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Entry version 153 (03 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Zinc finger protein 440

Gene

ZNF440

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 448C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri458 – 480C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 440
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF440
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20874 ZNF440

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYI8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000171295

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134917447

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF440

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30580626

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475891 – 595Zinc finger protein 440Add BLAST595

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IYI8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IYI8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYI8

PeptideAtlas

More...
PeptideAtlasi
Q8IYI8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYI8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71181

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171295 Expressed in 167 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYI8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYI8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047845

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125953, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYI8, 26 interactors

Molecular INTeraction database

More...
MINTi
Q8IYI8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305373

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYI8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 448C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri458 – 480C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163273

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYI8

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
AFTCPRY

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYI8

TreeFam database of animal gene trees

More...
TreeFami
TF338854

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8IYI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPVAFKDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSLGKRWKDQ
60 70 80 90 100
NIEYEHQNPR RNFRSLIEEK VNEIKDDSHC GETFTPVPDD RLNFQEKKAS
110 120 130 140 150
PEVKSCESFV CGEVGLGNSS FNMNIRGDIG HKAYEYQEYG PKPCKCQQPK
160 170 180 190 200
KAFRYRPSFR TQERDHTGEK PNACKVCGKT FISHSSVRRH MVMHSGDGPY
210 220 230 240 250
KCKFCGKAFH CLRLYLIHER IHTGEKPCEC KQCGKSFSYS ATHRIHKRTH
260 270 280 290 300
TGEKPYEYQE CGKAFHSPRS YRRHERIHMG EKAYQCKECG KAFTCPRYVR
310 320 330 340 350
IHERTHSRKN LYECKQCGKA LSSLTSFQTH VRLHSGERPY ECKICGKDFC
360 370 380 390 400
SVNSFQRHEK IHSGEKPYKC KQCGKAFPHS SSLRYHERTH TGEKPYECKQ
410 420 430 440 450
CGKAFRSASH LRVHGRTHTG EKPYECKECG KAFRYVNNLQ SHERTQTHIR
460 470 480 490 500
IHSGERRYKC KICGKGFYCP KSFQRHEKTH TGEKLYECKQ RSVVPSVVPV
510 520 530 540 550
PFDIMKGLTL ERSPINASNV GKPSELCQSF ECMVGLTLKR NPMSVSNDGK
560 570 580 590
PSDLPHTFEY VVGHTMERSP MHVRNVGNPS DLPRTFEFMK GHKHT
Length:595
Mass (Da):69,106
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DCCDFB698E40661
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JG89C9JG89_HUMAN
Zinc finger protein 440
ZNF440
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JV94C9JV94_HUMAN
Zinc finger protein 440
ZNF440
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3D9C9J3D9_HUMAN
Zinc finger protein 440
ZNF440
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ55K7EJ55_HUMAN
Zinc finger protein 440
ZNF440
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40L → M in BAC04510 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05991543L → I. Corresponds to variant dbSNP:rs424132Ensembl.1
Natural variantiVAR_05282888P → R. Corresponds to variant dbSNP:rs448446Ensembl.1
Natural variantiVAR_059916124N → S. Corresponds to variant dbSNP:rs427880Ensembl.1
Natural variantiVAR_052829569S → N1 PublicationCorresponds to variant dbSNP:rs400106Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC035760 mRNA Translation: AAH35760.1
AK095252 mRNA Translation: BAC04510.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42503.1

NCBI Reference Sequences

More...
RefSeqi
NP_689570.2, NM_152357.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304060; ENSP00000305373; ENSG00000171295

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
126070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126070

UCSC genome browser

More...
UCSCi
uc002msp.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035760 mRNA Translation: AAH35760.1
AK095252 mRNA Translation: BAC04510.1
CCDSiCCDS42503.1
RefSeqiNP_689570.2, NM_152357.2

3D structure databases

SMRiQ8IYI8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125953, 14 interactors
IntActiQ8IYI8, 26 interactors
MINTiQ8IYI8
STRINGi9606.ENSP00000305373

PTM databases

iPTMnetiQ8IYI8
PhosphoSitePlusiQ8IYI8

Polymorphism and mutation databases

BioMutaiZNF440
DMDMi30580626

Proteomic databases

jPOSTiQ8IYI8
MaxQBiQ8IYI8
PaxDbiQ8IYI8
PeptideAtlasiQ8IYI8
PRIDEiQ8IYI8
ProteomicsDBi71181

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
126070
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304060; ENSP00000305373; ENSG00000171295
GeneIDi126070
KEGGihsa:126070
UCSCiuc002msp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126070

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF440
HGNCiHGNC:20874 ZNF440
HPAiHPA047845
neXtProtiNX_Q8IYI8
OpenTargetsiENSG00000171295
PharmGKBiPA134917447

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163273
HOGENOMiHOG000234617
InParanoidiQ8IYI8
KOiK09228
OMAiAFTCPRY
OrthoDBi1318335at2759
PhylomeDBiQ8IYI8
TreeFamiTF338854

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126070

Protein Ontology

More...
PROi
PR:Q8IYI8

Gene expression databases

BgeeiENSG00000171295 Expressed in 167 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ8IYI8 baseline and differential
GenevisibleiQ8IYI8 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN440_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYI8
Secondary accession number(s): Q8N1R9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2003
Last modified: July 3, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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