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Entry version 151 (16 Oct 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Zinc finger protein 420

Gene

ZNF420

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri139 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 420
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF420
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20649 ZNF420

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TAQ5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000197050

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134958420

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TAQ5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF420

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153480

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475751 – 688Zinc finger protein 420Add BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki298Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TAQ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TAQ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TAQ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TAQ5

PeptideAtlas

More...
PeptideAtlasi
Q8TAQ5

PRoteomics IDEntifications database

More...
PRIDEi
Q8TAQ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73908 [Q8TAQ5-1]
77371

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TAQ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TAQ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197050 Expressed in 205 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TAQ5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TAQ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059675

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127098, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TAQ5, 16 interactors

Molecular INTeraction database

More...
MINTi
Q8TAQ5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000338770

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TAQ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 86KRABPROSITE-ProRule annotationAdd BLAST81

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 161C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri447 – 469C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri475 – 497C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri503 – 525C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri531 – 553C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri559 – 581C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri587 – 609C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri615 – 637C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri643 – 665C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TAQ5

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQHAYLS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TAQ5

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TAQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARKLVMFRD VAIDFSQEEW ECLDSAQRDL YRDVMLENYS NLVSLDLPSR
60 70 80 90 100
CASKDLSPEK NTYETELSQW EMSDRLENCD LEESNSRDYL EAKGKMEKQQ
110 120 130 140 150
ENQKEYFRQG MIIYDKMSIF NQHTYLSQHS RCHSTEKPYK CKECGKAFRR
160 170 180 190 200
ASHLTQHQSI HTGEKPYECK QCGKAFSRDS QLSLHQRLHT GEKPYACKEC
210 220 230 240 250
GKAFTQSSQL ILHHRIHTGE KPYKCEECGK AFIRSSQLTR HQKVHTGEKP
260 270 280 290 300
YECKECGKAF TQNSQLTLHQ RLHTGEKLYE CKECRKVFTQ LSQLILHKRI
310 320 330 340 350
HTGEKPYECK ECGKAFICGS QLSQHQKIHN GEKPYECKEC GRAFIRGSLL
360 370 380 390 400
MQHQRIHTGE KPYKCEECGK AFIRGSQLTQ HQRIHTNEKP YECKECGKMF
410 420 430 440 450
SHGSQLTQHQ RIHTGEKPYQ CKECGKAFNR GSLLTRHQRI HTGEKPYECK
460 470 480 490 500
ECGKTFSRGS ELTQHERIHT GEKPYECKEC GKSFIRGSQL TQHQRIHTGE
510 520 530 540 550
KPYECKECRM AFTQSSHLSQ HQRLHTGEKP YVCNECGKAF ARGLLLIQHQ
560 570 580 590 600
RIHTGEKPYQ CKECGKAFIR GSQLTQHQRI HTGEKPYECK ECGKAFSHGS
610 620 630 640 650
QLTLHQRIHT GEKPYECREC RKAFTQSSHL SRHQRIHTGE KPYQCKECGK
660 670 680
AFTRGSQLTQ HQRIHISEKS FEYKECGIDF SHGSQVYM
Length:688
Mass (Da):80,247
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70E984F166F8A975
GO
Isoform 2 (identifier: Q8TAQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-536: GEKPYECKEC...GEKPYVCNEC → AFLAGQQDRS...EQKYRRSLQP
     537-688: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):62,957
Checksum:iF98B57D73A99A255
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQC9K7EQC9_HUMAN
Zinc finger protein 420
ZNF420
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJW2K7EJW2_HUMAN
Zinc finger protein 420
ZNF420
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELF6K7ELF6_HUMAN
Zinc finger protein 420
ZNF420
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPG0K7EPG0_HUMAN
Zinc finger protein 420
ZNF420
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESJ1K7ESJ1_HUMAN
Zinc finger protein 420
ZNF420
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERS3K7ERS3_HUMAN
Zinc finger protein 420
ZNF420
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055951471 – 536GEKPY…VCNEC → AFLAGQQDRSDIYMSRRFTK SIFPVFFSVPTMWTSKLELR YSHGDFENGIWVLWIMEQKY RRSLQP in isoform 2. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_055952537 – 688Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK056753 mRNA Translation: BAB71272.1
AK315728 mRNA Translation: BAG38083.1
AC008733 Genomic DNA No translation available.
AC010632 Genomic DNA No translation available.
AC012309 Genomic DNA No translation available.
BC026210 mRNA Translation: AAH26210.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12498.1 [Q8TAQ5-1]
CCDS86757.1 [Q8TAQ5-2]

