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Entry version 152 (16 Oct 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Prokineticin receptor 2

Gene

PROKR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8NFJ6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prokineticin receptor 2
Short name:
PK-R2
Alternative name(s):
G-protein coupled receptor 73-like 1
G-protein coupled receptor I5E
GPR73b
GPRg2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PROKR2
Synonyms:GPR73L1, PKR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15836 PROKR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607123 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8NFJ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 54ExtracellularSequence analysisAdd BLAST54
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei55 – 75Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini76 – 89CytoplasmicSequence analysisAdd BLAST14
Transmembranei90 – 110Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini111 – 136ExtracellularSequence analysisAdd BLAST26
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 171CytoplasmicSequence analysisAdd BLAST14
Transmembranei172 – 192Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini193 – 223ExtracellularSequence analysisAdd BLAST31
Transmembranei224 – 244Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini245 – 273CytoplasmicSequence analysisAdd BLAST29
Transmembranei274 – 294Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini295 – 313ExtracellularSequence analysisAdd BLAST19
Transmembranei314 – 334Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini335 – 384CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)6 Publications
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROKR2 as well as in other HH-associated genes including KAL1, SEMA3A, PROK2, GNRH1 and FGFR1 (PubMed:17054399, PubMed:22927827, PubMed:23643382).4 Publications
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03095785R → C in HH3; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; decreased signaling activity. 4 PublicationsCorresponds to variant dbSNP:rs141090506EnsemblClinVar.1
Natural variantiVAR_03095885R → H in HH3; decreased signaling activity. 3 PublicationsCorresponds to variant dbSNP:rs74315418EnsemblClinVar.1
Natural variantiVAR_072173113Y → H in HH3. 2 PublicationsCorresponds to variant dbSNP:rs202203360EnsemblClinVar.1
Natural variantiVAR_069964115V → M in HH3; phenotype consistent with Kallmann syndrome. 2 PublicationsCorresponds to variant dbSNP:rs138672528EnsemblClinVar.1
Natural variantiVAR_072978158V → I in HH3; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs368732206Ensembl.1
Natural variantiVAR_030959164R → Q in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 3 PublicationsCorresponds to variant dbSNP:rs751875578Ensembl.1
Natural variantiVAR_030960173L → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 4 PublicationsCorresponds to variant dbSNP:rs74315416EnsemblClinVar.1
Natural variantiVAR_030961178W → S in HH3; decreased signaling activity. 3 PublicationsCorresponds to variant dbSNP:rs201835496EnsemblClinVar.1
Natural variantiVAR_072174188S → L in HH3. 1 PublicationCorresponds to variant dbSNP:rs376239580EnsemblClinVar.1
Natural variantiVAR_069965202S → G in HH3; triallelic inheritance; the patient also carries mutations in GNRH1 and FGFR1. 1 PublicationCorresponds to variant dbSNP:rs200755554Ensembl.1
Natural variantiVAR_030962210Q → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity; abolished ligand binding. 2 PublicationsCorresponds to variant dbSNP:rs74315417EnsemblClinVar.1
Natural variantiVAR_072175248R → Q in HH3. 1 PublicationCorresponds to variant dbSNP:rs376142095EnsemblClinVar.1
Natural variantiVAR_030963268R → C in HH3; uncertain pathological significance; signaling activity is impaired. 3 PublicationsCorresponds to variant dbSNP:rs78861628EnsemblClinVar.1
Natural variantiVAR_030964290P → S in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired; impaired cell surface-targeting. 3 PublicationsCorresponds to variant dbSNP:rs149992595Ensembl.1
Natural variantiVAR_030965323M → I in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired. 2 PublicationsCorresponds to variant dbSNP:rs74315419EnsemblClinVar.1
Natural variantiVAR_030966331V → M in HH3; uncertain pathological significance. 4 PublicationsCorresponds to variant dbSNP:rs117106081EnsemblClinVar.1
Natural variantiVAR_072979334V → M in HH3; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs371564610Ensembl.1
Natural variantiVAR_072176357R → W in HH3. 1 PublicationCorresponds to variant dbSNP:rs375036628Ensembl.1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNET

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DisGeNETi
128674

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
PROKR2

MalaCards human disease database

More...
MalaCardsi
PROKR2
MIMi244200 phenotype

Open Targets

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OpenTargetsi
ENSG00000101292

