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Entry version 155 (18 Sep 2019)
Sequence version 2 (04 Apr 2003)
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Protein

Sodium bicarbonate transporter-like protein 11

Gene

SLC4A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Ion transport, Symport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.31.4.1 the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium bicarbonate transporter-like protein 11
Alternative name(s):
Bicarbonate transporter-related protein 1
Sodium borate cotransporter 1
Short name:
NaBC1
Solute carrier family 4 member 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A11
Synonyms:BTR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16438 SLC4A11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610206 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NBS3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 375CytoplasmicSequence analysisAdd BLAST375
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 571ExtracellularSequence analysisAdd BLAST58
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Topological domaini593 – 653CytoplasmicSequence analysisAdd BLAST61
Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Transmembranei700 – 720HelicalSequence analysisAdd BLAST21
Transmembranei759 – 779HelicalSequence analysisAdd BLAST21
Transmembranei782 – 802HelicalSequence analysisAdd BLAST21
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Transmembranei853 – 873HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Corneal dystrophy and perceptive deafness (CDPD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn ocular disease characterized by the association of corneal clouding with progressive perceptive hearing loss.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034946213S → P in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909395Ensembl.1
Natural variantiVAR_034947488R → K in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909393Ensembl.1
Natural variantiVAR_034951843L → P in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909394Ensembl.1
Natural variantiVAR_034953856M → V in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909396Ensembl.1
Corneal endothelial dystrophy (CHED)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital corneal dystrophy characterized by thickening and opacification of the cornea, altered morphology of the endothelium, and secretion of an abnormal collagenous layer at the Descemet membrane.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063713125R → H in CHED. 1 PublicationCorresponds to variant dbSNP:rs1276051624Ensembl.1
Natural variantiVAR_067272143E → K in CHED; the mutant protein is retained intracellularly; coexpression with wild-type protein partially rescues the cell surface trafficking of CHED2 mutant. 2 PublicationsCorresponds to variant dbSNP:rs1482631297Ensembl.1
Natural variantiVAR_034945160A → T in CHED. 2 PublicationsCorresponds to variant dbSNP:rs752287261EnsemblClinVar.1
Natural variantiVAR_064978209R → W in CHED. 1 PublicationCorresponds to variant dbSNP:rs566507872Ensembl.1
Natural variantiVAR_064979213S → L in CHED. 1 PublicationCorresponds to variant dbSNP:rs759667344Ensembl.1
Natural variantiVAR_064980233R → C in CHED. 1 PublicationCorresponds to variant dbSNP:rs762942751Ensembl.1
Natural variantiVAR_063714269A → V in CHED; affects transport to the cell surface. 2 PublicationsCorresponds to variant dbSNP:rs1298347142Ensembl.1
Natural variantiVAR_063715386C → R in CHED; the mutant protein is retained intracellularly; coexpression with wild-type protein partially rescues the cell surface trafficking of CHED2 mutant. 4 Publications1
Natural variantiVAR_064981394G → R in CHED. 2 PublicationsCorresponds to variant dbSNP:rs780171125Ensembl.1
Natural variantiVAR_064982401T → K in CHED. 1 Publication1
Natural variantiVAR_064983418G → D in CHED. 2 Publications1
