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Entry version 158 (16 Oct 2019)
Sequence version 3 (12 Sep 2018)
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Protein

m7GpppN-mRNA hydrolase

Gene

DCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N6-methyladenosine methylation at the second transcribed position of mRNAs (N6,2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication, Mg2+1 PublicationNote: Mn2+ ion is required for highest activity. Can also utilize magnesium ions.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi144ManganeseBy similarity1
Metal bindingi148ManganeseBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding
Biological processNonsense-mediated mRNA decay
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.1.62 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
m7GpppN-mRNA hydrolaseCurated (EC:3.6.1.624 Publications)
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 20
Short name:
Nudix motif 20
mRNA-decapping enzyme 2
Short name:
hDpc
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCP2
Synonyms:NUDT20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24452 DCP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609844 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IU60

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi147E → Q: Loss of decapping activity; when associated with Q-148. 1
Mutagenesisi148E → Q: Strongly reduced decapping activity. 1 Publication1
Mutagenesisi249S → A: Leads to the accumulation of autophagosomes under normal growth conditions. 1 Publication1
Mutagenesisi249S → D: Leads to reduced autophagosome formation under autophagy-inducing conditions. 1 Publication1

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000172795

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134898646

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IU60

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849560

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000570511 – 420m7GpppN-mRNA hydrolaseAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei246PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at ser-249 in a MTOR-dependent manner (PubMed:26098573).

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IU60

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IU60

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IU60

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IU60

PeptideAtlas

More...
PeptideAtlasi
Q8IU60

PRoteomics IDEntifications database

More...
PRIDEi
Q8IU60

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70509 [Q8IU60-1]
70510 [Q8IU60-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IU60

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IU60

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and testis. Not detected in heart (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172795 Expressed in 232 organ(s), highest expression level in chorionic villus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IU60 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IU60 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011677
HPA057676

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2 and UPF3B (PubMed:12417715, PubMed:12515382, PubMed:14527413).

Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC4/HEDLS (PubMed:15231747, PubMed:15067023, PubMed:16364915).

Interacts with DPC1B (PubMed:15231747).

Interacts (via N-terminus and C-terminus) with TRIM21 (via N-terminus and C-terminus) (PubMed:18361920). Associates with polysomes (PubMed:12218187).

Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046).

Interacts with DDX17 in an RNA-dependent manner (PubMed:21876179).

Interacts with ZC3HAV1 (PubMed:21876179).

Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599).

Interacts with ZFP36L1 (via N-terminus) (PubMed:15687258).

Interacts with NBDY (PubMed:27918561).

13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127944, 69 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IU60

Database of interacting proteins

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DIPi
DIP-31126N

Protein interaction database and analysis system

More...
IntActi
Q8IU60, 29 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000373715

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1420
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IU60

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 226Nudix hydrolasePROSITE-ProRule annotationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi129 – 150Nudix boxAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Nudix hydrolase family. DCP2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2937 Eukaryota
COG0494 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000018878

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000005974

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IU60

KEGG Orthology (KO)

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KOi
K12613

Identification of Orthologs from Complete Genome Data

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OMAi
IMKCFDY

Database of Orthologous Groups

More...
OrthoDBi
1230808at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IU60

TreeFam database of animal gene trees

More...
TreeFami
TF314180

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.1050, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007722 DCP2_BoxA
IPR036189 DCP2_BoxA_sf
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05026 DCP2, 1 hit
PF00293 NUDIX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01125 DCP2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140586 SSF140586, 1 hit
SSF55811 SSF55811, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IU60-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METKRVEIPG SVLDDLCSRF ILHIPSEERD NAIRVCFQIE LAHWFYLDFY
60 70 80 90 100
MQNTPGLPQC GIRDFAKAVF SHCPFLLPQG EDVEKVLDEW KEYKMGVPTY
110 120 130 140 150
GAIILDETLE NVLLVQGYLA KSGWGFPKGK VNKEEAPHDC AAREVFEETG
160 170 180 190 200
FDIKDYICKD DYIELRINDQ LARLYIIPGI PKDTKFNPKT RREIRNIEWF
210 220 230 240 250
SIEKLPCHRN DMTPKSKLGL APNKFFMAIP FIRPLRDWLS RRFGDSSDSD
260 270 280 290 300
NGFSSTGSTP AKPTVEKLSR TKFRHSQQLF PDGSPGDQWV KHRQPLQQKP
310 320 330 340 350
YNNHSEMSDL LKGKNQSMRG NGRKQYQDSP NQKKRTNGLQ PAKQQNSLMK
360 370 380 390 400
CEKKLHPRKL QDNFETDAVY DLPSSSEDQL LEHAEGQPVA CNGHCKFPFS
410 420
SRAFLSFKFD HNAIMKILDL
Length:420
Mass (Da):48,423
Last modified:September 12, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0FA503A0C797967
GO
Isoform 2 (identifier: Q8IU60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     315-349: Missing.

