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Entry version 109 (18 Sep 2019)
Sequence version 1 (01 Jun 2002)
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Protein

DNA-dependent protein kinase catalytic subunit

Gene

PRKDC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-351433 ATM mediated phosphorylation of repair proteins
R-GGA-353423 Non-homologous end joining (NHEJ)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-dependent protein kinase catalytic subunit (EC:2.7.11.1)
Short name:
DNA-PK catalytic subunit
Short name:
DNA-PKcs
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKDC
Synonyms:XRCC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002256331 – 4134DNA-dependent protein kinase catalytic subunitAdd BLAST4134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2055Phosphoserine; by autocatalysisBy similarity1
Modified residuei2609Phosphothreonine; by autocatalysisBy similarity1
Modified residuei2612Phosphoserine; by autocatalysisBy similarity1
Modified residuei2638Phosphothreonine; by autocatalysisBy similarity1
Modified residuei2647Phosphothreonine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on Ser-2055, Thr-2609, Thr-2638 and Thr-2647. Ser-2055 and Thr-2609 are DNA damage-inducible phosphorylation sites (inducible with ionizing radiation, IR) dephosphorylated by PPP5C. Autophosphorylation induces a conformational change that leads to remodeling of the DNA-PK complex, requisite for efficient end processing and DNA repair (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8QGX4

PRoteomics IDEntifications database

More...
PRIDEi
Q8QGX4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

DNA-PK is a heterotrimer of PRKDC and the Ku p70/YRCC6-p86/XRCC5 dimer. Formation of this complex may be promoted by interaction with ILF3. Associates with the DNA-bound Ku heterodimer, but it can also bind to and be activated by free DNA. The DNA-PK heterotrimer associates with the LIG4-XRCC4 complex to form the core of the non-homologous end joining (NHEJ) complex. Additional components of the NHEJ complex include NHEJ1/XLF and PAXX.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000021030

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati900 – 937HEAT 1Add BLAST38
Repeati1000 – 1036HEAT 2Add BLAST37
Repeati1050 – 1085HEAT 3Add BLAST36
Repeati1265 – 1305TPR 1Add BLAST41
Repeati1722 – 1755TPR 2Add BLAST34
Repeati2207 – 2240TPR 3Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2880 – 3545FATPROSITE-ProRule annotationAdd BLAST666
Domaini3754 – 4021PI3K/PI4KPROSITE-ProRule annotationAdd BLAST268
Domaini4102 – 4134FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0891 Eukaryota
COG5032 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168371

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8QGX4

KEGG Orthology (KO)

