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Entry version 149 (13 Nov 2019)
Sequence version 1 (01 Oct 2002)
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Protein

SH2 domain-containing protein 3C

Gene

SH2D3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: InterPro
  • SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8N5H7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH2 domain-containing protein 3C
Alternative name(s):
Novel SH2-containing protein 3
SH2 domain-containing Eph receptor-binding protein 1
Short name:
SHEP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH2D3C
Synonyms:NSP3
ORF Names:UNQ272/PRO309/PRO34088
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16884 SH2D3C

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604722 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N5H7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10044

Open Targets

More...
OpenTargetsi
ENSG00000095370

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38191

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N5H7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH2D3C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002288331 – 860SH2 domain-containing protein 3CAdd BLAST860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineBy similarity1
Modified residuei278PhosphotyrosineBy similarity1
Modified residuei283PhosphotyrosineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei440PhosphoserineCombined sources1
Modified residuei793PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8N5H7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N5H7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N5H7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N5H7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N5H7

PeptideAtlas

More...
PeptideAtlasi
Q8N5H7

PRoteomics IDEntifications database

More...
PRIDEi
Q8N5H7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
20244
72054 [Q8N5H7-1]
72055 [Q8N5H7-2]
72056 [Q8N5H7-3]
72057 [Q8N5H7-4]
72058 [Q8N5H7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N5H7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N5H7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095370 Expressed in 167 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N5H7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N5H7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047586

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTK2B.

Interacts with NEDD9/HEF1 (By similarity).

Interacts (via C-terminus) with BCAR1/CAS.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115355, 6 interactors

Database of interacting proteins

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DIPi
DIP-59443N

Protein interaction database and analysis system

More...
IntActi
Q8N5H7, 8 interactors

Molecular INTeraction database

More...
MINTi
Q8N5H7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317817

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1860
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N5H7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini220 – 319SH2PROSITE-ProRule annotationAdd BLAST100
Domaini586 – 854Ras-GEFPROSITE-ProRule annotationAdd BLAST269

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal Cdc25-homology/Ras-GEF domain adopts a closed conformation rendering it incapable of carrying out canonical exchange factor function, this closed conformation is required for interaction with BCAR1.

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFQG Eukaryota
ENOG410XTJR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154130

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231595

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N5H7

KEGG Orthology (KO)

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KOi
K23690

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTMSIMI

Database of Orthologous Groups

More...
OrthoDBi
138275at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N5H7

TreeFam database of animal gene trees

More...
TreeFami
TF323756

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.840.10, 1 hit
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR000980 SH2
IPR036860 SH2_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00617 RasGEF, 1 hit
PF00017 SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00147 RasGEF, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366 SSF48366, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50009 RASGEF_CAT, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N5H7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEGTKKTSK KFKFFKFKGF GSLSNLPRSF TLRRSSASIS RQSHLEPDTF
60 70 80 90 100
EATQDDMVTV PKSPPAYARS SDMYSHMGTM PRPSIKKAQN SQAARQAQEA
110 120 130 140 150
GPKPNLVPGG VPDPPGLEAA KEVMVKATGP LEDTPAMEPN PSAVEVDPIR
160 170 180 190 200
KPEVPTGDVE EERPPRDVHS ERAAGEPEAG SDYVKFSKEK YILDSSPEKL
210 220 230 240 250
HKELEEELKL SSTDLRSHAW YHGRIPREVS ETLVQRNGDF LIRDSLTSLG
260 270 280 290 300
DYVLTCRWRN QALHFKINKV VVKAGESYTH IQYLFEQESF DHVPALVRYH
310 320 330 340 350
VGSRKAVSEQ SGAIIYCPVN RTFPLRYLEA SYGLGQGSSK PASPVSPSGP
360 370 380 390 400
KGSHMKRRSV TMTDGLTADK VTRSDGCPTS TSLPRPRDSI RSCALSMDQI
410 420 430 440 450
PDLHSPMSPI SESPSSPAYS TVTRVHAAPA APSATALPAS PVARRSSEPQ
460 470 480 490 500
LCPGSAPKTH GESDKGPHTS PSHTLGKASP SPSLSSYSDP DSGHYCQLQP
510 520 530 540 550
PVRGSREWAA TETSSQQARS YGERLKELSE NGAPEGDWGK TFTVPIVEVT
560 570 580 590 600
SSFNPATFQS LLIPRDNRPL EVGLLRKVKE LLAEVDARTL ARHVTKVDCL
610 620 630 640 650
VARILGVTKE MQTLMGVRWG MELLTLPHGR QLRLDLLERF HTMSIMLAVD
660 670 680 690 700
ILGCTGSAEE RAALLHKTIQ LAAELRGTMG NMFSFAAVMG ALDMAQISRL
710 720 730 740 750
EQTWVTLRQR HTEGAILYEK KLKPFLKSLN EGKEGPPLSN TTFPHVLPLI
760 770 780 790 800
TLLECDSAPP EGPEPWGSTE HGVEVVLAHL EAARTVAHHG GLYHTNAEVK
810 820 830 840 850
LQGFQARPEL LEVFSTEFQM RLLWGSQGAS SSQARRYEKF DKVLTALSHK
860
LEPAVRSSEL
Length:860
Mass (Da):94,411
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62598F2F643147C5
GO
Isoform 2 (identifier: Q8N5H7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MTEGTKKTSK...RPPRDVHSER → MTAVGRRCPALGSRG

