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Entry version 135 (18 Sep 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Ral GTPase-activating protein subunit beta

Gene

RALGAPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ral GTPase-activating protein subunit beta
Alternative name(s):
p170
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RALGAPB
Synonyms:KIAA1219
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29221 RALGAPB

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86X10

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57148

Open Targets

More...
OpenTargetsi
ENSG00000170471

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165392608

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RALGAPB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45477126

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567561 – 1494Ral GTPase-activating protein subunit betaAdd BLAST1494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei359PhosphoserineCombined sources1
Modified residuei363PhosphothreonineBy similarity1
Modified residuei379PhosphothreonineCombined sources1
Modified residuei421PhosphoserineBy similarity1
Modified residuei720PhosphoserineCombined sources1
Modified residuei734PhosphothreonineCombined sources1
Modified residuei1285PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86X10

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86X10

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86X10

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86X10

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86X10

PeptideAtlas

More...
PeptideAtlasi
Q86X10

PRoteomics IDEntifications database

More...
PRIDEi
Q86X10

ProteomicsDB human proteome resource

More...
ProteomicsDBi
195
70218 [Q86X10-1]
70219 [Q86X10-2]
70220 [Q86X10-3]
70221 [Q86X10-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86X10

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86X10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, mostly in amygdala.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170471 Expressed in 226 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86X10 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86X10 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051454

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121405, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q86X10, 22 interactors

Molecular INTeraction database

More...
MINTi
Q86X10

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262879

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1149 – 1392Rap-GAPPROSITE-ProRule annotationAdd BLAST244

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3652 Eukaryota
ENOG411027C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00700000104550

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230877

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86X10

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYMKAGQ

Database of Orthologous Groups

More...
OrthoDBi
54832at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86X10