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KOi
K06642

Database of Orthologous Groups

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OrthoDBi
26975at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8QGX4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05172 PIKKc_DNA-PK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037706 DNA-PK_dom
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR012582 NUC194
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08163 NUC194, 1 hit
PF00454 PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343 FATC, 1 hit
SM01344 NUC194, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8QGX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGVQECLQ ELHGCLQPGD AMRGYGLLRG LGEACLTCLA GGALALHVSL
60 70 80 90 100
VFAPERGLLA FVCRSLGVEE FRECREEALK FLCVFLERIG ERAHPYACSL
110 120 130 140 150
KQTCISVYTK ERAAKCKIPA LELLIKLLQS LRRSCLMEEM KVGEIFNKFY
160 170 180 190 200
GELAVRSKIS DTVLEKIYEL LGVLGEVHPA DMINNSEKLF RAYLGELKTQ
210 220 230 240 250
MTSATRVPKL PIVAGCLRGL TALMYNFTKS VDEDAQTSKE IFDFAVKAIR
260 270 280 290 300
PQVDQKRYAV HLAGLQLFSW HAAQFGTLLL DSYVMLFETM CRWCGHTNQE
310 320 330 340 350
LKKAGHNALD SFLKQMSLMV AKDAELHKSK LKFFMEQFYG IIRRMDSSNK
360 370 380 390 400
ELSIAIRGYG LFAAPCKAMH PADVDAMYIE LLQRCKQMYL TEAETIDDHL
410 420 430 440 450
YQLPSFLQSI ASVIFHLDTI PEVYTPVLEH LVVLQINSFP RYSEKMQLVC
460 470 480 490 500
CRSIIKVFLA LSIKGPVLWN FISTVVHQGL IRVFSKPMKF SKDVFGKETS
510 520 530 540 550
GSEEFPESGE VDTARWKVPT YKDYLYLFRS LLSCDTMKES IFEEENFLTG
560 570 580 590 600
NSPLQSLNRL LYDELIKSIL KIIEKLDLTV QKLNVHEQDE NETDSAFIGP
610 620 630 640 650
TSDPASNLQP KKPTDFIAFI NLVEFCRDIL PDKHVEYFQP WVYSFGYELI
660 670 680 690 700
IHSTRLPLIS GFYKLLSVTM KIAKKIKYFE GVGPKSLRKA TEDPEKSSCF
710 720 730 740 750
ALFAKFGKEV TAKMKQYKDE LLASCLNFLL SLPHDIVMLD IKAYIPALQN
760 770 780 790 800
AFKLGLSCTP MADLGLDALE DWSAHIPRHI MQPYYKDVLP LLDGYLKNSA
810 820 830 840 850
TTVEPQNNWE VRKLSRAAQK GFNKIVIQRL RKAKTSSLDD NPSLEAVRTR
860 870 880 890 900
VARLLGSLGG QINHNLITAT SAEEMMKKCV SWDTKNHLSF AVPFADMKPV
910 920 930 940 950
IYLDVFLPRV TDLALSASDR QTKIAACELL HSIVAYMLGK ASQMPERQQG
960 970 980 990 1000
PPPMHQLYKR IFPVLLRLAC DVDQVTRQLY EPLVMQLIHW FTNNKKFESQ
1010 1020 1030 1040 1050
DTVTFLEAIL SGIVDPVDST LRDFCGQCVR EFLKWSIKQT TPKQQEKSPA
1060 1070 1080 1090 1100
NTKSLFKRLY SLALHPSAFK RLGAALAFNS IYREFREENS LVEQFVFEAL
1110 1120 1130 1140 1150
VVFLESLALT HTDEKSLGTT QQCCDAINHL KRIIKHKAPA LNKEGKRRVP
1160 1170 1180 1190 1200
RGFPATKSVC LQDVVMWLLV QCGRPQTECR HKAMELFYEF VPLLPGNNSP
1210 1220 1230 1240 1250
SSWLADVLKK RDVSFLINKF EGGGSDAKSP SGILSQPTLR DMQEPFSLLT
1260 1270 1280 1290 1300
VMRWMDMFLA ALDCYNTFFE LRMIKPHEIL GVNERSSFLE AVDFFLETIA
1310 1320 1330 1340 1350
LHDIHAAEQC FDCRSRGNIF SPQEREVYNY SKCTIIVRIM EFVTMILEIC
1360 1370 1380 1390 1400
QQDFWKLLEK ELLNANFIEL LVMTVCDPSH IGFNTADVQV MKNLPDISVR
1410 1420 1430 1440 1450
LLKALMKSPY KEYLQLCLKK RITPQSFEDL CSVDLFNSDA RFDQVRFSAV
1460 1470 1480 1490 1500
LSACKQLQKS GLLHSVLHSQ DERPHPSIGS KLLSVVYKSI APGSERSSLP
1510 1520 1530 1540 1550
AVDISSKRLA DRLLQLAFAI DDQCEELVSL LLNTVVLSVP LSKASERNFV
1560 1570 1580 1590 1600
DFSHGQYFYS LFSDTINQQL LKNLDVIVIH LMESSVSNPQ MVGSILNGML
1610 1620 1630 1640 1650
DQSFRERTIR KQQGVKLVTA VLRNWKRLDS WWAKDSSPES KMAVLTLLAK
1660 1670 1680 1690 1700
VLQIDSSVSF NTSHEAFTAV FDTYTSLLTD QNLGLNLKGH AVIILPFFTN
1710 1720 1730 1740 1750
LSGEKLHDLK NALDQLVAFN FPMSSDEFPK GTLKHNNYVD CTKKFLDALE
1760 1770 1780 1790 1800
LSQSPMLLQL MTEVLCRDHR HSMEDLFQAS FKRISRRSST DKQVVLLDTV
1810 1820 1830 1840 1850
HKMFQNEDLL SNIVRQAFVD RSLLTLMSHC SLDALREFFC KIIVQAMDTL
1860 1870 1880 1890 1900
NSRFTKSNEC VFDTQITKKM GYYKMLEVMY IRLSKDDVHS KDSKINQAYR
1910 1920 1930 1940 1950
GSVSVEGNEL TKALIKLCYD AFTENMAGEN QLLEKRRQYH CAAYNCAIAV
1960 1970 1980 1990 2000
ISCVFTESKF YQGFLFTEKS EKNLLIFENL IDLKRQYVFP VEIEVPLERK
2010 2020 2030 2040 2050
