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Entry version 155 (31 Jul 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Latent-transforming growth factor beta-binding protein 4

Gene

Ltbp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2129379 Molecules associated with elastic fibres

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Latent-transforming growth factor beta-binding protein 4
Short name:
LTBP-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ltbp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1321395 Ltbp4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice reveal significant disruption of elastic fibers in multiple tissues. They develop pulmonary septation defects, rectal prolapse, colorectal adenomas, and dilated cardiomyopathy. They survive up to six months (mid-adult age) without major clinical symptoms.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000764825 – 1666Latent-transforming growth factor beta-binding protein 4Add BLAST1642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi152 ↔ 162PROSITE-ProRule annotation
Disulfide bondi156 ↔ 168PROSITE-ProRule annotation
Disulfide bondi170 ↔ 179PROSITE-ProRule annotation
Disulfide bondi288 ↔ 310PROSITE-ProRule annotation
Disulfide bondi297 ↔ 323PROSITE-ProRule annotation
Disulfide bondi311 ↔ 326PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi360 ↔ 371PROSITE-ProRule annotation
Disulfide bondi366 ↔ 380PROSITE-ProRule annotation
Disulfide bondi382 ↔ 395PROSITE-ProRule annotation
Disulfide bondi408 ↔ 430PROSITE-ProRule annotation
Disulfide bondi417 ↔ 443PROSITE-ProRule annotation
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 446PROSITE-ProRule annotation
Disulfide bondi432 ↔ 458PROSITE-ProRule annotation
Disulfide bondi592 ↔ 604PROSITE-ProRule annotation
Disulfide bondi599 ↔ 613PROSITE-ProRule annotation
Disulfide bondi615 ↔ 628PROSITE-ProRule annotation
Disulfide bondi634 ↔ 646PROSITE-ProRule annotation
Disulfide bondi641 ↔ 655PROSITE-ProRule annotation
Disulfide bondi657 ↔ 670PROSITE-ProRule annotation
Disulfide bondi676 ↔ 688PROSITE-ProRule annotation
Disulfide bondi683 ↔ 697PROSITE-ProRule annotation
Disulfide bondi699 ↔ 712PROSITE-ProRule annotation
Disulfide bondi718 ↔ 730PROSITE-ProRule annotation
Disulfide bondi725 ↔ 739PROSITE-ProRule annotation
Disulfide bondi741 ↔ 750PROSITE-ProRule annotation
Disulfide bondi757 ↔ 769PROSITE-ProRule annotation
Disulfide bondi764 ↔ 778PROSITE-ProRule annotation
Disulfide bondi780 ↔ 793PROSITE-ProRule annotation
Disulfide bondi799 ↔ 811PROSITE-ProRule annotation
Disulfide bondi806 ↔ 820PROSITE-ProRule annotation
Disulfide bondi822 ↔ 835PROSITE-ProRule annotation
Disulfide bondi881 ↔ 893PROSITE-ProRule annotation
Disulfide bondi887 ↔ 902PROSITE-ProRule annotation
Disulfide bondi904 ↔ 918PROSITE-ProRule annotation
Disulfide bondi924 ↔ 936PROSITE-ProRule annotation
Disulfide bondi930 ↔ 945PROSITE-ProRule annotation
Disulfide bondi947 ↔ 960PROSITE-ProRule annotation
Disulfide bondi966 ↔ 977PROSITE-ProRule annotation
Disulfide bondi972 ↔ 986PROSITE-ProRule annotation
Disulfide bondi988 ↔ 1001PROSITE-ProRule annotation
Disulfide bondi1095 ↔ 1107PROSITE-ProRule annotation
Glycosylationi1097N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1101 ↔ 1116PROSITE-ProRule annotation
Disulfide bondi1118 ↔ 1131PROSITE-ProRule annotation
Disulfide bondi1225 ↔ 1248PROSITE-ProRule annotation
Disulfide bondi1235 ↔ 1260PROSITE-ProRule annotation
Disulfide bondi1235Interchain (with C-33 in TGFB1); in linked formBy similarity
Glycosylationi1242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1249 ↔ 1265PROSITE-ProRule annotation
Disulfide bondi1250 ↔ 1277PROSITE-ProRule annotation
Disulfide bondi1260Interchain (with C-33 in TGFB1); in linked formBy similarity
Disulfide bondi1299 ↔ 1312PROSITE-ProRule annotation
Disulfide bondi1307 ↔ 1321PROSITE-ProRule annotation
Disulfide bondi1323 ↔ 1336PROSITE-ProRule annotation
Disulfide bondi1342 ↔ 1354PROSITE-ProRule annotation
Disulfide bondi1349 ↔ 1363PROSITE-ProRule annotation
Disulfide bondi1365 ↔ 1378PROSITE-ProRule annotation
Glycosylationi1381N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1393 ↔ 1417PROSITE-ProRule annotation
Disulfide bondi1403 ↔ 1429PROSITE-ProRule annotation
Disulfide bondi1418 ↔ 1432PROSITE-ProRule annotation
Disulfide bondi1419 ↔ 1444PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1564PhosphothreonineCombined sources1
Disulfide bondi1579 ↔ 1590PROSITE-ProRule annotation
Disulfide bondi1585 ↔ 1599PROSITE-ProRule annotation
Disulfide bondi1601 ↔ 1614PROSITE-ProRule annotation
Disulfide bondi1620 ↔ 1635PROSITE-ProRule annotation
Disulfide bondi1630 ↔ 1644PROSITE-ProRule annotation
Disulfide bondi1646 ↔ 1659PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Contains hydroxylated asparagine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3427

