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Entry version 127 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Solute carrier family 13 member 5

Gene

SLC13A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q86YT5

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.47.1.9 the divalent anion:na(+) symporter (dass) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 13 member 5
Alternative name(s):
Na(+)/citrate cotransporter
Short name:
NaCT
Sodium-coupled citrate transporter
Sodium-dependent citrate transporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC13A5
Synonyms:NACT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23089 SLC13A5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608305 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86YT5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei487 – 507HelicalSequence analysisAdd BLAST21
Transmembranei528 – 548HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epileptic encephalopathy, early infantile, 25, with amelogenesis imperfecta (EIEE25)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disease characterized by subclinical seizures appearing in the first days of life, evolving to severe epileptic disease. Affected individuals have profound or severe delayed development with lack of speech, and most patients do not acquire the ability to sit. Additional variable features include axial hypotonia, peripheral hypertonia, and abnormal involuntary movements such as dystonia and choreoathetosis. Dental abnormalities, including delayed eruption, hypodontia, tooth hypoplasia, yellow discoloration, thin enamel, and enamel chipping are observed in most patients.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078912142T → M in EIEE25; loss of localization to plasma membrane; loss of function in citrate transport. 1 PublicationCorresponds to variant dbSNP:rs761917087EnsemblClinVar.1
Natural variantiVAR_078913219G → R in EIEE25; loss of function in citrate transport; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs144332569EnsemblClinVar.1
Natural variantiVAR_078914227T → M in EIEE25; loss of function in citrate transport; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs587777577EnsemblClinVar.1
Natural variantiVAR_078915341 – 568Missing in EIEE25; loss of localization to plasma membrane; loss of function in citrate transport. 1 PublicationAdd BLAST228
Natural variantiVAR_078916427S → L in EIEE25; loss of localization to plasma membrane; loss of function in citrate transport. 1 PublicationCorresponds to variant dbSNP:rs548065551EnsemblClinVar.1
Natural variantiVAR_078917488L → P in EIEE25. 1 PublicationCorresponds to variant dbSNP:rs587777578EnsemblClinVar.1
Natural variantiVAR_078918524D → H in EIEE25; loss of function in citrate transport; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs863225448Ensembl.1

Keywords - Diseasei

Amelogenesis imperfecta, Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...
DisGeNETi
284111

MalaCards human disease database

More...
MalaCardsi
SLC13A5
MIMi615905 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000141485

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1946 Amelocerebrohypohidrotic syndrome
3006 Pyridoxine-dependent epilepsy
442835 Undetermined early-onset epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134950956

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86YT5

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3769293

Drug and drug target database

More...
DrugBanki
DB09154 Sodium citrate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC13A5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74714197

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002601011 – 568Solute carrier family 13 member 5Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi562N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86YT5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86YT5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86YT5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86YT5

PeptideAtlas

More...
PeptideAtlasi
Q86YT5

PRoteomics IDEntifications database

More...
PRIDEi
Q86YT5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
29975
70466 [Q86YT5-1]
70467 [Q86YT5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86YT5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86YT5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141485 Expressed in 96 organ(s), highest expression level in parotid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86YT5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86YT5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044343
HPA057088

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129763, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q86YT5, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406220

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q86YT5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1281 Eukaryota
COG0471 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000278432

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86YT5

KEGG Orthology (KO)

More...
KOi
K14445

Identification of Orthologs from Complete Genome Data

More...
OMAi
QMEPLHT

Database of Orthologous Groups

More...
OrthoDBi
389981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86YT5