Natural variantiVAR_030662464G → D in CHED; affects protein processing and transport to the cell surface. 1 PublicationCorresponds to variant dbSNP:rs121909389Ensembl.1
Natural variantiVAR_064984473L → R in CHED. 1 Publication1
Natural variantiVAR_030663489S → L in CHED; affects protein processing and transport to the cell surface. 2 PublicationsCorresponds to variant dbSNP:rs121909388Ensembl.1
Natural variantiVAR_064985584T → K in CHED. 1 Publication1
Natural variantiVAR_074015675E → A in CHED. 1 PublicationCorresponds to variant dbSNP:rs749826950Ensembl.1
Natural variantiVAR_030664755R → Q in CHED; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein partially rescues the cell surface trafficking of CHED mutant. 4 PublicationsCorresponds to variant dbSNP:rs121909387Ensembl.1
Natural variantiVAR_063716755R → W in CHED. 4 PublicationsCorresponds to variant dbSNP:rs757553189Ensembl.1
Natural variantiVAR_063717773P → L in CHED. 2 PublicationsCorresponds to variant dbSNP:rs1465111896Ensembl.1
Natural variantiVAR_034948804R → H in CHED. 1 PublicationCorresponds to variant dbSNP:rs766567944Ensembl.1
Natural variantiVAR_034949824V → M in CHED; deafness not assessed. 3 PublicationsCorresponds to variant dbSNP:rs757244518Ensembl.1
Natural variantiVAR_034950833T → M in CHED. 1 PublicationCorresponds to variant dbSNP:rs1422526172Ensembl.1
Natural variantiVAR_030665869R → C in CHED; affects protein processing and transport to the cell surface. 3 PublicationsCorresponds to variant dbSNP:rs121909391Ensembl.1
Natural variantiVAR_034954869R → H in CHED. 1 PublicationCorresponds to variant dbSNP:rs121909392Ensembl.1
Natural variantiVAR_063718873L → P in CHED. 1 Publication1
Corneal dystrophy, Fuchs endothelial, 4 (FECD4)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064422167E → D in FECD4; interferes with post-translational processing; the mutant protein localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs141836046Ensembl.1
Natural variantiVAR_075537240W → S in FECD4; decreases cell surface expression; abolishes functional activity. 1 PublicationCorresponds to variant dbSNP:rs746532062Ensembl.1
Natural variantiVAR_064423282R → P in FECD4; interferes with post-translational processing; the mutant protein localizes to the cytoplasm. 1 Publication1
Natural variantiVAR_047809399E → K in FECD4; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein does not rescue the cell surface trafficking of FECD4 mutant. 3 PublicationsCorresponds to variant dbSNP:rs267607065Ensembl.1
Natural variantiVAR_075538434T → I in FECD4; decreases cell surface expression; highly reduces functional activity. 1 Publication1
Natural variantiVAR_075539507V → I in FECD4; slightly decreases cell surface expression; reduces. 1 PublicationCorresponds to variant dbSNP:rs532728316Ensembl.1
Natural variantiVAR_064424526Y → C in FECD4; does not interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs150571742Ensembl.1
Natural variantiVAR_064425575V → M in FECD4; does not interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs144734280Ensembl.1
Natural variantiVAR_064426583G → D in FECD4; interferes with post-translational processing; the mutant protein localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs139078082Ensembl.1
Natural variantiVAR_047812709G → E in FECD4; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein does not rescue the cell surface trafficking of FECD4 mutant. 2 PublicationsCorresponds to variant dbSNP:rs267607064Ensembl.1
Natural variantiVAR_064427742G → R in FECD4; interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs143965185Ensembl.1
Natural variantiVAR_047813754T → M in FECD4; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein does not rescue the cell surface trafficking of FECD4 mutant. 2 PublicationsCorresponds to variant dbSNP:rs267607066Ensembl.1
Natural variantiVAR_064428834G → S in FECD4; does not interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs144586846Ensembl.1

