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1 to 25 of 229  Show
  1. 1
    "Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium."
    Amae S., Fuse N., Yasumoto K., Sato S., Yajima I., Yamamoto H., Udono T., Durlu Y.K., Tamai M., Takahashi K., Shibahara S.
    Biochem. Biophys. Res. Commun. 247:710-715(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Tissue: Kidney.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 2 and mapped to 8 other entries.

  2. 2
    "Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene."
    Morii E., Oboki K., Kataoka T.R., Igarashi K., Kitamura Y.
    J. Biol. Chem. 277:8566-8571(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction, Sequences.
    Annotation: MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF.
    Source: GeneRIF:4286.

    This publication is mapped to 34 other entries.

  3. 3
    "Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation."
    Shibahara S., Takeda K., Yasumoto K., Udono T., Watanabe K., Saito H., Takahashi K.
    J. Investig. Dermatol. Symp. Proc. 6:99-104(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Review.
    Source: GeneRIF:4286.

    This publication is mapped to 15 other entries.

  4. 4
    "Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling."
    Yasumoto K., Takeda K., Saito H., Watanabe K., Takahashi K., Shibahara S.
    EMBO J. 21:2703-2714(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Microphthalmia-associated transcription factor interacts with LEF-1 a mediator of Wnt signaling.
    Source: GeneRIF:4286.

    This publication is mapped to 14 other entries.

  5. 5
    "Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1."
    Saito H., Yasumoto K., Takeda K., Takahashi K., Fukuzaki A., Orikasa S., Shibahara S.
    J. Biol. Chem. 277:28787-28794(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: MITF-M transactivates its own promoter (M promoter) by interacting with LEF-1.
    Source: GeneRIF:4286.

    This publication is mapped to 14 other entries.

  6. 6
    "Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability."
    McGill G.G., Horstmann M., Widlund H.R., Du J., Motyckova G., Nishimura E.K., Lin Y.L., Ramaswamy S., Avery W., Ding H.F., Jordan S.A., Jackson I.J., Korsmeyer S.J., Golub T.R., Fisher D.E.
    Cell 109:707-718(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.
    Source: GeneRIF:4286.

    This publication is mapped to 30 other entries.

  7. 7
    "Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)."
    Aoki H., Moro O.
    Life Sci. 71:2171-2179(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: MITF regulates not only the expression of enzymes involved in melanin synthesis but also the expression of a receptor which plays an essential role in melanocyte functions.
    Source: GeneRIF:4286.

    This publication is mapped to 33 other entries.

  8. 8
    "Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor."
    Widlund H.R., Horstmann M.A., Price E.R., Cui J., Lessnick S.L., Wu M., He X., Fisher D.E.
    J. Cell Biol. 158:1079-1087(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Beta catenin induced human melanoma growth requires the downstream target MITF.
    Source: GeneRIF:4286.

    This publication is mapped to 49 other entries.

  9. 9
    "[Clinical and molecular genetic investigation of Waardenburg syndrome type 1]."
    Markova T.G., Megrelishvilli S.M., Shevtsov S.P., Shvarts E.I.
    Vestn. Otorinolaringol. 2003:17-19(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: MITF gene may be implicated in Waardenburg syndrome.
    Source: GeneRIF:4286.

    This publication is mapped to 15 other entries.

  10. 10
    "Microphthalmia-associated transcription factor in the Wnt signaling pathway."
    Saito H., Yasumoto K., Takeda K., Takahashi K., Yamamoto H., Shibahara S.
    Pigment Cell Res. 16:261-265(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: MITF-M plays dual roles in the Wnt signaling pathway; MITF-M represents a downstream target and a nuclear mediator of Wnt signals in melanocytes.
    Source: GeneRIF:4286.

    This publication is mapped to 15 other entries.

  11. 11
    "MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma."
    Du J., Miller A.J., Widlund H.R., Horstmann M.A., Ramaswamy S., Fisher D.E.
    Am. J. Pathol. 163:333-343(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Data show that MITF appears to regulate the expression of the SILV and MLANA genes.
    Source: GeneRIF:4286.

    This publication is mapped to 12 other entries.

  12. 12
    "A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes."
    Huber W.E., Price E.R., Widlund H.R., Du J., Davis I.J., Wegner M., Fisher D.E.
    J. Biol. Chem. 278:45224-45230(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: MITF expression in melanocytes is regulated by alpha-melanocyte-stimulating hormone modulated by SOX10.
    Source: GeneRIF:4286.

    This publication is mapped to 31 other entries.

  13. 13
    "STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression."
    Joo A., Aburatani H., Morii E., Iba H., Yoshimura A.
    Oncogene 23:726-734(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: MITF and STAT3 cooperatively induce c-fos resulting in cellular transformation.
    Source: GeneRIF:4286.

    This publication is mapped to 28 other entries.

  14. 14
    "Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma."
    Miller A.J., Du J., Rowan S., Hershey C.L., Widlund H.R., Fisher D.E.
    Cancer Res. 64:509-516(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: MITF as a major transcriptional regulator of studies identify MITF as a major transcriptional regulator of TRPM1 and suggest that its prognostic value may be linked to MITF-mediated regulation of cellular differentiation.
    Source: GeneRIF:4286.

