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Entry version 151 (13 Nov 2019)
Sequence version 1 (01 Mar 2003)
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Protein

5'-3' exoribonuclease 1

Gene

XRN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).By similarity1 Publication

Miscellaneous

Down-regulated in OGS biopsy.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Exonuclease, Hydrolase, Nuclease, RNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q8IZH2 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-3' exoribonuclease 1 (EC:3.1.13.-)
Alternative name(s):
Strand-exchange protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XRN1
Synonyms:SEP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30654 XRN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607994 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZH2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
54464

Open Targets

More...
OpenTargetsi
ENSG00000114127

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134878471

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZH2

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XRN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74714582

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000713921 – 17065'-3' exoribonuclease 1Add BLAST1706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1348PhosphoserineBy similarity1
Modified residuei1645PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IZH2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZH2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IZH2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZH2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZH2

PeptideAtlas

More...
PeptideAtlasi
Q8IZH2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZH2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71350 [Q8IZH2-1]
71351 [Q8IZH2-2]
71352 [Q8IZH2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZH2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IZH2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By GDNF/glial cell line-derived neurotrophic factor.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114127 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZH2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZH2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035005
HPA035006

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1 (PubMed:14527413). Associates with alpha and beta tubulins (By similarity).

Interacts with DIS3L2 (PubMed:23756462).

Interacts with ZC3HAV1 in an RNA-dependent manner (PubMed:21876179).

Interacts with ZFP36L1 (PubMed:15687258).

Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).

Interacts with YTHDC2 (via ANK repeats) (PubMed:29033321).

By similarity6 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119970, 125 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IZH2

Database of interacting proteins

More...
DIPi
DIP-31174N

Protein interaction database and analysis system

More...
IntActi
Q8IZH2, 61 interactors

Molecular INTeraction database

More...
MINTi
Q8IZH2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264951

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZH2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-3' exonuclease family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2044 Eukaryota
KOG2045 Eukaryota
COG5049 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00670000098080

KEGG Orthology (KO)

More...
KOi
K12618

Identification of Orthologs from Complete Genome Data

More...
OMAi
YPAISQL

Database of Orthologous Groups

More...
OrthoDBi
685597at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZH2

TreeFam database of animal gene trees

More...
TreeFami
TF105757

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR041385 SH3_12
IPR040992 XRN1_D1
IPR041106 XRN1_D2_D3
IPR041412 Xrn1_helical

The PANTHER Classification System

More...
PANTHERi
PTHR12341 PTHR12341, 1 hit
PTHR12341:SF7 PTHR12341:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18129 SH3_12, 1 hit
PF18332 XRN1_D1, 1 hit
PF18334 XRN1_D2_D3, 1 hit
PF17846 XRN_M, 1 hit
PF03159 XRN_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006743 Exonuclease_Xnr1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD
60 70 80 90 100
VHFRISDDKI FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR
110 120 130 140 150
RFRSAKEAED KIKKAIEKGE TLPTEARFDS NCITPGTEFM ARLHEHLKYF
160 170 180 190 200
VNMKISTDKS WQGVTIYFSG HETPGEGEHK IMEFIRSEKA KPDHDPNTRH
210 220 230 240 250
CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA PEETTFHLLH
260 270 280 290 300
LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL
310 320 330 340 350
HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH
360 370 380 390 400
FSEVFVDLKW FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT
410 420 430 440 450
ALDKNEGEMI TSKDNLEDET EDDDLFETEF RQYKRTYYMT KMGVDVVSDD
460 470 480 490 500
FLADQAACYV QAIQWILHYY YHGVQSWSWY YPYHYAPFLS DIHNISTLKI
510 520 530 540 550
HFELGKPFKP FEQLLAVLPA ASKNLLPACY QHLMTNEDSP IIEYYPPDFK
560 570 580 590 600
TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM
610 620 630 640 650
CWYDRDTEFI YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRID
660 670 680 690 700
QKALYFCGFP TLKHIRHKFF LKKSGVQVFQ QSSRGENMML EILVDAESDE
710 720 730 740 750
LTVENVASSV LGKSVFVNWP HLEEARVVAV SDGETKFYLE EPPGTQKLYS
760 770 780 790 800
GRTAPPSKVV HLGDKEQSNW AKEVQGISEH YLRRKGIIIN ETSAVVYAQL
810 820 830 840 850
LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD SRFSNIKTLD
860 870 880 890 900
DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL
910 920 930 940 950
IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK
960 970 980 990 1000
ANVGLNLKFN KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY
1010 1020 1030 1040 1050
IAKNSQEDVF YEDDIWPGEN ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ
1060 1070 1080 1090 1100
ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV KPHLLYRPLE QQHGVIPDRD
1110 1120 1130 1140 1150
AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF EVLFDEEFPG
1160 1170 1180 1190 1200
GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHQHSS
1210 1220 1230 1240 1250
SSSVSSGHLG ALNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKMQYFQ
1260 1270 1280 1290 1300
PTIQEKGAVL PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEECKSP
1310 1320 1330 1340 1350
KAECWSQKMS NKQPNSGIEN FLASLNISKE NEVQSSHHGE PPSEEHLSPQ
1360 1370 1380 1390 1400
SFAMGTRMLK EILKIDGSNT VDHKNEIKQI ANEIPVSSNR RDEYGLPSQP
1410 1420 1430 1440 1450
KQNKKLASYM NKPHSANEYH NVQSMDNMCW PAPSQIPPVS TPVTELSRIC
1460 1470 1480 1490 1500
SLVGMPQPDF SFLRMPQTMT VCQVKLSNGL LVHGPQCHSE NEAKEKAALF
1510 1520 1530 1540 1550
ALQQLGSLGM NFPLPSQVFA NYPSAVPPGT IPPAFPPPTG WDHYGSNYAL
1560 1570 1580 1590 1600
GAANIMPSSS HLFGSMPWGP SVPVPGKPFH HTLYSGTMPM AGGIPGGVHN
1610 1620 1630 1640 1650
QFIPLQVTKK RVANKKNFEN KEAQSSQATP VQTSQPDSSN IVKVSPRESS
1660 1670 1680 1690 1700
SASLKSSPIA QPASSFQVET ASQGHSISHH KSTPISSSRR KSRKLAVNFG

