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Entry version 145 (18 Sep 2019)
Sequence version 2 (15 Nov 2002)
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Protein

Short transient receptor potential channel 4-associated protein

Gene

TRPC4AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3295583 TRP channels

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Short transient receptor potential channel 4-associated protein
Short name:
Trp4-associated protein
Short name:
Trpc4-associated protein
Alternative name(s):
Protein TAP1
TNF-receptor ubiquitous scaffolding/signaling protein
Short name:
Protein TRUSS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRPC4AP
Synonyms:C20orf188, TRRP4AP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16181 TRPC4AP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608430 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TEL6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26133

Open Targets

More...
OpenTargetsi
ENSG00000100991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25730

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRPC4AP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25091357

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726412 – 797Short transient receptor potential channel 4-associated proteinAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TEL6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TEL6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TEL6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TEL6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TEL6

PeptideAtlas

More...
PeptideAtlasi
Q8TEL6

PRoteomics IDEntifications database

More...
PRIDEi
Q8TEL6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
15211
74470 [Q8TEL6-1]
74471 [Q8TEL6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TEL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TEL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100991 Expressed in 222 organ(s), highest expression level in left lobe of thyroid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TEL6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051197
HPA065061

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Constitutively associated with TNFRSF1A. Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG.

Interacts with TRPC1, TRPC4 and TRPC5 (By similarity).

Component of the DCX(TRUSS) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1.

Interacts directly with DDB1.

Interacts with MYC.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621362EBI-2559060,EBI-357253

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117569, 57 interactors

Database of interacting proteins

More...
DIPi
DIP-42719N

Protein interaction database and analysis system

More...
IntActi
Q8TEL6, 38 interactors

Molecular INTeraction database

More...
MINTi
Q8TEL6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000252015

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 400Interaction with TNFRSF1ABy similarityAdd BLAST399

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH9D Eukaryota
ENOG410ZAXR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018330

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231794

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TEL6

KEGG Orthology (KO)

More...
KOi
K11796

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGFILNN

Database of Orthologous Groups

More...
OrthoDBi
240503at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TEL6

TreeFam database of animal gene trees

More...
TreeFami
TF329145

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR022162 TRPC4AP

The PANTHER Classification System

More...
PANTHERi
PTHR31743 PTHR31743, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12463 DUF3689, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TEL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPVAAGS GAGRGRRSAA TVAAWGGWGG RPRPGNILLQ LRQGQLTGRG
60 70 80 90 100
LVRAVQFTET FLTERDKQSK WSGIPQLLLK LHTTSHLHSD FVECQNILKE
110 120 130 140 150
ISPLLSMEAM AFVTEERKLT QETTYPNTYI FDLFGGVDLL VEILMRPTIS
160 170 180 190 200
IRGQKLKISD EMSKDCLSIL YNTCVCTEGV TKRLAEKNDF VIFLFTLMTS
210 220 230 240 250
KKTFLQTATL IEDILGVKKE MIRLDEVPNL SSLVSNFDQQ QLANFCRILA
260 270 280 290 300
VTISEMDTGN DDKHTLLAKN AQQKKSLSLG PSAAEINQAA LLSIPGFVER
310 320 330 340 350
LCKLATRKVS ESTGTASFLQ ELEEWYTWLD NALVLDALMR VANEESEHNQ
360 370 380 390 400
ASIVFPPPGA SEENGLPHTS ARTQLPQSMK IMHEIMYKLE VLYVLCVLLM
410 420 430 440 450
GRQRNQVHRM IAEFKLIPGL NNLFDKLIWR KHSASALVLH GHNQNCDCSP
460 470 480 490 500
DITLKIQFLR LLQSFSDHHE NKYLLLNNQE LNELSAISLK ANIPEVEAVL
510 520 530 540 550
NTDRSLVCDG KRGLLTRLLQ VMKKEPAESS FRFWQARAVE SFLRGTTSYA
560 570 580 590 600
DQMFLLKRGL LEHILYCIVD SECKSRDVLQ SYFDLLGELM KFNVDAFKRF
610 620 630 640 650
NKYINTDAKF QVFLKQINSS LVDSNMLVRC VTLSLDRFEN QVDMKVAEVL
660 670 680 690 700
SECRLLAYIS QVPTQMSFLF RLINIIHVQT LTQENVSCLN TSLVILMLAR
710 720 730 740 750
RKERLPLYLR LLQRMEHSKK YPGFLLNNFH NLLRFWQQHY LHKDKDSTCL
760 770 780 790
ENSSCISFSY WKETVSILLN PDRQSPSALV SYIEEPYMDI DRDFTEE
Length:797
Mass (Da):90,852
Last modified:November 15, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i999A8CA3B0D2CEEE
GO
Isoform 2 (identifier: Q8TEL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     533-797: Missing.