Show »
Length:703
Mass (Da):77,141
Checksum:i005B0EA32F7CA869
GO
Isoform 3 (identifier: Q8N5H7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-354: Missing.

Show »
Length:506
Mass (Da):55,191
Checksum:i6A525DAC855CF389
GO
Isoform 4 (identifier: Q8N5H7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MTEGTKKTSK...RPPRDVHSER → MAPALPSPHK...GRCPLLLCGG

Note: No experimental confirmation available.
Show »
Length:792
Mass (Da):86,436
Checksum:iCF76362417FEC80E
GO
Isoform 5 (identifier: Q8N5H7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ
     186-186: F → VQF

Note: No experimental confirmation available.
Show »
Length:702
Mass (Da):77,349
Checksum:iF1B0521F92431081
GO
Isoform 6 (identifier: Q8N5H7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-185: MTEGTKKTSK...EPEAGSDYVK → MTERCSLWSALSAAACCFYRGSFVQ

Note: No experimental confirmation available.
Show »
Length:700
Mass (Da):77,122
Checksum:i26650B429A943FF8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5X5H0Y5X5_HUMAN
SH2 domain-containing protein 3C
SH2D3C
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JU32Q5JU32_HUMAN
SH2 domain-containing protein 3C
SH2D3C
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ88456 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti445R → C in AAD28246 (PubMed:10187783).Curated1
Sequence conflicti445R → C in AAQ89948 (PubMed:12975309).Curated1
Sequence conflicti723K → E in BAF84082 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q8N5H7-3)
Sequence conflicti29L → T in CAI46101 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05135223L → F. Corresponds to variant dbSNP:rs10760500Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0177061 – 354Missing in isoform 3. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_0445811 – 185MTEGT…SDYVK → MTERCSLWSALSAAACCFYR GSFVQ in isoform 5 and isoform 6. 1 PublicationAdd BLAST185
Alternative sequenceiVSP_0177071 – 172MTEGT…VHSER → MTAVGRRCPALGSRG in isoform 2. 3 PublicationsAdd BLAST172
Alternative sequenceiVSP_0177081 – 172MTEGT…VHSER → MAPALPSPHKAVARPELLLD TAAHSGKLRAPDGGEGAECA GHNGGPSWGVGQGQSQEPSR QGIPQAPWLVSWQRRGFPPS SFCPGPLRTEKLRAGRCPLL LCGG in isoform 4. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_044582186F → VQF in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF124251 mRNA Translation: AAD28246.1
AY358089 Transcribed RNA Translation: AAQ88456.1 Different initiation.
AY358440 mRNA Translation: AAQ89948.1
AK056068 mRNA Translation: BAG51614.1
AK291393 mRNA Translation: BAF84082.1
BX647905 mRNA Translation: CAI46101.1
AL162586 Genomic DNA No translation available.
AL162426 Genomic DNA No translation available.
BC027962 mRNA Translation: AAH27962.1
BC032365 mRNA Translation: AAH32365.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS48026.1 [Q8N5H7-5]
CCDS48027.1 [Q8N5H7-6]
CCDS48028.1 [Q8N5H7-3]
CCDS59145.1 [Q8N5H7-4]
CCDS6877.1 [Q8N5H7-1]
CCDS6878.1 [Q8N5H7-2]

NCBI Reference Sequences

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RefSeqi
NP_001136004.1, NM_001142532.1 [Q8N5H7-3]
NP_001136005.1, NM_001142533.1 [Q8N5H7-5]
NP_001136006.1, NM_001142534.1 [Q8N5H7-6]
NP_001239263.1, NM_001252334.1 [Q8N5H7-4]
NP_005480.2, NM_005489.3 [Q8N5H7-2]
NP_733745.1, NM_170600.2 [Q8N5H7-1]
XP_005251696.1, XM_005251639.1
XP_011516419.1, XM_011518117.2
XP_016869663.1, XM_017014174.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000314830; ENSP00000317817; ENSG00000095370 [Q8N5H7-1]
ENST00000373276; ENSP00000362373; ENSG00000095370 [Q8N5H7-4]
ENST00000373277; ENSP00000362374; ENSG00000095370 [Q8N5H7-2]
ENST00000420366; ENSP00000388536; ENSG00000095370 [Q8N5H7-5]
ENST00000429553; ENSP00000394632; ENSG00000095370 [Q8N5H7-3]
ENST00000629203; ENSP00000485866; ENSG00000095370 [Q8N5H7-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10044

