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Entry version 125 (05 Jun 2019)
Sequence version 2 (22 Sep 2009)
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Protein

Phosphoinositide phospholipase C

Gene

PF3D7_1013500

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationImported
Biological processLipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-PFA-114604 GPVI-mediated activation cascade
R-PFA-1169408 ISG15 antiviral mechanism
R-PFA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-PFA-202433 Generation of second messenger molecules
R-PFA-5607764 CLEC7A (Dectin-1) signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1013500Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1013500

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8IJR0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8IJR0, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini984 – 1087PI-PLC Y-boxInterPro annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni335 – 357DisorderedSequence analysisAdd BLAST23
Regioni912 – 938DisorderedSequence analysisAdd BLAST27
Regioni1235 – 1254DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi339 – 357PolyampholyteSequence analysisAdd BLAST19
Compositional biasi912 – 936PolarSequence analysisAdd BLAST25

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
AKILICI

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit
3.20.20.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035892 C2_domain_sf
IPR024774 PH_dom-Mcp5-type
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...
PANTHERi
PTHR10336 PTHR10336, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12814 Mcp5_PH, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390 PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51695 SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50008 PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IJR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLSAKIDSN GYNNNIVEKN DDKRIGRIMS DDENERKDII YNNEKNKRTS
60 70 80 90 100
EIKVLKNDMD NNKNDNSIQS KLSFDIKNVL THAYLPICLE KMKEGEYVYK
110 120 130 140 150
WNNNIFQKKT LKFFYLDVNN YCIRWNSKKK KLSEKKNPSL YICDIIKILD
160 170 180 190 200
GSESLFFKKK EDDKNLSIEI ISTQRNLRLT FLDIQRWKMW LFGLMYYQYK
210 220 230 240 250
LVNKGNGKKK MKSFLYESNK LYDNYIISGL KDINALTLSQ LYIILRSLNI
260 270 280 290 300
YLNMQILYHY FSIYKNKAVI NYIGFTKILE HIFSNTHISI YFNEYKDKKF
310 320 330 340 350
NYIDKKKFIE FLIDIQCEGK CEEFIFNNYY QNDTNPNLTR EKNTEKLERE
360 370 380 390 400
KKNDEDDTHY NLDMMQSSAH NNKIYNVNNQ MDDISIKYKN EDDVKPKHIF
410 420 430 440 450
NNDNKENCNK EENNYSKSEN NTYFNNDNNN NNKVRNEAII NNYDCNIIKK
460 470 480 490 500
ISNQYINQDD IKYNMDISNT LIFSDNSIIH DEDYFLILDI LKSKYFYHDQ
510 520 530 540 550
NKVGNKKNTH DNNYNNYNNN SANASCHHNL KDEKESKLNS NNNNNNNNNN
560 570 580 590 600
NVDTCINVIN KNIPNIYPIK VNVIYKLLNI IKKYNIPFVI NNDDNQYLTE
610 620 630 640 650
IGLVYFLLSK ENSIMCPEYA KVYQNMNLPL CNYWINSSHN SYLARKQIFS
660 670 680 690 700
TSNIEQYIYI LLDGCRCVEF DCYYFNKNIV VYHGFYGYKL TSSILFCDTL
710 720 730 740 750
IACKMFGFTT SPYPIILSLE IHCKNKHKNL IAKILISILG NQLYIPKTTD
760 770 780 790 800
EINNITPNNC KNKFLVKYKH FENNDSSGFY YLFEGLQSVM YDELNYMSDI
810 820 830 840 850
LDENDELDYD NEDMDVLQQN CQGELLHNDD VDVENFDADE DEYEMEKTFG
860 870 880 890 900
EYIEKSIEKK YNQDSINHKQ LYMKNSDSNN NVSIEKENYE EKHNKFVEDT
910 920 930 940 950
KKPRNILNII KKNDNNMDND SSDNNNNNNV KIPKNSITSC IEKKDKSKDL
960 970 980 990 1000
EEQKKKHILK KTDNFNLKNN NLLNEYSCLK GYVFRNFYET RNYNEICSIS
1010 1020 1030 1040 1050
ENKFIKLIKK NENEIIKYNQ KTLTRVYPSG TRLASTNFNP LIFWNAGIQV
1060 1070 1080 1090 1100
VALNYQYNGL SMLLNKGRFL ENGGKHSGYI LKPELLRFNE KQDYNTLLLD
1110 1120 1130 1140 1150
LQILSLHQIN LLFSIKNKYH EKKLKKKLFQ MDMIQRIQTH KKIKKKIKNW
1160 1170 1180 1190 1200
KDLQKLEKEK KNILFSDVQS DDNKNKHISY ELLLNKINDN DDVNYIHNKC
1210 1220 1230 1240 1250
LNVEKKYEDM LTEYKSFLLC SSSLSHSSSF NSCSSNTTTS NDGNKTHSNK
1260 1270 1280 1290 1300
NNSSKYKNKN FYQTFEELKK ANNLFFYLYL TISIHGYNEN KYYFKTEIAK
1310 1320 1330 1340 1350
VNFYDINYCW SKPSTFQMKI SYPSLALIVF ELKAYDTVKS EIIACACFPV
1360 1370 1380
KCLREGLRFV PLCDKYLKDI KGSGILVNLK INQEN
Length:1,385
Mass (Da):164,152
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2BA7F68FC3032D8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999944 Genomic DNA Translation: CZT98385.1

NCBI Reference Sequences

More...
RefSeqi
XP_001347417.2, XM_001347381.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT98385; CZT98385; PF3D7_1013500

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1013500.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
810290

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1013500

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999944 Genomic DNA Translation: CZT98385.1
RefSeqiXP_001347417.2, XM_001347381.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8IJR0, 1 interactor

Proteomic databases

PRIDEiQ8IJR0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCZT98385; CZT98385; PF3D7_1013500
GeneDBiPF3D7_1013500.1:pep
GeneIDi810290
KEGGipfa:PF3D7_1013500

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1013500

Phylogenomic databases

OMAiAKILICI

Enzyme and pathway databases

ReactomeiR-PFA-114604 GPVI-mediated activation cascade
R-PFA-1169408 ISG15 antiviral mechanism
R-PFA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-PFA-202433 Generation of second messenger molecules
R-PFA-5607764 CLEC7A (Dectin-1) signaling

Family and domain databases

Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR024774 PH_dom-Mcp5-type
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 2 hits
PfamiView protein in Pfam
PF12814 Mcp5_PH, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50008 PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8IJR0_PLAF7
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IJR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: September 22, 2009
Last modified: June 5, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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