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
478 Kallmann syndrome
432 Normosmic congenital hypogonadotropic hypogonadism
95496 Pituitary stalk interruption syndrome
3157 Septo-optic dysplasia spectrum

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30014

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8NFJ6

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5548

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
336

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PROKR2

Domain mapping of disease mutations (DMDM)

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DMDMi
33112425

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700831 – 384Prokineticin receptor 2Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi128 ↔ 208PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8NFJ6

PeptideAtlas

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PeptideAtlasi
Q8NFJ6

PRoteomics IDEntifications database

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PRIDEi
Q8NFJ6

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
73317

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8NFJ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8NFJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary and brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000101292 Expressed in 21 organ(s), highest expression level in anterior cingulate cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8NFJ6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA047281

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126143, 1 interactor

Protein interaction database and analysis system

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IntActi
Q8NFJ6, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000217270

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q8NFJ6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154544

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231664

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8NFJ6

KEGG Orthology (KO)

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KOi
K08380

Identification of Orthologs from Complete Genome Data

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OMAi
QMYYKSY

Database of Orthologous Groups

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OrthoDBi
1247924at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8NFJ6

TreeFam database of animal gene trees

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TreeFami
TF315303

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000611 NPY_rcpt

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00237 GPCRRHODOPSN
PR01012 NRPEPTIDEYR

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8NFJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQNGNTSF TPNFNPPQDH ASSLSFNFSY GDYDLPMDED EDMTKTRTFF
60 70 80 90 100
AAKIVIGIAL AGIMLVCGIG NFVFIAALTR YKKLRNLTNL LIANLAISDF
110 120 130 140 150
LVAIICCPFE MDYYVVRQLS WEHGHVLCAS VNYLRTVSLY VSTNALLAIA
160 170 180 190 200
IDRYLAIVHP LKPRMNYQTA SFLIALVWMV SILIAIPSAY FATETVLFIV
210 220 230 240 250
KSQEKIFCGQ IWPVDQQLYY KSYFLFIFGV EFVGPVVTMT LCYARISREL
260 270 280 290 300
WFKAVPGFQT EQIRKRLRCR RKTVLVLMCI LTAYVLCWAP FYGFTIVRDF
310 320 330 340 350
FPTVFVKEKH YLTAFYVVEC IAMSNSMINT VCFVTVKNNT MKYFKKMMLL
360 370 380
HWRPSQRGSK SSADLDLRTN GVPTTEEVDC IRLK
Length:384
Mass (Da):43,996
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D5BFA3655347B5E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03095785R → C in HH3; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; decreased signaling activity. 4 PublicationsCorresponds to variant dbSNP:rs141090506EnsemblClinVar.1
Natural variantiVAR_03095885R → H in HH3; decreased signaling activity. 3 PublicationsCorresponds to variant dbSNP:rs74315418EnsemblClinVar.1
Natural variantiVAR_072173113Y → H in HH3. 2 PublicationsCorresponds to variant dbSNP:rs202203360EnsemblClinVar.1
Natural variantiVAR_069964115V → M in HH3; phenotype consistent with Kallmann syndrome. 2 PublicationsCorresponds to variant dbSNP:rs138672528EnsemblClinVar.1
Natural variantiVAR_072978158V → I in HH3; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs368732206Ensembl.1
Natural variantiVAR_030959164R → Q in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 3 PublicationsCorresponds to variant dbSNP:rs751875578Ensembl.1
Natural variantiVAR_030960173L → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity. 4 PublicationsCorresponds to variant dbSNP:rs74315416EnsemblClinVar.1
Natural variantiVAR_030961178W → S in HH3; decreased signaling activity. 3 PublicationsCorresponds to variant dbSNP:rs201835496EnsemblClinVar.1
Natural variantiVAR_072174188S → L in HH3. 1 PublicationCorresponds to variant dbSNP:rs376239580EnsemblClinVar.1
Natural variantiVAR_069965202S → G in HH3; triallelic inheritance; the patient also carries mutations in GNRH1 and FGFR1. 1 PublicationCorresponds to variant dbSNP:rs200755554Ensembl.1
Natural variantiVAR_030962210Q → R in HH3; phenotype consistent with Kallmann syndrome; decreased signaling activity; abolished ligand binding. 2 PublicationsCorresponds to variant dbSNP:rs74315417EnsemblClinVar.1
Natural variantiVAR_072175248R → Q in HH3. 1 PublicationCorresponds to variant dbSNP:rs376142095EnsemblClinVar.1
Natural variantiVAR_030963268R → C in HH3; uncertain pathological significance; signaling activity is impaired. 3 PublicationsCorresponds to variant dbSNP:rs78861628EnsemblClinVar.1
Natural variantiVAR_030964290P → S in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired; impaired cell surface-targeting. 3 PublicationsCorresponds to variant dbSNP:rs149992595Ensembl.1
Natural variantiVAR_030965323M → I in HH3; phenotype consistent with Kallmann syndrome; signaling activity is impaired. 2 PublicationsCorresponds to variant dbSNP:rs74315419EnsemblClinVar.1
Natural variantiVAR_030966331V → M in HH3; uncertain pathological significance. 4 PublicationsCorresponds to variant dbSNP:rs117106081EnsemblClinVar.1
Natural variantiVAR_072979334V → M in HH3; phenotype consistent with Kallmann syndrome. 1 PublicationCorresponds to variant dbSNP:rs371564610Ensembl.1
Natural variantiVAR_030967335T → M1 PublicationCorresponds to variant dbSNP:rs755562438Ensembl.1
Natural variantiVAR_072176357R → W in HH3. 1 PublicationCorresponds to variant dbSNP:rs375036628Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF506288 mRNA Translation: AAM48128.1
AB084081 mRNA Translation: BAC24022.1
EF577398 mRNA Translation: ABQ52418.1
AL121755 Genomic DNA No translation available.
BC104959 mRNA Translation: AAI04960.1
BC104961 mRNA Translation: AAI04962.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13089.1