TreeFam database of animal gene trees

More...
TreeFami
TF324460

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039930 RALGAPB
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR21344 PTHR21344, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86X10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYSEWRSLHL VIQNDQGHTS VLHSYPESVG REVANAVVRP LGQVLGTPSV
60 70 80 90 100
AGSENLLKTD KEVKWTMEVI CYGLTLPLDG ETVKYCVDVY TDWIMALVLP
110 120 130 140 150
KDSIPLPVIK EPNQYVQTIL KHLQNLFVPR QEQGSSQIRL CLQVLRAIQK
160 170 180 190 200
LARESSLMAR ETWEVLLLFL LQINDILLAP PTVQGGIAEN LAEKLIGVLF
210 220 230 240 250
EVWLLACTRC FPTPPYWKTA KEMVANWRHH PAVVEQWSKV ICALTSRLLR
260 270 280 290 300
FTYGPSFPAF KVPDEDASLI PPEMDNECVA QTWFRFLHML SNPVDLSNPA
310 320 330 340 350
IISSTPKFQE QFLNVSGMPQ ELNQYPCLKH LPQIFFRAMR GISCLVDAFL
360 370 380 390 400
GISRPRSDSA PPTPVNRLSM PQSAAVSTTP PHNRRHRAVT VNKATMKTST
410 420 430 440 450
VSTAHASKVQ HQTSSTSPLS SPNQTSSEPR PLPAPRRPKV NSILNLFGSW
460 470 480 490 500
LFDAAFVHCK LHNGINRDSS MTAITTQASM EFRRKGSQMS TDTMVSNPMF
510 520 530 540 550
DASEFPDNYE AGRAEACGTL CRIFCSKKTG EEILPAYLSR FYMLLIQGLQ
560 570 580 590 600
INDYVCHPVL ASVILNSPPL FCCDLKGIDV VVPYFISALE TILPDRELSK
610 620 630 640 650
FKSYVNPTEL RRSSINILLS LLPLPHHFGT VKSEVVLEGK FSNDDSSSYD
660 670 680 690 700
KPITFLSLKL RLVNILIGAL QTETDPNNTQ MILGAMLNIV QDSALLEAIG
710 720 730 740 750
CQMEMGGGEN NLKSHSRTNS GISSASGGST EPTTPDSERP AQALLRDYAL
760 770 780 790 800
NTDSAAGLLI RSIHLVTQRL NSQWRQDMSI SLAALELLSG LAKVKVMVDS
810 820 830 840 850
GDRKRAISSV CTYIVYQCSR PAPLHSRDLH SMIVAAFQCL CVWLTEHPDM
860 870 880 890 900
LDEKDCLKEV LEIVELGISG SKSKNNEQEV KYKGDKEPNP ASMRVKDAAE
910 920 930 940 950
ATLTCIMQLL GAFPSPSGPA SPCSLVNETT LIKYSRLPTI NKHSFRYFVL
960 970 980 990 1000
DNSVILAMLE QPLGNEQNDF FPSVTVLVRG MSGRLAWAQQ LCLLPRGAKA
1010 1020 1030 1040 1050
NQKLFVPEPR PVPKNDVGFK YSVKHRPFPE EVDKIPFVKA DLSIPDLHEI
1060 1070 1080 1090 1100
VTEELEERHE KLRSGMAQQI AYEIHLEQQS EEELQKRSFP DPVTDCKPPP
1110 1120 1130 1140 1150
PAQEFQTARL FLSHFGFLSL EALKEPANSR LPPHLIALDS TIPGFFDDIG
1160 1170 1180 1190 1200
YLDLLPCRPF DTVFIFYMKP GQKTNQEILK NVESSRTVQP HFLEFLLSLG
1210 1220 1230 1240 1250
WSVDVGRHPG WTGHVSTSWS INCCDDGEGS QQEVISSEDI GASIFNGQKK
1260 1270 1280 1290 1300
VLYYADALTE IAFVVPSPVE SLTDSLESNI SDQDSDSNMD LMPGILKQPS
1310 1320 1330 1340 1350
LTLELFPNHT DNLNSSQRLS PSSRMRKLPQ GRPVPPLGPE TRVSVVWVER
1360 1370 1380 1390 1400
YDDIENFPLS ELMTEISTGV ETTANSSTSL RSTTLEKEVP VIFIHPLNTG
1410 1420 1430 1440 1450
LFRIKIQGAT GKFNMVIPLV DGMIVSRRAL GFLVRQTVIN ICRRKRLESD
1460 1470 1480 1490
SYSPPHVRRK QKITDIVNKY RNKQLEPEFY TSLFQEVGLK NCSS
Length:1,494
Mass (Da):166,799
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FEDBB0CB269F8CE
GO
Isoform 2 (identifier: Q86X10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-222: Missing.
     1233-1233: E → EE

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:1,273
Mass (Da):141,866
Checksum:i024E924F27623CC2
GO
Isoform 3 (identifier: Q86X10-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     749-752: Missing.
     1233-1233: E → EE

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:1,491
Mass (Da):166,528
Checksum:i49C23593DB561453
GO
Isoform 4 (identifier: Q86X10-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     943-1473: Missing.

Note: Splicing acceptor site is not canonical. No experimental confirmation available.
Show »
Length:963
Mass (Da):106,838
Checksum:i13AF758962E013A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2F0A2A2F0_HUMAN
Ral GTPase-activating protein subun...
RALGAPB
1,323Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YW54A0A0J9YW54_HUMAN
Ral GTPase-activating protein subun...
RALGAPB
866Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86533 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC85649 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB61346 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD39096 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti326P → S in CAD39096 (PubMed:10574462).Curated1
Sequence conflicti1072Y → G in AAH18668 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0096931 – 222Missing in isoform 2. 1 PublicationAdd BLAST222
Alternative sequenceiVSP_009694749 – 752Missing in isoform 3. 1 Publication4
Alternative sequenceiVSP_009695943 – 1473Missing in isoform 4. 1 PublicationAdd BLAST531
Alternative sequenceiVSP_0096961233E → EE in isoform 2 and isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033045 mRNA Translation: BAA86533.3 Different initiation.
AL834436 mRNA Translation: CAD39096.1 Different initiation.
AL132998 mRNA Translation: CAB61346.1 Different initiation.
AL035419 Genomic DNA No translation available.
AL049868 Genomic DNA No translation available.
BC010916 mRNA Translation: AAH10916.2
BC018668 mRNA Translation: AAH18668.1
BC047482 mRNA Translation: AAH47482.1
AK123576 mRNA Translation: BAC85649.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13305.1 [Q86X10-1]
CCDS63272.1 [Q86X10-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001269846.1, NM_001282917.1 [Q86X10-1]
NP_001269847.1, NM_001282918.1 [Q86X10-3]
NP_065069.1, NM_020336.3 [Q86X10-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262879; ENSP00000262879; ENSG00000170471 [Q86X10-1]
ENST00000397040; ENSP00000380233; ENSG00000170471 [Q86X10-1]
ENST00000397042; ENSP00000380235; ENSG00000170471 [Q86X10-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57148

