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Entry version 122 (16 Oct 2019)
Sequence version 2 (29 Aug 2003)
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Protein

Cilia- and flagella-associated protein 206

Gene

CFAP206

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate cilium motility through its role in the assembly of the axonemal radial spokes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cilia- and flagella-associated protein 206Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP206Imported
Synonyms:C6orf165Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21405 CFAP206

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IYR0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000213204
ENSG00000272514

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134983540

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IYR0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CFAP206

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395551

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895531 – 622Cilia- and flagella-associated protein 206Add BLAST622

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IYR0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IYR0

PeptideAtlas

More...
PeptideAtlasi
Q8IYR0

PRoteomics IDEntifications database

More...
PRIDEi
Q8IYR0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71214

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IYR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IYR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213204 Expressed in 85 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IYR0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IYR0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044891
HPA072261

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127543, 29 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IYR0, 60 interactors

Molecular INTeraction database

More...
MINTi
Q8IYR0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358575

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IYR0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CFAP206 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH8G Eukaryota
ENOG410XS92 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016036

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000031483

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IYR0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPTACAI

Database of Orthologous Groups

More...
OrthoDBi
357137at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IYR0

TreeFam database of animal gene trees

More...
TreeFami
TF323439

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021897 FAP206

The PANTHER Classification System

More...
PANTHERi
PTHR21442 PTHR21442, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12018 FAP206, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8IYR0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPTQAESVI RSIIREIGQE CAAHGEIVSE TLIAFMVKAV VLDPSNGFNM
60 70 80 90 100
DRTLMKSDVQ NLVKLCMTRL LDTKNPSLDT IKMQVYFDMN YTNRVEFLEE
110 120 130 140 150
HHRVLESRLG SVTREITDNR ACAKEELESL YRKIISYVLL RSGLGSPTDI
160 170 180 190 200
KTVREVTAAL QSVFPQAELG TFLTLSKKDK ERQLKELTMI VTGIRLFNRD
210 220 230 240 250
CGKGGEGIDD LPAVLHVAIP ATMQHIDYQL ETARSQVYRY TAILEKAAND
260 270 280 290 300
PLMRAELQPY MLKEALYNIR QYEVFLQIIL SDIITGAQEV EMMTKQLGAH
310 320 330 340 350
LEQLKMTIKS KIAVPTSQVF PIFIALSTLW TSLQDETIVV GVLSNLFTHI
360 370 380 390 400
QPFLGAHELY FPERVMQCHL NGATVKTDVC RMKEHMEDRV NVADFRKLEW
410 420 430 440 450
LFPETTANFD KLLIQYRGFC AYTFAATDGL LLPGNPAIGI LKYKEKYYTF
460 470 480 490 500
NSKDAAYSFA ENPEHYIDIV REKAKKNTEL IQLLELHQQF ETFIPYSQMR
510 520 530 540 550
DADKHYIKPI TKCESSTQTN THILPPTIVR SYEWNEWELR RKAIKLANLR
560 570 580 590 600
QKVTHSVQTD LSHLRRENCS QVYPPKDTST QSMREDSTGV PRPQIYLAGL
610 620
RGGKSEITDE VKVNLTRDVD ET
Length:622
Mass (Da):71,193
Last modified:August 29, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC3818B8596C0B1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBZ4D6RBZ4_HUMAN
Cilia- and flagella-associated prot...
CFAP206
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9L9D6R9L9_HUMAN
Cilia- and flagella-associated prot...
CFAP206
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04234 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti489Q → R in BAF85273 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033679154R → K. Corresponds to variant dbSNP:rs13219364Ensembl.1
Natural variantiVAR_033680170G → A. Corresponds to variant dbSNP:rs16879281Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093830 mRNA Translation: BAC04234.1 Sequence problems.
AK292584 mRNA Translation: BAF85273.1
AL049697 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48594.1
CH471051 Genomic DNA Translation: EAW48596.1
CH471051 Genomic DNA Translation: EAW48598.1
BC035083 mRNA Translation: AAH35083.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34498.1

NCBI Reference Sequences

More...
RefSeqi
NP_001026913.1, NM_001031743.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369562; ENSP00000358575; ENSG00000272514

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154313

UCSC genome browser

More...
UCSCi
uc003plv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093830 mRNA Translation: BAC04234.1 Sequence problems.
AK292584 mRNA Translation: BAF85273.1
AL049697 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48594.1
CH471051 Genomic DNA Translation: EAW48596.1
CH471051 Genomic DNA Translation: EAW48598.1
BC035083 mRNA Translation: AAH35083.2
CCDSiCCDS34498.1
RefSeqiNP_001026913.1, NM_001031743.2

3D structure databases

SMRiQ8IYR0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127543, 29 interactors
IntActiQ8IYR0, 60 interactors
MINTiQ8IYR0
STRINGi9606.ENSP00000358575

PTM databases

iPTMnetiQ8IYR0
PhosphoSitePlusiQ8IYR0

Polymorphism and mutation databases

BioMutaiCFAP206
DMDMi34395551

Proteomic databases

MassIVEiQ8IYR0
PaxDbiQ8IYR0
PeptideAtlasiQ8IYR0
PRIDEiQ8IYR0
ProteomicsDBi71214

Genome annotation databases

EnsembliENST00000369562; ENSP00000358575; ENSG00000272514
GeneIDi154313
KEGGihsa:154313
UCSCiuc003plv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154313

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CFAP206
HGNCiHGNC:21405 CFAP206
HPAiHPA044891
HPA072261
neXtProtiNX_Q8IYR0
OpenTargetsiENSG00000213204
ENSG00000272514
PharmGKBiPA134983540

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH8G Eukaryota
ENOG410XS92 LUCA
GeneTreeiENSGT00390000016036
HOGENOMiHOG000031483
InParanoidiQ8IYR0
OMAiKPTACAI
OrthoDBi357137at2759
PhylomeDBiQ8IYR0
TreeFamiTF323439

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CFAP206 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
154313
PharosiQ8IYR0

Protein Ontology

More...
PROi
PR:Q8IYR0

Gene expression databases

BgeeiENSG00000213204 Expressed in 85 organ(s), highest expression level in testis
ExpressionAtlasiQ8IYR0 baseline and differential
GenevisibleiQ8IYR0 HS

Family and domain databases

InterProiView protein in InterPro
IPR021897 FAP206
PANTHERiPTHR21442 PTHR21442, 1 hit
PfamiView protein in Pfam
PF12018 FAP206, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCF206_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IYR0
Secondary accession number(s): A8K969, E1P507, Q8N9U4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: October 16, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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