Keywords - Diseasei

Corneal dystrophy, Deafness, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
83959

MalaCards human disease database

More...
MalaCardsi
SLC4A11
MIMi217400 phenotype
217700 phenotype
613268 phenotype

Open Targets

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OpenTargetsi
ENSG00000088836

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
293603 Congenital hereditary endothelial dystrophy type II
1490 Corneal dystrophy-perceptive deafness syndrome
98974 Fuchs endothelial corneal dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38139

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC4A11

Domain mapping of disease mutations (DMDM)

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DMDMi
29611858

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000792361 – 891Sodium bicarbonate transporter-like protein 11Add BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi553N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8NBS3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8NBS3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NBS3

PeptideAtlas

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PeptideAtlasi
Q8NBS3

PRoteomics IDEntifications database

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PRIDEi
Q8NBS3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
32378
72815 [Q8NBS3-1]
72816 [Q8NBS3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NBS3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8NBS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000088836 Expressed in 139 organ(s), highest expression level in nasal cavity epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8NBS3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NBS3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018120
HPA058377

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8NBS3, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000369399

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8NBS3

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni376 – 891Membrane (bicarbonate transporter)Add BLAST516

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172 Eukaryota
ENOG410XPHD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000016966

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NBS3

KEGG Orthology (KO)

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KOi
K13862

Identification of Orthologs from Complete Genome Data

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OMAi
LNWCNFL

Database of Orthologous Groups

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OrthoDBi
999958at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NBS3

TreeFam database of animal gene trees

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TreeFami
TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

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PANTHERi
PTHR11453 PTHR11453, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01231 HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804 SSF55804, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8NBS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQVGGRGDR CTQEVQGLVH GAGDLSASLA ENSPTMSQNG YFEDSSYYKC
60 70 80 90 100
DTDDTFEARE EILGDEAFDT ANSSIVSGES IRFFVNVNLE MQATNTENEA
110 120 130 140 150
TSGGCVLLHT SRKYLKLKNF KEEIRAHRDL DGFLAQASIV LNETATSLDN
160 170 180 190 200
VLRTMLRRFA RDPDNNEPNC NLDLLMAMLF TDAGAPMRGK VHLLSDTIQG
210 220 230 240 250
VTATVTGVRY QQSWLCIICT MKALQKRHVC ISRLVRPQNW GENSCEVRFV
260 270 280 290 300
ILVLAPPKMK STKTAMEVAR TFATMFSDIA FRQKLLETRT EEEFKEALVH
310 320 330 340 350
QRQLLTMVSH GPVAPRTKER STVSLPAHRH PEPPKCKDFV PFGKGIREDI
360 370 380 390 400
ARRFPLYPLD FTDGIIGKNK AVGKYITTTL FLYFACLLPT IAFGSLNDEN
410 420 430 440 450
TDGAIDVQKT IAGQSIGGLL YALFSGQPLV ILLTTAPLAL YIQVIRVICD
460 470 480 490 500
DYDLDFNSFY AWTGLWNSFF LALYAFFNLS LVMSLFKRST EEIIALFISI
510 520 530 540 550
TFVLDAVKGT VKIFWKYYYG HYLDDYHTKR TSSLVSLSGL GASLNASLHT
560 570 580 590 600
ALNASFLASP TELPSATHSG QATAVLSLLI MLGTLWLGYT LYQFKKSPYL
610 620 630 640 650
HPCVREILSD CALPIAVLAF SLISSHGFRE IEMSKFRYNP SESPFAMAQI
660 670 680 690 700
QSLSLRAVSG AMGLGFLLSM LFFIEQNLVA ALVNAPENRL VKGTAYHWDL
710 720 730 740 750
LLLAIINTGL SLFGLPWIHA AYPHSPLHVR ALALVEERVE NGHIYDTIVN
760 770 780 790 800
VKETRLTSLG ASVLVGLSLL LLPVPLQWIP KPVLYGLFLY IALTSLDGNQ
810 820 830 840 850
LVQRVALLLK EQTAYPPTHY IRRVPQRKIH YFTGLQVLQL LLLCAFGMSS
860 870 880 890
LPYMKMIFPL IMIAMIPIRY ILLPRIIEAK YLDVMDAEHR P
Length:891
Mass (Da):99,581
Last modified:April 4, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06AC2FED156BF535
GO
Isoform 2 (identifier: Q8NBS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-482: Missing.

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):45,762
Checksum:iA3AED736B90209A7
GO
Isoform 3 (identifier: Q8NBS3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MSQVGGRGDRCTQEVQGLVHGAGDLSASLA → MAAATRRVFHLQPC

Note: No experimental confirmation available.
Show »
Length:875
Mass (Da):98,181
Checksum:i6BEDDC9939BADF10
GO
Isoform 4 (identifier: Q8NBS3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MSQVGGRGDRCTQEVQGLVHGAGDLSASLA → MGVYGPQDRS...FLRKTWISEH

