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Entry version 133 (16 Oct 2019)
Sequence version 3 (07 Dec 2004)
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Protein

Liprin-beta-1

Gene

Ppfibp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity).By similarity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-388844 Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Liprin-beta-1
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
Short name:
PTPRF-interacting protein-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppfibp1
Synonyms:Kiaa1230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914783 Ppfibp1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910351 – 969Liprin-beta-1Add BLAST969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineBy similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei40PhosphoserineCombined sources1
Modified residuei291N6-acetyllysineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei435PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei500PhosphoserineBy similarity1
Modified residuei538PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei957PhosphoserineBy similarity1
Modified residuei959PhosphoserineBy similarity1
Modified residuei961PhosphoserineCombined sources1
Modified residuei963PhosphothreonineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C8U0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8C8U0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C8U0

PeptideAtlas

More...
PeptideAtlasi
Q8C8U0

PRoteomics IDEntifications database

More...
PRIDEi
Q8C8U0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C8U0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C8U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000016487 Expressed in 249 organ(s), highest expression level in cumulus cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C8U0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C8U0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homodimers and heterodimers.

Interacts with S100A4 in a calcium-dependent mode (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
212256, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8C8U0, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8C8U0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107250

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1969
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C8U0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini606 – 670SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini678 – 741SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini763 – 835SAM 3PROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili99 – 310Sequence analysisAdd BLAST212

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4 (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1899 Eukaryota
ENOG410XSFF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082535

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C8U0

Identification of Orthologs from Complete Genome Data

More...
OMAi
CNWLQDQ

Database of Orthologous Groups

More...
OrthoDBi
558442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C8U0

TreeFam database of animal gene trees

More...
TreeFami
TF314207

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 3 hits
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042180 IF_rod_dom_coil1B
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00454 SAM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C8U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE VLIEWLQNQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKLNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL ELMAEISNLK LKLTAVEKDR LDYEDRFRDT
210 220 230 240 250
EGLIQEINDL RLKVNEMDGE RLQYEKKLKS TKDELASLKE QLEEKECEVK
260 270 280 290 300
RLQERLVCKA KGEGIEVLDR DIEVQKMKKA VESLMAANEE KERKIEDLRQ
310 320 330 340 350
CLSRYRKMQD PAVLAQGQDS ECEGLFHSSS ISTLLDAQGF SDLERSTSST
360 370 380 390 400
PGMGSPSRDL LHTSAPEEFH TSVLQASIPS LLPPSVDVDT CEKPKLPTKP
410 420 430 440 450
ETSFEEGDGR AILGAAAEVS LSDGVSTSSL QKSSSLGNLK KEASDGTDKA
460 470 480 490 500
PTDSRTFGTL PPKVPGHEAS VDDNPFGTRK ARSSFGRGFF KIKSGKRTAS
510 520 530 540 550
APNLAETEKE TAEHLNLAGT SRSKGSQGTS PFPMSPPSPD SRKKSRGIMR
560 570 580 590 600
LFGKLRRSQS TTFNPDDMSE PEFKRGGTRA TAGPRLGWSR DLGQSNSDLD
610 620 630 640 650
MPFAKWTKEQ VCSWLAEQGL GSYLSSGKHW IISGQTLLQA SQQDLEKELG
660 670 680 690 700
IKHSLHRKKL QLALQALGSE EETNYGKLDF NWVTRWLDDI GLPQYKTQFD
710 720 730 740 750
EGRVDGRMLH YMTVDDLLSL KVVSVLHHLS IKRAIQVLRI NNFEPNCLRR
760 770 780 790 800
RPSDENSITP SEVQQWTNHR VMEWLRSVDL AEYAPNLRGS GVHGGLMVLE
810 820 830 840 850
PRFNVETMAQ LLNIPPNKTL LRRHLATHFN LLIGAEAQHQ KRDAMELPDY
860 870 880 890 900
VLLTATAKVK PKKLTFSNFG NLRKKKHEDG EEYVCPMELG QASGSSQKGF
910 920 930 940 950
RPGLDMRLYE EDDLDRLEQM EDSEGTVRQI GAFSEGINNL THMLKEDDMF
960
KDFAARSPSA SITDEDSNV
Note: No experimental confirmation available.
Length:969
Mass (Da):108,540
Last modified:December 7, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7322E25285DDF499
GO
Isoform 2 (identifier: Q8C8U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.

