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UniProtKB - Q92372 (RFA1_SCHPO)

Entry version 151 (16 Oct 2019)
Sequence version 1 (01 Feb 1997)
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Protein

Replication factor A protein 1

Gene

ssb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi192 – 278OBAdd BLAST87
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri477 – 498C4-typeSequence analysisAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SPO-110312 Translesion synthesis by REV1
R-SPO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SPO-110320 Translesion Synthesis by POLH
R-SPO-174437 Removal of the Flap Intermediate from the C-strand
R-SPO-176187 Activation of ATR in response to replication stress
R-SPO-3371453 Regulation of HSF1-mediated heat shock response
R-SPO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-SPO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-SPO-5655862 Translesion synthesis by POLK
R-SPO-5656121 Translesion synthesis by POLI
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5685938 HDR through Single Strand Annealing (SSA)
R-SPO-5693607 Processing of DNA double-strand break ends
R-SPO-5696395 Formation of Incision Complex in GG-NER
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-68962 Activation of the pre-replicative complex
R-SPO-69166 Removal of the Flap Intermediate

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replication factor A protein 1
Alternative name(s):
Single-stranded DNA-binding protein p68 subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ssb1
Synonyms:rad11, rpa1
ORF Names:SPBC660.13c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:SPBC660.13c

Schizosaccharomyces pombe database

More...PomBasei		SPBC660.13c ssb1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000972661 – 609Replication factor A protein 1Add BLAST609

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q92372

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q92372

PRoteomics IDEntifications database

More...PRIDEi		Q92372

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q92372

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the heterotrimeric canonical replication protein A complex (RPA).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P365922EBI-966394,EBI-966242

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		277673, 26 interactors

Database of interacting proteins

More...DIPi		DIP-29237N

Protein interaction database and analysis system

More...IntActi		Q92372, 4 interactors

STRING: functional protein association networks

More...STRINGi		4896.SPBC660.13c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q92372

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the replication factor A protein 1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri477 – 498C4-typeSequence analysisAdd BLAST22

Keywords - Domaini

Zinc-finger

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000162322

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q92372

KEGG Orthology (KO)

More...KOi		K07466

Identification of Orthologs from Complete Genome Data

More...OMAi		YRLLINM

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q92372

Family and domain databases

Conserved Domains Database

More...CDDi		cd04476 RPA1_DBD_C, 1 hit
cd04477 RPA1N, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
IPR013955 Rep_factor-A_C
IPR007199 Rep_factor-A_N
IPR031657 REPA_OB_2
IPR004591 Rfa1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04057 Rep-A_N, 1 hit
PF08646 Rep_fac-A_C, 1 hit
PF16900 REPA_OB_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249 SSF50249, 4 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00617 rpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q92372-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERLSVGAL RIINTSDASS FPPNPILQVL TVKELNSNPT SGAPKRYRVV 
        60         70         80         90        100
LSDSINYAQS MLSTQLNHLV AENKLQKGAF VQLTQFTVNV MKERKILIVL 
       110        120        130        140        150
GLNVLTELGV MDKIGNPAGL ETVDALRQQQ NEQNNASAPR TGISTSTNSF 
       160        170        180        190        200
YGNNAAATAP APPPMMKKPA APNSLSTIIY PIEGLSPYQN KWTIRARVTN 
       210        220        230        240        250
KSEVKHWHNQ RGEGKLFSVN LLDESGEIRA TGFNDQVDAF YDILQEGSVY 
       260        270        280        290        300
YISRCRVNIA KKQYTNVQNE YELMFERDTE IRKAEDQTAV PVAKFSFVSL 
       310        320        330        340        350
QEVGDVAKDA VIDVIGVLQN VGPVQQITSR ATSRGFDKRD ITIVDQTGYE 
       360        370        380        390        400
MRVTLWGKTA IEFSVSEESI LAFKGVKVND FQGRSLSMLT SSTMSVDPDI 
       410        420        430        440        450
QESHLLKGWY DGQGRGQEFA KHSVISSTLS TTGRSAERKN IAEVQAEHLG 
       460        470        480        490        500
MSETPDYFSL KGTIVYIRKK NVSYPACPAA DCNKKVFDQG GSWRCEKCNK 
       510        520        530        540        550
EYDAPQYRYI ITIAVGDHTG QLWLNVFDDV GKLIMHKTAD ELNDLQENDE 
       560        570        580        590        600
NAFMNCMAEA CYMPYIFQCR AKQDNFKGEM RVRYTVMSIN QMDWKEESKR 

LINFIESAQ
Length:609
Mass (Da):68,197
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F2E77A0E12022EA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U59385 mRNA Translation: AAC49437.1
U75446 Genomic DNA Translation: AAC49694.1
CU329671 Genomic DNA Translation: CAA22533.1

Protein sequence database of the Protein Information Resource

More...PIRi		T40625

NCBI Reference Sequences

More...RefSeqi		NP_595092.1, NM_001020999.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPBC660.13c.1; SPBC660.13c.1:pep; SPBC660.13c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2541158

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPBC660.13c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59385 mRNA Translation: AAC49437.1
U75446 Genomic DNA Translation: AAC49694.1
CU329671 Genomic DNA Translation: CAA22533.1
PIRiT40625
RefSeqiNP_595092.1, NM_001020999.2

3D structure databases

SMRiQ92372
ModBaseiSearch...

Protein-protein interaction databases

BioGridi277673, 26 interactors
DIPiDIP-29237N
IntActiQ92372, 4 interactors
STRINGi4896.SPBC660.13c.1

PTM databases

iPTMnetiQ92372

Proteomic databases

MaxQBiQ92372
PaxDbiQ92372
PRIDEiQ92372

Genome annotation databases

EnsemblFungiiSPBC660.13c.1; SPBC660.13c.1:pep; SPBC660.13c
GeneIDi2541158
KEGGispo:SPBC660.13c

Organism-specific databases

EuPathDBiFungiDB:SPBC660.13c
PomBaseiSPBC660.13c ssb1

Phylogenomic databases

HOGENOMiHOG000162322
InParanoidiQ92372
KOiK07466
OMAiYRLLINM
PhylomeDBiQ92372

Enzyme and pathway databases

ReactomeiR-SPO-110312 Translesion synthesis by REV1
R-SPO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SPO-110320 Translesion Synthesis by POLH
R-SPO-174437 Removal of the Flap Intermediate from the C-strand
R-SPO-176187 Activation of ATR in response to replication stress
R-SPO-3371453 Regulation of HSF1-mediated heat shock response
R-SPO-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-SPO-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-SPO-5655862 Translesion synthesis by POLK
R-SPO-5656121 Translesion synthesis by POLI
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5685938 HDR through Single Strand Annealing (SSA)
R-SPO-5693607 Processing of DNA double-strand break ends
R-SPO-5696395 Formation of Incision Complex in GG-NER
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-68962 Activation of the pre-replicative complex
R-SPO-69166 Removal of the Flap Intermediate

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q92372

Family and domain databases

CDDicd04476 RPA1_DBD_C, 1 hit
cd04477 RPA1N, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
IPR013955 Rep_factor-A_C
IPR007199 Rep_factor-A_N
IPR031657 REPA_OB_2
IPR004591 Rfa1
PfamiView protein in Pfam
PF04057 Rep-A_N, 1 hit
PF08646 Rep_fac-A_C, 1 hit
PF16900 REPA_OB_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
SUPFAMiSSF50249 SSF50249, 4 hits
TIGRFAMsiTIGR00617 rpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFA1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92372
Secondary accession number(s): Q92382
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 16, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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