    This publication is mapped to 35 other entries.

  15. 15
    "Immunohistochemical evaluation of microphthalmia-associated transcription factor expression in giant cell lesions."
    Seethala R.R., Goldblum J.R., Hicks D.G., Lehman M., Khurana J.S., Pasha T.L., Zhang P.J.
    Mod. Pathol. 17:1491-1496(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Mitf might play a role in the multinucleation process of giant cells and giant cell lesions.
    Source: GeneRIF:4286.

    This publication is mapped to 8 other entries.

  16. 16
    "Sumoylation of MITF and its related family members TFE3 and TFEB."
    Miller A.J., Levy C., Davis I.J., Razin E., Fisher D.E.
    J. Biol. Chem. 280:146-155(2005) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: the functional consequences of MITF sumoylation depend on promoter context. Sumoylation provides a possible mechanism for altering the effects of MITF by affecting the target genes that it activates.
    Source: GeneRIF:4286.

    This publication is cited by 2 and mapped to 10 other entries.

  17. 17
    "MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A."
    Loercher A.E., Tank E.M., Delston R.B., Harbour J.W.
    J. Cell Biol. 168:35-40(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: MITF regulates p16INK4A expression in melanocytes.
    Source: GeneRIF:4286.

    This publication is mapped to 8 other entries.

  18. 18
    "Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform."
    Hershey C.L., Fisher D.E.
    Gene 347:73-82(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: The majority of isoforms were found to be broadly expressed with the M- and Mc-isoforms being tissue-restricted to melanocytes and mast cells respectively.
    Source: GeneRIF:4286.

    This publication is cited by 1 and mapped to 13 other entries.

  19. 19
    "Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma."
    Hallor K.H., Mertens F., Jin Y., Meis-Kindblom J.M., Kindblom L.-G., Behrendtz M., Kalen A., Mandahl N., Panagopoulos I.
    Genes Chromosomes Cancer 44:97-102(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Simultaneous expression of the EWSR1-ATF1 and MITF-M transcripts in clear cell carcinoma has led to the proposal that the MITF-M promoter is transactivated by EWSR1-ATF1.
    Source: GeneRIF:4286.

    This publication is cited by 1 and mapped to 12 other entries.

  20. 20
    "Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells."
    Busca R., Berra E., Gaggioli C., Khaled M., Bille K., Marchetti B., Thyss R., Fitsialos G., Larribere L., Bertolotto C., Virolle T., Barbry P., Pouyssegur J., Ponzio G., Ballotti R.
    J. Cell Biol. 170:49-59(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: We therefore conclude that the alpha-MSH/cAMP pathway using MITF as a signal transducer and HIF1alpha as a target might contribute to melanoma progression.
    Source: GeneRIF:4286.

    This publication is mapped to 39 other entries.

  21. 21
    Category: Sequences.
    Annotation: MITF represents a distinct class of 'lineage survival' or 'lineage addiction' oncogenes required for both tissue-specific cancer development and tumour progression.
    Source: GeneRIF:4286.

    This publication is mapped to 8 other entries.

  22. 22
    "Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation."
    Wellbrock C., Marais R.
    J. Cell Biol. 170:703-708(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: These data suggest that MITF is an anti-proliferation factor that is down-regulated by B-RAF signaling and that this is a crucial event for the progression of melanomas that harbor oncogenic B-RAF.
    Source: GeneRIF:4286.

    This publication is mapped to 21 other entries.

  23. 23
    "The cleavage of microphthalmia-associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis."
    Larribere L., Hilmi C., Khaled M., Gaggioli C., Bille K., Auberger P., Ortonne J.P., Ballotti R., Bertolotto C.
    Genes Dev. 19:1980-1985(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: identified MITF as a new substrate of caspases and we characterized the cleavage site after Asp 345 in the C-terminal domain.
    Source: GeneRIF:4286.

    This publication is mapped to 15 other entries.

  24. 24
    "MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytes."
    Park H.Y., Wu C., Yonemoto L., Murphy-Smith M., Wu H., Stachur C.M., Gilchrest B.A.
    Biochem. J. 395:571-578(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: MITF specifically MITF-M is a key transcription factor for protein kinase C-beta (PKC-beta) linking the PKC- and cAMP-dependent pathways in regulation of melanogenesis.
    Source: GeneRIF:4286.

    This publication is mapped to 8 other entries.

  25. 25
    "Glutamate receptors on human melanocytes regulate the expression of MiTF."
    Hoogduijn M.J., Hitchcock I.S., Smit N.P., Gillbro J.M., Schallreuter K.U., Genever P.G.
    Pigment Cell Res. 19:58-67(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: The results of this study demonstrate a role for glutamate in MiTF regulation that may have implications in melanocyte associated disorders.
    Source: GeneRIF:4286.

    This publication is mapped to 8 other entries.

1 to 25 of 229  Show
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