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Entry version 147 (16 Oct 2019)
Sequence version 2 (05 Jul 2004)
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Protein

Exocyst complex component 8

Gene

EXOC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.2.1.2 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 8
Alternative name(s):
Exocyst complex 84 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOC8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24659 EXOC8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615283 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYI6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
149371

Open Targets

More...
OpenTargetsi
ENSG00000116903

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134991382

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYI6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EXOC8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750763

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002275501 – 725Exocyst complex component 8Add BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei142PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IYI6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYI6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYI6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYI6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYI6

PeptideAtlas

More...
PeptideAtlasi
Q8IYI6

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYI6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71180

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYI6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYI6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116903 Expressed in 203 organ(s), highest expression level in epithelial cell of pancreas

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYI6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027438

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity).

Interacts (via PH domain) with GTP-bound RALA and RALB (PubMed:14525976, PubMed:18756269).

Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127206, 60 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IYI6

Protein interaction database and analysis system

More...
IntActi
Q8IYI6, 105 interactors

Molecular INTeraction database

More...
MINTi
Q8IYI6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355605

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYI6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 282PHPROSITE-ProRule annotationAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi108 – 117Poly-Ala10
Compositional biasi316 – 319Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EXO84 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2215 Eukaryota
ENOG410XT7U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015936

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYI6

KEGG Orthology (KO)

More...
KOi
K19986

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKILMFP

Database of Orthologous Groups

More...
OrthoDBi
1357584at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYI6

TreeFam database of animal gene trees

More...
TreeFami
TF105819

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.1210, 1 hit
1.20.58.1220, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR033961 Exo84
IPR032403 Exo84_C
IPR042561 Exo84_C_1
IPR042560 Exo84_C_2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR21426 PTHR21426, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16528 Exo84_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74788 SSF74788, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IYI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMAMSDSGA SRLRRQLESG GFEARLYVKQ LSQQSDGDRD LQEHRQRIQA
60 70 80 90 100
LAEETAQNLK RNVYQNYRQF IETAREISYL ESEMYQLSHL LTEQKSSLES
110 120 130 140 150
IPLTLLPAAA AAGAAAASGG EEGVGGAGGR DHLRGQAGFF STPGGASRDG
160 170 180 190 200
SGPGEEGKQR TLTTLLEKVE GCRHLLETPG QYLVYNGDLV EYDADHMAQL
210 220 230 240 250
QRVHGFLMND CLLVATWLPQ RRGMYRYNAL YSLDGLAVVN VKDNPPMKDM
260 270 280 290 300
FKLLMFPESR IFQAENAKIK REWLEVLEDT KRALSEKRRR EQEEAAAPRG
310 320 330 340 350
PPQVTSKATN PFEDDEEEEP AVPEVEEEKV DLSMEWIQEL PEDLDVCIAQ
360 370 380 390 400
RDFEGAVDLL DKLNHYLEDK PSPPPVKELR AKVEERVRQL TEVLVFELSP
410 420 430 440 450
DRSLRGGPKA TRRAVSQLIR LGQCTKACEL FLRNRAAAVH TAIRQLRIEG
460 470 480 490 500
ATLLYIHKLC HVFFTSLLET AREFEIDFAG TDSGCYSAFV VWARSAMGMF
510 520 530 540 550
VDAFSKQVFD SKESLSTAAE CVKVAKEHCQ QLGDIGLDLT FIIHALLVKD
560 570 580 590 600
IQGALHSYKE IIIEATKHRN SEEMWRRMNL MTPEALGKLK EEMKSCGVSN
610 620 630 640 650
FEQYTGDDCW VNLSYTVVAF TKQTMGFLEE ALKLYFPELH MVLLESLVEI
660 670 680 690 700
ILVAVQHVDY SLRCEQDPEK KAFIRQNASF LYETVLPVVE KRFEEGVGKP
710 720
AKQLQDLRNA SRLIRVNPES TTSVV
Length:725
Mass (Da):81,799
Last modified:July 5, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4E5E344EF24FDCA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082196265E → G Found in a patient with Joubert syndrome; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK096460 mRNA Translation: BAG53295.1
AL117352 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69955.1
BC035763 mRNA Translation: AAH35763.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1593.1

NCBI Reference Sequences

More...
RefSeqi
NP_787072.2, NM_175876.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366645; ENSP00000355605; ENSG00000116903

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
149371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:149371

UCSC genome browser

More...
UCSCi
uc001huq.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096460 mRNA Translation: BAG53295.1
AL117352 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69955.1
BC035763 mRNA Translation: AAH35763.2
CCDSiCCDS1593.1
RefSeqiNP_787072.2, NM_175876.4

3D structure databases

SMRiQ8IYI6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127206, 60 interactors
CORUMiQ8IYI6
IntActiQ8IYI6, 105 interactors
MINTiQ8IYI6
STRINGi9606.ENSP00000355605

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ8IYI6
PhosphoSitePlusiQ8IYI6

Polymorphism and mutation databases

BioMutaiEXOC8
DMDMi74750763

Proteomic databases

EPDiQ8IYI6
jPOSTiQ8IYI6
MassIVEiQ8IYI6
MaxQBiQ8IYI6
PaxDbiQ8IYI6
PeptideAtlasiQ8IYI6
PRIDEiQ8IYI6
ProteomicsDBi71180

Genome annotation databases

EnsembliENST00000366645; ENSP00000355605; ENSG00000116903
GeneIDi149371
KEGGihsa:149371
UCSCiuc001huq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
149371
DisGeNETi149371

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EXOC8
HGNCiHGNC:24659 EXOC8
HPAiHPA027438
MIMi615283 gene
neXtProtiNX_Q8IYI6
OpenTargetsiENSG00000116903
PharmGKBiPA134991382

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2215 Eukaryota
ENOG410XT7U LUCA
GeneTreeiENSGT00390000015936
HOGENOMiHOG000006737
InParanoidiQ8IYI6
KOiK19986
OMAiFKILMFP
OrthoDBi1357584at2759
PhylomeDBiQ8IYI6
TreeFamiTF105819

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EXOC8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
149371
PharosiQ8IYI6

Protein Ontology

More...
PROi
PR:Q8IYI6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116903 Expressed in 203 organ(s), highest expression level in epithelial cell of pancreas
GenevisibleiQ8IYI6 HS

Family and domain databases

Gene3Di1.20.58.1210, 1 hit
1.20.58.1220, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR033961 Exo84
IPR032403 Exo84_C
IPR042561 Exo84_C_1
IPR042560 Exo84_C_2
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR21426 PTHR21426, 1 hit
PfamiView protein in Pfam
PF16528 Exo84_C, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYI6
Secondary accession number(s): B3KU33, Q5TE82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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