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Entry version 149 (13 Nov 2019)
Sequence version 1 (01 Oct 2002)
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Protein

39S ribosomal protein L43, mitochondrial

Gene

MRPL43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
39S ribosomal protein L43, mitochondrial
Short name:
L43mt
Short name:
MRP-L43
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL431 Publication
Mitochondrial ribosomal protein bMRP36a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRPL43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:14517 MRPL43

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611848 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8N983

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
84545

Open Targets

More...
OpenTargetsi
ENSG00000055950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30975

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8N983

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MRPL43

Domain mapping of disease mutations (DMDM)

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DMDMi
50401603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000030561? – 21539S ribosomal protein L43, mitochondrial

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8N983

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8N983

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8N983

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8N983

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8N983

PeptideAtlas

More...
PeptideAtlasi
Q8N983

PRoteomics IDEntifications database

More...
PRIDEi
Q8N983

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
3124
72499 [Q8N983-1]
72500 [Q8N983-2]
72501 [Q8N983-3]
72502 [Q8N983-4]
8648

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q8N983-4 [Q8N983-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8N983

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8N983

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High relative levels in skeletal muscle and testis. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with TWNK.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000055950 Expressed in 200 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8N983 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8N983 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA073022

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P511163EBI-1043145,EBI-740459

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124130, 65 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8N983

Protein interaction database and analysis system

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IntActi
Q8N983, 32 interactors

Molecular INTeraction database

More...
MINTi
Q8N983

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339844

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8N983

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3445 Eukaryota
ENOG4111S17 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000015375

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000177285

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8N983

KEGG Orthology (KO)

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KOi
K17424

Identification of Orthologs from Complete Genome Data

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OMAi
ISKWIDL

Database of Orthologous Groups

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OrthoDBi
1620056at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8N983

TreeFam database of animal gene trees

More...
TreeFami
TF314535

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039927 MRPL43/MRPL51
IPR007741 Ribosome/NADH_DH
IPR036249 Thioredoxin-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21396 PTHR21396, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05047 L51_S25_CI-B8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00916 L51_S25_CI-B8, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833 SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8N983-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE
60 70 80 90 100
VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL
110 120 130 140 150
VQKLADQSGL DVIRIRKPFH TDNPSIQGQW HPFTNKPTTF RGLRPREVQD
160 170 180 190 200
PAPAQDTGLR LSAVAPQILL PGWPDPPDLP TVDPISSSLT SAPAPMLSAV
210
SCLPIVPALT TVCSA
Length:215
Mass (Da):23,431
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i059C6E36FEB0D235
GO
Isoform 2 (identifier: Q8N983-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-215: PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA → ISVQSSDLPWGNTHYRPEPLSSTTWL

Show »
Length:202
Mass (Da):22,580
Checksum:i30A1ACC6D3F30CA8
GO
Isoform 3 (identifier: Q8N983-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-164: DTGLRLSAV → CLLLGAVTL
     165-215: Missing.

Show »
Length:164
Mass (Da):18,311
Checksum:i8BBA76364E45CA58
GO
Isoform 4 (identifier: Q8N983-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-159: DTGL → VQAQ
     160-215: Missing.

Show »
Length:159
Mass (Da):17,853
Checksum:i3430B94F1152F375
GO
Isoform 5 (identifier: Q8N983-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...SSLGKYPLPS

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:235
Mass (Da):25,862
Checksum:iC47FD0F42CE0F80E
GO
Isoform 6 (identifier: Q8N983-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-215: TGLRLSAVAP...VPALTTVCSA → AAEFLGEGAG...DHCVLSVKAA