Show »
Length:918
Mass (Da):103,145
Checksum:iBA314E50D8F6CD48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYK6V9GYK6_HUMAN
Sodium bicarbonate transporter-like...
SLC4A11 hCG_39254
574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFD9A0A2R8YFD9_HUMAN
Sodium bicarbonate transporter-like...
SLC4A11
837Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7S1A0A2R8Y7S1_HUMAN
Sodium bicarbonate transporter-like...
SLC4A11
852Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4A6A0A2R8Y4A6_HUMAN
Sodium bicarbonate transporter-like...
SLC4A11
808Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6X5A0A2R8Y6X5_HUMAN
Sodium bicarbonate transporter-like...
SLC4A11
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXZ2V9GXZ2_HUMAN
Sodium bicarbonate transporter-like...
SLC4A11
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEG3A0A2R8YEG3_HUMAN
Sodium bicarbonate transporter-like...
SLC4A11
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11536 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324S → P in BAC11536 (PubMed:14702039).Curated1
Sequence conflicti576L → P in BAG59341 (PubMed:14702039).Curated1
Sequence conflicti684N → S in BAG59140 (PubMed:14702039).Curated1
Sequence conflicti784L → R in AAI10541 (PubMed:15489334).Curated1
Sequence conflicti834G → D in BAG59341 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04780672N → T1 PublicationCorresponds to variant dbSNP:rs778688114Ensembl.1
Natural variantiVAR_04780791M → V1 PublicationCorresponds to variant dbSNP:rs200940928Ensembl.1
Natural variantiVAR_063713125R → H in CHED. 1 PublicationCorresponds to variant dbSNP:rs1276051624Ensembl.1
Natural variantiVAR_067272143E → K in CHED; the mutant protein is retained intracellularly; coexpression with wild-type protein partially rescues the cell surface trafficking of CHED2 mutant. 2 PublicationsCorresponds to variant dbSNP:rs1482631297Ensembl.1
Natural variantiVAR_034944150N → S. Corresponds to variant dbSNP:rs34520315Ensembl.1
Natural variantiVAR_034945160A → T in CHED. 2 PublicationsCorresponds to variant dbSNP:rs752287261EnsemblClinVar.1
Natural variantiVAR_064422167E → D in FECD4; interferes with post-translational processing; the mutant protein localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs141836046Ensembl.1
Natural variantiVAR_064978209R → W in CHED. 1 PublicationCorresponds to variant dbSNP:rs566507872Ensembl.1
Natural variantiVAR_064979213S → L in CHED. 1 PublicationCorresponds to variant dbSNP:rs759667344Ensembl.1
Natural variantiVAR_034946213S → P in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909395Ensembl.1
Natural variantiVAR_064980233R → C in CHED. 1 PublicationCorresponds to variant dbSNP:rs762942751Ensembl.1
Natural variantiVAR_075537240W → S in FECD4; decreases cell surface expression; abolishes functional activity. 1 PublicationCorresponds to variant dbSNP:rs746532062Ensembl.1
Natural variantiVAR_063714269A → V in CHED; affects transport to the cell surface. 2 PublicationsCorresponds to variant dbSNP:rs1298347142Ensembl.1
Natural variantiVAR_064423282R → P in FECD4; interferes with post-translational processing; the mutant protein localizes to the cytoplasm. 1 Publication1
Natural variantiVAR_047808327A → V1 PublicationCorresponds to variant dbSNP:rs760889152Ensembl.1
Natural variantiVAR_063715386C → R in CHED; the mutant protein is retained intracellularly; coexpression with wild-type protein partially rescues the cell surface trafficking of CHED2 mutant. 4 Publications1
Natural variantiVAR_064981394G → R in CHED. 2 PublicationsCorresponds to variant dbSNP:rs780171125Ensembl.1
Natural variantiVAR_047809399E → K in FECD4; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein does not rescue the cell surface trafficking of FECD4 mutant. 3 PublicationsCorresponds to variant dbSNP:rs267607065Ensembl.1
Natural variantiVAR_064982401T → K in CHED. 1 Publication1
Natural variantiVAR_015521408Q → H1 Publication1
Natural variantiVAR_015522409K → N1 Publication1
Natural variantiVAR_064983418G → D in CHED. 2 Publications1
Natural variantiVAR_075538434T → I in FECD4; decreases cell surface expression; highly reduces functional activity. 1 Publication1
Natural variantiVAR_030662464G → D in CHED; affects protein processing and transport to the cell surface. 1 PublicationCorresponds to variant dbSNP:rs121909389Ensembl.1
Natural variantiVAR_064984473L → R in CHED. 1 Publication1
Natural variantiVAR_015523483M → T1 Publication1
Natural variantiVAR_034947488R → K in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909393Ensembl.1
Natural variantiVAR_030663489S → L in CHED; affects protein processing and transport to the cell surface. 2 PublicationsCorresponds to variant dbSNP:rs121909388Ensembl.1
