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Entry version 121 (16 Oct 2019)
Sequence version 2 (15 Jan 2008)
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Protein

DIS3-like exonuclease 1

Gene

DIS3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.2 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
LigandMagnesium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DIS3-like exonuclease 1 (EC:3.1.13.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DIS3L
Synonyms:DIS3L1, KIAA1955
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28698 DIS3L

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614183 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF46

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Exosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi62D → N: No change of exonuclease activity. 1 Publication1
Mutagenesisi166D → N: No change of exonuclease activity. 1 Publication1
Mutagenesisi486D → N: Complete loss of exonuclease activity. 2 Publications1

Organism-specific databases

DisGeNET

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DisGeNETi
115752

Open Targets

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OpenTargetsi
ENSG00000166938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162383675

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q8TF46

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DIS3L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166201903

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148101 – 1054DIS3-like exonuclease 1Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei989PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TF46

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TF46

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8TF46

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TF46

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF46

PeptideAtlas

More...
PeptideAtlasi
Q8TF46

PRoteomics IDEntifications database

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PRIDEi
Q8TF46

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
74555 [Q8TF46-1]
74556 [Q8TF46-2]
74557 [Q8TF46-3]
74558 [Q8TF46-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF46

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TF46

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166938 Expressed in 207 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TF46 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TF46 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041805

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125453, 29 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-592 Cytoplasmic exosome complex, DIS3L variant
CPX-600 Cytoplasmic exosome complex, DIS3L-EXOSC10 variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8TF46

Protein interaction database and analysis system

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IntActi
Q8TF46, 23 interactors

Molecular INTeraction database

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MINTi
Q8TF46

STRING: functional protein association networks

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STRINGi
9606.ENSP00000321711

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TF46

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNR ribonuclease family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2102 Eukaryota
COG0557 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000191945

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TF46

KEGG Orthology (KO)

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KOi
K18681

Identification of Orthologs from Complete Genome Data

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OMAi
FSIDTRS

Database of Orthologous Groups

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OrthoDBi
1104619at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TF46

TreeFam database of animal gene trees

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TreeFami
TF105755

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041505 Dis3_CSD2
IPR031192 DIS3L
IPR012340 NA-bd_OB-fold
IPR001900 RNase_II/R
IPR022966 RNase_II/R_CS
IPR033771 Rrp44_CSD1
IPR033770 RRP44_S1

The PANTHER Classification System

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PANTHERi
PTHR23355:SF30 PTHR23355:SF30, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF17849 OB_Dis3, 1 hit
PF00773 RNB, 1 hit
PF17216 Rrp44_CSD1, 1 hit
PF17215 Rrp44_S1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00955 RNB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50249 SSF50249, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLQKREKVLL LRTFQGRTLR IVREHYLRPC VPCHSPLCPQ PAACSHDGKL
60 70 80 90 100
LSSDVTHYVI PDWKVVQDYL EILEFPELKG IIFMQTACQA VQHQRGRRQY
110 120 130 140 150
NKLRNLLKDA RHDCILFANE FQQCCYLPRE RGESMEKWQT RSIYNAAVWY
160 170 180 190 200
YHHCQDRMPI VMVTEDEEAI QQYGSETEGV FVITFKNYLD NFWPDLKAAH
210 220 230 240 250
ELCDSILQSR RERENESQES HGKEYPEHLP LEVLEAGIKS GRYIQGILNV
260 270 280 290 300
NKHRAQIEAF VRLQGASSKD SDLVSDILIH GMKARNRSIH GDVVVVELLP
310 320 330 340 350
KNEWKGRTVA LCENDCDDKA SGESPSEPMP TGRVVGILQK NWRDYVVTFP
360 370 380 390 400
SKEEVQSQGK NAQKILVTPW DYRIPKIRIS TQQAETLQDF RVVVRIDSWE
410 420 430 440 450
STSVYPNGHF VRVLGRIGDL EGEIATILVE NSISVIPFSE AQMCEMPVNT
460 470 480 490 500
PESPWKVSPE EEQKRKDLRK SHLVFSIDPK GCEDVDDTLS VRTLNNGNLE
510 520 530 540 550
LGVHIADVTH FVAPNSYIDI EARTRATTYY LADRRYDMLP SVLSADLCSL
560 570 580 590 600
LGGVDRYAVS IMWELDKASY EIKKVWYGRT IIRSAYKLFY EAAQELLDGN
610 620 630 640 650
LSVVDDIPEF KDLDEKSRQA KLEELVWAIG KLTDIARHVR AKRDGCGALE
660 670 680 690 700
LEGVEVCVQL DDKKNIHDLI PKQPLEVHET VAECMILANH WVAKKIWESF
710 720 730 740 750
PHQALLRQHP PPHQEFFSEL RECAKAKGFF IDTRSNKTLA DSLDNANDPH
760 770 780 790 800
DPIVNRLLRS MATQAMSNAL YFSTGSCAEE EFHHYGLALD KYTHFTSPIR
810 820 830 840 850
RYSDIVVHRL LMAAISKDKK MEIKGNLFSN KDLEELCRHI NNRNQAAQHS
860 870 880 890 900
QKQSTELFQC MYFKDKDPAT EERCISDGVI YSIRTNGVLL FIPRFGIKGA
910 920 930 940 950
AYLKNKDGLV ISCGPDSCSE WKPGSLQRFQ NKITSTTTDG ESVTFHLFDH
960 970 980 990 1000
VTVRISIQAS RCHSDTIRLE IISNKPYKIP NTELIHQSSP LLKSELVKEV
1010 1020 1030 1040 1050
TKSVEEAQLA QEVKVNIIQE EYQEYRQTKG RSLYTLLEEI RDLALLDVSN

