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Entry version 134 (08 May 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Glucosamine-6-phosphate isomerase 2

Gene

GNPDA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei72Proton acceptor; for enolization stepBy similarity1
Active sitei141For ring-opening stepBy similarity1
Active sitei143Proton acceptor; for ring-opening stepBy similarity1
Active sitei148For ring-opening stepBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.99.6 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70171 Glycolysis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucosamine-6-phosphate isomerase 2 (EC:3.5.99.6)
Alternative name(s):
Glucosamine-6-phosphate deaminase 2
Short name:
GNPDA 2
Short name:
GlcN6P deaminase 2
Glucosamine-6-phosphate isomerase SB52
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNPDA2
Synonyms:GNP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21526 GNPDA2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613222 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TDQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
132789

Open Targets

More...
OpenTargetsi
ENSG00000163281

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134939177

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GNPDA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74723936

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003432051 – 276Glucosamine-6-phosphate isomerase 2Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei161PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TDQ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TDQ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TDQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TDQ7

PeptideAtlas

More...
PeptideAtlasi
Q8TDQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q8TDQ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74327
74328 [Q8TDQ7-2]
74329 [Q8TDQ7-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8TDQ7-2 [Q8TDQ7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TDQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TDQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163281 Expressed in 161 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TDQ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TDQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000499
HPA046891

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126335, 15 interactors

Database of interacting proteins

More...
DIPi
DIP-62122N

Protein interaction database and analysis system

More...
IntActi
Q8TDQ7, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295448

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TDQ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili105 – 130Sequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3148 Eukaryota
COG0363 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014316

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000064979

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TDQ7

KEGG Orthology (KO)

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KOi
K02564

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLHSMKE

Database of Orthologous Groups

More...
OrthoDBi
1425290at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TDQ7

TreeFam database of animal gene trees

More...
TreeFami
TF300841

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01399 GlcN6P_deaminase, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01241 GlcN6P_deamin, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like

The PANTHER Classification System

More...
PANTHERi
PTHR11280 PTHR11280, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01182 Glucosamine_iso, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100950 SSF100950, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00502 nagB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TDQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLVILDNYD LASEWAAKYI CNRIIQFKPG QDRYFTLGLP TGSTPLGCYK
60 70 80 90 100
KLIEYHKNGH LSFKYVKTFN MDEYVGLPRN HPESYHSYMW NNFFKHIDID
110 120 130 140 150
PNNAHILDGN AADLQAECDA FENKIKEAGG IDLFVGGIGP DGHIAFNEPG
160 170 180 190 200
SSLVSRTRLK TLAMDTILAN AKYFDGDLSK VPTMALTVGV GTVMDAREVM
210 220 230 240 250
ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTIFVCD EDATLELRVK
260 270
TVKYFKGLMH VHNKLVDPLF SMKDGN
Length:276
Mass (Da):31,085
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BCFD72F734639D0
GO
Isoform 2 (identifier: Q8TDQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-217: Missing.

Show »
Length:275
Mass (Da):30,956
Checksum:i6DB65CA86569D445
GO
Isoform 3 (identifier: Q8TDQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-276: LMHVHNKLVDPLFSMKDGN → EH

Show »
Length:259
Mass (Da):29,173
Checksum:i1C0DB9A7FFDB5C92
GO
Isoform 4 (identifier: Q8TDQ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:206
Mass (Da):22,912
Checksum:iE3D8A72A584D3F06
GO
Isoform 5 (identifier: Q8TDQ7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-76: Missing.

Show »
Length:242
Mass (Da):27,091
Checksum:iBA5F01D6E1F5C015
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYK3V9GYK3_HUMAN
Glucosamine-6-phosphate isomerase 2
GNPDA2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYW0V9GYW0_HUMAN
Glucosamine-6-phosphate isomerase 2
GNPDA2
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93141 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37L → P in BAB70977 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044348182P → S1 PublicationCorresponds to variant dbSNP:rs17851302Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0470331 – 70Missing in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_04703443 – 76Missing in isoform 5. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_034579217Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_034580258 – 276LMHVH…MKDGN → EH in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF247786 mRNA Translation: AAL95691.1
AY173948 mRNA Translation: AAO49718.1
AK055639 mRNA Translation: BAB70977.1
AK296051 mRNA Translation: BAG58815.1
AB209904 mRNA Translation: BAD93141.1 Different initiation.
AC096586 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93019.1
BC015532 mRNA Translation: AAH15532.1
AL834506 mRNA Translation: CAD39163.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3469.1 [Q8TDQ7-1]
CCDS59472.1 [Q8TDQ7-4]
CCDS59473.1 [Q8TDQ7-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001257809.1, NM_001270880.1 [Q8TDQ7-5]
NP_001257810.1, NM_001270881.1 [Q8TDQ7-4]
NP_612208.1, NM_138335.2 [Q8TDQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1]
ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4]
ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5]
ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
132789