VSKPSE
Length:1,706
Mass (Da):194,107
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD06A76208DE78698
GO
Isoform 2 (identifier: Q8IZH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1354-1354: M → MK
     1540-1552: Missing.

Show »
Length:1,694
Mass (Da):192,843
Checksum:i25AD7CD0191A4E05
GO
Isoform 3 (identifier: Q8IZH2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-459: DDFLADQAACY → EYVFANAFILK
     460-1706: Missing.

Show »
Length:459
Mass (Da):53,818
Checksum:i2C546FA5EDB81BC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5E4H7C5E4_HUMAN
5'-3' exoribonuclease 1
XRN1
1,160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCZ8C9JCZ8_HUMAN
5'-3' exoribonuclease 1
XRN1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDA0F8WDA0_HUMAN
5'-3' exoribonuclease 1
XRN1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C583H7C583_HUMAN
5'-3' exoribonuclease 1
XRN1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48D → G in CAE45950 (PubMed:17974005).Curated1
Sequence conflicti55I → T in BAC04718 (PubMed:14702039).Curated1
Sequence conflicti113K → E in CAH18332 (PubMed:17974005).Curated1
Sequence conflicti142R → K in AAH48104 (PubMed:15489334).Curated1
Sequence conflicti148K → E in CAH18332 (PubMed:17974005).Curated1
Sequence conflicti572Missing in CAB63749 (PubMed:17974005).Curated1
Sequence conflicti722L → I in CAE45950 (PubMed:17974005).Curated1
Sequence conflicti834K → R in CAH18332 (PubMed:17974005).Curated1
Sequence conflicti1250Q → R in CAH18332 (PubMed:17974005).Curated1
Sequence conflicti1463L → F in CAE45950 (PubMed:17974005).Curated1
Sequence conflicti1686S → P in CAH18332 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053000674S → G. Corresponds to variant dbSNP:rs35214510Ensembl.1
Natural variantiVAR_0530011259V → A. Corresponds to variant dbSNP:rs35902661Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016692449 – 459DDFLADQAACY → EYVFANAFILK in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_016693460 – 1706Missing in isoform 3. 1 PublicationAdd BLAST1247
Alternative sequenceiVSP_0166941354M → MK in isoform 2. 1 Publication1
Alternative sequenceiVSP_0166951540 – 1552Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY137776 mRNA Translation: AAN11306.1
AL133623 mRNA Translation: CAB63749.1
BX640905 mRNA Translation: CAE45950.1
CR627396 mRNA Translation: CAH10490.1
CR749518 mRNA Translation: CAH18332.1
BC039314 mRNA Translation: AAH39314.1
BC048104 mRNA Translation: AAH48104.1
AK096177 mRNA Translation: BAC04718.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3123.1 [Q8IZH2-1]
CCDS63801.1 [Q8IZH2-2]
CCDS75028.1 [Q8IZH2-3]

