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Entry version 138 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
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Protein

ORM1-like protein 3

Gene

ORMDL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.1 Publication

Miscellaneous

SNPs on 17q21 locus that are associated with childhood asthma also show a consistent and strong association with transcript levels of ORMDL3, indicating that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ORM1-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ORMDL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16038 ORMDL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610075 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N138

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 94LumenalSequence analysisAdd BLAST52
Transmembranei95 – 117HelicalSequence analysisAdd BLAST23
Topological domaini118 – 153CytoplasmicSequence analysisAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Asthma (ASTHMA)3 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Related information in OMIM

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNET

More...
DisGeNETi
94103
MIMi600807 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000172057

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32821

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N138

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ORMDL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728486

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002156391 – 153ORM1-like protein 3Add BLAST153

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N138

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N138

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N138

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N138

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N138

PeptideAtlas

More...
PeptideAtlasi
Q8N138

PRoteomics IDEntifications database

More...
PRIDEi
Q8N138

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71543 [Q8N138-1]
71544 [Q8N138-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8N138-1 [Q8N138-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N138

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N138

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172057 Expressed in 203 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N138 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N138 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065643

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SPTLC1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SPTLC1O152692EBI-721750,EBI-1044323

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125114, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8N138

Database of interacting proteins

More...
DIPi
DIP-48687N

Protein interaction database and analysis system

More...
IntActi
Q8N138, 30 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377724

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3319 Eukaryota
COG5081 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183178

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000192741

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N138

Identification of Orthologs from Complete Genome Data

More...
OMAi
RIHFIIN

Database of Orthologous Groups

More...
OrthoDBi
1405600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N138

TreeFam database of animal gene trees

More...
TreeFami
TF323369

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007203 ORMDL
IPR029883 ORML3

The PANTHER Classification System

More...
PANTHERi
PTHR12665 PTHR12665, 1 hit
PTHR12665:SF11 PTHR12665:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04061 ORMDL, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF018147 ORMDL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N138-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHIVLLSI PFVSVPVVWT
60 70 80 90 100
LTNLIHNMGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK
110 120 130 140 150
FLTITPIVLY FLTSFYTKYD QIHFVLNTVS LMSVLIPKLP QLHGVRIFGI

NKY
Length:153
Mass (Da):17,495
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EF483CA5C03EC2E
GO
Isoform 2 (identifier: Q8N138-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-58: Missing.

Note: No experimental confirmation available.
Show »
Length:137
Mass (Da):15,689
Checksum:i63B59033E286DF75
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRM9J3QRM9_HUMAN
ORM1-like protein 3
ORMDL3
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTF9J3KTF9_HUMAN
ORM1-like protein 3
ORMDL3
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01605243 – 58Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF395708 mRNA Translation: AAM43507.1
AF373101 mRNA Translation: AAN76521.1
AF373102 mRNA Translation: AAN76522.1
AK074811 mRNA Translation: BAC11223.1
AY357943 mRNA Translation: AAQ57273.1
AK075212 mRNA Translation: BAC11476.1
AK093063 mRNA Translation: BAG52645.1
CH471152 Genomic DNA Translation: EAW60617.1
BC017087 mRNA Translation: AAH17087.1
BC071833 mRNA Translation: AAH71833.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11355.1 [Q8N138-1]

NCBI Reference Sequences

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RefSeqi
NP_001307730.1, NM_001320801.1 [Q8N138-1]
NP_001307731.1, NM_001320802.1 [Q8N138-1]
NP_001307732.1, NM_001320803.1 [Q8N138-1]
NP_644809.1, NM_139280.3 [Q8N138-1]
XP_016880835.1, XM_017025346.1
XP_016880836.1, XM_017025347.1
XP_016880837.1, XM_017025348.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304046; ENSP00000304858; ENSG00000172057 [Q8N138-1]
ENST00000394169; ENSP00000377724; ENSG00000172057 [Q8N138-1]
ENST00000579695; ENSP00000464693; ENSG00000172057 [Q8N138-1]
ENST00000584220; ENSP00000464455; ENSG00000172057 [Q8N138-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
94103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:94103

UCSC genome browser

More...
UCSCi
uc002htj.3 human [Q8N138-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF395708 mRNA Translation: AAM43507.1
AF373101 mRNA Translation: AAN76521.1
AF373102 mRNA Translation: AAN76522.1
AK074811 mRNA Translation: BAC11223.1
AY357943 mRNA Translation: AAQ57273.1
AK075212 mRNA Translation: BAC11476.1
AK093063 mRNA Translation: BAG52645.1
CH471152 Genomic DNA Translation: EAW60617.1
BC017087 mRNA Translation: AAH17087.1
BC071833 mRNA Translation: AAH71833.1
CCDSiCCDS11355.1 [Q8N138-1]
RefSeqiNP_001307730.1, NM_001320801.1 [Q8N138-1]
NP_001307731.1, NM_001320802.1 [Q8N138-1]
NP_001307732.1, NM_001320803.1 [Q8N138-1]
NP_644809.1, NM_139280.3 [Q8N138-1]
XP_016880835.1, XM_017025346.1
XP_016880836.1, XM_017025347.1
XP_016880837.1, XM_017025348.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125114, 13 interactors
CORUMiQ8N138
DIPiDIP-48687N
IntActiQ8N138, 30 interactors
STRINGi9606.ENSP00000377724

PTM databases

iPTMnetiQ8N138
PhosphoSitePlusiQ8N138

Polymorphism and mutation databases

BioMutaiORMDL3
DMDMi74728486

Proteomic databases

EPDiQ8N138
jPOSTiQ8N138
MassIVEiQ8N138
MaxQBiQ8N138
PaxDbiQ8N138
PeptideAtlasiQ8N138
PRIDEiQ8N138
ProteomicsDBi71543 [Q8N138-1]
71544 [Q8N138-4]
TopDownProteomicsiQ8N138-1 [Q8N138-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
94103

Genome annotation databases

EnsembliENST00000304046; ENSP00000304858; ENSG00000172057 [Q8N138-1]
ENST00000394169; ENSP00000377724; ENSG00000172057 [Q8N138-1]
ENST00000579695; ENSP00000464693; ENSG00000172057 [Q8N138-1]
ENST00000584220; ENSP00000464455; ENSG00000172057 [Q8N138-4]
GeneIDi94103
KEGGihsa:94103
UCSCiuc002htj.3 human [Q8N138-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94103
DisGeNETi94103

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ORMDL3
HGNCiHGNC:16038 ORMDL3
HPAiHPA065643
MIMi600807 phenotype
610075 gene
neXtProtiNX_Q8N138
OpenTargetsiENSG00000172057
PharmGKBiPA32821

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3319 Eukaryota
COG5081 LUCA
GeneTreeiENSGT00950000183178
HOGENOMiHOG000192741
InParanoidiQ8N138
OMAiRIHFIIN
OrthoDBi1405600at2759
PhylomeDBiQ8N138
TreeFamiTF323369

Enzyme and pathway databases

ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ORMDL3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
94103
PharosiQ8N138

Protein Ontology

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PROi
PR:Q8N138

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000172057 Expressed in 203 organ(s), highest expression level in liver
ExpressionAtlasiQ8N138 baseline and differential
GenevisibleiQ8N138 HS

Family and domain databases

InterProiView protein in InterPro
IPR007203 ORMDL
IPR029883 ORML3
PANTHERiPTHR12665 PTHR12665, 1 hit
PTHR12665:SF11 PTHR12665:SF11, 1 hit
PfamiView protein in Pfam
PF04061 ORMDL, 1 hit
PIRSFiPIRSF018147 ORMDL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiORML3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N138
Secondary accession number(s): B3KS83, Q6UY83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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