NYGI
Length:1,054
Mass (Da):120,787
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB57B691CC25F65B8
GO
Isoform 2 (identifier: Q8TF46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Note: No experimental confirmation available.
Show »
Length:920
Mass (Da):105,012
Checksum:i2F7FB46F906C79A0
GO
Isoform 3 (identifier: Q8TF46-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     735-750: SNKTLADSLDNANDPH → YSSFEGAEEWSGMLYI
     751-1054: Missing.

Note: No experimental confirmation available.
Show »
Length:750
Mass (Da):86,260
Checksum:iDBACF862A569703A
GO
Isoform 4 (identifier: Q8TF46-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Note: No experimental confirmation available.
Show »
Length:971
Mass (Da):111,119
Checksum:iA3145DE249DF5279
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI20E9PI20_HUMAN
DIS3-like exonuclease 1
DIS3L
103Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI27E9PI27_HUMAN
DIS3-like exonuclease 1
DIS3L
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIL0E9PIL0_HUMAN
DIS3-like exonuclease 1
DIS3L
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS35E9PS35_HUMAN
DIS3-like exonuclease 1
DIS3L
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKI7E9PKI7_HUMAN
DIS3-like exonuclease 1
DIS3L
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85541 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038056518I → V. Corresponds to variant dbSNP:rs34668776Ensembl.1
Natural variantiVAR_038057614D → G2 PublicationsCorresponds to variant dbSNP:rs3803412Ensembl.1
Natural variantiVAR_038058747N → S. Corresponds to variant dbSNP:rs17258507Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0303661 – 134Missing in isoform 2. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_0303671 – 83Missing in isoform 4. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_030368735 – 750SNKTL…ANDPH → YSSFEGAEEWSGMLYI in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_030369751 – 1054Missing in isoform 3. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB075835 mRNA Translation: BAB85541.1 Different initiation.
AK095407 mRNA Translation: BAC04542.1
AC055855 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77759.1
BC014124 mRNA Translation: AAH14124.2
BC022089 mRNA Translation: AAH22089.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10214.1 [Q8TF46-4]
CCDS45286.1 [Q8TF46-1]

NCBI Reference Sequences

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RefSeqi
NP_001137160.1, NM_001143688.2 [Q8TF46-1]
NP_001310865.1, NM_001323936.1 [Q8TF46-4]
NP_001310867.1, NM_001323938.1 [Q8TF46-2]
NP_001310868.1, NM_001323939.1 [Q8TF46-2]
NP_001310870.1, NM_001323941.1 [Q8TF46-2]
NP_001310874.1, NM_001323945.1 [Q8TF46-4]
NP_001310875.1, NM_001323946.1 [Q8TF46-2]
NP_588616.1, NM_133375.4 [Q8TF46-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000319194; ENSP00000321583; ENSG00000166938 [Q8TF46-4]
ENST00000319212; ENSP00000321711; ENSG00000166938 [Q8TF46-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
115752