TreeFam database of animal gene trees

More...
TreeFami
TF312913

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031312 Na/sul_symport_CS
IPR001898 SLC13A/DASS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00939 Na_sulph_symp, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01271 NA_SULFATE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86YT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASALSYVSK FKSFVILFVT PLLLLPLVIL MPAKFVRCAY VIILMAIYWC
60 70 80 90 100
TEVIPLAVTS LMPVLLFPLF QILDSRQVCV QYMKDTNMLF LGGLIVAVAV
110 120 130 140 150
ERWNLHKRIA LRTLLWVGAK PARLMLGFMG VTALLSMWIS NTATTAMMVP
160 170 180 190 200
IVEAILQQME ATSAATEAGL ELVDKGKAKE LPGSQVIFEG PTLGQQEDQE
210 220 230 240 250
RKRLCKAMTL CICYAASIGG TATLTGTGPN VVLLGQMNEL FPDSKDLVNF
260 270 280 290 300
ASWFAFAFPN MLVMLLFAWL WLQFVYMRFN FKKSWGCGLE SKKNEKAALK
310 320 330 340 350
VLQEEYRKLG PLSFAEINVL ICFFLLVILW FSRDPGFMPG WLTVAWVEGE
360 370 380 390 400
TKYVSDATVA IFVATLLFIV PSQKPKFNFR SQTEEERKTP FYPPPLLDWK
410 420 430 440 450
VTQEKVPWGI VLLLGGGFAL AKGSEASGLS VWMGKQMEPL HAVPPAAITL
460 470 480 490 500
ILSLLVAVFT ECTSNVATTT LFLPIFASMS RSIGLNPLYI MLPCTLSASF
510 520 530 540 550
AFMLPVATPP NAIVFTYGHL KVADMVKTGV IMNIIGVFCV FLAVNTWGRA
560
IFDLDHFPDW ANVTHIET
Length:568
Mass (Da):63,062
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8995E56618DECCB
GO
Isoform 2 (identifier: Q86YT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     479-524: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):58,110
Checksum:iCD82CB02F6D574C7
GO
Isoform 3 (identifier: Q86YT5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-140: Missing.

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):61,210
Checksum:iB14F022B99048FF6
GO
Isoform 4 (identifier: Q86YT5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-77: Missing.

Note: No experimental confirmation available.
Show »
Length:525
Mass (Da):58,092
Checksum:iF2D93F70F424B588
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2Y7I3L2Y7_HUMAN
Solute carrier family 13 member 5
SLC13A5
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4X6I3L4X6_HUMAN
Solute carrier family 13 member 5
SLC13A5
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L424I3L424_HUMAN
Solute carrier family 13 member 5
SLC13A5
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4S9I3L4S9_HUMAN
Solute carrier family 13 member 5
SLC13A5
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti269W → R in BAD18766 (PubMed:14702039).Curated1
Sequence conflicti330W → R in BAH12628 (PubMed:14702039).Curated1
Sequence conflicti376K → R in BAD18766 (PubMed:14702039).Curated1
Sequence conflicti475I → V in BAH12628 (PubMed:14702039).Curated1
Sequence conflicti548G → E in BAH12628 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078912142T → M in EIEE25; loss of localization to plasma membrane; loss of function in citrate transport. 1 PublicationCorresponds to variant dbSNP:rs761917087EnsemblClinVar.1
Natural variantiVAR_078913219G → R in EIEE25; loss of function in citrate transport; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs144332569EnsemblClinVar.1
Natural variantiVAR_078914227T → M in EIEE25; loss of function in citrate transport; no effect on localization to plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs587777577EnsemblClinVar.1
Natural variantiVAR_078915341 – 568Missing in EIEE25; loss of localization to plasma membrane; loss of function in citrate transport. 1 PublicationAdd BLAST228
Natural variantiVAR_078916427S → L in EIEE25; loss of localization to plasma membrane; loss of function in citrate transport. 1 PublicationCorresponds to variant dbSNP:rs548065551EnsemblClinVar.1
Natural variantiVAR_078917488L → P in EIEE25. 1 PublicationCorresponds to variant dbSNP:rs587777578EnsemblClinVar.1
Natural variantiVAR_078918524D → H in EIEE25; loss of function in citrate transport; no effect on localization to plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs863225448Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05565235 – 77Missing in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_054910124 – 140Missing in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_043098479 – 524Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY151833 mRNA Translation: AAN86530.1
AK172785 mRNA Translation: BAD18766.1
AK127797 mRNA Translation: BAG54572.1
AK297612 mRNA Translation: BAH12628.1
AC004706 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90292.1
BC104795 mRNA Translation: AAI04796.1
BC112151 mRNA Translation: AAI12152.1
BC143689 mRNA Translation: AAI43690.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11079.1 [Q86YT5-1]
CCDS45593.1 [Q86YT5-2]
CCDS67136.1 [Q86YT5-4]
CCDS67137.1 [Q86YT5-3]

NCBI Reference Sequences

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RefSeqi
NP_001137310.1, NM_001143838.2 [Q86YT5-2]
NP_001271438.1, NM_001284509.1 [Q86YT5-3]
NP_001271439.1, NM_001284510.1 [Q86YT5-4]
NP_808218.1, NM_177550.4 [Q86YT5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000293800; ENSP00000293800; ENSG00000141485 [Q86YT5-3]
ENST00000381074; ENSP00000370464; ENSG00000141485 [Q86YT5-4]
ENST00000433363; ENSP00000406220; ENSG00000141485 [Q86YT5-1]
ENST00000573648; ENSP00000459372; ENSG00000141485 [Q86YT5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284111

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284111

UCSC genome browser

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UCSCi
uc002gdj.5 human [Q86YT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151833 mRNA Translation: AAN86530.1
AK172785 mRNA Translation: BAD18766.1
AK127797 mRNA Translation: BAG54572.1
AK297612 mRNA Translation: BAH12628.1
AC004706 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90292.1
BC104795 mRNA Translation: AAI04796.1
BC112151 mRNA Translation: AAI12152.1
BC143689 mRNA Translation: AAI43690.1
CCDSiCCDS11079.1 [Q86YT5-1]
CCDS45593.1 [Q86YT5-2]
CCDS67136.1 [Q86YT5-4]
CCDS67137.1 [Q86YT5-3]
RefSeqiNP_001137310.1, NM_001143838.2 [Q86YT5-2]
NP_001271438.1, NM_001284509.1 [Q86YT5-3]
NP_001271439.1, NM_001284510.1 [Q86YT5-4]
NP_808218.1, NM_177550.4 [Q86YT5-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi129763, 2 interactors
IntActiQ86YT5, 18 interactors
STRINGi9606.ENSP00000406220

Chemistry databases

BindingDBiQ86YT5
ChEMBLiCHEMBL3769293
DrugBankiDB09154 Sodium citrate

Protein family/group databases

TCDBi2.A.47.1.9 the divalent anion:na(+) symporter (dass) family

PTM databases

iPTMnetiQ86YT5
PhosphoSitePlusiQ86YT5

Polymorphism and mutation databases

BioMutaiSLC13A5
DMDMi74714197

Proteomic databases

jPOSTiQ86YT5
MassIVEiQ86YT5
MaxQBiQ86YT5
PaxDbiQ86YT5
PeptideAtlasiQ86YT5
PRIDEiQ86YT5
ProteomicsDBi29975
70466 [Q86YT5-1]
70467 [Q86YT5-2]

Genome annotation databases

EnsembliENST00000293800; ENSP00000293800; ENSG00000141485 [Q86YT5-3]
ENST00000381074; ENSP00000370464; ENSG00000141485 [Q86YT5-4]
ENST00000433363; ENSP00000406220; ENSG00000141485 [Q86YT5-1]
ENST00000573648; ENSP00000459372; ENSG00000141485 [Q86YT5-2]
GeneIDi284111
KEGGihsa:284111
UCSCiuc002gdj.5 human [Q86YT5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
284111
DisGeNETi284111

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC13A5
HGNCiHGNC:23089 SLC13A5
HPAiHPA044343
HPA057088
MalaCardsiSLC13A5
MIMi608305 gene
615905 phenotype
neXtProtiNX_Q86YT5
OpenTargetsiENSG00000141485
Orphaneti1946 Amelocerebrohypohidrotic syndrome
3006 Pyridoxine-dependent epilepsy
442835 Undetermined early-onset epileptic encephalopathy
PharmGKBiPA134950956

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1281 Eukaryota
COG0471 LUCA
GeneTreeiENSGT00950000182724
HOGENOMiHOG000278432
InParanoidiQ86YT5
KOiK14445
OMAiQMEPLHT
OrthoDBi389981at2759
PhylomeDBiQ86YT5
TreeFamiTF312913

Enzyme and pathway databases

ReactomeiR-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters
SABIO-RKiQ86YT5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC13A5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284111
PharosiQ86YT5

Protein Ontology

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PROi
PR:Q86YT5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141485 Expressed in 96 organ(s), highest expression level in parotid gland
ExpressionAtlasiQ86YT5 baseline and differential
GenevisibleiQ86YT5 HS

Family and domain databases

InterProiView protein in InterPro
IPR031312 Na/sul_symport_CS
IPR001898 SLC13A/DASS
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit
PROSITEiView protein in PROSITE
PS01271 NA_SULFATE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS13A5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86YT5
Secondary accession number(s): B3KXR0
, B7Z4P2, B7ZLB4, F8W7N2, Q6ZMG1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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