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Entry version 146 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Zinc finger protein 433

Gene

ZNF433

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 433
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF433
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20811 ZNF433

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8N7K0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
163059

Open Targets

More...
OpenTargetsi
ENSG00000197647

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134943717

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N7K0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF433

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30173446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475811 – 673Zinc finger protein 433Add BLAST673

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N7K0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N7K0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8N7K0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8N7K0

PeptideAtlas

More...
PeptideAtlasi
Q8N7K0

PRoteomics IDEntifications database

More...
PRIDEi
Q8N7K0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
72301 [Q8N7K0-1]
72302 [Q8N7K0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N7K0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N7K0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197647 Expressed in 91 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8N7K0 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA073724

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127846, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q8N7K0, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339767

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8N7K0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 85KRABPROSITE-ProRule annotationAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri142 – 164C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182755

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8N7K0

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHERTHC

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8N7K0

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N7K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMFQDSVAFE DVAVTFTQEE WALLDPSQKN LCRDVMQETF RNLASIGKKW
60 70 80 90 100
KPQNIYVEYE NLRRNLRIVG ERLFESKEGH QHGEILTQVP DDMLKKTTTG
110 120 130 140 150
VKSCESSVYG EVGSAHSSLN RHIRDDTGHK AYEYQEYGQK PYKCKYCKKP
160 170 180 190 200
FNCLSSVQTH ERAHSGRKLY VCEECGKTFI SHSNLQRHRI MHRGDGPYKC
210 220 230 240 250
KFCGKALMFL SLYLIHKRTH TGEKPYQCKQ CGKAFSHSSS LRIHERTHTG
260 270 280 290 300
EKPYKCNECG KAFHSSTCLH AHKRTHTGEK PYECKQCGKA FSSSHSFQIH
310 320 330 340 350
ERTHTGEKPY ECKECGKAFK CPSSVRRHER THSRKKPYEC KHCGKVLSYL
360 370 380 390 400
TSFQNHLGMH TGEISHKCKI CGKAFYSPSS LQTHEKTHTG EKPYKCNQCG
410 420 430 440 450
KAFNSSSSFR YHERTHTGEK PYECKQCGKA FRSASLLQTH GRTHTGEKPY
460 470 480 490 500
ACKECGKPFS NFSFFQIHER MHREEKPYEC KGYGKTFSLP SLFHRHERTH
510 520 530 540 550
TGGKTYECKQ CGRSFNCSSS FRYHGRTHTG EKPYECKQCG KAFRSASQLQ
560 570 580 590 600
IHGRTHTGEK PYECKQCGKA FGSASHLQMH GRTHTGEKPY ECKQCGKSFG
610 620 630 640 650
CASRLQMHGR THTGEKPYKC KQCGKAFGCP SNLRRHGRTH TGEKPYKCNQ
660 670
CGKVFRCSSQ LQVHGRAHCI DTP
Length:673
Mass (Da):77,243
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C8B1B6D272D08FC
GO
Isoform 2 (identifier: Q8N7K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:638
Mass (Da):73,196
Checksum:i4E05BFC8FB53F1FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQA6C9JQA6_HUMAN
Zinc finger protein 433
ZNF433
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU36F8VU36_HUMAN
Zinc finger protein 433
ZNF433
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VTV7F8VTV7_HUMAN
Zinc finger protein 433
ZNF433
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0C9F8W0C9_HUMAN
Zinc finger protein 433
ZNF433
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUV2C9JUV2_HUMAN
Zinc finger protein 433
ZNF433
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXJ9F8VXJ9_HUMAN
Zinc finger protein 433
ZNF433
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W652F8W652_HUMAN
Zinc finger protein 433
ZNF433
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP42F8VP42_HUMAN
Zinc finger protein 433
ZNF433
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0355231 – 35Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK098300 mRNA Translation: BAC05279.1
CH471106 Genomic DNA Translation: EAW84254.1
BC047412 mRNA Translation: AAH47412.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45983.1 [Q8N7K0-1]
CCDS77240.1 [Q8N7K0-2]

NCBI Reference Sequences

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RefSeqi
NP_001073880.1, NM_001080411.2 [Q8N7K0-1]
NP_001295275.1, NM_001308346.1
NP_001295277.1, NM_001308348.1
NP_001295280.1, NM_001308351.1 [Q8N7K0-2]
NP_001295284.1, NM_001308355.1 [Q8N7K0-2]
NP_001295286.1, NM_001308357.1 [Q8N7K0-2]
XP_006722724.1, XM_006722661.3 [Q8N7K0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
163059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:163059

UCSC genome browser

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UCSCi
uc002msy.2 human [Q8N7K0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098300 mRNA Translation: BAC05279.1
CH471106 Genomic DNA Translation: EAW84254.1
BC047412 mRNA Translation: AAH47412.1
CCDSiCCDS45983.1 [Q8N7K0-1]
CCDS77240.1 [Q8N7K0-2]
RefSeqiNP_001073880.1, NM_001080411.2 [Q8N7K0-1]
NP_001295275.1, NM_001308346.1
NP_001295277.1, NM_001308348.1
NP_001295280.1, NM_001308351.1 [Q8N7K0-2]
NP_001295284.1, NM_001308355.1 [Q8N7K0-2]
NP_001295286.1, NM_001308357.1 [Q8N7K0-2]
XP_006722724.1, XM_006722661.3 [Q8N7K0-2]

3D structure databases

SMRiQ8N7K0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127846, 7 interactors
IntActiQ8N7K0, 7 interactors
STRINGi9606.ENSP00000339767

PTM databases

iPTMnetiQ8N7K0
PhosphoSitePlusiQ8N7K0

Polymorphism and mutation databases

BioMutaiZNF433
DMDMi30173446

Proteomic databases

jPOSTiQ8N7K0
MassIVEiQ8N7K0
MaxQBiQ8N7K0
PaxDbiQ8N7K0
PeptideAtlasiQ8N7K0
PRIDEiQ8N7K0
ProteomicsDBi72301 [Q8N7K0-1]
72302 [Q8N7K0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
163059

Genome annotation databases

EnsembliENST00000344980; ENSP00000339767; ENSG00000197647 [Q8N7K0-1]
ENST00000419886; ENSP00000393416; ENSG00000197647 [Q8N7K0-2]
GeneIDi163059
KEGGihsa:163059
UCSCiuc002msy.2 human [Q8N7K0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
163059
DisGeNETi163059

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF433
HGNCiHGNC:20811 ZNF433
HPAiHPA073724
neXtProtiNX_Q8N7K0
OpenTargetsiENSG00000197647
PharmGKBiPA134943717

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00950000182755
HOGENOMiHOG000234617
InParanoidiQ8N7K0
KOiK09228
OMAiVHERTHC
OrthoDBi1318335at2759
PhylomeDBiQ8N7K0
TreeFamiTF343410

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF433 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
163059
PharosiQ8N7K0

Protein Ontology

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PROi
PR:Q8N7K0

Gene expression databases

BgeeiENSG00000197647 Expressed in 91 organ(s), highest expression level in testis
ExpressionAtlasiQ8N7K0 baseline and differential

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 18 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN433_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N7K0
Secondary accession number(s): Q86VX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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