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:115752

UCSC genome browser

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UCSCi
uc002app.4 human [Q8TF46-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075835 mRNA Translation: BAB85541.1 Different initiation.
AK095407 mRNA Translation: BAC04542.1
AC055855 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77759.1
BC014124 mRNA Translation: AAH14124.2
BC022089 mRNA Translation: AAH22089.1
CCDSiCCDS10214.1 [Q8TF46-4]
CCDS45286.1 [Q8TF46-1]
RefSeqiNP_001137160.1, NM_001143688.2 [Q8TF46-1]
NP_001310865.1, NM_001323936.1 [Q8TF46-4]
NP_001310867.1, NM_001323938.1 [Q8TF46-2]
NP_001310868.1, NM_001323939.1 [Q8TF46-2]
NP_001310870.1, NM_001323941.1 [Q8TF46-2]
NP_001310874.1, NM_001323945.1 [Q8TF46-4]
NP_001310875.1, NM_001323946.1 [Q8TF46-2]
NP_588616.1, NM_133375.4 [Q8TF46-4]

3D structure databases

SMRiQ8TF46
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125453, 29 interactors
ComplexPortaliCPX-592 Cytoplasmic exosome complex, DIS3L variant
CPX-600 Cytoplasmic exosome complex, DIS3L-EXOSC10 variant
CORUMiQ8TF46
IntActiQ8TF46, 23 interactors
MINTiQ8TF46
STRINGi9606.ENSP00000321711

PTM databases

iPTMnetiQ8TF46
PhosphoSitePlusiQ8TF46

Polymorphism and mutation databases

BioMutaiDIS3L
DMDMi166201903

Proteomic databases

EPDiQ8TF46
jPOSTiQ8TF46
MassIVEiQ8TF46
MaxQBiQ8TF46
PaxDbiQ8TF46
PeptideAtlasiQ8TF46
PRIDEiQ8TF46
ProteomicsDBi74555 [Q8TF46-1]
74556 [Q8TF46-2]
74557 [Q8TF46-3]
74558 [Q8TF46-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
115752

Genome annotation databases

EnsembliENST00000319194; ENSP00000321583; ENSG00000166938 [Q8TF46-4]
ENST00000319212; ENSP00000321711; ENSG00000166938 [Q8TF46-1]
GeneIDi115752
KEGGihsa:115752
UCSCiuc002app.4 human [Q8TF46-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
115752
DisGeNETi115752

GeneCards: human genes, protein and diseases

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GeneCardsi
DIS3L
HGNCiHGNC:28698 DIS3L
HPAiHPA041805
MIMi614183 gene
neXtProtiNX_Q8TF46
OpenTargetsiENSG00000166938
PharmGKBiPA162383675

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2102 Eukaryota
COG0557 LUCA
GeneTreeiENSGT00530000063106
HOGENOMiHOG000191945
InParanoidiQ8TF46
KOiK18681
OMAiFSIDTRS
OrthoDBi1104619at2759
PhylomeDBiQ8TF46
TreeFamiTF105755

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DIS3L human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DIS3L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
115752
PharosiQ8TF46

Protein Ontology

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PROi
PR:Q8TF46

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166938 Expressed in 207 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ8TF46 baseline and differential
GenevisibleiQ8TF46 HS

Family and domain databases

InterProiView protein in InterPro
IPR041505 Dis3_CSD2
IPR031192 DIS3L
IPR012340 NA-bd_OB-fold
IPR001900 RNase_II/R
IPR022966 RNase_II/R_CS
IPR033771 Rrp44_CSD1
IPR033770 RRP44_S1
PANTHERiPTHR23355:SF30 PTHR23355:SF30, 1 hit
PfamiView protein in Pfam
PF17849 OB_Dis3, 1 hit
PF00773 RNB, 1 hit
PF17216 Rrp44_CSD1, 1 hit
PF17215 Rrp44_S1, 1 hit
SMARTiView protein in SMART
SM00955 RNB, 1 hit
SUPFAMiSSF50249 SSF50249, 3 hits
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDI3L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF46
Secondary accession number(s): Q8N1N8, Q8WTU9, Q96CM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 16, 2019
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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