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Entry version 125 (13 Nov 2019)
Sequence version 4 (13 Nov 2019)
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Protein

Methylcytosine dioxygenase TET3

Gene

Tet3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity).By similarity7 Publications

Caution

Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi57ZincBy similarity1
Metal bindingi60ZincBy similarity1
Metal bindingi63ZincBy similarity1
Metal bindingi69ZincBy similarity1
Metal bindingi72ZincBy similarity1
Metal bindingi75ZincBy similarity1
Metal bindingi84ZincBy similarity1
Metal bindingi89ZincBy similarity1
Metal bindingi836Zinc 1By similarity1
Metal bindingi838Zinc 1By similarity1
Metal bindingi896Zinc 2By similarity1
Metal bindingi922Zinc 1; via pros nitrogenBy similarity1
Metal bindingi924Zinc 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei9642-oxoglutarateBy similarity1
Metal bindingi974Zinc 2By similarity1
Metal bindingi976Zinc 2By similarity1
Metal bindingi992Zinc 3By similarity1
Metal bindingi1001Zinc 3By similarity1
Metal bindingi1061Zinc 3By similarity1
Binding sitei10772-oxoglutarateBy similarity1
Metal bindingi1083Zinc 2; via tele nitrogenBy similarity1
Metal bindingi1085Iron; catalyticBy similarity1
Metal bindingi1087Iron; catalyticBy similarity1
Binding sitei1090SubstrateBy similarity1
Binding sitei11192-oxoglutarateBy similarity1
Metal bindingi1681Iron; catalyticBy similarity1
Metal bindingi1712Zinc 3; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri50 – 90CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST41

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Dioxygenase, DNA-binding, Oxidoreductase
LigandIron, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylcytosine dioxygenase TET3 (EC:1.14.11.n24 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tet3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2446229 Tet3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Neonatal lethality. A germline-specific conditional knockout produces females that are normal in growth and morphology but display much reduced fecundity in terms of the frequency of successful pregnancy per mating and the litter size. No 5hmC signal is detected in the late male pronuclei of zygotes collected from the conditional knockout females mated with wild-type males. In contrast, deletion of Tet3 from the male germ cells does not seem to affect the change in 5hmC and 5mC.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1085H → Y: Loss of enzyme activity; when associated with A-1087. 2 Publications1
Mutagenesisi1087D → A: Loss of enzyme activity; when associated with Y-1085. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003402281 – 1803Methylcytosine dioxygenase TET3Add BLAST1803

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki490Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1271Asymmetric dimethylarginineCombined sources1
Cross-linki1405Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1569Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
K9JH93

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8BG87

PeptideAtlas

More...
PeptideAtlasi
Q8BG87

PRoteomics IDEntifications database

More...
PRIDEi
Q8BG87

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8BG87

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8BG87

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in oocytes and zygotes. Not expressed in embryonic stem cells (ES cells).5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally. Expressed at high levels in oocytes and zygotes, with rapidly declining levels at the two-cell stage.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034832 Expressed in 125 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8BG87 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8BG87 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HCFC1 and OGT.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O152942EBI-9031997,EBI-539828From Homo sapiens.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228786, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8BG87, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8BG87

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000087049

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11803
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8BG87

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni993 – 1006Interaction with DNABy similarityAdd BLAST14
Regioni1696 – 16982-oxoglutarate bindingBy similarity3
Regioni1702 – 1704Substrate bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CXXC-type zinc-finger domain mediates binding to DNA sequences containing unmethylated cytosine or 5-carboxylcytosine in 5'-CCG-3' DNA sequence motifs (PubMed:26774490). It mediates binding to CpG-DNA (By similarity).By similarity1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 90CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST41

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE22 Eukaryota
ENOG410XPWW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157631

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000203929

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8BG87

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEDVQAH

Database of Orthologous Groups

More...
OrthoDBi
29059at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8BG87