Natural variantiVAR_075539507V → I in FECD4; slightly decreases cell surface expression; reduces. 1 PublicationCorresponds to variant dbSNP:rs532728316Ensembl.1
Natural variantiVAR_064424526Y → C in FECD4; does not interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs150571742Ensembl.1
Natural variantiVAR_047810561T → M1 PublicationCorresponds to variant dbSNP:rs755379986Ensembl.1
Natural variantiVAR_047811565S → L1 PublicationCorresponds to variant dbSNP:rs754745672Ensembl.1
Natural variantiVAR_064425575V → M in FECD4; does not interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs144734280Ensembl.1
Natural variantiVAR_064426583G → D in FECD4; interferes with post-translational processing; the mutant protein localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs139078082Ensembl.1
Natural variantiVAR_064985584T → K in CHED. 1 Publication1
Natural variantiVAR_074015675E → A in CHED. 1 PublicationCorresponds to variant dbSNP:rs749826950Ensembl.1
Natural variantiVAR_015524708T → A1 PublicationCorresponds to variant dbSNP:rs1180556979Ensembl.1
Natural variantiVAR_047812709G → E in FECD4; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein does not rescue the cell surface trafficking of FECD4 mutant. 2 PublicationsCorresponds to variant dbSNP:rs267607064Ensembl.1
Natural variantiVAR_064427742G → R in FECD4; interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs143965185Ensembl.1
Natural variantiVAR_047813754T → M in FECD4; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein does not rescue the cell surface trafficking of FECD4 mutant. 2 PublicationsCorresponds to variant dbSNP:rs267607066Ensembl.1
Natural variantiVAR_030664755R → Q in CHED; affects protein processing and transport to the cell surface; the mutant protein is retained intracellularly; coexpression with wild-type protein partially rescues the cell surface trafficking of CHED mutant. 4 PublicationsCorresponds to variant dbSNP:rs121909387Ensembl.1
Natural variantiVAR_063716755R → W in CHED. 4 PublicationsCorresponds to variant dbSNP:rs757553189Ensembl.1
Natural variantiVAR_063717773P → L in CHED. 2 PublicationsCorresponds to variant dbSNP:rs1465111896Ensembl.1
Natural variantiVAR_034948804R → H in CHED. 1 PublicationCorresponds to variant dbSNP:rs766567944Ensembl.1
Natural variantiVAR_034949824V → M in CHED; deafness not assessed. 3 PublicationsCorresponds to variant dbSNP:rs757244518Ensembl.1
Natural variantiVAR_034950833T → M in CHED. 1 PublicationCorresponds to variant dbSNP:rs1422526172Ensembl.1
Natural variantiVAR_064428834G → S in FECD4; does not interferes with post-translational processing; the mutant protein partially localizes to the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs144586846Ensembl.1
Natural variantiVAR_034951843L → P in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909394Ensembl.1
Natural variantiVAR_034952848M → I. Corresponds to variant dbSNP:rs34224785Ensembl.1
Natural variantiVAR_034953856M → V in CDPD. 1 PublicationCorresponds to variant dbSNP:rs121909396Ensembl.1
Natural variantiVAR_030665869R → C in CHED; affects protein processing and transport to the cell surface. 3 PublicationsCorresponds to variant dbSNP:rs121909391Ensembl.1
Natural variantiVAR_034954869R → H in CHED. 1 PublicationCorresponds to variant dbSNP:rs121909392Ensembl.1
Natural variantiVAR_063718873L → P in CHED. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0358911 – 482Missing in isoform 2. 1 PublicationAdd BLAST482
Alternative sequenceiVSP_0448461 – 30MSQVG…SASLA → MAAATRRVFHLQPC in isoform 3. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_0540491 – 30MSQVG…SASLA → MGVYGPQDRSESEKRDVQRD PPPWHPRREGERPARARSLP LAAAGQGFLRKTWISEH in isoform 4. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF336127 mRNA Translation: AAK16734.1
AK075303 mRNA Translation: BAC11536.1 Different initiation.
AK296508 mRNA Translation: BAG59140.1
AK296760 mRNA Translation: BAG59341.1
AL109976 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10536.1
BC110540 mRNA Translation: AAI10541.1
BC110541 mRNA Translation: AAI10542.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13052.1 [Q8NBS3-1]
CCDS54445.1 [Q8NBS3-4]
CCDS54446.1 [Q8NBS3-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001167560.1, NM_001174089.1 [Q8NBS3-3]
NP_001167561.1, NM_001174090.1 [Q8NBS3-4]
NP_114423.1, NM_032034.3 [Q8NBS3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380056; ENSP00000369396; ENSG00000088836 [Q8NBS3-1]
ENST00000380059; ENSP00000369399; ENSG00000088836 [Q8NBS3-4]
ENST00000642402; ENSP00000493503; ENSG00000088836 [Q8NBS3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83959