NCBI Reference Sequences

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RefSeqi
NP_658986.1, NM_144773.3
XP_016883135.1, XM_017027646.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000217270; ENSP00000217270; ENSG00000101292

Database of genes from NCBI RefSeq genomes

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GeneIDi
128674

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:128674

UCSC genome browser

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UCSCi
uc010zqw.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506288 mRNA Translation: AAM48128.1
AB084081 mRNA Translation: BAC24022.1
EF577398 mRNA Translation: ABQ52418.1
AL121755 Genomic DNA No translation available.
BC104959 mRNA Translation: AAI04960.1
BC104961 mRNA Translation: AAI04962.1
CCDSiCCDS13089.1
RefSeqiNP_658986.1, NM_144773.3
XP_016883135.1, XM_017027646.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126143, 1 interactor
IntActiQ8NFJ6, 5 interactors
STRINGi9606.ENSP00000217270

Chemistry databases

BindingDBiQ8NFJ6
ChEMBLiCHEMBL5548
GuidetoPHARMACOLOGYi336

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiQ8NFJ6
PhosphoSitePlusiQ8NFJ6

Polymorphism and mutation databases

BioMutaiPROKR2
DMDMi33112425

Proteomic databases

PaxDbiQ8NFJ6
PeptideAtlasiQ8NFJ6
PRIDEiQ8NFJ6
ProteomicsDBi73317

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
128674

Genome annotation databases

EnsembliENST00000217270; ENSP00000217270; ENSG00000101292
GeneIDi128674
KEGGihsa:128674
UCSCiuc010zqw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
128674
DisGeNETi128674

GeneCards: human genes, protein and diseases

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GeneCardsi
PROKR2
GeneReviewsiPROKR2
HGNCiHGNC:15836 PROKR2
HPAiHPA047281
MalaCardsiPROKR2
MIMi244200 phenotype
607123 gene
neXtProtiNX_Q8NFJ6
OpenTargetsiENSG00000101292
Orphaneti478 Kallmann syndrome
432 Normosmic congenital hypogonadotropic hypogonadism
95496 Pituitary stalk interruption syndrome
3157 Septo-optic dysplasia spectrum
PharmGKBiPA30014

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000154544
HOGENOMiHOG000231664
InParanoidiQ8NFJ6
KOiK08380
OMAiQMYYKSY
OrthoDBi1247924at2759
PhylomeDBiQ8NFJ6
TreeFamiTF315303

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiQ8NFJ6

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Prokineticin_receptor_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
128674
PharosiQ8NFJ6

Protein Ontology

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PROi
PR:Q8NFJ6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101292 Expressed in 21 organ(s), highest expression level in anterior cingulate cortex
GenevisibleiQ8NFJ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000611 NPY_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8NFJ6
Secondary accession number(s): A5JUU1
, Q2M3C0, Q5TDY1, Q9NTT0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2002
Last modified: October 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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