TreeFam database of animal gene trees

More...
TreeFami
TF342373

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3

The PANTHER Classification System

More...
PANTHERi
PTHR23358 PTHR23358, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12851 Tet_JBP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01333 Tet_JBP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058 ZF_CXXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: Q8BG87-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQFQVPLAV QPDLSGLYDF PQGQVMVGGF QGPGLPMAGS ETQLRGGGDG
60 70 80 90 100
RKKRKRCGTC DPCRRLENCG SCTSCTNRRT HQICKLRKCE VLKKKAGLLK
110 120 130 140 150
EVEINAREGT GPWAQGATVK TGSELSPVDG PVPGQMDSGP VYHGDSRQLS
160 170 180 190 200
TSGAPVNGAR EPAGPGLLGA AGPWRVDQKP DWEAASGPTH AARLEDAHDL
210 220 230 240 250
VAFSAVAEAV SSYGALSTRL YETFNREMSR EAGSNGRGPR PESCSEGSED
260 270 280 290 300
LDTLQTALAL ARHGMKPPNC TCDGPECPDF LEWLEGKIKS MAMEGGQGRP
310 320 330 340 350
RLPGALPPSE AGLPAPSTRP PLLSSEVPQV PPLEGLPLSQ SALSIAKEKN
360 370 380 390 400
ISLQTAIAIE ALTQLSSALP QPSHSTSQAS CPLPEALSPS APFRSPQSYL
410 420 430 440 450
RAPSWPVVPP EEHPSFAPDS PAFPPATPRP EFSEAWGTDT PPATPRNSWP
460 470 480 490 500
VPRPSPDPMA ELEQLLGSAS DYIQSVFKRP EALPTKPKVK VEAPSSSPAP
510 520 530 540 550
VPSPISQREA PLLSSEPDTH QKAQTALQQH LHHKRNLFLE QAQDASFPTS
560 570 580 590 600
TEPQAPGWWA PPGSPAPRPP DKPPKEKKKK PPTPAGGPVG AEKTTPGIKT
610 620 630 640 650
SVRKPIQIKK SRSRDMQPLF LPVRQIVLEG LKPQASEGQA PLPAQLSVPP
660 670 680 690 700
PASQGAASQS CATPLTPEPS LALFAPSPSG DSLLPPTQEM RSPSPMVALQ
710 720 730 740 750
SGSTGGPLPP ADDKLEELIR QFEAEFGDSF GLPGPPSVPI QEPENQSTCL
760 770 780 790 800
PAPESPFATR SPKKIKIESS GAVTVLSTTC FHSEEGGQEA TPTKAENPLT
810 820 830 840 850
PTLSGFLESP LKYLDTPTKS LLDTPAKKAQ SEFPTCDCVE QIVEKDEGPY
860 870 880 890 900
YTHLGSGPTV ASIRELMEDR YGEKGKAIRI EKVIYTGKEG KSSRGCPIAK
910 920 930 940 950
WVIRRHTLEE KLLCLVRHRA GHHCQNAVIV ILILAWEGIP RSLGDTLYQE
960 970 980 990 1000
LTDTLRKYGN PTSRRCGLND DRTCACQGKD PNTCGASFSF GCSWSMYFNG
1010 1020 1030 1040 1050
CKYARSKTPR KFRLTGDNPK EEEVLRNSFQ DLATEVAPLY KRLAPQAYQN
1060 1070 1080 1090 1100
QVTNEDVAID CRLGLKEGRP FSGVTACMDF CAHAHKDQHN LYNGCTVVCT
1110 1120 1130 1140 1150
LTKEDNRCVG QIPEDEQLHV LPLYKMASTD EFGSEENQNA KVSSGAIQVL
1160 1170 1180 1190 1200
TAFPREVRRL PEPAKSCRQR QLEARKAAAE KKKLQKEKLS TPEKIKQEAL
1210 1220 1230 1240 1250
ELAGVTTDPG LSLKGGLSQQ SLKPSLKVEP QNHFSSFKYS GNAVVESYSV
1260 1270 1280 1290 1300
LGSCRPSDPY SMSSVYSYHS RYAQPGLASV NGFHSKYTLP SFGYYGFPSS
1310 1320 1330 1340 1350
NPVFPSQFLG PSAWGHGGSG GSFEKKPDLH ALHNSLNPAY GGAEFAELPG
1360 1370 1380 1390 1400
QAVATDNHHP IPHHQQPAYP GPKEYLLPKV PQLHPASRDP SPFAQSSSCY
1410 1420 1430 1440 1450
NRSIKQEPID PLTQAESIPR DSAKMSRTPL PEASQNGGPS HLWGQYSGGP
1460 1470 1480 1490 1500
SMSPKRTNSV GGNWGVFPPG ESPTIVPDKL NSFGASCLTP SHFPESQWGL
1510 1520 1530 1540 1550
FTGEGQQSAP HAGARLRGKP WSPCKFGNGT SALTGPSLTE KPWGMGTGDF
1560 1570 1580 1590 1600
NPALKGGPGF QDKLWNPVKV EEGRIPTPGA NPLDKAWQAF GMPLSSNEKL
1610 1620 1630 1640 1650
FGALKSEEKL WDPFSLEEGT AEEPPSKGVV KEEKSGPTVE EDEEELWSDS
1660 1670 1680 1690 1700
EHNFLDENIG GVAVAPAHCS ILIECARREL HATTPLKKPN RCHPTRISLV
1710 1720 1730 1740 1750
FYQHKNLNQP NHGLALWEAK MKQLAERARQ RQEEAARLGL GQQEAKLYGK
1760 1770 1780 1790 1800
KRKWGGAMVA EPQHKEKKGA IPTRQALAMP TDSAVTVSSY AYTKVTGPYS

RWI
Length:1,803
Mass (Da):194,792
Last modified:November 13, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE0492ADBC4EBFD5
GO
Isoform 2 (identifier: Q8BG87-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.
     840-854: EQIVEKDEGPYYTHL → GRWEWSRAFFLSVEH
     855-1803: Missing.