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K4G1

PeptideAtlas

More...
PeptideAtlasi
Q8K4G1

PRoteomics IDEntifications database

More...
PRIDEi
Q8K4G1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K4G1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K4G1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040488 Expressed in 243 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8K4G1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K4G1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex.

Interacts with LTBP1 and TGFB1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8K4G1, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8K4G1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000037536

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8K4G1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini148 – 180EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini286 – 338TB 1PROSITE-ProRule annotationAdd BLAST53
Domaini356 – 396EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini406 – 458TB 2PROSITE-ProRule annotationAdd BLAST53
Domaini588 – 629EGF-like 3PROSITE-ProRule annotationAdd BLAST42
Domaini630 – 671EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini672 – 713EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini714 – 751EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini753 – 794EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini795 – 836EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini877 – 919EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini920 – 961EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini962 – 1002EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1091 – 1132EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1223 – 1277TB 3PROSITE-ProRule annotationAdd BLAST55
Domaini1295 – 1337EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1338 – 1379EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini1391 – 1444TB 4PROSITE-ProRule annotationAdd BLAST54
Domaini1575 – 1615EGF-like 15PROSITE-ProRule annotationAdd BLAST41
Domaini1616 – 1660EGF-like 16PROSITE-ProRule annotationAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi477 – 608Pro-richAdd BLAST132
Compositional biasi592 – 1160Cys-richAdd BLAST569
Compositional biasi1161 – 1217Pro-richAdd BLAST57
Compositional biasi1449 – 1534Pro-richAdd BLAST86

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LTBP family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410YAPY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158234

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293153

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K4G1

KEGG Orthology (KO)

More...
KOi
K08023

Database of Orthologous Groups

More...
OrthoDBi
1174178at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317514

