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Entry version 151 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
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Protein

G-protein coupled receptor 161

Gene

GPR161

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5632684 Hedgehog 'on' state

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.1.11 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor 161
Alternative name(s):
G-protein coupled receptor RE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR161
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23694 GPR161

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612250 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N6U8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 64CytoplasmicSequence analysisAdd BLAST13
Transmembranei65 – 85Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini86 – 101ExtracellularSequence analysisAdd BLAST16
Transmembranei102 – 123Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini124 – 143CytoplasmicSequence analysisAdd BLAST20
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 190ExtracellularSequence analysisAdd BLAST26
Transmembranei191 – 211Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini212 – 269CytoplasmicSequence analysisAdd BLAST58
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 306ExtracellularSequence analysisAdd BLAST16
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 529CytoplasmicSequence analysisAdd BLAST202

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23432

MalaCards human disease database

More...
MalaCardsi
GPR161

Open Targets

More...
OpenTargetsi
ENSG00000143147

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
95496 Pituitary stalk interruption syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134931474

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPR161

Domain mapping of disease mutations (DMDM)

More...
DMDMi
48428085

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696461 – 529G-protein coupled receptor 161Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8N6U8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8N6U8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N6U8

PeptideAtlas

More...
PeptideAtlasi
Q8N6U8

PRoteomics IDEntifications database

More...
PRIDEi
Q8N6U8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
24390
27210
6685
72236 [Q8N6U8-1]
72237 [Q8N6U8-2]
72238 [Q8N6U8-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8N6U8-1 [Q8N6U8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N6U8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N6U8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143147 Expressed in 217 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N6U8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8N6U8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015576
HPA072047

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117000, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N6U8, 23 interactors

Molecular INTeraction database

More...
MINTi
Q8N6U8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441039

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157829

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112777

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N6U8

KEGG Orthology (KO)

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KOi
K08439

Identification of Orthologs from Complete Genome Data

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OMAi
IWCALLP

Database of Orthologous Groups

More...
OrthoDBi
1262707at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N6U8

TreeFam database of animal gene trees

More...
TreeFami
TF331895

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N6U8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLNSSLSCR KELSNLTEEE GGEGGVIITQ FIAIIVITIF VCLGNLVIVV
60 70 80 90 100
TLYKKSYLLT LSNKFVFSLT LSNFLLSVLV LPFVVTSSIR REWIFGVVWC
110 120 130 140 150
NFSALLYLLI SSASMLTLGV IAIDRYYAVL YPMVYPMKIT GNRAVMALVY
160 170 180 190 200
IWLHSLIGCL PPLFGWSSVE FDEFKWMCVA AWHREPGYTA FWQIWCALFP
210 220 230 240 250
FLVMLVCYGF IFRVARVKAR KVHCGTVVIV EEDAQRTGRK NSSTSTSSSG
260 270 280 290 300
SRRNAFQGVV YSANQCKALI TILVVLGAFM VTWGPYMVVI ASEALWGKSS
310 320 330 340 350
VSPSLETWAT WLSFASAVCH PLIYGLWNKT VRKELLGMCF GDRYYREPFV
360 370 380 390 400
QRQRTSRLFS ISNRITDLGL SPHLTALMAG GQPLGHSSST GDTGFSCSQD
410 420 430 440 450
SGTDMMLLED YTSDDNPPSH CTCPPKRRSS VTFEDEVEQI KEAAKNSILH
460 470 480 490 500
VKAEVHKSLD SYAASLAKAI EAEAKINLFG EEALPGVLVT ARTVPGGGFG
510 520
GRRGSRTLVS QRLQLQSIEE GDVLAAEQR
Length:529
Mass (Da):58,559
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC7D1AC0894DC3F3
GO
Isoform 2 (identifier: Q8N6U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-407: TDMML → NLRAL
     408-529: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):45,363
Checksum:i00078B8EB5BC1F21
GO
Isoform 3 (identifier: Q8N6U8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.
Show »
Length:397
Mass (Da):43,906
Checksum:i426288987F5CF53F
GO
Isoform 4 (identifier: Q8N6U8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: MSLNSSLSCR...TIFVCLGNLV → MGGRRCVPGT...APRLESVRTS
     48-125: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,701
Checksum:i0FAEB6C663961C79
GO
Isoform 5 (identifier: Q8N6U8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: MSLNSSLSCR...LTLGVIAIDR → MLVPVGWMNES