Show »
Length:719
Mass (Da):76,256
Checksum:iB555784E77D63C5B
GO
Isoform 1 (identifier: Q8BG87-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-120: Missing.

Show »
Length:1,784
Mass (Da):192,826
Checksum:i7F2E0BF6BE491516
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WP90A0A087WP90_MOUSE
Methylcytosine dioxygenase TET3
Tet3
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH96437 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH96437 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1097V → A in AAH96437 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0604041 – 135Missing in isoform 2. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_060405102 – 120Missing in isoform 1. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_060406840 – 854EQIVE…YYTHL → GRWEWSRAFFLSVEH in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_060407855 – 1803Missing in isoform 2. 1 PublicationAdd BLAST949

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ423151 mRNA Translation: ADR57137.1
HQ423152 mRNA Translation: ADR57138.1
JX946278 mRNA Translation: AGB05430.1
AK044758 mRNA Translation: BAC32068.1
AK046543 mRNA Translation: BAC32779.1
AK046552 mRNA Translation: BAC32784.1
AK046553 mRNA Translation: BAC32785.1
GL456132 Genomic DNA No translation available.
BC096437 mRNA Translation: AAH96437.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51820.1 [Q8BG87-1]
CCDS85071.1 [Q8BG87-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001334242.1, NM_001347313.1 [Q8BG87-4]
NP_898961.2, NM_183138.2 [Q8BG87-1]
XP_006505838.1, XM_006505775.3 [Q8BG87-4]
XP_006505839.1, XM_006505776.3 [Q8BG87-4]
XP_017176954.1, XM_017321465.1 [Q8BG87-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000089622; ENSMUSP00000087049; ENSMUSG00000034832 [Q8BG87-1]
ENSMUST00000186548; ENSMUSP00000139630; ENSMUSG00000034832 [Q8BG87-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
194388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:194388

UCSC genome browser

More...
UCSCi
uc009cni.2 mouse [Q8BG87-1]
uc009cnl.1 mouse [Q8BG87-2]
uc033isr.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ423151 mRNA Translation: ADR57137.1
HQ423152 mRNA Translation: ADR57138.1
JX946278 mRNA Translation: AGB05430.1
AK044758 mRNA Translation: BAC32068.1
AK046543 mRNA Translation: BAC32779.1
AK046552 mRNA Translation: BAC32784.1
AK046553 mRNA Translation: BAC32785.1
GL456132 Genomic DNA No translation available.
BC096437 mRNA Translation: AAH96437.1 Sequence problems.
CCDSiCCDS51820.1 [Q8BG87-1]
CCDS85071.1 [Q8BG87-4]
RefSeqiNP_001334242.1, NM_001347313.1 [Q8BG87-4]
NP_898961.2, NM_183138.2 [Q8BG87-1]
XP_006505838.1, XM_006505775.3 [Q8BG87-4]
XP_006505839.1, XM_006505776.3 [Q8BG87-4]
XP_017176954.1, XM_017321465.1 [Q8BG87-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EXHX-ray1.30C51-96[»]
SMRiQ8BG87
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi228786, 1 interactor
IntActiQ8BG87, 1 interactor
MINTiQ8BG87
STRINGi10090.ENSMUSP00000087049

PTM databases

iPTMnetiQ8BG87
PhosphoSitePlusiQ8BG87

Proteomic databases

EPDiK9JH93
PaxDbiQ8BG87
PeptideAtlasiQ8BG87
PRIDEiQ8BG87

Genome annotation databases

EnsembliENSMUST00000089622; ENSMUSP00000087049; ENSMUSG00000034832 [Q8BG87-1]
ENSMUST00000186548; ENSMUSP00000139630; ENSMUSG00000034832 [Q8BG87-4]
GeneIDi194388
KEGGimmu:194388
UCSCiuc009cni.2 mouse [Q8BG87-1]
uc009cnl.1 mouse [Q8BG87-2]
uc033isr.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
200424
MGIiMGI:2446229 Tet3

Phylogenomic databases

eggNOGiENOG410IE22 Eukaryota
ENOG410XPWW LUCA
GeneTreeiENSGT00940000157631
HOGENOMiHOG000203929
InParanoidiQ8BG87
OMAiSEDVQAH
OrthoDBi29059at2759
PhylomeDBiQ8BG87
TreeFamiTF342373

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tet3 mouse

Protein Ontology

More...
PROi
PR:Q8BG87

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034832 Expressed in 125 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8BG87 baseline and differential
GenevisibleiQ8BG87 MM

Family and domain databases

InterProiView protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3
PANTHERiPTHR23358 PTHR23358, 1 hit
PfamiView protein in Pfam
PF12851 Tet_JBP, 1 hit
SMARTiView protein in SMART
SM01333 Tet_JBP, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8BG87
Secondary accession number(s): K9JH93
, L0HN04, Q4VAD3, Q8C8N8, Q8CI60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 13, 2019
Last modified: November 13, 2019
This is version 125 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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