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Entry version 140 (16 Oct 2019)
Sequence version 3 (13 Nov 2013)
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Protein

Carcinoembryonic antigen-related cell adhesion molecule 2

Gene

Ceacam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.
Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium.

Miscellaneous

The human orthologous protein seems not to exist. In mice, both Ceacam1 and Ceacam2 are the paralogs of human CEACAM1.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1566977 Fibronectin matrix formation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 2
Short name:
CEA-related cell adhesion molecule 2
Alternative name(s):
Biliary glycoprotein 2
Short name:
BGP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ceacam2
Synonyms:Bgp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1347246 Ceacam2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini35 – 422ExtracellularSequence analysisAdd BLAST388
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 520CytoplasmicSequence analysisAdd BLAST77

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Sexually dimorphic effect. Homozygous null mutant female mice exhibit obesity that results from hyperphagia and reduced energy expenditure. Hyperphagia leads to peripheral insulin resistance. Insulin action is normal in liver but is compromised in skeletal muscle; the mice have incomplete fatty acid oxidation and impaired glucose uptake and disposal. Hyperphagia appears to result partly from increased hyperinsulinemia-induced hypothalamic fatty acid synthase levels and activity. Hyperinsulinemia is caused by increased insulin secretion. Homozygous null mutant male mice show total fat mass reduction, which ows to the hypermetabolic state despite hyperphagia. They also exhibit insulin sensitivity with elevated beta-oxidation in skeletal muscle, which is likely to offset the effects of increased food intake. Both males and females have increased brown adipogenesis. However, only males have increased activation of sympathetic tone regulation of adipose tissue and increased spontaneous activity.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028709535 – 520Carcinoembryonic antigen-related cell adhesion molecule 2Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 217PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi210N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi261 ↔ 301PROSITE-ProRule annotation
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 394PROSITE-ProRule annotation
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei487PhosphotyrosineBy similarity1
Modified residuei502PhosphoserineBy similarity1
Modified residuei514PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q925P2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q925P2

PeptideAtlas

More...
PeptideAtlasi
Q925P2

PRoteomics IDEntifications database

More...
PRIDEi
Q925P2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q925P2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q925P2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is detected in elongating spermatids within the seminiferous epithelium (at protein level). Expressed in kidney, colon, uterus, gut mononuclear cells, crypt epithelia of intestinal tissues, and to a lesser extent, in spleen. Expressed in brain including VMH, globus pallidus, ventral pallidum, striatum, olfactory bulb and hippocampus. Also detected in rectal carcinoma cell line CMT93. Isoform 2 and isoform 3 are expressed in testis. Isoform 2 is detected in seminiferous tubule, not detected in epididymal spermatozoa. Also not observed on spermatogonia, spermatocytes, round spermatids or somatic Sertoli cells. During stages I-VII of spermatogenesis, detected on the elongating spermatids. At spermiation (stage VIII) and subsequent stages IX-XII, levels are drastically reduced or absent in the seminiferous tubules. Sometimes weakly detected in the apical region of stage-VIII seminiferous epithelium. Isoform 2 level is very low in stomach, kidney, intestine, liver and spleen.5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic development. Isoform 2 first appears faintly in the testis 3 weeks into postnatal development and its expression level increases after 5 weeks.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Levels in brain increase at fasting and decrease at 4 and 7 hours of refeeding.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054385 Expressed in 73 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q925P2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts weakly with MHV spike protein in tissue culture.

2 Publications

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 141Ig-like V-typeAdd BLAST107
Domaini145 – 234Ig-like C2-type 1Add BLAST90
Domaini239 – 319Ig-like C2-type 2Add BLAST81
Domaini327 – 411Ig-like C2-type 3Add BLAST85

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFE1 Eukaryota
ENOG410YR1P LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00960000186634

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233417

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q925P2

KEGG Orthology (KO)

More...
KOi
K06499

Identification of Orthologs from Complete Genome Data

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OMAi
NTSYLWS

Database of Orthologous Groups

More...
OrthoDBi
998214at2759

TreeFam database of animal gene trees

More...
TreeFami
TF336859

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q925P2-1) [UniParc]FASTAAdd to basket
Also known as: Bgp2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELASAHLHK GQVPWFGLLL TASLLASWSP PTTAQVTVMA FPLHAAEGNN
60 70 80 90 100
VILVVYNMMK GVSAFSWHKG STTSTNAEIV RFVTGTNKTI KGPVHSGRET
110 120 130 140 150
LYSNGSLLIQ RVTMKDTGVY TIEMTDQNYR RRVLTGQFHV HTLLLKSNIT
160 170 180 190 200
SNNSNPVEGD DSVSLTCDSY TDPDNITYLW SRNGESLSEG DRLKLSEGNR
210 220 230 240 250
TLTLLNVTRN DTGPYVCETR NPVSVNRSDP FSLNIIYGPD TPIISPSDIY
260 270 280 290 300
LHPGSNLNLS CHAASNPPAQ YFWLINEKPH ASSQELFIPN ITTNNSGTYT
310 320 330 340 350
CFVNNSVTGL SRTTVKNITV LEPVTQPSLQ VTNTTVKELD SVTLTCLSKD
360 370 380 390 400
RQAHIHWIFN NDTLLITEKM TTSQAGLILK IDPIKREDAG EYQCEISNPV
410 420 430 440 450
SVKRSNSIKL EVIFDSTYDI SDVPIAVIIT GAVAGVILIA GLAYRLCSRK
460 470 480 490 500
SRWGSDQRDL TEHKPSASNH NLAPSDNSPN KVDDVAYTVL NFNSQQPNRP
510 520
TSAPSSPRAT ETVYSEVKKK
Length:520
Mass (Da):57,202
Last modified:November 13, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC55CA7D26F57C19A
GO
Isoform 2 (identifier: Q925P2-2) [UniParc]FASTAAdd to basket
Also known as: Bgp2, Bgp2L, Ceacam2-Long, Ceacam2-L