NCBI Reference Sequences

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RefSeqi
NP_001316451.1, NM_001329522.1 [Q8TAQ5-2]
NP_653290.2, NM_144689.4 [Q8TAQ5-1]
XP_011524805.1, XM_011526503.2 [Q8TAQ5-1]
XP_011524806.1, XM_011526504.2 [Q8TAQ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304239; ENSP00000306102; ENSG00000197050 [Q8TAQ5-2]
ENST00000337995; ENSP00000338770; ENSG00000197050 [Q8TAQ5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
147923

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:147923

UCSC genome browser

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UCSCi
uc002ofl.4 human [Q8TAQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056753 mRNA Translation: BAB71272.1
AK315728 mRNA Translation: BAG38083.1
AC008733 Genomic DNA No translation available.
AC010632 Genomic DNA No translation available.
AC012309 Genomic DNA No translation available.
BC026210 mRNA Translation: AAH26210.1
CCDSiCCDS12498.1 [Q8TAQ5-1]
CCDS86757.1 [Q8TAQ5-2]
RefSeqiNP_001316451.1, NM_001329522.1 [Q8TAQ5-2]
NP_653290.2, NM_144689.4 [Q8TAQ5-1]
XP_011524805.1, XM_011526503.2 [Q8TAQ5-1]
XP_011524806.1, XM_011526504.2 [Q8TAQ5-1]

3D structure databases

SMRiQ8TAQ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127098, 19 interactors
IntActiQ8TAQ5, 16 interactors
MINTiQ8TAQ5
STRINGi9606.ENSP00000338770

PTM databases

iPTMnetiQ8TAQ5
PhosphoSitePlusiQ8TAQ5

Polymorphism and mutation databases

BioMutaiZNF420
DMDMi71153480

Proteomic databases

EPDiQ8TAQ5
jPOSTiQ8TAQ5
MassIVEiQ8TAQ5
PaxDbiQ8TAQ5
PeptideAtlasiQ8TAQ5
PRIDEiQ8TAQ5
ProteomicsDBi73908 [Q8TAQ5-1]
77371

Genome annotation databases

EnsembliENST00000304239; ENSP00000306102; ENSG00000197050 [Q8TAQ5-2]
ENST00000337995; ENSP00000338770; ENSG00000197050 [Q8TAQ5-1]
GeneIDi147923
KEGGihsa:147923
UCSCiuc002ofl.4 human [Q8TAQ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
147923

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF420
HGNCiHGNC:20649 ZNF420
HPAiHPA059675
neXtProtiNX_Q8TAQ5
OpenTargetsiENSG00000197050
PharmGKBiPA134958420

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161335
HOGENOMiHOG000234617
InParanoidiQ8TAQ5
KOiK09228
OMAiNQHAYLS
PhylomeDBiQ8TAQ5
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF420 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
147923
PharosiQ8TAQ5

Protein Ontology

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PROi
PR:Q8TAQ5

Gene expression databases

BgeeiENSG00000197050 Expressed in 205 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ8TAQ5 baseline and differential
GenevisibleiQ8TAQ5 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 16 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 19 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN420_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TAQ5
Secondary accession number(s): B2RDY6, Q96ML5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: October 16, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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