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Entry version 149 (13 Nov 2019)
Sequence version 2 (01 Jun 2003)
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Protein

Histone-lysine N-methyltransferase trr

Gene

trr

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post-furrow differentiation of the retinal epithelium, notably by activating expression of hh. Also required for wing and abdominal development.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1895 – 1935C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1956 – 2003PHD-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase trr (EC:2.1.1.43)
Alternative name(s):
Lysine N-methyltransferase 2C
Trithorax-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trr
Synonyms:KMT2C
ORF Names:CG3848
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0023518 trr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defects in mechanosensory bristle spacing and differentiation in wings and lack of chaetes and macrochaetes in abdominal a4 and a5 segments.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595241 – 2431Histone-lysine N-methyltransferase trrAdd BLAST2431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1486Phosphothreonine1 Publication1
Modified residuei1488Phosphoserine1 Publication1
Modified residuei1490Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IRW8

PRoteomics IDEntifications database

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PRIDEi
Q8IRW8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IRW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Abundantly expressed in 1-7 than in 7-20 hours old embryos. Expressed uniformly at the preblastoderm stage, prior to the onset of zygotic transcription. In ovaries, it is not expressed in ovarian stem cells, oogonia or early cysts and is first detectable at stage 8 in nurse cells. At stage 10, it is expressed in the anterior end of the oocyte, and is uniformly distributed later on. Expressed almost uniformly in embryos from precellular blastoderm stage to the germband extended stage. At the germband extended stage, it is enriched in the mesoderm. During germband retraction, it is strongly expressed in the anterior and posterior midgut. At the germband retracted stage, it becomes less abundant and is mainly localized to the ventral nerve cord and the brain. In third instar larvae, it is strongly and almost ubiquitously expressed in all imaginal disks. Also weakly expressed expression in salivary glands. Not expressed in larval brain and gut tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0023518 Expressed in 32 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IRW8 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6.

Interacts with nuclear receptor EcR in an ecdysone-dependent manner.

Interacts with ash2; the interaction stabilizes trr.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
57695, 18 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8IRW8

Protein interaction database and analysis system

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IntActi
Q8IRW8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070347

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IRW8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2061 – 2121FYR N-terminalPROSITE-ProRule annotationAdd BLAST61
Domaini2122 – 2209FYR C-terminalPROSITE-ProRule annotationAdd BLAST88
Domaini2291 – 2407SETPROSITE-ProRule annotationAdd BLAST117
Domaini2415 – 2431Post-SETPROSITE-ProRule annotationAdd BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi801 – 805LXXLL motif 15
Motifi1652 – 1656LXXLL motif 25
Motifi2060 – 2064LXXLL motif 35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi172 – 225Ser-richAdd BLAST54
Compositional biasi226 – 288Thr-richAdd BLAST63
Compositional biasi430 – 448Gln-richAdd BLAST19
Compositional biasi926 – 976Gln-richAdd BLAST51
Compositional biasi1169 – 1240Gln-richAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1895 – 1935C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri1956 – 2003PHD-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4443 Eukaryota
COG2940 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168851

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IRW8

KEGG Orthology (KO)