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645 EGF_CA, 17 hits
PF00683 TB, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 20 hits
SM00179 EGF_CA, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 5 hits
SSF57581 SSF57581, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 14 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 16 hits
PS01187 EGF_CA, 17 hits
PS51364 TB, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K4G1-1) [UniParc]FASTAAdd to basket
Also known as: LTBP4L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRPGLGGPC PLLLLLLLPA ATSASGSSPS PSPSPIEKAV VPSHQAGVAA
60 70 80 90 100
CHCCLDQTPK SSRCTRASCR VRNCPPAKCT GLEGCLTPTP SVPSPSRSPV
110 120 130 140 150
EKSQVSLNWQ PLTLQEARAL LRQRRPRGPW ARALLKRRPP HRAPAGQARV
160 170 180 190 200
LCPLICHNGG VCVKPDRCLC PPDFAGKFCQ LHSSGARPPA PAMPGLTRSV
210 220 230 240 250
YTMPLANHRD DEHGVASMVS VHVEHPQEAS VVVHQVERVS GPWEEANPEA
260 270 280 290 300
LARAEAAARA EAAAPYTVLA QSAPREDGYS DASGFGYCFR ELRGSECASP
310 320 330 340 350
LPGLRTQEVC CRGEGLAWGV HDCHPCAEHL RNSNQVSGPN GPCPPGFERV
360 370 380 390 400
NGSCVDVDEC ATGGRCQHGE CANTRGGYTC VCPDGFLLDS SRSSCISQHV
410 420 430 440 450
ISEAKGPCYR VLHDGGCSLP ILRNITKQIC CCSRVGKAWG RGCQLCPPYG
460 470 480 490 500
SEGFREICPA GPGYHYSASD LRYNTRPLNQ DPPRVTFNQP RVPPATPRPP
510 520 530 540 550
TGFLPTRRPE PRPDPGPQPE PRPRPEPRPR PESRPRPEPR PRPEPRPQPE
560 570 580 590 600
SQPRPESRPR PESQPWPEFP LPSIPAWTGP EIPESGPSSS MCQRNPQVCG
610 620 630 640 650
PGRCVPRPSG YTCACDPGFR LGPQGTRCID IDECRRVPTP CAPGRCENTP
660 670 680 690 700
GSFRCVCGTG FQAGPRATEC LDVDECRRVP PPCDRGRCEN TPGSFLCVCP
710 720 730 740 750
AGYQAAPHGA SCQDVDECTQ SPGLCGRGVC ENLPGSFRCV CPAGFRGSAC
760 770 780 790 800
EEDVDECAQQ PPPCGPGRCD NTAGSFHCAC PAGFRSRGPG APCQDVDECS
810 820 830 840 850
RSPSPCAYGR CENTEGSFKC VCPTGFQPNA AGSECEDVDE CENRLACPGQ
860 870 880 890 900
ECVNSPGSFQ CRACPVGHHL HRGRCTDVDE CSSGTPCGLH GQCTNTKGSF
910 920 930 940 950
HCSCSTGYRA PSGQPGPCAD INECLEGDFC FPHGECLNTD GSFTCTCAPG
960 970 980 990 1000
YRPGPRGASC LDVDECSEED LCQSGICTNT DGSFECICPP GHRAGPDLAS
1010 1020 1030 1040 1050
CLDIDECRER GPALCGSQRC ENSPGSYRCV RDCDPGYHPG PEGTCDDIDE
1060 1070 1080 1090 1100
CREYGSAICG AQRCENTPGS YRCTPACDPG YQPTPGGGCQ DVDECRNRSF
1110 1120 1130 1140 1150
CGAHAMCQNL PGSFQCVCDQ GYEGARDGRH CVDVNECETL QGVCGSALCE
1160 1170 1180 1190 1200
NVEGSFLCVC PNSPEEFDPM TGRCVPPRAP AGTFPGSQPQ APASPSLPAR
1210 1220 1230 1240 1250
PPAPPPPRRP SPPRQGPVSS GRRECYFDTA APDACDNILA RNVTWQECCC
1260 1270 1280 1290 1300
TVGEGWGSGC RIQQCPGTET AEYQSLCPHG RGYLVPSGDL SARRDVDECQ
1310 1320 1330 1340 1350
LFQDQVCKSG VCVNTAPGYS CYCSNGFYYH AHRLECVDND ECADEEPACE
1360 1370 1380 1390 1400
GGRCVNTVGS YHCTCEPPLV LDGSRRRCVS NESQSLDDNL GVCWQEVGPD
1410 1420 1430 1440 1450
LVCSRPRLDR QATYTECCCL YGEAWGMDCA LCPAQDSDDF EALCNVLRPP
1460 1470 1480 1490 1500
AYGPPRPGGF GIPYEYGPDI GPPYQSLPYG PDLYPPPVLP YDPYPPPPGP
1510 1520 1530 1540 1550
FARREAPYGA PPFDMPDFED DGGPYGESET PDPPSRGTGW PYRSRDTRGS
1560 1570 1580 1590 1600
FPEPEESSER GSYTGALSEP YEGLEAEECG ILDGCPHGRC VRVPEGFTCD
1610 1620 1630 1640 1650
CFDGYRLDIT RMSCVDVNEC DEAEATSPLC VNARCVNTDG SFRCICRPGF
1660
APTHQPHHCA PARPRA
Length:1,666
Mass (Da):178,642
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3784110C2B714E7D
GO
Isoform 2 (identifier: Q8K4G1-2) [UniParc]FASTAAdd to basket
Also known as: LTBP4S

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.
     67-150: ASCRVRNCPP...HRAPAGQARV → MAGGAQLLWV...APGGPGFRAF

Show »
Length:1,600
Mass (Da):171,304
Checksum:i988B6E43BA69E164
GO
Isoform 3 (identifier: Q8K4G1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-150: KSSRCTRASC...HRAPAGQARV → RHEAALQPWR...APGGPGFRAF