Note: No experimental confirmation available.
Show »
Length:693
Mass (Da):76,921
Checksum:iDA531714968AEC25
GO
Isoform 3 (identifier: Q8C8U0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-271: D → DENIKKKLKEKN

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):109,894
Checksum:i867A8633F7167EAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6S1C4F6S1C4_MOUSE
Liprin-beta-1
Ppfibp1
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YZ95F6YZ95_MOUSE
Liprin-beta-1
Ppfibp1
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CUU8F7CUU8_MOUSE
Liprin-beta-1
Ppfibp1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SUZ5A0A0N4SUZ5_MOUSE
Liprin-beta-1
Ppfibp1
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0N4SVG3A0A0N4SVG3_MOUSE
Liprin-beta-1
Ppfibp1
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32411 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti360L → P in BAD32411 (PubMed:15489334).Curated1
Sequence conflicti389D → E (PubMed:16141072).Curated1
Sequence conflicti389D → E (PubMed:15489334).Curated1
Sequence conflicti817 – 874NKTLL…GNLRK → CQQHLHLPLTVLFLYIFLNT CIYTVYRKQNLYFVTQGSKD HIKMKKPQYFNDHIPADS in BAC31950 (PubMed:16141072).CuratedAdd BLAST58
Sequence conflicti875 – 969Missing (PubMed:16141072).CuratedAdd BLAST95

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0120951 – 276Missing in isoform 2. 1 PublicationAdd BLAST276
Alternative sequenceiVSP_012096271D → DENIKKKLKEKN in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK044496 mRNA Translation: BAC31950.1
AK014559 mRNA Translation: BAB29428.1
AK173133 mRNA Translation: BAD32411.1 Different initiation.
BC049862 mRNA Translation: AAH49862.1
BC058176 mRNA Translation: AAH58176.1
BC072603 mRNA Translation: AAH72603.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39715.1 [Q8C8U0-1]
CCDS51958.1 [Q8C8U0-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001163904.1, NM_001170433.1 [Q8C8U0-3]
NP_080497.1, NM_026221.2 [Q8C8U0-1]
XP_017177208.1, XM_017321719.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000016631; ENSMUSP00000016631; ENSMUSG00000016487 [Q8C8U0-1]
ENSMUST00000111623; ENSMUSP00000107250; ENSMUSG00000016487 [Q8C8U0-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67533

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67533

UCSC genome browser

More...
UCSCi
uc009esm.2 mouse [Q8C8U0-1]
uc009esn.2 mouse [Q8C8U0-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044496 mRNA Translation: BAC31950.1
AK014559 mRNA Translation: BAB29428.1
AK173133 mRNA Translation: BAD32411.1 Different initiation.
BC049862 mRNA Translation: AAH49862.1
BC058176 mRNA Translation: AAH58176.1
BC072603 mRNA Translation: AAH72603.1
CCDSiCCDS39715.1 [Q8C8U0-1]
CCDS51958.1 [Q8C8U0-3]
RefSeqiNP_001163904.1, NM_001170433.1 [Q8C8U0-3]
NP_080497.1, NM_026221.2 [Q8C8U0-1]
XP_017177208.1, XM_017321719.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TADX-ray2.90C/D593-853[»]
SMRiQ8C8U0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi212256, 1 interactor
IntActiQ8C8U0, 2 interactors
MINTiQ8C8U0
STRINGi10090.ENSMUSP00000107250

PTM databases

iPTMnetiQ8C8U0
PhosphoSitePlusiQ8C8U0

Proteomic databases

EPDiQ8C8U0
jPOSTiQ8C8U0
PaxDbiQ8C8U0
PeptideAtlasiQ8C8U0
PRIDEiQ8C8U0

Genome annotation databases

EnsembliENSMUST00000016631; ENSMUSP00000016631; ENSMUSG00000016487 [Q8C8U0-1]
ENSMUST00000111623; ENSMUSP00000107250; ENSMUSG00000016487 [Q8C8U0-3]
GeneIDi67533
KEGGimmu:67533
UCSCiuc009esm.2 mouse [Q8C8U0-1]
uc009esn.2 mouse [Q8C8U0-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8496
MGIiMGI:1914783 Ppfibp1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1899 Eukaryota
ENOG410XSFF LUCA
GeneTreeiENSGT00950000182675
HOGENOMiHOG000082535
InParanoidiQ8C8U0
OMAiCNWLQDQ
OrthoDBi558442at2759
PhylomeDBiQ8C8U0
TreeFamiTF314207

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ppfibp1 mouse

Protein Ontology

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PROi
PR:Q8C8U0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000016487 Expressed in 249 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ8C8U0 baseline and differential
GenevisibleiQ8C8U0 MM

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
Gene3Di1.10.150.50, 3 hits
1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR042180 IF_rod_dom_coil1B
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIPB1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C8U0
Secondary accession number(s): Q69ZN5
, Q6GQV3, Q80VB4, Q9CUT7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 7, 2004
Last modified: October 16, 2019
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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