Show »
Length:415
Mass (Da):46,021
Checksum:iDCC21C091A3A3B4B
GO
Isoform 6 (identifier: Q8N6U8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSARGVVQHALPTPRRGALTM

Show »
Length:549
Mass (Da):60,659
Checksum:i6FDA02198DEB9F8F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQW8A0A0A0MQW8_HUMAN
G protein-coupled receptor 161, iso...
GPR161 hCG_42392
546Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti193Q → R in BAH12873 (PubMed:14702039).Curated1
Sequence conflicti195W → R in BAH13082 (PubMed:14702039).Curated1
Sequence conflicti324Y → N in BAH12873 (PubMed:14702039).Curated1
Sequence conflicti421C → S in BAH13082 (PubMed:14702039).Curated1
Sequence conflicti500G → V in BAH12873 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0355611 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_0453291 – 125MSLNS…IAIDR → MLVPVGWMNES in isoform 5. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_0447781 – 47MSLNS…LGNLV → MGGRRCVPGTLPMRAAPPGA KRLHVPLRAKGVGRSGHAPR LESVRTS in isoform 4. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_0462991M → MSARGVVQHALPTPRRGALT M in isoform 6. 1 Publication1
Alternative sequenceiVSP_04477948 – 125Missing in isoform 4. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_010560403 – 407TDMML → NLRAL in isoform 2. 1 Publication5
Alternative sequenceiVSP_010561408 – 529Missing in isoform 2. 1 PublicationAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY275468 mRNA Translation: AAP32300.1
AF091890 mRNA Translation: AAC61598.1
AK056040 mRNA Translation: BAG51611.1
AK122656 mRNA Translation: BAG53646.1
AK298797 mRNA Translation: BAH12873.1
AK298850 mRNA Translation: BAH12884.1
AK299634 mRNA Translation: BAH13082.1
AL033532 Genomic DNA No translation available.
BC028163 mRNA Translation: AAH28163.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1268.1 [Q8N6U8-1]
CCDS58042.1 [Q8N6U8-3]
CCDS58043.1 [Q8N6U8-6]
CCDS58044.1 [Q8N6U8-4]
CCDS58045.1 [Q8N6U8-5]

NCBI Reference Sequences

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RefSeqi
NP_001254538.1, NM_001267609.1 [Q8N6U8-6]
NP_001254539.1, NM_001267610.1 [Q8N6U8-1]
NP_001254541.1, NM_001267612.1 [Q8N6U8-3]
NP_001254542.1, NM_001267613.1 [Q8N6U8-4]
NP_001254543.1, NM_001267614.1 [Q8N6U8-5]
NP_722561.1, NM_153832.2 [Q8N6U8-1]
XP_005245112.1, XM_005245055.2 [Q8N6U8-6]
XP_005245113.1, XM_005245056.2 [Q8N6U8-1]
XP_005245114.1, XM_005245057.4 [Q8N6U8-1]
XP_011507677.1, XM_011509375.2
XP_011507678.1, XM_011509376.2 [Q8N6U8-1]
XP_011507679.1, XM_011509377.1
XP_011507680.1, XM_011509378.1 [Q8N6U8-1]
XP_016856348.1, XM_017000859.1
XP_016856349.1, XM_017000860.1
XP_016856350.1, XM_017000861.1
XP_016856351.1, XM_017000862.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367835; ENSP00000356809; ENSG00000143147 [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147 [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147 [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147 [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147 [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147 [Q8N6U8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23432