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:83959

UCSC genome browser

More...
UCSCi
uc002wig.3 human [Q8NBS3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336127 mRNA Translation: AAK16734.1
AK075303 mRNA Translation: BAC11536.1 Different initiation.
AK296508 mRNA Translation: BAG59140.1
AK296760 mRNA Translation: BAG59341.1
AL109976 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10536.1
BC110540 mRNA Translation: AAI10541.1
BC110541 mRNA Translation: AAI10542.1
CCDSiCCDS13052.1 [Q8NBS3-1]
CCDS54445.1 [Q8NBS3-4]
CCDS54446.1 [Q8NBS3-3]
RefSeqiNP_001167560.1, NM_001174089.1 [Q8NBS3-3]
NP_001167561.1, NM_001174090.1 [Q8NBS3-4]
NP_114423.1, NM_032034.3 [Q8NBS3-1]

3D structure databases

SMRiQ8NBS3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8NBS3, 1 interactor
STRINGi9606.ENSP00000369399

Protein family/group databases

TCDBi2.A.31.4.1 the anion exchanger (ae) family

PTM databases

iPTMnetiQ8NBS3
PhosphoSitePlusiQ8NBS3

Polymorphism and mutation databases

BioMutaiSLC4A11
DMDMi29611858

Proteomic databases

MassIVEiQ8NBS3
MaxQBiQ8NBS3
PaxDbiQ8NBS3
PeptideAtlasiQ8NBS3
PRIDEiQ8NBS3
ProteomicsDBi32378
72815 [Q8NBS3-1]
72816 [Q8NBS3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380056; ENSP00000369396; ENSG00000088836 [Q8NBS3-1]
ENST00000380059; ENSP00000369399; ENSG00000088836 [Q8NBS3-4]
ENST00000642402; ENSP00000493503; ENSG00000088836 [Q8NBS3-3]
GeneIDi83959
KEGGihsa:83959
UCSCiuc002wig.3 human [Q8NBS3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83959
DisGeNETi83959

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC4A11
HGNCiHGNC:16438 SLC4A11
HPAiHPA018120
HPA058377
MalaCardsiSLC4A11
MIMi217400 phenotype
217700 phenotype
610206 gene
613268 phenotype
neXtProtiNX_Q8NBS3
OpenTargetsiENSG00000088836
Orphaneti293603 Congenital hereditary endothelial dystrophy type II
1490 Corneal dystrophy-perceptive deafness syndrome
98974 Fuchs endothelial corneal dystrophy
PharmGKBiPA38139

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00940000154894
HOGENOMiHOG000016966
InParanoidiQ8NBS3
KOiK13862
OMAiLNWCNFL
OrthoDBi999958at2759
PhylomeDBiQ8NBS3
TreeFamiTF313630

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC4A11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC4A11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
83959

Pharos

More...
Pharosi
Q8NBS3

Protein Ontology

More...
PROi
PR:Q8NBS3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088836 Expressed in 139 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasiQ8NBS3 baseline and differential
GenevisibleiQ8NBS3 HS

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
SUPFAMiSSF55804 SSF55804, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NBS3
Secondary accession number(s): B4DKC8
, B4DKX9, G3V1M3, Q2TB62, Q2TB63, Q9BXF4, Q9NTW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: September 18, 2019
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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