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:132789

UCSC genome browser

More...
UCSCi
uc003gwy.5 human [Q8TDQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247786 mRNA Translation: AAL95691.1
AY173948 mRNA Translation: AAO49718.1
AK055639 mRNA Translation: BAB70977.1
AK296051 mRNA Translation: BAG58815.1
AB209904 mRNA Translation: BAD93141.1 Different initiation.
AC096586 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93019.1
BC015532 mRNA Translation: AAH15532.1
AL834506 mRNA Translation: CAD39163.1
CCDSiCCDS3469.1 [Q8TDQ7-1]
CCDS59472.1 [Q8TDQ7-4]
CCDS59473.1 [Q8TDQ7-5]
RefSeqiNP_001257809.1, NM_001270880.1 [Q8TDQ7-5]
NP_001257810.1, NM_001270881.1 [Q8TDQ7-4]
NP_612208.1, NM_138335.2 [Q8TDQ7-1]

3D structure databases

SMRiQ8TDQ7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126335, 15 interactors
DIPiDIP-62122N
IntActiQ8TDQ7, 5 interactors
STRINGi9606.ENSP00000295448

PTM databases

iPTMnetiQ8TDQ7
PhosphoSitePlusiQ8TDQ7

Polymorphism and mutation databases

BioMutaiGNPDA2
DMDMi74723936

Proteomic databases

EPDiQ8TDQ7
jPOSTiQ8TDQ7
MaxQBiQ8TDQ7
PaxDbiQ8TDQ7
PeptideAtlasiQ8TDQ7
PRIDEiQ8TDQ7
ProteomicsDBi74327
74328 [Q8TDQ7-2]
74329 [Q8TDQ7-3]
TopDownProteomicsiQ8TDQ7-2 [Q8TDQ7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
132789
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295448; ENSP00000295448; ENSG00000163281 [Q8TDQ7-1]
ENST00000507534; ENSP00000427423; ENSG00000163281 [Q8TDQ7-4]
ENST00000507917; ENSP00000425868; ENSG00000163281 [Q8TDQ7-5]
ENST00000509756; ENSP00000424061; ENSG00000163281 [Q8TDQ7-3]
GeneIDi132789
KEGGihsa:132789
UCSCiuc003gwy.5 human [Q8TDQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
132789
DisGeNETi132789

GeneCards: human genes, protein and diseases

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GeneCardsi
GNPDA2
HGNCiHGNC:21526 GNPDA2
HPAiHPA000499
HPA046891
MIMi613222 gene
neXtProtiNX_Q8TDQ7
OpenTargetsiENSG00000163281
PharmGKBiPA134939177

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3148 Eukaryota
COG0363 LUCA
GeneTreeiENSGT00390000014316
HOGENOMiHOG000064979
InParanoidiQ8TDQ7
KOiK02564
OMAiPLHSMKE
OrthoDBi1425290at2759
PhylomeDBiQ8TDQ7
TreeFamiTF300841

Enzyme and pathway databases

BRENDAi3.5.99.6 2681
ReactomeiR-HSA-70171 Glycolysis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GNPDA2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GNPDA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
132789

Protein Ontology

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PROi
PR:Q8TDQ7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000163281 Expressed in 161 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8TDQ7 baseline and differential
GenevisibleiQ8TDQ7 HS

Family and domain databases

CDDicd01399 GlcN6P_deaminase, 1 hit
HAMAPiMF_01241 GlcN6P_deamin, 1 hit
InterProiView protein in InterPro
IPR006148 Glc/Gal-6P_isomerase
IPR004547 Glucosamine6P_isomerase
IPR018321 Glucosamine6P_isomerase_CS
IPR037171 NagB/RpiA_transferase-like
PANTHERiPTHR11280 PTHR11280, 1 hit
PfamiView protein in Pfam
PF01182 Glucosamine_iso, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00502 nagB, 1 hit
PROSITEiView protein in PROSITE
PS01161 GLC_GALNAC_ISOMERASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGNPI2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TDQ7
Secondary accession number(s): B4DJF3
, Q2VYF1, Q59EA7, Q8NCZ8, Q96BJ4, Q96NC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2002
Last modified: May 8, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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