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Entry version 102 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Protein APCDD1-like

Gene

APCDD1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein APCDD1-like
Alternative name(s):
Adenomatosis polyposis coli down-regulated 1 protein-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APCDD1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26892 APCDD1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NCL9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei481 – 501HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198768

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145149831

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APCDD1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74751192

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000026423425 – 501Protein APCDD1-likeAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8NCL9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8NCL9

PeptideAtlas

More...
PeptideAtlasi
Q8NCL9

PRoteomics IDEntifications database

More...
PRIDEi
Q8NCL9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
72905

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8NCL9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8NCL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198768 Expressed in 136 organ(s), highest expression level in saliva-secreting gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8NCL9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8NCL9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067015

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q8NCL9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360191

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGKQ Eukaryota
ENOG410XSNW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00640000091492

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8NCL9

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWITRGA

Database of Orthologous Groups

More...
OrthoDBi
613671at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8NCL9

TreeFam database of animal gene trees

More...
TreeFami
TF329491

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042425 APCDD1
IPR029405 APCDD1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR31021 PTHR31021, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14921 APCDDC, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01352 APCDDC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8NCL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAAMLPYAC VLVLLGAHTA PAAGEAGGSC LRWEPHCQQP LPDRVPSTAI
60 70 80 90 100
LPPRLNGPWI STGCEVRPGP EFLTRAYTFY PSRLFRAHQF YYEDPFCGEP
110 120 130 140 150
AHSLLVKGKV RLRRASWVTR GATEADYHLH KVGIVFHSRR ALVDVTGRLN
160 170 180 190 200
QTRAGRDCAR RLPPARAWLP GALYELRSAR AQGDCLEALG LTMHELSLVR
210 220 230 240 250
VQRRLQPQPR ASPRLVEELY LGDIHTDPAE RRHYRPTGYQ RPLQSALHHV
260 270 280 290 300
QPCPACGLIA RSDVHHPPVL PPPLALPLHL GGWWVSSGCE VRPAVLFLTR
310 320 330 340 350
LFTFHGHSRS WEGYYHHFSD PACRQPTFTV YAAGRYTRGT PSTRVRGGTE
360 370 380 390 400
LVFEVTRAHV TPMDQVTTAM LNFSEPSSCG GAGAWSMGTE RDVTATNGCL
410 420 430 440 450
PLGIRLPHVE YELFKMEQDP LGQSLLFIGQ RPTDGSSPDT PEKRPTSYQA
460 470 480 490 500
PLVLCHGEAP DFSRPPQHRP SLQKHPSTGG LHIAPFPLLP LVLGLAFLHW

L
Length:501
Mass (Da):55,635
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7B18440E789EEBF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2P3A2A2P3_HUMAN
Protein APCDD1-like
APCDD1L
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02962530C → R. Corresponds to variant dbSNP:rs3946003Ensembl.1
Natural variantiVAR_02962680Y → H. Corresponds to variant dbSNP:rs7265854Ensembl.1
Natural variantiVAR_05066883R → Q. Corresponds to variant dbSNP:rs7265902Ensembl.1
Natural variantiVAR_029627261R → C. Corresponds to variant dbSNP:rs16981999Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074647 mRNA Translation: BAC11111.1
AL118513 Genomic DNA No translation available.
BC101760 mRNA Translation: AAI01761.1
BC101758 mRNA Translation: AAI01759.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13467.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291716.1, NM_001304787.1
NP_699191.1, NM_153360.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371149; ENSP00000360191; ENSG00000198768

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
164284

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:164284

UCSC genome browser

More...
UCSCi
uc002xze.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074647 mRNA Translation: BAC11111.1
AL118513 Genomic DNA No translation available.
BC101760 mRNA Translation: AAI01761.1
BC101758 mRNA Translation: AAI01759.1
CCDSiCCDS13467.1
RefSeqiNP_001291716.1, NM_001304787.1
NP_699191.1, NM_153360.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ8NCL9, 3 interactors
STRINGi9606.ENSP00000360191

PTM databases

iPTMnetiQ8NCL9
PhosphoSitePlusiQ8NCL9

Polymorphism and mutation databases

BioMutaiAPCDD1L
DMDMi74751192

Proteomic databases

MassIVEiQ8NCL9
PaxDbiQ8NCL9
PeptideAtlasiQ8NCL9
PRIDEiQ8NCL9
ProteomicsDBi72905

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371149; ENSP00000360191; ENSG00000198768
GeneIDi164284
KEGGihsa:164284
UCSCiuc002xze.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
164284

GeneCards: human genes, protein and diseases

More...
GeneCardsi
APCDD1L
HGNCiHGNC:26892 APCDD1L
HPAiHPA067015
neXtProtiNX_Q8NCL9
OpenTargetsiENSG00000198768
PharmGKBiPA145149831

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGKQ Eukaryota
ENOG410XSNW LUCA
GeneTreeiENSGT00640000091492
InParanoidiQ8NCL9
OMAiSWITRGA
OrthoDBi613671at2759
PhylomeDBiQ8NCL9
TreeFamiTF329491

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
164284

Pharos

More...
Pharosi
Q8NCL9

Protein Ontology

More...
PROi
PR:Q8NCL9

Gene expression databases

BgeeiENSG00000198768 Expressed in 136 organ(s), highest expression level in saliva-secreting gland
ExpressionAtlasiQ8NCL9 baseline and differential
GenevisibleiQ8NCL9 HS

Family and domain databases

InterProiView protein in InterPro
IPR042425 APCDD1
IPR029405 APCDD1_dom
PANTHERiPTHR31021 PTHR31021, 1 hit
PfamiView protein in Pfam
PF14921 APCDDC, 2 hits
SMARTiView protein in SMART
SM01352 APCDDC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPCDL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NCL9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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