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KOi
K09188

Identification of Orthologs from Complete Genome Data

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OMAi
FKPGEAQ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IRW8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00856 SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IRW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNIPKVTTSL GAAEKAKPER VASVAAAAFN AVSLQKRSGD DTATPAEDPT
60 70 80 90 100
RKKAKTELLL GTGTAAPSLP AKASSTAPQQ LLYQRSGQQA KAQVKAASEP
110 120 130 140 150
QDVETADGVW DARDQQIIVC NFGSGTEMGA IKAEDADKQS EYRISTPRNS
160 170 180 190 200
QSNPLLHRNT AFTSFTKKEG ASSSASSSSS TASVISIEPS GSGQDHAENS
210 220 230 240 250
GKSEDLDYVL MPASGADSST SVGNSTGTGT PAGTPIGATT STIILNANNG
260 270 280 290 300
TAGVSGAGTT TILTQKSGHT NYNIFNTTAT GSQTPTTTLL NRVNLHPKMK
310 320 330 340 350
TQLMVNAKKL SEVTQTTAKV SIGNKTISVP LLKPLMSASG AATAGGATIV
360 370 380 390 400
ESKQLLQPGG QVTTVMSAAQ QSGGQQVHPH VHSHAHHNFT KLIKRGPKNS
410 420 430 440 450
GTIVSFSGLQ IKPANTKIVA TKVVSKKMLQ LQQHQQQIQQ QQQLQQLQVT
460 470 480 490 500
SGGGLAPPTG SIVTITTTNP SQTYAMVQDS ATVGPAAHSE DDAPAPRKIT
510 520 530 540 550
AYSENLQKIL NKSKSQESTG GPEEFTNINS VVIKPLDKNT LNCPPSFNIF
560 570 580 590 600
KQQQHSQAAQ SQSISAVGSG AGTPVTFTMA SGNASDLATT STVSVSAGTI
610 620 630 640 650
CINSPMMGTR PIISIQNKNI SLVLSKTTMA QQKPKMITTT TLSSQAALQM
660 670 680 690 700
HHALIQDSSA DKAGSSANSG SATSGASMQL KLTTANTPTK LSVSLAPDVV
710 720 730 740 750
KLEEVGSESK AKLLVKQEAV VKDSTGTPTS EERAEEIGTP EKRLNANATM
760 770 780 790 800
TAINQVQNQS ANQIQMATST STASNPSTPN PTVNATPMNN QRSAAEDNAL
810 820 830 840 850
LKQLLQNNSS SHSLNQISIT SAHVGSASAS APLSARKVIN VRAPSMGKVR
860 870 880 890 900
SLEDQLARPV IPPVPTATQA AGSSSSSGSV ATSTTTTTVA SGGSSQQVAT
910 920 930 940 950
ASATALPVSA VAITTPGVGG EAKLEQKSDQ PAAIMQNQSQ NQAPPPPPPP
960 970 980 990 1000
QQQQQQQLHQ PQQLQPSPHQ VKQTVQIVSK ETSFISGPVA AKTLVTEATS
1010 1020 1030 1040 1050
KPAELLPPPP YEMATAPISN VTISISTKQA APKELQMKPK AVAMSLPMEQ
1060 1070 1080 1090 1100
GDESLPEQAE PPLHSEQGAT AAGVAPHSGG PLVSAQWTNN HLEGGVATTK
1110 1120 1130 1140 1150
IPFKPGEPQK RKLPMHPQLD EKQIQQQAEI PISTSLPTTP TGQGTPDKVQ
1160 1170 1180 1190 1200
LISAIATYVK KSGVPNEAQP IQNQSQGQVQ MQAQMQATMQ GHLSGQMSGQ
1210 1220 1230 1240 1250
ISGHAAGQIP AQMHLQVQHQ LHMAVHPQQQ QQQLHQNQPQ NATIPLPVTG
1260 1270 1280 1290 1300
QGAVPIPVPT MESKAGDQRK RRKREVQKPR RTNLNAGQAG GALKDLTGPL
1310 1320 1330 1340 1350
PAGAMVQLAG MPPGTQYIQG AASGTGHVIT STGQGVTLGG VGASTGASSS
1360 1370 1380 1390 1400
PMLKKRVRKF SKVEEDHDAF TEKLLTHIRQ MQPLQVLEPH LNRNFHFLIG
1410 1420 1430 1440 1450
SNETSGGGSP ASMSSAASAG SSSAGGGKLK GGSRGWPLSR HLEGLEDCDG
1460 1470 1480 1490 1500
TVLGRYGRVN LPGIPSLYDS ERFGGSRGLV GGSARTRSPS PAESPGAEKM
1510 1520 1530 1540 1550
LPMSSIQNDF YDQEFSTHME RNPRERLVRH IGAVKDCNLE TVDLVESEGV
1560 1570 1580 1590 1600
AAWATLPRLT RYPGLILLNG NSRCHGRMSP VALPEDPLTM RFPVSPLLRS
1610 1620 1630 1640 1650
CGEELRKTQQ MELGMGPLGN NNNNNYQQKN QNVILALPAS ASENIAGVLR
1660 1670 1680 1690 1700
DLANLLHLAP ALTCKIIEDK IGNKLEDQFM NQDDEKHVDF KRPLSQVSHG
1710 1720 1730 1740 1750
HLRKILNGRR KLCRSCGNVV HATGLRVPRH SVPALEEQLP RLAQLMDMLP
1760 1770 1780 1790 1800
RKSVPPPFVY FCDRACFARF KWNGKDGQAE AASLLLQPAG GSAVKSSNGD
1810 1820 1830 1840 1850
SPGSFCASST APAEMVVKQE PEDEDEKTPS VPGNPTNIPA QRKCIVKCFS
1860 1870 1880 1890 1900
ADCFTTDSAP SGLELDGTAG AGTGAGPVNN TVWETETSGL QLEDTRQCVF
1910 1920 1930 1940 1950
CNQRGDGQAD GPSRLLNFDV DKWVHLNCAL WSNGVYETVS GALMNFQTAL
1960 1970 1980 1990 2000
QAGLSQACSA CHQPGATIKC FKSRCNSLYH LPCAIREECV FYKNKSVHCS
2010 2020 2030 2040 2050
VHGHAHAGIT MGAGAGATTG AGLGGSVADN ELSSLVVHRR VFVDRDENRQ
2060 2070 2080 2090 2100
VATVMHYSEL SNLLRVGNMT FLNVGQLLPH QLEAFHTPHY IYPIGYKVSR
2110 2120 2130 2140 2150
YYWCVRRPNR RCRYICSIAE AGCKPEFRIQ VQDAGDKEPE REFRGSSPSA
2160 2170 2180 2190 2200
VWQQILQPIT RLRKVHKWLQ LFPQHISGED LFGLTEPAIV RILESLPGIE
2210 2220 2230 2240 2250
TLTDYRFKYG RNPLLEFPLA INPSGAARTE PKQRQLLVWR KPHTQRTAGS
2260 2270 2280 2290 2300
CSTQRMANSA AIAGEVACPY SKQFVHSKSS QYKKMKQEWR NNVYLARSKI
2310 2320 2330 2340 2350
QGLGLYAARD IEKHTMIIEY IGEVIRTEVS EIREKQYESK NRGIYMFRLD
2360 2370 2380 2390 2400
EDRVVDATLS GGLARYINHS CNPNCVTEIV EVDRDVRIII FAKRKIYRGE
2410 2420 2430
ELSYDYKFDI EDESHKIPCA CGAPNCRKWM N
Length:2,431
Mass (Da):259,828
Last modified:June 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF444825B956A87AA
GO
Isoform 2 (identifier: Q8IRW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-161: SEYRISTPRNSQSNPLLHRNTA → T

