UniProtKB - Q8NGJ1 (OR4D6_HUMAN)
Protein
Olfactory receptor 4D6
Gene
OR4D6
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 4D6Alternative name(s): Olfactory receptor OR11-250 |
Gene namesi | Name:OR4D6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15175 OR4D6 |
neXtProti | NX_Q8NGJ1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 50 – 57 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 58 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 80 – 100 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 159 – 195 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 196 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 220 – 235 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 236 – 258 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 259 – 269 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 270 – 289 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 290 – 314 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 219983 |
OpenTargetsi | ENSG00000166884 |
PharmGKBi | PA32273 |
Miscellaneous databases
Pharosi | Q8NGJ1 |
Polymorphism and mutation databases
BioMutai | OR4D6 |
DMDMi | 38372703 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150540 | 1 – 314 | Olfactory receptor 4D6Add BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q8NGJ1 |
PaxDbi | Q8NGJ1 |
PeptideAtlasi | Q8NGJ1 |
PRIDEi | Q8NGJ1 |
ProteomicsDBi | 73527 |
PTM databases
PhosphoSitePlusi | Q8NGJ1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166884 Expressed in 8 organ(s), highest expression level in adipose tissue |
Interactioni
Protein-protein interaction databases
BioGridi | 128611, 2 interactors |
IntActi | Q8NGJ1, 1 interactor |
MINTi | Q8NGJ1 |
STRINGi | 9606.ENSP00000300127 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IFP2 Eukaryota ENOG4111DX6 LUCA |
GeneTreei | ENSGT00940000163118 |
HOGENOMi | HOG000041362 |
InParanoidi | Q8NGJ1 |
KOi | K04257 |
OMAi | IMRREVW |
OrthoDBi | 987267at2759 |
PhylomeDBi | Q8NGJ1 |
TreeFami | TF352732 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8NGJ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDQINHTNVK EFFFLELTRS RELEFFLFVV FFAVYVATVL GNALIVVTIT
60 70 80 90 100
CESRLHTPMY FLLRNKSVLD IVFSSITVPK FLVDLLSDRK TISYNDCMAQ
110 120 130 140 150
IFFFHFAGGA DIFFLSVMAY DRYLAIAKPL HYVTMMRKEV WVALVVASWV
160 170 180 190 200
SGGLHSIIQV ILMLPFPFCG PNTLDAFYCY VLQVVKLACT DTFALELFMI
210 220 230 240 250
SNNGLVTLLW FLLLLGSYTV ILVMLRSHSG EGRNKALSTC TSHMLVVTLH
260 270 280 290 300
FVPCVYIYCR PFMTLPMDTT ISINNTVITP MLNPIIYSLR NQEMKSAMQR
310
LQRRLGPSES RKWG
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034194 | 11 | E → Q. Corresponds to variant dbSNP:rs17153766Ensembl. | 1 | |
Natural variantiVAR_053169 | 59 | M → V. Corresponds to variant dbSNP:rs1453544Ensembl. | 1 | |
Natural variantiVAR_024091 | 96 | D → G2 PublicationsCorresponds to variant dbSNP:rs1453543Ensembl. | 1 | |
Natural variantiVAR_034195 | 102 | F → S. Corresponds to variant dbSNP:rs17153770Ensembl. | 1 | |
Natural variantiVAR_034196 | 111 | D → A. Corresponds to variant dbSNP:rs17500380Ensembl. | 1 | |
Natural variantiVAR_024092 | 151 | S → T. Corresponds to variant dbSNP:rs1453542Ensembl. | 1 | |
Natural variantiVAR_024093 | 263 | M → T. Corresponds to variant dbSNP:rs1453541Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065803 Genomic DNA Translation: BAC06022.1 CH471076 Genomic DNA Translation: EAW73845.1 BC137028 mRNA Translation: AAI37029.1 BC137029 mRNA Translation: AAI37030.1 AF399569 Genomic DNA Translation: AAK95054.1 BK004307 Genomic DNA Translation: DAA04705.1 |
CCDSi | CCDS31562.1 |
RefSeqi | NP_001004708.1, NM_001004708.1 |
Genome annotation databases
Ensembli | ENST00000300127; ENSP00000300127; ENSG00000166884 |
GeneIDi | 219983 |
KEGGi | hsa:219983 |
UCSCi | uc010rku.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB065803 Genomic DNA Translation: BAC06022.1 CH471076 Genomic DNA Translation: EAW73845.1 BC137028 mRNA Translation: AAI37029.1 BC137029 mRNA Translation: AAI37030.1 AF399569 Genomic DNA Translation: AAK95054.1 BK004307 Genomic DNA Translation: DAA04705.1 |
CCDSi | CCDS31562.1 |
RefSeqi | NP_001004708.1, NM_001004708.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 128611, 2 interactors |
IntActi | Q8NGJ1, 1 interactor |
MINTi | Q8NGJ1 |
STRINGi | 9606.ENSP00000300127 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q8NGJ1 |
Polymorphism and mutation databases
BioMutai | OR4D6 |
DMDMi | 38372703 |
Proteomic databases
jPOSTi | Q8NGJ1 |
PaxDbi | Q8NGJ1 |
PeptideAtlasi | Q8NGJ1 |
PRIDEi | Q8NGJ1 |
ProteomicsDBi | 73527 |
Genome annotation databases
Ensembli | ENST00000300127; ENSP00000300127; ENSG00000166884 |
GeneIDi | 219983 |
KEGGi | hsa:219983 |
UCSCi | uc010rku.3 human |
Organism-specific databases
CTDi | 219983 |
DisGeNETi | 219983 |
GeneCardsi | OR4D6 |
HGNCi | HGNC:15175 OR4D6 |
neXtProti | NX_Q8NGJ1 |
OpenTargetsi | ENSG00000166884 |
PharmGKBi | PA32273 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IFP2 Eukaryota ENOG4111DX6 LUCA |
GeneTreei | ENSGT00940000163118 |
HOGENOMi | HOG000041362 |
InParanoidi | Q8NGJ1 |
KOi | K04257 |
OMAi | IMRREVW |
OrthoDBi | 987267at2759 |
PhylomeDBi | Q8NGJ1 |
TreeFami | TF352732 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR4D6 |
GenomeRNAii | 219983 |
Pharosi | Q8NGJ1 |
PROi | PR:Q8NGJ1 |
Gene expression databases
Bgeei | ENSG00000166884 Expressed in 8 organ(s), highest expression level in adipose tissue |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OR4D6_HUMAN | |
Accessioni | Q8NGJ1Primary (citable) accession number: Q8NGJ1 Secondary accession number(s): B2RNP7, Q6IFF5, Q96R74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | October 16, 2019 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations