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Entry version 151 (31 Jul 2019)
Sequence version 2 (06 Dec 2005)
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Protein

Mediator of RNA polymerase II transcription subunit 1

Gene

Med1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (By similarity).By similarity10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-212436 Generic Transcription Pathway
R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 1
Alternative name(s):
Mediator complex subunit 1
Peroxisome proliferator-activated receptor-binding protein
Short name:
PBP
Short name:
PPAR-binding protein
Thyroid hormone receptor-associated protein complex 220 kDa component
Short name:
Trap220
Thyroid receptor-interacting protein 2
Short name:
TR-interacting protein 2
Short name:
TRIP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Med1
Synonyms:Crsp210, Drip205, Pbp, Pparbp, Trap220, Trip2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1100846 Med1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000585531 – 1575Mediator of RNA polymerase II transcription subunit 1Add BLAST1575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei588PhosphoserineBy similarity1
Modified residuei664PhosphoserineCombined sources1
Modified residuei795PhosphoserineBy similarity1
Modified residuei805PhosphothreonineCombined sources1
Modified residuei953PhosphoserineCombined sources1
Modified residuei955PhosphoserineCombined sources1
Modified residuei1032Phosphothreonine; by MAPK1 or MAPK3By similarity1
Modified residuei1051PhosphothreonineCombined sources1
Modified residuei1057PhosphothreonineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1179N6-acetyllysineBy similarity1
Modified residuei1209PhosphoserineCombined sources1
Modified residuei1217PhosphothreonineBy similarity1
Modified residuei1225PhosphoserineBy similarity1
Modified residuei1304PhosphoserineBy similarity1
Modified residuei1349PhosphoserineBy similarity1
Modified residuei1405PhosphoserineBy similarity1
Modified residuei1435PhosphoserineCombined sources1
Modified residuei1442PhosphothreonineCombined sources1
Modified residuei1459Phosphothreonine; by MAPK1 or MAPK3By similarity1
Modified residuei1465PhosphoserineCombined sources1
Modified residuei1467PhosphoserineCombined sources1
Modified residuei1481PhosphoserineCombined sources1
Modified residuei1483PhosphoserineBy similarity1
Modified residuei1484PhosphoserineCombined sources1
Modified residuei1523N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q925J9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q925J9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q925J9

PeptideAtlas

More...
PeptideAtlasi
Q925J9

PRoteomics IDEntifications database

More...
PRIDEi
Q925J9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q925J9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q925J9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in the adult, with high levels of expression in the liver, lung, intestinal mucosa, kidney cortex, thymic cortex, splenic follicle and seminiferous epithelium in testis. Also expressed in the adult heart, brain, spleen and skeletal muscle.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed during embryonic development; at stages 9.5 dpc-10.5 dpc, expression is strongest in neural tissues. At 11.5 dpc-12.5 dpc, expression is abundant throughout embryonic tissues, being strongest in the developing liver, primitive gut, nasopharynx, and developing limb buds. Moderately expressed at this stage in the brain and optic stalk, branchial arch and urogential ridge. Expressed at a low level in the heart. By stage 13.5 dpc-14.5 dpc, expression is abundant in the forebrain, vagus nerve, dorsal root ganglia, nasopharynx, kidney, liver, pancreas, intestine, gut, thymus, lung, genital tubercle, tongue and lower jaw. Moderately expressed in the midbrain and expressed at a low level in the heart and large blood vessels. In the developing placenta, expression is moderate in the giant and spongiotrophoblast cell layers and strongest in the labyrinthine portion throughout 9.5 dpc-13.5 dpc.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000018160 Expressed in 296 organ(s), highest expression level in rostral migratory stream

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q925J9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q925J9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR.

Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53.

Interacts with GATA1 and YWHAH.

Interacts with CLOCK; this interaction requires the presence of THRAP3.

Interacts with CCAR1 (By similarity).

Interacts with NR4A3 (PubMed:12709428).

By similarity9 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
202318, 5 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3264 Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q925J9

Database of interacting proteins

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DIPi
DIP-59232N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q925J9

Protein interaction database and analysis system

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IntActi
Q925J9, 10 interactors

Molecular INTeraction database

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MINTi
Q925J9

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000103169

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11575
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q925J9

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q925J9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 670Interaction with the Mediator complex and THRABy similarityAdd BLAST670
Regioni16 – 590Interaction with ESR1By similarityAdd BLAST575
Regioni108 – 212Interaction with the Mediator complexBy similarityAdd BLAST105
Regioni215 – 390Interaction with the Mediator complexBy similarityAdd BLAST176
Regioni405 – 644Interaction with THRABy similarityAdd BLAST240
Regioni542 – 789Interaction with VDRBy similarityAdd BLAST248
Regioni622 – 701Interaction with GATA11 PublicationAdd BLAST80
Regioni622 – 701Interaction with PPARGC1A and THRABy similarityAdd BLAST80
Regioni656 – 1066Interaction with ESR1By similarityAdd BLAST411
Regioni1251 – 1423Interaction with TP53By similarityAdd BLAST173

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi604 – 608LXXLL motif 15
Motifi645 – 649LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1078 – 1484Ser-richSequence analysisAdd BLAST407
Compositional biasi1498 – 1523Lys-richSequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEFR Eukaryota
ENOG410XR2E LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00660000095569

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q925J9

KEGG Orthology (KO)

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KOi
K15144

Identification of Orthologs from Complete Genome Data

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OMAi
HPVDNKG

Database of Orthologous Groups

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OrthoDBi
57581at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q925J9

TreeFam database of animal gene trees

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TreeFami
TF324954

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019680 Mediator_Med1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10744 Med1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q925J9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKAQGETEDS ERLSKMSSLL ERLHAKFNQN RPWSETIKLV RQVMEKRVVM
60 70 80 90 100
SSGGHQHLVS CLETLQKALK VTSLPAMTDR LESIARQNGL GSHLSASGTE
110 120 130 140 150
CYITSDMFYV EVQLDPAGQL CDVKVAHHGE NPVSCPELVQ QLREKNFEEF
160 170 180 190 200
SKHLKGLVNL YNLPGDNKLK TKMYLALQSL EQDLSKMAIM YWKATNAAPL
210 220 230 240 250
DKILHGSVGY LTPRSGGHLM NMKYYASPSD LLDDKTASPI ILHEKNVPRS
260 270 280 290 300
LGMNASVTIE GTSAMYKLPI APLIMGSHPA DNKWTPSFSA VTSANSVDLP
310 320 330 340 350
ACFFLKFPQP IPVSKAFVQK LQNCTGIPLF ETPPTYLPLY ELITQFELSK
360 370 380 390 400
DPDPLPLNHN MRFYAALPGQ QHCYFLNKDA PLPDGQSLQG TLVSKITFQH
410 420 430 440 450
PGRVPLILNM IRHQVAYNTL IGSCVKRTIL KEDSPGLLQF EVCPLSESRF
460 470 480 490 500
SVSFQHPVND SLVCVVMDVQ DSTHVSCKLY KGLSDALICT DDFIAKVVQR
510 520 530 540 550
CMSIPVTMRA IRRKAETIQA DTPALSLIAE TVEDMVKKNL PPASSPGYGM
560 570 580 590 600
TTGNNPMSGT TTPTNTFPGG PITTLFNMSM SIKDRHESVG HGEDFSKVSQ
610 620 630 640 650
NPILTSLLQI TGNGGSTIGS SPTPPHHTPP PVSSMAGNTK NHPMLMNLLK
660 670 680 690 700
DNPAQDFSTL YGSSPLERQN SSSGSPRMEM CSGSNKAKKK KSSRVPPDKP
710 720 730 740 750
KHQTEDDFQR ELFSMDVDSQ NPMFDVSMTA DALDTPHITP APSQCSTPPA
760 770 780 790 800
TYPQPVSHPQ PSIQRMVRLS SSDSIGPDVT DILSDIAEEA SKLPSTSDDC
810 820 830 840 850
PPIGTPVRDS SSSGHSQSAL FDSDVFQTNN NENPYTDPAD LIADAAGSPN
860 870 880 890 900
SDSPTNHFFP DGVDFNPDLL NSQSQSGFGE EYFDESSQSG DNDDFKGFAS
910 920 930 940 950
QALNTLGMPM LGGDNGEPKF KGSSQADTVD FSIISVAGKA LGAADLMEHH
960 970 980 990 1000
SGSQSPLLTT GELGKEKTQK RVKEGNGTGA SSGSGPGSDS KPGKRSRTPS
1010 1020 1030 1040 1050
NDGKSKDKPP KRKKADTEGK SPSHSSSNRP FTPPTSTGGS KSPGSSGRSQ
1060 1070 1080 1090 1100
TPPGVATPPI PKITIQIPKG TVMVGKPSSH SQYTSSGSVS SSGSKSHHSH
1110 1120 1130 1140 1150
SSSSSSLASA STSGKVKSSK SEGSSSSKLS GSMYASQGSS GSSQSKNSSQ
1160 1170 1180 1190 1200
TGGKPGSSPI TKHGLSSGSS STKMKPQGKP SSLMNPSISK PNISPSHSRP
1210 1220 1230 1240 1250
PGGSDKLASP MKPVPGTPPS SKAKSPISSG SSGSHVSGTS SSSGMKSSSG
1260 1270 1280 1290 1300
SASSGSVSQK TPPASNSCTP SSSSFSSSGS SMSSSQNQHG SSKGKSPSRN
1310 1320 1330 1340 1350
KKPSLTAVID KLKHGVVTSG PGGEDPIDSQ MGASTNSSNH PMSSKHNTSG
1360 1370 1380 1390 1400
GEFQSKREKS DKDKSKVSAS GGSVDSSKKT SESKNVGSTG VAKIIISKHD
1410 1420 1430 1440 1450
GGSPSIKAKV TLQKPGESGG DGLRPQIASS KNYGSPLISG STPKHERGSP
1460 1470 1480 1490 1500
SHSKSPAYTP QNVDSESESG SSIAERSYQN SPSSEDGIRP LPEYSTEKHK
1510 1520 1530 1540 1550
KHKKEKKKVR DKDRDKKKSH SMKPENWSKS PISSDPTASV TNNPILSADR
1560 1570
PSRLSPDFMI GEEDDDLMDV ALIGN
Note: No experimental confirmation available.Curated
Length:1,575
Mass (Da):167,141
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3B8121A26003A22
GO
Isoform 21 Publication (identifier: Q925J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-632: YGMTTGNNPM...TPPHHTPPPV → VEEKRQDKPS...SDVQEYFSVS
     633-1575: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:632
Mass (Da):70,473
Checksum:i21A6BD89B50EA9F2
GO
Isoform 31 Publication (identifier: Q925J9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-556: YGMTTGNNP → SKNPELGSG
     557-1575: Missing.

Show »
Length:556
Mass (Da):61,566
Checksum:i4E8E3E79087D4B3A
GO
Isoform 42 Publications (identifier: Q925J9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Show »
Length:1,560
Mass (Da):165,450
Checksum:iC1408AE8196A6C76
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQH6B1AQH6_MOUSE
Mediator of RNA polymerase II trans...
Med1 Pparbp, mCG_21903
629Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH21440 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84I → L in AAC31118 (PubMed:9325263).Curated1
Sequence conflicti198A → T in AAH21440 (PubMed:15489334).Curated1
Sequence conflicti211L → H in BAE27757 (PubMed:16141072).Curated1
Sequence conflicti303F → S in AAC31118 (PubMed:9325263).Curated1
Sequence conflicti382 – 389LPDGQSLQ → VLPNKAVS in BAC35779 (PubMed:16141072).Curated8
Sequence conflicti948E → K in BAC33607 (PubMed:16141072).Curated1
Sequence conflicti964G → A in BAC33607 (PubMed:16141072).Curated1
Sequence conflicti1323G → S in AAC31118 (PubMed:9325263).Curated1
Sequence conflicti1387G → R in AAC31118 (PubMed:9325263).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti960T → S in strain: ISS and 129/Ola. 2 Publications1
Natural varianti1348T → M in strain: ISS and 129/Ola. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0518921 – 15Missing in isoform 4. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_051893548 – 632YGMTT…TPPPV → VEEKRQDKPSLGHLPPIQVC SPSCLKDGKDMKSTCTYLLL LLLLLEFMVFCFFFFFLTYS SVFGLHVKGLWTKICSDVQE YFSVS in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_051894548 – 556YGMTTGNNP → SKNPELGSG in isoform 3. 2 Publications9
Alternative sequenceiVSP_051895557 – 1575Missing in isoform 3. 2 PublicationsAdd BLAST1019
Alternative sequenceiVSP_051896633 – 1575Missing in isoform 2. 1 PublicationAdd BLAST943

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF000294 mRNA Translation: AAC31118.1
AF332073 mRNA Translation: AAK56101.1
AF332074 mRNA Translation: AAK56102.1
AY176046 Genomic DNA Translation: AAN75014.1
AK049203 mRNA Translation: BAC33607.2
AK054437 mRNA Translation: BAC35779.2
AK147199 mRNA Translation: BAE27757.1
AL591205 Genomic DNA No translation available.
BC021440 mRNA Translation: AAH21440.1 Different initiation.
BC079636 mRNA Translation: AAH79636.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25341.1 [Q925J9-4]
CCDS36300.1 [Q925J9-1]

Protein sequence database of the Protein Information Resource

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PIRi
T02885

NCBI Reference Sequences

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RefSeqi
NP_001073587.1, NM_001080118.1 [Q925J9-1]
NP_038662.2, NM_013634.2 [Q925J9-4]
NP_598788.2, NM_134027.2 [Q925J9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000018304; ENSMUSP00000018304; ENSMUSG00000018160 [Q925J9-4]
ENSMUST00000107545; ENSMUSP00000103169; ENSMUSG00000018160 [Q925J9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
19014

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:19014

UCSC genome browser

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UCSCi
uc007lfo.1 mouse [Q925J9-3]
uc007lfp.1 mouse [Q925J9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000294 mRNA Translation: AAC31118.1
AF332073 mRNA Translation: AAK56101.1
AF332074 mRNA Translation: AAK56102.1
AY176046 Genomic DNA Translation: AAN75014.1
AK049203 mRNA Translation: BAC33607.2
AK054437 mRNA Translation: BAC35779.2
AK147199 mRNA Translation: BAE27757.1
AL591205 Genomic DNA No translation available.
BC021440 mRNA Translation: AAH21440.1 Different initiation.
BC079636 mRNA Translation: AAH79636.1
CCDSiCCDS25341.1 [Q925J9-4]
CCDS36300.1 [Q925J9-1]
PIRiT02885
RefSeqiNP_001073587.1, NM_001080118.1 [Q925J9-1]
NP_038662.2, NM_013634.2 [Q925J9-4]
NP_598788.2, NM_134027.2 [Q925J9-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XDKX-ray2.90C/D/G/H641-654[»]
SMRiQ925J9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi202318, 5 interactors
ComplexPortaliCPX-3264 Core mediator complex
CORUMiQ925J9
DIPiDIP-59232N
ELMiQ925J9
IntActiQ925J9, 10 interactors
MINTiQ925J9
STRINGi10090.ENSMUSP00000103169

PTM databases

iPTMnetiQ925J9
PhosphoSitePlusiQ925J9

Proteomic databases

EPDiQ925J9
jPOSTiQ925J9
PaxDbiQ925J9
PeptideAtlasiQ925J9
PRIDEiQ925J9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018304; ENSMUSP00000018304; ENSMUSG00000018160 [Q925J9-4]
ENSMUST00000107545; ENSMUSP00000103169; ENSMUSG00000018160 [Q925J9-1]
GeneIDi19014
KEGGimmu:19014
UCSCiuc007lfo.1 mouse [Q925J9-3]
uc007lfp.1 mouse [Q925J9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5469
MGIiMGI:1100846 Med1

Phylogenomic databases

eggNOGiENOG410IEFR Eukaryota
ENOG410XR2E LUCA
GeneTreeiENSGT00660000095569
InParanoidiQ925J9
KOiK15144
OMAiHPVDNKG
OrthoDBi57581at2759
PhylomeDBiQ925J9
TreeFamiTF324954

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway
R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

EvolutionaryTraceiQ925J9

Protein Ontology

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PROi
PR:Q925J9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000018160 Expressed in 296 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiQ925J9 baseline and differential
GenevisibleiQ925J9 MM

Family and domain databases

InterProiView protein in InterPro
IPR019680 Mediator_Med1
PfamiView protein in Pfam
PF10744 Med1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q925J9
Secondary accession number(s): A2A526
, A2A528, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 31, 2019
This is version 151 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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