Note: Produced by alternative promoter usage. No experimental confirmation available.
Show »
Length:2,410
Mass (Da):257,406
Checksum:i7A3D39B822C64BCA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39418 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAM29656 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA15944 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti219S → A in CAA15944 (PubMed:10731137).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021439140 – 161SEYRI…HRNTA → T in isoform 2. CuratedAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45684.2
AE014298 Genomic DNA Translation: AAN09063.2
AL021106 Genomic DNA Translation: CAA15944.1 Sequence problems.
AY069273 mRNA Translation: AAL39418.1 Different initiation.
AY113651 mRNA Translation: AAM29656.1 Different initiation.

Protein sequence database of the Protein Information Resource

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PIRi
T12687

NCBI Reference Sequences

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RefSeqi
NP_525040.2, NM_080301.3 [Q8IRW8-2]
NP_726773.2, NM_166911.4 [Q8IRW8-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0070362; FBpp0070346; FBgn0023518 [Q8IRW8-2]
FBtr0070363; FBpp0070347; FBgn0023518 [Q8IRW8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
31149

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3848

UCSC genome browser

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UCSCi
CG3848-RC d. melanogaster [Q8IRW8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45684.2
AE014298 Genomic DNA Translation: AAN09063.2
AL021106 Genomic DNA Translation: CAA15944.1 Sequence problems.
AY069273 mRNA Translation: AAL39418.1 Different initiation.
AY113651 mRNA Translation: AAM29656.1 Different initiation.
PIRiT12687
RefSeqiNP_525040.2, NM_080301.3 [Q8IRW8-2]
NP_726773.2, NM_166911.4 [Q8IRW8-1]

3D structure databases

SMRiQ8IRW8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi57695, 18 interactors
ELMiQ8IRW8
IntActiQ8IRW8, 2 interactors
STRINGi7227.FBpp0070347

PTM databases

iPTMnetiQ8IRW8

Proteomic databases

PaxDbiQ8IRW8
PRIDEiQ8IRW8

Genome annotation databases

EnsemblMetazoaiFBtr0070362; FBpp0070346; FBgn0023518 [Q8IRW8-2]
FBtr0070363; FBpp0070347; FBgn0023518 [Q8IRW8-1]
GeneIDi31149
KEGGidme:Dmel_CG3848
UCSCiCG3848-RC d. melanogaster [Q8IRW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7870
FlyBaseiFBgn0023518 trr

Phylogenomic databases

eggNOGiKOG4443 Eukaryota
COG2940 LUCA
GeneTreeiENSGT00940000168851
InParanoidiQ8IRW8
KOiK09188
OMAiFKPGEAQ
PhylomeDBiQ8IRW8

Enzyme and pathway databases

ReactomeiR-DME-201722 Formation of the beta-catenin:TCF transactivating complex
R-DME-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31149

Protein Ontology

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PROi
PR:Q8IRW8

Gene expression databases

BgeeiFBgn0023518 Expressed in 32 organ(s), highest expression level in embryo
GenevisibleiQ8IRW8 DM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR034732 EPHD
IPR003889 FYrich_C
IPR003888 FYrich_N
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51805 EPHD, 1 hit
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRR_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IRW8
Secondary accession number(s): O46083
, Q8MYR5, Q8T9I7, Q9W548
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2003
Last modified: November 13, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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