The sequence of this isoform differs from the canonical sequence as follows:
     142-322: TLLLKSNITS...TTVKNITVLE → K

Show »
Length:340
Mass (Da):37,477
Checksum:i8CAA5A02C2D81A5E
GO
Isoform 3 (identifier: Q925P2-3) [UniParc]FASTAAdd to basket
Also known as: Bgp2, Bgp2S, Ceacam2-Short, Ceacam2-S

The sequence of this isoform differs from the canonical sequence as follows:
     142-322: TLLLKSNITS...TTVKNITVLE → K
     453-520: Missing.

Show »
Length:272
Mass (Da):29,984
Checksum:i27C18C401781C37D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16F → V in AAK52602 (PubMed:11284729).Curated1
Sequence conflicti16F → V in BAI49177 (PubMed:20410265).Curated1
Sequence conflicti63S → L in AAK52602 (PubMed:11284729).Curated1
Sequence conflicti100T → A in AAK52602 (PubMed:11284729).Curated1
Sequence conflicti128N → D in AAK52602 (PubMed:11284729).Curated1
Sequence conflicti302F → L in AAK52602 (PubMed:11284729).Curated1
Sequence conflicti351R → S in AAK52602 (PubMed:11284729).Curated1
Sequence conflicti421S → L in AAK52602 (PubMed:11284729).Curated1
Sequence conflicti467A → T in AAC99458 (PubMed:8207827).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025300142 – 322TLLLK…ITVLE → K in isoform 2 and isoform 3. 4 PublicationsAdd BLAST181
Alternative sequenceiVSP_025301453 – 520Missing in isoform 3. 3 PublicationsAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF101164 mRNA Translation: AAC99458.1
X76085 mRNA Translation: CAA53699.1
AF287912 Genomic DNA Translation: AAK52602.1
AB500065 mRNA Translation: BAI49177.1
AB731450 mRNA Translation: BAM29120.1
AC162443 Genomic DNA No translation available.
BC024320 mRNA Translation: AAH24320.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS20986.1 [Q925P2-3]
CCDS52152.1 [Q925P2-2]
CCDS52153.1 [Q925P2-1]

Protein sequence database of the Protein Information Resource

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PIRi
I48268

NCBI Reference Sequences

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RefSeqi
NP_001106839.1, NM_001113368.1 [Q925P2-1]
NP_001106840.1, NM_001113369.1 [Q925P2-2]
NP_031569.1, NM_007543.4 [Q925P2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044547; ENSMUSP00000048118; ENSMUSG00000054385 [Q925P2-1]
ENSMUST00000064862; ENSMUSP00000068540; ENSMUSG00000054385 [Q925P2-3]
ENSMUST00000066503; ENSMUSP00000064255; ENSMUSG00000054385 [Q925P2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26367

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:26367

UCSC genome browser

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UCSCi
uc009ftc.2 mouse [Q925P2-3]
uc012ffv.1 mouse [Q925P2-1]
uc012ffw.1 mouse [Q925P2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101164 mRNA Translation: AAC99458.1
X76085 mRNA Translation: CAA53699.1
AF287912 Genomic DNA Translation: AAK52602.1
AB500065 mRNA Translation: BAI49177.1
AB731450 mRNA Translation: BAM29120.1
AC162443 Genomic DNA No translation available.
BC024320 mRNA Translation: AAH24320.1
CCDSiCCDS20986.1 [Q925P2-3]
CCDS52152.1 [Q925P2-2]
CCDS52153.1 [Q925P2-1]
PIRiI48268
RefSeqiNP_001106839.1, NM_001113368.1 [Q925P2-1]
NP_001106840.1, NM_001113369.1 [Q925P2-2]
NP_031569.1, NM_007543.4 [Q925P2-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ925P2
PhosphoSitePlusiQ925P2

Proteomic databases

jPOSTiQ925P2
PaxDbiQ925P2
PeptideAtlasiQ925P2
PRIDEiQ925P2

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q925P2

Genome annotation databases

EnsembliENSMUST00000044547; ENSMUSP00000048118; ENSMUSG00000054385 [Q925P2-1]
ENSMUST00000064862; ENSMUSP00000068540; ENSMUSG00000054385 [Q925P2-3]
ENSMUST00000066503; ENSMUSP00000064255; ENSMUSG00000054385 [Q925P2-2]
GeneIDi26367
KEGGimmu:26367
UCSCiuc009ftc.2 mouse [Q925P2-3]
uc012ffv.1 mouse [Q925P2-1]
uc012ffw.1 mouse [Q925P2-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26367
MGIiMGI:1347246 Ceacam2

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
GeneTreeiENSGT00960000186634
HOGENOMiHOG000233417
InParanoidiQ925P2
KOiK06499
OMAiNTSYLWS
OrthoDBi998214at2759
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-MMU-1566977 Fibronectin matrix formation
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

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PROi
PR:Q925P2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000054385 Expressed in 73 organ(s), highest expression level in testis
GenevisibleiQ925P2 MM

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEAM2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q925P2
Secondary accession number(s): D0VY57
, E9QLI9, I7HDK2, Q61349, Q8R1N5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 13, 2013
Last modified: October 16, 2019
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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