Note: Sequence incomplete.
Show »
Length:1,666
Mass (Da):178,036
Checksum:i96DDC2CF571CC22D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6B8E9Q6B8_MOUSE
Latent-transforming growth factor b...
Ltbp4
1,147Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z598D3Z598_MOUSE
Latent-transforming growth factor b...
Ltbp4
1,558Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QPS5E9QPS5_MOUSE
Latent-transforming growth factor b...
Ltbp4
1,665Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W6Z0F6W6Z0_MOUSE
Latent-transforming growth factor b...
Ltbp4
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti361A → S in AAH59016 (PubMed:15489334).Curated1
Sequence conflicti625G → D in AAN04661 (PubMed:12208849).Curated1
Sequence conflicti1631V → I in AAN04661 (PubMed:12208849).Curated1
Sequence conflicti1631V → I in AAN04662 (PubMed:12208849).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0092481 – 66Missing in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_00924960 – 150KSSRC…GQARV → RHEAALQPWRAARSCSGCRY WCCWRSWGRSPYWADPESVF ACASPPLCAACVASTGPLAP AVPRPARPATPPVDSGAPGG AAPGGPGFRAF in isoform 3. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_00925067 – 150ASCRV…GQARV → MAGGAQLLWVSLLVLLAQLG PQPVLGRPRERLRVRFTPAV CGLRCIHGPTGSRCTPTCAP RNATSVDSGAPGGAAPGGPG FRAF in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF410798 mRNA Translation: AAN04661.1
AF410799 mRNA Translation: AAN04662.1
AC157561 Genomic DNA No translation available.
BC059016 mRNA Translation: AAH59016.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21017.1 [Q8K4G1-1]
CCDS52158.1 [Q8K4G1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001107021.1, NM_001113549.1 [Q8K4G1-2]
NP_783572.2, NM_175641.2 [Q8K4G1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038618; ENSMUSP00000037536; ENSMUSG00000040488 [Q8K4G1-1]
ENSMUST00000121175; ENSMUSP00000113674; ENSMUSG00000040488 [Q8K4G1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
108075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:108075

UCSC genome browser

More...
UCSCi
uc009fvs.2 mouse [Q8K4G1-2]
uc009fvt.2 mouse [Q8K4G1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410798 mRNA Translation: AAN04661.1
AF410799 mRNA Translation: AAN04662.1
AC157561 Genomic DNA No translation available.
BC059016 mRNA Translation: AAH59016.1
CCDSiCCDS21017.1 [Q8K4G1-1]
CCDS52158.1 [Q8K4G1-2]
RefSeqiNP_001107021.1, NM_001113549.1 [Q8K4G1-2]
NP_783572.2, NM_175641.2 [Q8K4G1-1]

3D structure databases

SMRiQ8K4G1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8K4G1, 2 interactors
MINTiQ8K4G1
STRINGi10090.ENSMUSP00000037536

PTM databases

iPTMnetiQ8K4G1
PhosphoSitePlusiQ8K4G1

Proteomic databases

CPTACinon-CPTAC-3427
PaxDbiQ8K4G1
PeptideAtlasiQ8K4G1
PRIDEiQ8K4G1

Genome annotation databases

EnsembliENSMUST00000038618; ENSMUSP00000037536; ENSMUSG00000040488 [Q8K4G1-1]
ENSMUST00000121175; ENSMUSP00000113674; ENSMUSG00000040488 [Q8K4G1-2]
GeneIDi108075
KEGGimmu:108075
UCSCiuc009fvs.2 mouse [Q8K4G1-2]
uc009fvt.2 mouse [Q8K4G1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8425
MGIiMGI:1321395 Ltbp4

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410YAPY LUCA
GeneTreeiENSGT00940000158234
HOGENOMiHOG000293153
InParanoidiQ8K4G1
KOiK08023
OrthoDBi1174178at2759
TreeFamiTF317514

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ltbp4 mouse

Protein Ontology

More...
PROi
PR:Q8K4G1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040488 Expressed in 243 organ(s), highest expression level in lung
ExpressionAtlasiQ8K4G1 baseline and differential
GenevisibleiQ8K4G1 MM

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF07645 EGF_CA, 17 hits
PF00683 TB, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 20 hits
SM00179 EGF_CA, 19 hits
SUPFAMiSSF57184 SSF57184, 5 hits
SSF57581 SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 14 hits
PS00022 EGF_1, 2 hits
PS01186 EGF_2, 12 hits
PS50026 EGF_3, 16 hits
PS01187 EGF_CA, 17 hits
PS51364 TB, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTBP4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K4G1
Secondary accession number(s): E9QPD9, Q8K4G0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: July 27, 2011
Last modified: July 31, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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