Note: No experimental confirmation available.
Show »
Length:261
Mass (Da):28,676
Checksum:i4A4FAA0C31C80A5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBU8H0YBU8_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AL05B1AL05_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6Y8H0Y6Y8_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R051M0R051_HUMAN
39S ribosomal protein L43, mitochon...
MRPL43
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB40861 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011027156 – 164DTGLRLSAV → CLLLGAVTL in isoform 3. 1 Publication9
Alternative sequenceiVSP_011029156 – 159DTGL → VQAQ in isoform 4. 2 Publications4
Alternative sequenceiVSP_054092157 – 215TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPNISSVIRSSLGKYPLPS in isoform 5. CuratedAdd BLAST59
Alternative sequenceiVSP_054093157 – 215TGLRL…TVCSA → AAEFLGEGAGPCWYSIVALP QKHIAIAIHPPQPAGQCHQA IGHWPETVCSCTADPPARLA RPTRPPHSGSYLILIDLCSS PYAVRSFLPPDCPCTDHCVL SVKAA in isoform 6. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_011030160 – 215Missing in isoform 4. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_011028165 – 215Missing in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_011026177 – 215PDLPT…TVCSA → ISVQSSDLPWGNTHYRPEPL SSTTWL in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB049656 mRNA Translation: BAB40861.1 Frameshift.
AK095556 mRNA Translation: BAC04572.1
AK300237 mRNA Translation: BAG62005.1
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49795.1
CH471066 Genomic DNA Translation: EAW49796.1
CH471066 Genomic DNA Translation: EAW49797.1
CH471066 Genomic DNA Translation: EAW49799.1
BC015905 mRNA Translation: AAH15905.1
BC041165 mRNA Translation: AAH41165.1
BC052639 mRNA Translation: AAH52639.1
BC053373 mRNA Translation: AAH53373.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7502.1 [Q8N983-1]
CCDS7503.1 [Q8N983-2]
CCDS7504.1 [Q8N983-6]
CCDS7505.1 [Q8N983-4]
CCDS76331.1 [Q8N983-3]

NCBI Reference Sequences

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RefSeqi
NP_001295325.1, NM_001308396.1 [Q8N983-3]
NP_115488.2, NM_032112.2 [Q8N983-4]
NP_789762.1, NM_176792.2 [Q8N983-1]
NP_789763.1, NM_176793.1 [Q8N983-2]
NP_789764.1, NM_176794.1 [Q8N983-6]
XP_005270288.1, XM_005270231.2 [Q8N983-4]
XP_006718098.1, XM_006718035.3 [Q8N983-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299179; ENSP00000299179; ENSG00000055950 [Q8N983-2]
ENST00000318325; ENSP00000315364; ENSG00000055950 [Q8N983-1]
ENST00000318364; ENSP00000315948; ENSG00000055950 [Q8N983-4]
ENST00000342071; ENSP00000339844; ENSG00000055950 [Q8N983-6]
ENST00000370234; ENSP00000359254; ENSG00000055950 [Q8N983-3]
ENST00000370236; ENSP00000359256; ENSG00000055950 [Q8N983-4]
ENST00000370242; ENSP00000359262; ENSG00000055950 [Q8N983-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84545