KRYIAIRKEA REAWNDGQDE PKYLASASYM MDSSLSEEMS QFDFSTGVQG
2060 2070 2080 2090 2100
FSYSSQDVTA SSAHFRRKET SEYMVLNDEM ELEMDELNQH ECMAPLTTLI
2110 2120 2130 2140 2150
KHMQRNQITP KVEEGVIPVD LPLWMKFLHS KLGNPSVPLN IRLFIAKLIV
2160 2170 2180 2190 2200
NTEDVFRPYA KQWLGPMLQL VVSGDNGGEG IHYMVVEIAV TVLSWTSVTT
2210 2220 2230 2240 2250
PKGNIKDEIL ANRLLEFLMK NAFHQKRAVF RHNLEIIKTV IECWKNCLSI
2260 2270 2280 2290 2300
PYSLIFEKFS SGDPDTKDNS VGIQLLGIVL ANNLPPFDLK CEIDRVRYFQ
2310 2320 2330 2340 2350
ALVSNMGLLR YKEVYAAAAE VLGLALQYIA ERQNILEDPV YDCVIKQLKR
2360 2370 2380 2390 2400
HQNTQQDKFI ICLNKVVKNF PPLADRFMNA VFFLIPKLHG VMKNYCLEVI
2410 2420 2430 2440 2450
MCRAEEIPDL YLQLKSKDFI QIMKHRDDER QRVCLDIIYK MLSTLKPPEL
2460 2470 2480 2490 2500
KELLPGVTGF ISHPSVICRQ RMYDILMWIY DNYSDPESQA DGDSQEVLSL
2510 2520 2530 2540 2550
AKEILLQGLI DENAELQLIV RNFWSDETRL PANILDRMLM LLNSLYSAKI
2560 2570 2580 2590 2600
ETQYLSLITN FLLEMTSKSP DYSRKIFEHP LSECKFHDFV IDSSWRYRST
2610 2620 2630 2640 2650
MLTPMFVETQ ASQSTNRNSS QERSLSISGS VGGRVRATQR QYEFTPTQNV
2660 2670 2680 2690 2700
SGRSSFNWLT GNSIDTLAEY TVPSSSESLS SSMLLVNKRS EKFKQAAFKP
2710 2720 2730 2740 2750
VGPDFGKKRL SLPGDKVDSK TKGIDERAEI LRLRRRFLKD QEKVSLIYAR
2760 2770 2780 2790 2800
KGVAEQKREK EMKSELKMKF DGQVTLYRSY RVGDLPDIQI EHCSLIAPLQ
2810 2820 2830 2840 2850
GLAQKDPTFA KQLFSSLFGG IFCEVKKSKI PSEKKAIIQK LLKDFNHFLS
2860 2870 2880 2890 2900
TSVSYFPPFI ACIQEISYKH RELLELDSAN VSTSCLASLQ QPVGILLLEH
2910 2920 2930 2940 2950
ALMALSPAEE PPSKRMRGRT ELPPDVVKWL ELAKLYRSLG DYDVLRGIFS
2960 2970 2980 2990 3000
GKIGTKDITQ QALLAEARSD YAEAAKCYDE ALSKEDWEDG EPTEAEKDFW
3010 3020 3030 3040 3050
ELASLECYDH LTEWKSLEYC ATVNIDSGKP PDLNKTWSDP FYQETYLPYI
3060 3070 3080 3090 3100
IRSKLKLLLN GENDQTLLTF IDEAMKTEQK KALIEMHYSQ ELSLLYILQD
3110 3120 3130 3140 3150
DFDRAKYYIG NGIQIFMQSY SSIDTLLYQS RMSKLQSVQA LTEIQDFINF
3160 3170 3180 3190 3200
MTKTSNIASQ AKSLKRLLRT WTSRYPDAKM DPMNIWDDII TNRCFFLDKL
3210 3220 3230 3240 3250
QEKFLCDKAN DSMEVDEESS VGDQMEVDQQ DEDIHSMIRS CKFNMKLKMI
3260 3270 3280 3290 3300
ESARKQNSFS IAKKLLKGLR REAKTREDWL VRWNYAYCRF VHSCSQSQSC
3310 3320 3330 3340 3350
PERVLSVLKT ISLLEDTKSD YLNKNIMAFR NQNLLLGTTY HIMANALSQD
3360 3370 3380 3390 3400
PKCCEQIEEE KTGKILELSG ESSESPEKIL AGLNKRAFQC FSSAARKSEE
3410 3420 3430 3440 3450
EVQSLSMEHV DVKGVIDAYM TLVGFCDQHL RKEEEGSLEI NAADLQLFPA
3460 3470 3480 3490 3500
IVVEKMIKAL KLNSREARLR FPRLLQIIER YPAETLGLVT RELPSVPCWQ
3510 3520 3530 3540 3550
FIGWISQMMA LLDKDEAVAV QHTVEEIVDT YPQAIIYPFT ISSESYCFKD
3560 3570 3580 3590 3600
TAAGCRNKEF VASIKNKLDR GGVVQDFIHA LEQLSNPVML FKDWVADVRN
3610 3620 3630 3640 3650
ELVKTQRNKI ILKEMYEGMY KNLGDVKAPG LGWLRKRFVQ AFGKDFDSHF
3660 3670 3680 3690 3700
GKGGSKLLDM KISDFNEITT ALLTKMNKTH KEPGNLKECS PWMSEFRAEF
3710 3720 3730 3740 3750
LRNELEVPGQ YDGKGKPLPE YHVKISGFDE RIMVLESLRK PKRITIRGSD
3760 3770 3780 3790 3800
EQEHPFLVKG GEDLRQDQRI EQLFDVMNIV LSRDAACSQR NMQLKTYQVI
3810 3820 3830 3840 3850
PMTTRLGLIK WLENTCTLKE FLRNSMTEEE DANYNSLKGP RAAYSDWLSK
3860 3870 3880 3890 3900
MGGKAQGLSR YNAMYKNASR TETVIAFKSR ESSVPEDLLR RAFVKMSTSP
3910 3920 3930 3940 3950
EAFLALRSHF VSSHALMCVS HWILGIGDRH LSNFMINKET GGMVGIDFGH
3960 3970 3980 3990 4000
AFGSATQFLP VPELMPFRLT RQFVNLMMPV KEWGLIYSVM VHALRAYRAD
4010 4020 4030 4040 4050
PDLLISTMDV FVKEPSLDWK NFEQRQLKKG GTWIKEINTA EVNWYPLQKV
4060 4070 4080 4090 4100
SYVKRKLTGA NPARITCDEL RLGYEKLPFY NDFAAVARGS ADHNIRAKEP
4110 4120 4130
EDRLSEETQV RCLIDQATDP NLLGRVWEGW EPWM
Length:4,134
Mass (Da):472,657
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8907B1EA6E7E9AA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3796 – 3804TYQVIPMTT → VHISEYFCS in AAB41106 (Ref. 3) Curated9
Sequence conflicti3965 – 3968MPFR → DALP in AAB41106 (Ref. 3) Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB016240 mRNA Translation: BAA36956.1
AB028136 Genomic DNA Translation: BAB91148.1
U83109 mRNA Translation: AAB41106.1