Note: No experimental confirmation available.
Show »
Length:385
Mass (Da):44,409
Checksum:i85D8725238E3C367
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9T5H0Y9T5_HUMAN
m7GpppN-mRNA hydrolase
DCP2
402Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCL0D6RCL0_HUMAN
m7GpppN-mRNA hydrolase
DCP2
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103I → V in BAC03479 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05952816L → F1 PublicationCorresponds to variant dbSNP:rs33555Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012908315 – 349Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY146650 mRNA Translation: AAN62762.1
AY135173 mRNA Translation: AAN08884.1
AK090564 mRNA Translation: BAC03479.1
AC008536 Genomic DNA No translation available.
BC045596 mRNA Translation: AAH45596.1
BC064593 mRNA Translation: AAH64593.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34210.1 [Q8IU60-1]
CCDS56377.1 [Q8IU60-2]

NCBI Reference Sequences

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RefSeqi
NP_001229306.1, NM_001242377.1 [Q8IU60-2]
NP_689837.2, NM_152624.5 [Q8IU60-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000389063; ENSP00000373715; ENSG00000172795 [Q8IU60-1]
ENST00000515408; ENSP00000425770; ENSG00000172795 [Q8IU60-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
167227

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:167227

UCSC genome browser

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UCSCi
uc003kqh.4 human [Q8IU60-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY146650 mRNA Translation: AAN62762.1
AY135173 mRNA Translation: AAN08884.1
AK090564 mRNA Translation: BAC03479.1
AC008536 Genomic DNA No translation available.
BC045596 mRNA Translation: AAH45596.1
BC064593 mRNA Translation: AAH64593.1
CCDSiCCDS34210.1 [Q8IU60-1]
CCDS56377.1 [Q8IU60-2]
RefSeqiNP_001229306.1, NM_001242377.1 [Q8IU60-2]
NP_689837.2, NM_152624.5 [Q8IU60-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MP0X-ray1.63D95-260[»]
5QOHX-ray1.93A95-260[»]
5QOIX-ray1.99A95-260[»]
5QOJX-ray2.05A95-260[»]
5QOKX-ray2.28A95-260[»]
5QOLX-ray1.85A95-260[»]
5QOMX-ray1.87A95-260[»]
5QONX-ray1.80A95-260[»]
5QOOX-ray1.56A95-260[»]
5QOPX-ray1.86A95-260[»]
5QOQX-ray1.49A95-260[»]
5QORX-ray1.95A95-260[»]
5QOSX-ray1.70A95-260[»]
5QOTX-ray1.68A95-260[»]
5QOUX-ray2.19A95-260[»]
5QOVX-ray1.65A95-260[»]
5QOWX-ray1.82A95-260[»]
5QOXX-ray1.95A95-260[»]
5QOYX-ray1.69A95-260[»]
5QOZX-ray1.70A95-260[»]
5QP0X-ray2.00A95-260[»]
5QP1X-ray1.79A95-260[»]
5QP2X-ray1.83A95-260[»]
5QP3X-ray1.75A95-260[»]
5QP4X-ray1.71A95-260[»]
5QP5X-ray1.90A95-260[»]
5QP6X-ray1.65A95-260[»]
5QP7X-ray1.88A95-260[»]
5QP8X-ray1.64A95-260[»]
5QP9X-ray1.72A95-260[»]
5QPAX-ray1.61A95-260[»]
5QPBX-ray1.68A95-260[»]
5QPCX-ray1.66A95-260[»]
SMRiQ8IU60
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi127944, 69 interactors
CORUMiQ8IU60
DIPiDIP-31126N
IntActiQ8IU60, 29 interactors
STRINGi9606.ENSP00000373715

PTM databases

iPTMnetiQ8IU60
PhosphoSitePlusiQ8IU60

Polymorphism and mutation databases

BioMutaiDCP2
DMDMi269849560

Proteomic databases

EPDiQ8IU60
jPOSTiQ8IU60
MassIVEiQ8IU60
PaxDbiQ8IU60
PeptideAtlasiQ8IU60
PRIDEiQ8IU60
ProteomicsDBi70509 [Q8IU60-1]
70510 [Q8IU60-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
167227

Genome annotation databases

EnsembliENST00000389063; ENSP00000373715; ENSG00000172795 [Q8IU60-1]
ENST00000515408; ENSP00000425770; ENSG00000172795 [Q8IU60-2]
GeneIDi167227
KEGGihsa:167227
UCSCiuc003kqh.4 human [Q8IU60-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
167227

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCP2
HGNCiHGNC:24452 DCP2
HPAiCAB011677
HPA057676
MIMi609844 gene
neXtProtiNX_Q8IU60
OpenTargetsiENSG00000172795
PharmGKBiPA134898646

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2937 Eukaryota
COG0494 LUCA
GeneTreeiENSGT00390000018878
HOGENOMiHOG000005974
InParanoidiQ8IU60
KOiK12613
OMAiIMKCFDY
OrthoDBi1230808at2759
PhylomeDBiQ8IU60
TreeFamiTF314180

Enzyme and pathway databases

BRENDAi3.6.1.62 2681
ReactomeiR-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DCP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DCP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
167227
PharosiQ8IU60

Protein Ontology

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PROi
PR:Q8IU60

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172795 Expressed in 232 organ(s), highest expression level in chorionic villus
ExpressionAtlasiQ8IU60 baseline and differential
GenevisibleiQ8IU60 HS

Family and domain databases

Gene3Di1.10.10.1050, 1 hit
InterProiView protein in InterPro
IPR007722 DCP2_BoxA
IPR036189 DCP2_BoxA_sf
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
PfamiView protein in Pfam
PF05026 DCP2, 1 hit
PF00293 NUDIX, 1 hit
SMARTiView protein in SMART
SM01125 DCP2, 1 hit
SUPFAMiSSF140586 SSF140586, 1 hit
SSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IU60
Secondary accession number(s): C9J778
, Q6P2D4, Q7Z5W5, Q8NBG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 12, 2018
Last modified: October 16, 2019
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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