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84545

UCSC genome browser

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UCSCi
uc001kry.2 human [Q8N983-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049656 mRNA Translation: BAB40861.1 Frameshift.
AK095556 mRNA Translation: BAC04572.1
AK300237 mRNA Translation: BAG62005.1
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49795.1
CH471066 Genomic DNA Translation: EAW49796.1
CH471066 Genomic DNA Translation: EAW49797.1
CH471066 Genomic DNA Translation: EAW49799.1
BC015905 mRNA Translation: AAH15905.1
BC041165 mRNA Translation: AAH41165.1
BC052639 mRNA Translation: AAH52639.1
BC053373 mRNA Translation: AAH53373.1
CCDSiCCDS7502.1 [Q8N983-1]
CCDS7503.1 [Q8N983-2]
CCDS7504.1 [Q8N983-6]
CCDS7505.1 [Q8N983-4]
CCDS76331.1 [Q8N983-3]
RefSeqiNP_001295325.1, NM_001308396.1 [Q8N983-3]
NP_115488.2, NM_032112.2 [Q8N983-4]
NP_789762.1, NM_176792.2 [Q8N983-1]
NP_789763.1, NM_176793.1 [Q8N983-2]
NP_789764.1, NM_176794.1 [Q8N983-6]
XP_005270288.1, XM_005270231.2 [Q8N983-4]
XP_006718098.1, XM_006718035.3 [Q8N983-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40b1-155[»]
3J9Melectron microscopy3.50b1-155[»]
5OOLelectron microscopy3.06b1-215[»]
5OOMelectron microscopy3.03b1-215[»]
6NU2electron microscopy3.90b2-149[»]
6NU3electron microscopy4.40b1-215[»]
SMRiQ8N983
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124130, 65 interactors
CORUMiQ8N983
IntActiQ8N983, 32 interactors
MINTiQ8N983
STRINGi9606.ENSP00000339844

PTM databases

iPTMnetiQ8N983
PhosphoSitePlusiQ8N983

Polymorphism and mutation databases

BioMutaiMRPL43
DMDMi50401603

Proteomic databases

EPDiQ8N983
jPOSTiQ8N983
MassIVEiQ8N983
MaxQBiQ8N983
PaxDbiQ8N983
PeptideAtlasiQ8N983
PRIDEiQ8N983
ProteomicsDBi3124
72499 [Q8N983-1]
72500 [Q8N983-2]
72501 [Q8N983-3]
72502 [Q8N983-4]
8648
TopDownProteomicsiQ8N983-4 [Q8N983-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84545

Genome annotation databases

EnsembliENST00000299179; ENSP00000299179; ENSG00000055950 [Q8N983-2]
ENST00000318325; ENSP00000315364; ENSG00000055950 [Q8N983-1]
ENST00000318364; ENSP00000315948; ENSG00000055950 [Q8N983-4]
ENST00000342071; ENSP00000339844; ENSG00000055950 [Q8N983-6]
ENST00000370234; ENSP00000359254; ENSG00000055950 [Q8N983-3]
ENST00000370236; ENSP00000359256; ENSG00000055950 [Q8N983-4]
ENST00000370242; ENSP00000359262; ENSG00000055950 [Q8N983-7]
GeneIDi84545
KEGGihsa:84545
UCSCiuc001kry.2 human [Q8N983-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84545
DisGeNETi84545

GeneCards: human genes, protein and diseases

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GeneCardsi
MRPL43
HGNCiHGNC:14517 MRPL43
HPAiHPA073022
MIMi611848 gene
neXtProtiNX_Q8N983
OpenTargetsiENSG00000055950
PharmGKBiPA30975

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3445 Eukaryota
ENOG4111S17 LUCA
GeneTreeiENSGT00390000015375
HOGENOMiHOG000177285
InParanoidiQ8N983
KOiK17424
OMAiISKWIDL
OrthoDBi1620056at2759
PhylomeDBiQ8N983
TreeFamiTF314535

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MRPL43 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84545
PharosiQ8N983

Protein Ontology

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PROi
PR:Q8N983

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000055950 Expressed in 200 organ(s), highest expression level in testis
ExpressionAtlasiQ8N983 baseline and differential
GenevisibleiQ8N983 HS

Family and domain databases

Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR039927 MRPL43/MRPL51
IPR007741 Ribosome/NADH_DH
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR21396 PTHR21396, 1 hit
PfamiView protein in Pfam
PF05047 L51_S25_CI-B8, 1 hit
SMARTiView protein in SMART
SM00916 L51_S25_CI-B8, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRM43_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8N983
Secondary accession number(s): B1AL06
, B1AL07, B1AL09, B1AL10, C9J5Q3, D3DR71, Q5JW06, Q7Z719, Q7Z7H6, Q86XN1, Q9BYC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 13, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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