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57148

UCSC genome browser

More...
UCSCi
uc002xiw.5 human [Q86X10-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033045 mRNA Translation: BAA86533.3 Different initiation.
AL834436 mRNA Translation: CAD39096.1 Different initiation.
AL132998 mRNA Translation: CAB61346.1 Different initiation.
AL035419 Genomic DNA No translation available.
AL049868 Genomic DNA No translation available.
BC010916 mRNA Translation: AAH10916.2
BC018668 mRNA Translation: AAH18668.1
BC047482 mRNA Translation: AAH47482.1
AK123576 mRNA Translation: BAC85649.1 Different initiation.
CCDSiCCDS13305.1 [Q86X10-1]
CCDS63272.1 [Q86X10-3]
RefSeqiNP_001269846.1, NM_001282917.1 [Q86X10-1]
NP_001269847.1, NM_001282918.1 [Q86X10-3]
NP_065069.1, NM_020336.3 [Q86X10-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121405, 23 interactors
IntActiQ86X10, 22 interactors
MINTiQ86X10
STRINGi9606.ENSP00000262879

PTM databases

iPTMnetiQ86X10
PhosphoSitePlusiQ86X10

Polymorphism and mutation databases

BioMutaiRALGAPB
DMDMi45477126

Proteomic databases

EPDiQ86X10
jPOSTiQ86X10
MassIVEiQ86X10
MaxQBiQ86X10
PaxDbiQ86X10
PeptideAtlasiQ86X10
PRIDEiQ86X10
ProteomicsDBi195
70218 [Q86X10-1]
70219 [Q86X10-2]
70220 [Q86X10-3]
70221 [Q86X10-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262879; ENSP00000262879; ENSG00000170471 [Q86X10-1]
ENST00000397040; ENSP00000380233; ENSG00000170471 [Q86X10-1]
ENST00000397042; ENSP00000380235; ENSG00000170471 [Q86X10-3]
GeneIDi57148
KEGGihsa:57148
UCSCiuc002xiw.5 human [Q86X10-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57148
DisGeNETi57148

GeneCards: human genes, protein and diseases

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GeneCardsi
RALGAPB
HGNCiHGNC:29221 RALGAPB
HPAiHPA051454
neXtProtiNX_Q86X10
OpenTargetsiENSG00000170471
PharmGKBiPA165392608

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3652 Eukaryota
ENOG411027C LUCA
GeneTreeiENSGT00700000104550
HOGENOMiHOG000230877
InParanoidiQ86X10
OMAiFYMKAGQ
OrthoDBi54832at2759
PhylomeDBiQ86X10
TreeFamiTF324460

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RALGAPB human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA1219

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57148

Pharos

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Pharosi
Q86X10

Protein Ontology

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PROi
PR:Q86X10

Gene expression databases

BgeeiENSG00000170471 Expressed in 226 organ(s), highest expression level in forebrain
ExpressionAtlasiQ86X10 baseline and differential
GenevisibleiQ86X10 HS

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR039930 RALGAPB
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PANTHERiPTHR21344 PTHR21344, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRLGPB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86X10
Secondary accession number(s): A2A2E8
, A2A2E9, Q5TG31, Q8N3D1, Q8WWC0, Q9H3X8, Q9UJR1, Q9ULK1, Q9Y3G9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: September 18, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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