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Entry version 158 (16 Oct 2019)
Sequence version 2 (02 May 2006)
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Protein

Zinc finger protein 90 homolog

Gene

ZFP90

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.1 Publication
Isoform 2: Acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 90 homolog
Short name:
Zfp-90
Alternative name(s):
Zinc finger protein 756
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFP90
Synonyms:KIAA1954, ZNF756
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23329 ZFP90

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609451 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TF47

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
146198

Open Targets

More...
OpenTargetsi
ENSG00000184939

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134967487

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TF47

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZFP90

Domain mapping of disease mutations (DMDM)

More...
DMDMi
94730444

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473101 – 636Zinc finger protein 90 homologAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki448Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TF47

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TF47

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TF47

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TF47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TF47

PeptideAtlas

More...
PeptideAtlasi
Q8TF47

PRoteomics IDEntifications database

More...
PRIDEi
Q8TF47

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74559

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TF47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TF47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart (PubMed:21284946). Isoform 2: Highly expressed in regulatory T-cells (Treg) (PubMed:23543754).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184939 Expressed in 208 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TF47 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TF47 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029017

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N- and C-termini) with REST (via zinc-finger DNA-binding domain); the interaction inhibits REST repressor activity (PubMed:21284946). Isoform 2:

Interacts with FOXP3 and TRIM28 (PubMed:23543754).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126969, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8TF47

Protein interaction database and analysis system

More...
IntActi
Q8TF47, 23 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000460547

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TF47

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri211 – 233C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162132

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TF47

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRPFCSD

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TF47

TreeFam database of animal gene trees

More...
TreeFami
TF350822

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TF47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRPPTAAP QESVTFKDVS VDFTQEEWYH VDPAQRSLYR DVMLENYSHL
60 70 80 90 100
VSLGYQVSKP EVIFKLEQGE EPWISEGEIQ RPFYPDWKTR PEVKSSHLQQ
110 120 130 140 150
DVSEVSHCTH DLLHATLEDS WDVSSQLDRQ QENWKRHLGS EASTQKKIIT
160 170 180 190 200
PQENFEQNKF GENSRLNTNL VTQLNIPARI RPSECETLGS NLGHNADLLN
210 220 230 240 250
ENNILAKKKP YKCDKCRKAF IHRSSLTKHE KTHKGEGAFP NGTDQGIYPG
260 270 280 290 300
KKHHECTDCG KTFLWKTQLT EHQRIHTGEK PFECNVCGKA FRHSSSLGQH
310 320 330 340 350
ENAHTGEKPY QCSLCGKAFQ RSSSLVQHQR IHTGEKPYRC NLCGRSFRHG
360 370 380 390 400
TSLTQHEVTH SGEKPFQCKE CGKAFSRCSS LVQHERTHTG EKPFECSICG
410 420 430 440 450
RAFGQSPSLY KHMRIHKRGK PYQSSNYSID FKHSTSLTQD ESTLTEVKSY
460 470 480 490 500
HCNDCGEDFS HITDFTDHQR IHTAENPYDC EQAFSQQAIS HPGEKPYQCN
510 520 530 540 550
VCGKAFKRST SFIEHHRIHT GEKPYECNEC GEAFSRRSSL TQHERTHTGE
560 570 580 590 600
KPYECIDCGK AFSQSSSLIQ HERTHTGEKP YECNECGRAF RKKTNLHDHQ
610 620 630
RIHTGEKPYS CKECGKNFSR SSALTKHQRI HTRNKL
Length:636
Mass (Da):73,031
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D645DD5F5EFD8A6
GO
Isoform 2 (identifier: Q8TF47-3) [UniParc]FASTAAdd to basket
Also known as: FOXP3-interacting KRAB-domain containing protein, FIK1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     86-113: DWKTRPEVKSSHLQQDVSEVSHCTHDLL → GFVCLLPLSLPSGSKGERRQKLPRKNPE
     114-636: Missing.

Note: Interacts (via 75-113 AA) with FOXP3. Interacts (via KRAB domain) with TRIM28.1 Publication
Show »
Length:113
Mass (Da):13,006
Checksum:i61D16304A863D683
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L0X7I3L0X7_HUMAN
Zinc finger protein 90 homolog
ZFP90
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKQ8J3QKQ8_HUMAN
Zinc finger protein 90 homolog
ZFP90
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMI1H3BMI1_HUMAN
Zinc finger protein 90 homolog
ZFP90
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BVC6H3BVC6_HUMAN
Zinc finger protein 90 homolog
ZFP90
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3M0I3L3M0_HUMAN
Zinc finger protein 90 homolog
ZFP90
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1L4I3L1L4_HUMAN
Zinc finger protein 90 homolog
ZFP90
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0T2I3L0T2_HUMAN
Zinc finger protein 90 homolog
ZFP90
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2Q3I3L2Q3_HUMAN
Zinc finger protein 90 homolog
ZFP90
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AX721106 differs from that shown. Reason: Frameshift.Curated
The sequence BAB71228 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG53759 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti550E → V in BAB71228 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05751686 – 113DWKTR…THDLL → GFVCLLPLSLPSGSKGERRQ KLPRKNPE in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_057517114 – 636Missing in isoform 2. 1 PublicationAdd BLAST523