Protein sequence database of the Protein Information Resource

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PIRi
T43461

NCBI Reference Sequences

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RefSeqi
NP_001269786.1, NM_001282857.1 [Q8IZH2-2]
NP_001269788.1, NM_001282859.1 [Q8IZH2-3]
NP_061874.3, NM_019001.4 [Q8IZH2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264951; ENSP00000264951; ENSG00000114127 [Q8IZH2-1]
ENST00000392981; ENSP00000376707; ENSG00000114127 [Q8IZH2-2]
ENST00000463916; ENSP00000418404; ENSG00000114127 [Q8IZH2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54464

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54464

UCSC genome browser

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UCSCi
uc003eus.4 human [Q8IZH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY137776 mRNA Translation: AAN11306.1
AL133623 mRNA Translation: CAB63749.1
BX640905 mRNA Translation: CAE45950.1
CR627396 mRNA Translation: CAH10490.1
CR749518 mRNA Translation: CAH18332.1
BC039314 mRNA Translation: AAH39314.1
BC048104 mRNA Translation: AAH48104.1
AK096177 mRNA Translation: BAC04718.1
CCDSiCCDS3123.1 [Q8IZH2-1]
CCDS63801.1 [Q8IZH2-2]
CCDS75028.1 [Q8IZH2-3]
PIRiT43461
RefSeqiNP_001269786.1, NM_001282857.1 [Q8IZH2-2]
NP_001269788.1, NM_001282859.1 [Q8IZH2-3]
NP_061874.3, NM_019001.4 [Q8IZH2-1]

3D structure databases

SMRiQ8IZH2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119970, 125 interactors
CORUMiQ8IZH2
DIPiDIP-31174N
IntActiQ8IZH2, 61 interactors
MINTiQ8IZH2
STRINGi9606.ENSP00000264951

Protein family/group databases

MoonDBiQ8IZH2 Predicted

PTM databases

iPTMnetiQ8IZH2
PhosphoSitePlusiQ8IZH2

Polymorphism and mutation databases

BioMutaiXRN1
DMDMi74714582

Proteomic databases

EPDiQ8IZH2
jPOSTiQ8IZH2
MassIVEiQ8IZH2
MaxQBiQ8IZH2
PaxDbiQ8IZH2
PeptideAtlasiQ8IZH2
PRIDEiQ8IZH2
ProteomicsDBi71350 [Q8IZH2-1]
71351 [Q8IZH2-2]
71352 [Q8IZH2-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54464

Genome annotation databases

EnsembliENST00000264951; ENSP00000264951; ENSG00000114127 [Q8IZH2-1]
ENST00000392981; ENSP00000376707; ENSG00000114127 [Q8IZH2-2]
ENST00000463916; ENSP00000418404; ENSG00000114127 [Q8IZH2-3]
GeneIDi54464
KEGGihsa:54464
UCSCiuc003eus.4 human [Q8IZH2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54464
DisGeNETi54464

GeneCards: human genes, protein and diseases

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GeneCardsi
XRN1
HGNCiHGNC:30654 XRN1
HPAiHPA035005
HPA035006
MIMi607994 gene
neXtProtiNX_Q8IZH2
OpenTargetsiENSG00000114127
PharmGKBiPA134878471

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2044 Eukaryota
KOG2045 Eukaryota
COG5049 LUCA
GeneTreeiENSGT00670000098080
KOiK12618
OMAiYPAISQL
OrthoDBi685597at2759
PhylomeDBiQ8IZH2
TreeFamiTF105757

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
XRN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54464
PharosiQ8IZH2

Protein Ontology

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PROi
PR:Q8IZH2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114127 Expressed in 204 organ(s), highest expression level in epithelial cell of pancreas
ExpressionAtlasiQ8IZH2 baseline and differential
GenevisibleiQ8IZH2 HS

Family and domain databases

InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR016494 5_3_exoribonuclease_1
IPR004859 Put_53exo
IPR041385 SH3_12
IPR040992 XRN1_D1
IPR041106 XRN1_D2_D3
IPR041412 Xrn1_helical
PANTHERiPTHR12341 PTHR12341, 1 hit
PTHR12341:SF7 PTHR12341:SF7, 1 hit
PfamiView protein in Pfam
PF18129 SH3_12, 1 hit
PF18332 XRN1_D1, 1 hit
PF18334 XRN1_D2_D3, 1 hit
PF17846 XRN_M, 1 hit
PF03159 XRN_N, 1 hit
PIRSFiPIRSF006743 Exonuclease_Xnr1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZH2
Secondary accession number(s): Q4G0S3
, Q68D88, Q6AI24, Q6MZS8, Q86WS7, Q8N8U4, Q9UF39
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2003
Last modified: November 13, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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