Note: No experimental confirmation available.
Show »
Length:532
Mass (Da):59,547
Checksum:iD9E123C910E93950
GO
Isoform 3 (identifier: Q8TEL6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-358: Missing.

Show »
Length:789
Mass (Da):90,043
Checksum:i8FF952722B28B257
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84932 differs from that shown. Reason: Frameshift at position 43.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054231351 – 358Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_003982533 – 797Missing in isoform 2. 1 PublicationAdd BLAST265

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074106 mRNA Translation: BAB84932.1 Frameshift.
AB590540 mRNA Translation: BAJ20695.1
AL132825 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76233.1
CH471077 Genomic DNA Translation: EAW76235.1
CH471077 Genomic DNA Translation: EAW76229.1
CH471077 Genomic DNA Translation: EAW76234.1
BC001323 mRNA Translation: AAH01323.1
BC008836 mRNA Translation: AAH08836.2
BC013144 mRNA Translation: AAH13144.1
AL117480 mRNA Translation: CAB55953.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13246.1 [Q8TEL6-1]
CCDS46591.1 [Q8TEL6-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17263

NCBI Reference Sequences

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RefSeqi
NP_056453.1, NM_015638.2 [Q8TEL6-1]
NP_955400.1, NM_199368.1 [Q8TEL6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000252015; ENSP00000252015; ENSG00000100991 [Q8TEL6-1]
ENST00000451813; ENSP00000400614; ENSG00000100991 [Q8TEL6-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26133

UCSC genome browser

More...
UCSCi
uc002xbk.4 human [Q8TEL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074106 mRNA Translation: BAB84932.1 Frameshift.
AB590540 mRNA Translation: BAJ20695.1
AL132825 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76233.1
CH471077 Genomic DNA Translation: EAW76235.1
CH471077 Genomic DNA Translation: EAW76229.1
CH471077 Genomic DNA Translation: EAW76234.1
BC001323 mRNA Translation: AAH01323.1
BC008836 mRNA Translation: AAH08836.2
BC013144 mRNA Translation: AAH13144.1
AL117480 mRNA Translation: CAB55953.1
CCDSiCCDS13246.1 [Q8TEL6-1]
CCDS46591.1 [Q8TEL6-3]
PIRiT17263
RefSeqiNP_056453.1, NM_015638.2 [Q8TEL6-1]
NP_955400.1, NM_199368.1 [Q8TEL6-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117569, 57 interactors
DIPiDIP-42719N
IntActiQ8TEL6, 38 interactors
MINTiQ8TEL6
STRINGi9606.ENSP00000252015

PTM databases

iPTMnetiQ8TEL6
PhosphoSitePlusiQ8TEL6

Polymorphism and mutation databases

BioMutaiTRPC4AP
DMDMi25091357

Proteomic databases

EPDiQ8TEL6
jPOSTiQ8TEL6
MassIVEiQ8TEL6
MaxQBiQ8TEL6
PaxDbiQ8TEL6
PeptideAtlasiQ8TEL6
PRIDEiQ8TEL6
ProteomicsDBi15211
74470 [Q8TEL6-1]
74471 [Q8TEL6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26133
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252015; ENSP00000252015; ENSG00000100991 [Q8TEL6-1]
ENST00000451813; ENSP00000400614; ENSG00000100991 [Q8TEL6-3]
GeneIDi26133
KEGGihsa:26133
UCSCiuc002xbk.4 human [Q8TEL6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26133
DisGeNETi26133

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRPC4AP
HGNCiHGNC:16181 TRPC4AP
HPAiHPA051197
HPA065061
MIMi608430 gene
neXtProtiNX_Q8TEL6
OpenTargetsiENSG00000100991
PharmGKBiPA25730

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH9D Eukaryota
ENOG410ZAXR LUCA
GeneTreeiENSGT00390000018330
HOGENOMiHOG000231794
InParanoidiQ8TEL6
KOiK11796
OMAiPGFILNN
OrthoDBi240503at2759
PhylomeDBiQ8TEL6
TreeFamiTF329145

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-3295583 TRP channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRPC4AP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TRPC4AP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26133

Pharos

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Pharosi
Q8TEL6

Protein Ontology

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PROi
PR:Q8TEL6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100991 Expressed in 222 organ(s), highest expression level in left lobe of thyroid gland
GenevisibleiQ8TEL6 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022162 TRPC4AP
PANTHERiPTHR31743 PTHR31743, 1 hit
PfamiView protein in Pfam
PF12463 DUF3689, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTP4AP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TEL6
Secondary accession number(s): E1P5Q0
, E1P5Q1, Q96H82, Q9BVB8, Q9H429, Q9UFS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: September 18, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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