NCBI Reference Sequences

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RefSeqi
NP_989989.2, NM_204658.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
395376

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
gga:395376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016240 mRNA Translation: BAA36956.1
AB028136 Genomic DNA Translation: BAB91148.1
U83109 mRNA Translation: AAB41106.1
RefSeqiNP_989989.2, NM_204658.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021030

Proteomic databases

PaxDbiQ8QGX4
PRIDEiQ8QGX4

Genome annotation databases

GeneIDi395376
KEGGigga:395376

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5591

Phylogenomic databases

eggNOGiKOG0891 Eukaryota
COG5032 LUCA
HOGENOMiHOG000168371
InParanoidiQ8QGX4
KOiK06642
OrthoDBi26975at2759
PhylomeDBiQ8QGX4

Enzyme and pathway databases

ReactomeiR-GGA-351433 ATM mediated phosphorylation of repair proteins
R-GGA-353423 Non-homologous end joining (NHEJ)

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8QGX4

Family and domain databases

CDDicd05172 PIKKc_DNA-PK, 1 hit
Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037706 DNA-PK_dom
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR012582 NUC194
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF02260 FATC, 1 hit
PF08163 NUC194, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM01344 NUC194, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRKDC_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8QGX4
Secondary accession number(s): P79791, Q9DEI2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 1, 2002
Last modified: September 18, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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