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10044

UCSC genome browser

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UCSCi
uc004bry.4 human [Q8N5H7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124251 mRNA Translation: AAD28246.1
AY358089 Transcribed RNA Translation: AAQ88456.1 Different initiation.
AY358440 mRNA Translation: AAQ89948.1
AK056068 mRNA Translation: BAG51614.1
AK291393 mRNA Translation: BAF84082.1
BX647905 mRNA Translation: CAI46101.1
AL162586 Genomic DNA No translation available.
AL162426 Genomic DNA No translation available.
BC027962 mRNA Translation: AAH27962.1
BC032365 mRNA Translation: AAH32365.1
CCDSiCCDS48026.1 [Q8N5H7-5]
CCDS48027.1 [Q8N5H7-6]
CCDS48028.1 [Q8N5H7-3]
CCDS59145.1 [Q8N5H7-4]
CCDS6877.1 [Q8N5H7-1]
CCDS6878.1 [Q8N5H7-2]
RefSeqiNP_001136004.1, NM_001142532.1 [Q8N5H7-3]
NP_001136005.1, NM_001142533.1 [Q8N5H7-5]
NP_001136006.1, NM_001142534.1 [Q8N5H7-6]
NP_001239263.1, NM_001252334.1 [Q8N5H7-4]
NP_005480.2, NM_005489.3 [Q8N5H7-2]
NP_733745.1, NM_170600.2 [Q8N5H7-1]
XP_005251696.1, XM_005251639.1
XP_011516419.1, XM_011518117.2
XP_016869663.1, XM_017014174.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T6GX-ray2.50A/C539-860[»]
SMRiQ8N5H7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115355, 6 interactors
DIPiDIP-59443N
IntActiQ8N5H7, 8 interactors
MINTiQ8N5H7
STRINGi9606.ENSP00000317817

PTM databases

iPTMnetiQ8N5H7
PhosphoSitePlusiQ8N5H7

Polymorphism and mutation databases

BioMutaiSH2D3C
DMDMi74751027

Proteomic databases

EPDiQ8N5H7
jPOSTiQ8N5H7
MassIVEiQ8N5H7
MaxQBiQ8N5H7
PaxDbiQ8N5H7
PeptideAtlasiQ8N5H7
PRIDEiQ8N5H7
ProteomicsDBi20244
72054 [Q8N5H7-1]
72055 [Q8N5H7-2]
72056 [Q8N5H7-3]
72057 [Q8N5H7-4]
72058 [Q8N5H7-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10044

Genome annotation databases

EnsembliENST00000314830; ENSP00000317817; ENSG00000095370 [Q8N5H7-1]
ENST00000373276; ENSP00000362373; ENSG00000095370 [Q8N5H7-4]
ENST00000373277; ENSP00000362374; ENSG00000095370 [Q8N5H7-2]
ENST00000420366; ENSP00000388536; ENSG00000095370 [Q8N5H7-5]
ENST00000429553; ENSP00000394632; ENSG00000095370 [Q8N5H7-3]
ENST00000629203; ENSP00000485866; ENSG00000095370 [Q8N5H7-6]
GeneIDi10044
KEGGihsa:10044
UCSCiuc004bry.4 human [Q8N5H7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10044
DisGeNETi10044

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SH2D3C
HGNCiHGNC:16884 SH2D3C
HPAiHPA047586
MIMi604722 gene
neXtProtiNX_Q8N5H7
OpenTargetsiENSG00000095370
PharmGKBiPA38191

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFQG Eukaryota
ENOG410XTJR LUCA
GeneTreeiENSGT00940000154130
HOGENOMiHOG000231595
InParanoidiQ8N5H7
KOiK23690
OMAiHTMSIMI
OrthoDBi138275at2759
PhylomeDBiQ8N5H7
TreeFamiTF323756

Enzyme and pathway databases

SignaLinkiQ8N5H7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SH2D3C human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SH2D3C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10044
PharosiQ8N5H7

Protein Ontology

More...
PROi
PR:Q8N5H7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000095370 Expressed in 167 organ(s), highest expression level in right lung
ExpressionAtlasiQ8N5H7 baseline and differential
GenevisibleiQ8N5H7 HS

Family and domain databases

Gene3Di1.10.840.10, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50009 RASGEF_CAT, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSH2D3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N5H7
Secondary accession number(s): A8K5S8
, E9PG48, Q5HYE5, Q5JU31, Q6UY42, Q8N6X3, Q9Y2X5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: November 13, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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