mRNA Translation: AAH46159.1 Different initiation.
BC050281 mRNA Translation: AAH50281.1
CCDSiCCDS55812.1 [Q86W92-1]
CCDS55813.1 [Q86W92-4]
CCDS55814.1 [Q86W92-3]
CCDS8713.1 [Q86W92-2]
RefSeqiNP_001185844.1, NM_001198915.1 [Q86W92-3]
NP_001185845.1, NM_001198916.1 [Q86W92-4]
NP_003613.3, NM_003622.3 [Q86W92-2]
NP_803193.2, NM_177444.2 [Q86W92-1]

3D structure databases

SMRiQ86W92
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114068, 45 interactors
DIPiDIP-42195N
IntActiQ86W92, 32 interactors
MINTiQ86W92
STRINGi9606.ENSP00000314724

PTM databases

iPTMnetiQ86W92
PhosphoSitePlusiQ86W92

Polymorphism and mutation databases

BioMutaiPPFIBP1
DMDMi90185247

Proteomic databases

EPDiQ86W92
jPOSTiQ86W92
MassIVEiQ86W92
MaxQBiQ86W92
PaxDbiQ86W92
PeptideAtlasiQ86W92
PRIDEiQ86W92
ProteomicsDBi70131 [Q86W92-1]
70132 [Q86W92-2]
70133 [Q86W92-3]
70134 [Q86W92-4]
70135 [Q86W92-5]

Genome annotation databases

EnsembliENST00000228425; ENSP00000228425; ENSG00000110841 [Q86W92-2]
ENST00000318304; ENSP00000314724; ENSG00000110841 [Q86W92-1]
ENST00000535047; ENSP00000444046; ENSG00000110841 [Q86W92-5]
ENST00000537927; ENSP00000445425; ENSG00000110841 [Q86W92-3]
ENST00000542629; ENSP00000443442; ENSG00000110841 [Q86W92-4]
GeneIDi8496
KEGGihsa:8496
UCSCiuc001rhz.3 human [Q86W92-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8496
DisGeNETi8496

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPFIBP1
HGNCiHGNC:9249 PPFIBP1
HPAiHPA001924
MIMi603141 gene
neXtProtiNX_Q86W92
OpenTargetsiENSG00000110841
PharmGKBiPA33570

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1899 Eukaryota
ENOG410XSFF LUCA
GeneTreeiENSGT00950000182675
HOGENOMiHOG000082535
InParanoidiQ86W92
OMAiCNWLQDQ
PhylomeDBiQ86W92
TreeFamiTF314207

Enzyme and pathway databases

ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPFIBP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPFIBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8496
PharosiQ86W92

Protein Ontology

More...
PROi
PR:Q86W92

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000110841 Expressed in 234 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ86W92 baseline and differential
GenevisibleiQ86W92 HS

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
1.20.5.1160, 2 hits
InterProiView protein in InterPro
IPR042180 IF_rod_dom_coil1B
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86W92
Secondary accession number(s): O75336
, Q86X70, Q9NY03, Q9ULJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 7, 2006
Last modified: October 16, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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