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KC249978 mRNA Translation: AGC13464.1
AK056596 mRNA Translation: BAB71228.1 Different initiation.
AK122847 mRNA Translation: BAG53759.1 Sequence problems.
AK304152 mRNA Translation: BAG65042.1
AK316251 mRNA Translation: BAH14622.1
AC009162 Genomic DNA No translation available.
AC126773 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83234.1
BC033165 mRNA Translation: AAH33165.2
BC140886 mRNA Translation: AAI40887.1
BC140887 mRNA Translation: AAI40888.1
AX721106 mRNA No translation available.
AB075834 mRNA Translation: BAB85540.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42183.1 [Q8TF47-1]
CCDS76892.1 [Q8TF47-3]

NCBI Reference Sequences

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RefSeqi
NP_001292132.1, NM_001305203.1 [Q8TF47-1]
NP_001292133.1, NM_001305204.1 [Q8TF47-3]
NP_597715.2, NM_133458.3 [Q8TF47-1]
XP_005255861.1, XM_005255804.2 [Q8TF47-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398253; ENSP00000381304; ENSG00000184939 [Q8TF47-1]
ENST00000563169; ENSP00000454418; ENSG00000184939 [Q8TF47-1]
ENST00000570495; ENSP00000460547; ENSG00000184939 [Q8TF47-1]
ENST00000611381; ENSP00000480309; ENSG00000184939 [Q8TF47-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
146198

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:146198

UCSC genome browser

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UCSCi
uc002ewd.4 human [Q8TF47-1]
uc031qws.2 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC249978 mRNA Translation: AGC13464.1
AK056596 mRNA Translation: BAB71228.1 Different initiation.
AK122847 mRNA Translation: BAG53759.1 Sequence problems.
AK304152 mRNA Translation: BAG65042.1
AK316251 mRNA Translation: BAH14622.1
AC009162 Genomic DNA No translation available.
AC126773 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83234.1
BC033165 mRNA Translation: AAH33165.2
BC140886 mRNA Translation: AAI40887.1
BC140887 mRNA Translation: AAI40888.1
AX721106 mRNA No translation available.
AB075834 mRNA Translation: BAB85540.1
CCDSiCCDS42183.1 [Q8TF47-1]
CCDS76892.1 [Q8TF47-3]
RefSeqiNP_001292132.1, NM_001305203.1 [Q8TF47-1]
NP_001292133.1, NM_001305204.1 [Q8TF47-3]
NP_597715.2, NM_133458.3 [Q8TF47-1]
XP_005255861.1, XM_005255804.2 [Q8TF47-1]

3D structure databases

SMRiQ8TF47
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126969, 1 interactor
CORUMiQ8TF47
IntActiQ8TF47, 23 interactors
STRINGi9606.ENSP00000460547

PTM databases

iPTMnetiQ8TF47
PhosphoSitePlusiQ8TF47

Polymorphism and mutation databases

BioMutaiZFP90
DMDMi94730444

Proteomic databases

EPDiQ8TF47
jPOSTiQ8TF47
MassIVEiQ8TF47
MaxQBiQ8TF47
PaxDbiQ8TF47
PeptideAtlasiQ8TF47
PRIDEiQ8TF47
ProteomicsDBi74559

Genome annotation databases

EnsembliENST00000398253; ENSP00000381304; ENSG00000184939 [Q8TF47-1]
ENST00000563169; ENSP00000454418; ENSG00000184939 [Q8TF47-1]
ENST00000570495; ENSP00000460547; ENSG00000184939 [Q8TF47-1]
ENST00000611381; ENSP00000480309; ENSG00000184939 [Q8TF47-3]
GeneIDi146198
KEGGihsa:146198
UCSCiuc002ewd.4 human [Q8TF47-1]
uc031qws.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146198
DisGeNETi146198

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZFP90
HGNCiHGNC:23329 ZFP90
HPAiHPA029017
MIMi609451 gene
neXtProtiNX_Q8TF47
OpenTargetsiENSG00000184939
PharmGKBiPA134967487

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162132
HOGENOMiHOG000234617
InParanoidiQ8TF47
KOiK09228
OMAiQRPFCSD
OrthoDBi1318335at2759
PhylomeDBiQ8TF47
TreeFamiTF350822

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZFP90 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
146198
PharosiQ8TF47

Protein Ontology

More...
PROi
PR:Q8TF47

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184939 Expressed in 208 organ(s), highest expression level in female gonad
ExpressionAtlasiQ8TF47 baseline and differential
GenevisibleiQ8TF47 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFP90_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TF47
Secondary accession number(s): B2RU00
, B3KVE7, L7S2P3, Q49AD1, Q96MQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: May 2, 2006
Last modified: October 16, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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