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23432

UCSC genome browser

More...
UCSCi
uc001gfb.5 human [Q8N6U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY275468 mRNA Translation: AAP32300.1
AF091890 mRNA Translation: AAC61598.1
AK056040 mRNA Translation: BAG51611.1
AK122656 mRNA Translation: BAG53646.1
AK298797 mRNA Translation: BAH12873.1
AK298850 mRNA Translation: BAH12884.1
AK299634 mRNA Translation: BAH13082.1
AL033532 Genomic DNA No translation available.
BC028163 mRNA Translation: AAH28163.1
CCDSiCCDS1268.1 [Q8N6U8-1]
CCDS58042.1 [Q8N6U8-3]
CCDS58043.1 [Q8N6U8-6]
CCDS58044.1 [Q8N6U8-4]
CCDS58045.1 [Q8N6U8-5]
RefSeqiNP_001254538.1, NM_001267609.1 [Q8N6U8-6]
NP_001254539.1, NM_001267610.1 [Q8N6U8-1]
NP_001254541.1, NM_001267612.1 [Q8N6U8-3]
NP_001254542.1, NM_001267613.1 [Q8N6U8-4]
NP_001254543.1, NM_001267614.1 [Q8N6U8-5]
NP_722561.1, NM_153832.2 [Q8N6U8-1]
XP_005245112.1, XM_005245055.2 [Q8N6U8-6]
XP_005245113.1, XM_005245056.2 [Q8N6U8-1]
XP_005245114.1, XM_005245057.4 [Q8N6U8-1]
XP_011507677.1, XM_011509375.2
XP_011507678.1, XM_011509376.2 [Q8N6U8-1]
XP_011507679.1, XM_011509377.1
XP_011507680.1, XM_011509378.1 [Q8N6U8-1]
XP_016856348.1, XM_017000859.1
XP_016856349.1, XM_017000860.1
XP_016856350.1, XM_017000861.1
XP_016856351.1, XM_017000862.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117000, 18 interactors
IntActiQ8N6U8, 23 interactors
MINTiQ8N6U8
STRINGi9606.ENSP00000441039

Protein family/group databases

TCDBi9.A.14.1.11 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiQ8N6U8
PhosphoSitePlusiQ8N6U8

Polymorphism and mutation databases

BioMutaiGPR161
DMDMi48428085

Proteomic databases

jPOSTiQ8N6U8
MassIVEiQ8N6U8
PaxDbiQ8N6U8
PeptideAtlasiQ8N6U8
PRIDEiQ8N6U8
ProteomicsDBi24390
27210
6685
72236 [Q8N6U8-1]
72237 [Q8N6U8-2]
72238 [Q8N6U8-3]
TopDownProteomicsiQ8N6U8-1 [Q8N6U8-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23432
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367835; ENSP00000356809; ENSG00000143147 [Q8N6U8-1]
ENST00000367836; ENSP00000356810; ENSG00000143147 [Q8N6U8-3]
ENST00000367838; ENSP00000356812; ENSG00000143147 [Q8N6U8-1]
ENST00000537209; ENSP00000441039; ENSG00000143147 [Q8N6U8-6]
ENST00000539777; ENSP00000437576; ENSG00000143147 [Q8N6U8-4]
ENST00000546300; ENSP00000444348; ENSG00000143147 [Q8N6U8-5]
GeneIDi23432
KEGGihsa:23432
UCSCiuc001gfb.5 human [Q8N6U8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23432
DisGeNETi23432

GeneCards: human genes, protein and diseases

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GeneCardsi
GPR161
HGNCiHGNC:23694 GPR161
HPAiHPA015576
HPA072047
MalaCardsiGPR161
MIMi612250 gene
neXtProtiNX_Q8N6U8
OpenTargetsiENSG00000143147
Orphaneti95496 Pituitary stalk interruption syndrome
PharmGKBiPA134931474

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000157829
HOGENOMiHOG000112777
InParanoidiQ8N6U8
KOiK08439
OMAiIWCALLP
OrthoDBi1262707at2759
PhylomeDBiQ8N6U8
TreeFamiTF331895

Enzyme and pathway databases

ReactomeiR-HSA-5610787 Hedgehog 'off' state
R-HSA-5632684 Hedgehog 'on' state

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GPR161 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR161

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23432

Pharos

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Pharosi
Q8N6U8

Protein Ontology

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PROi
PR:Q8N6U8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000143147 Expressed in 217 organ(s), highest expression level in forebrain
ExpressionAtlasiQ8N6U8 baseline and differential
GenevisibleiQ8N6U8 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP161_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N6U8
Secondary accession number(s): B3KV34
, B7Z5D7, B7Z5E8, B7Z5Z6, F5GXD6, F5H6J7, O75963, Q5TGK0, Q5TGK1, Q5TGK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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