Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (08 May 2019)
Sequence version 2 (06 Mar 2007)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

G-patch domain and KOW motifs-containing protein

Gene

GPKOW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein involved in pre-mRNA splicing.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-patch domain and KOW motifs-containing protein
Alternative name(s):
G-patch domain-containing protein 5
Protein MOS2 homolog
Protein T54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPKOW
Synonyms:GPATC5, GPATCH5, T54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30677 GPKOW

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
301003 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92917

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27S → A: Reduced phosphorylation. Significant loss of phosphorylation and increased RNA-binding; when associated with A-316. 1 Publication1
Mutagenesisi176 – 177GW → AA: Significant loss of interaction with DHX16. No loss of pre-mRNA splicing activity. Able to suppress the splicing defect observed in dominant-negative DHX16 mutant expressing cells. 1 Publication2
Mutagenesisi259 – 260GK → AA: No loss of interaction with DHX16. Reduced pre-mRNA splicing activity. Decreased ability to suppress the splicing defect observed in dominant-negative DHX16 mutant expressing cells. 1 Publication2
Mutagenesisi316T → A: Reduced phosphorylation. Significant loss of phosphorylation and increased RNA-binding; when associated with A-27. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27238

Open Targets

More...
OpenTargetsi
ENSG00000068394

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2570 Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134956055

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPKOW

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134048659

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875592 – 476G-patch domain and KOW motifs-containing proteinAdd BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei27Phosphoserine; by PKA1 Publication1
Modified residuei35PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei216PhosphothreonineCombined sources1
Modified residuei316Phosphothreonine; by PKA1 Publication1
Modified residuei471PhosphoserineCombined sources1
Modified residuei473PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation regulates its ability to bind RNA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q92917

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92917

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92917

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92917

PeptideAtlas

More...
PeptideAtlasi
Q92917

PRoteomics IDEntifications database

More...
PRIDEi
Q92917

ProteomicsDB human proteome resource

More...
ProteomicsDBi
75602

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92917

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92917

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q92917

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000068394 Expressed in 218 organ(s), highest expression level in muscle of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92917 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000287
HPA001894

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRKX (PubMed:16491121).

Interacts with DHX16 (PubMed:25296192).

Interacts with PRKACB (PubMed:21880142).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118086, 38 interactors

Protein interaction database and analysis system

More...
IntActi
Q92917, 65 interactors

Molecular INTeraction database

More...
MINTi
Q92917

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000156109

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q92917

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini164 – 210G-patchPROSITE-ProRule annotationAdd BLAST47
Domaini240 – 267KOW 1Add BLAST28
Domaini415 – 442KOW 2Add BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MOS2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4315 Eukaryota
ENOG410YYBE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231362

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q92917

KEGG Orthology (KO)

More...
KOi
K13101

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTPSGEG

Database of Orthologous Groups

More...
OrthoDBi
1427830at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q92917

TreeFam database of animal gene trees

More...
TreeFami
TF316786

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13152 KOW_GPKOW_A, 1 hit
cd13153 KOW_GPKOW_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000467 G_patch_dom
IPR041993 GPKOW_KOW1
IPR041994 GPKOW_KOW2
IPR005824 KOW
IPR026822 Spp2/MOS2_G-patch

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12656 G-patch_2, 1 hit
PF00467 KOW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443 G_patch, 1 hit
SM00739 KOW, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50174 G_PATCH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q92917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSKEGVLP LTAASTAPIS FGFTRTSARR RLADSGDGAG PSPEEKDFLK
60 70 80 90 100
TVEGRELQSV KPQEAPKELV IPLIQNGHRR QPPARPPGPS TDTGALADGV
110 120 130 140 150
VSQAVKELIA ESKKSLEERE NAGVDPTLAI PMIQKGCTPS GEGADSEPRA
160 170 180 190 200
ETVPEEANYE AVPVEAYGLA MLRGMGWKPG EGIGRTFNQV VKPRVNSLRP
210 220 230 240 250
KGLGLGANLT EAQALTPTGP SRMPRPDEEQ EKDKEDQPQG LVPGGAVVVL
260 270 280 290 300
SGPHRGLYGK VEGLDPDNVR AMVRLAVGSR VVTVSEYYLR PVSQQEFDKN
310 320 330 340 350
TLDLRQQNGT ASSRKTLWNQ ELYIQQDNSE RKRKHLPDRQ DGPAAKSEKA
360 370 380 390 400
APRSQHWLHR DLRVRFVDNM YKGGQYYNTK MIIEDVLSPD TCVCRTDEGR
410 420 430 440 450
VLEGLREDML ETLVPKAEGD RVMVVLGPQT GRVGHLLSRD RARSRALVQL
460 470
PRENQVVELH YDAICQYMGP SDTDDD
Length:476
Mass (Da):52,229
Last modified:March 6, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36F1C5771969897D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB18640 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti317L → F in BAD93043 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U66359 mRNA Translation: AAB18640.1 Sequence problems.
BC000397 mRNA Translation: AAH00397.1
BC003148 mRNA Translation: AAH03148.1
AB209806 mRNA Translation: BAD93043.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35251.1

NCBI Reference Sequences

More...
RefSeqi
NP_056513.2, NM_015698.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000156109; ENSP00000156109; ENSG00000068394

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27238

UCSC genome browser

More...
UCSCi
uc004dmr.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66359 mRNA Translation: AAB18640.1 Sequence problems.
BC000397 mRNA Translation: AAH00397.1
BC003148 mRNA Translation: AAH03148.1
AB209806 mRNA Translation: BAD93043.1
CCDSiCCDS35251.1
RefSeqiNP_056513.2, NM_015698.5

3D structure databases

SMRiQ92917
ModBaseiSearch...

Protein-protein interaction databases

BioGridi118086, 38 interactors
IntActiQ92917, 65 interactors
MINTiQ92917
STRINGi9606.ENSP00000156109

PTM databases

iPTMnetiQ92917
PhosphoSitePlusiQ92917

Polymorphism and mutation databases

BioMutaiGPKOW
DMDMi134048659

Proteomic databases

EPDiQ92917
jPOSTiQ92917
MaxQBiQ92917
PaxDbiQ92917
PeptideAtlasiQ92917
PRIDEiQ92917
ProteomicsDBi75602

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
27238
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000156109; ENSP00000156109; ENSG00000068394
GeneIDi27238
KEGGihsa:27238
UCSCiuc004dmr.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27238
DisGeNETi27238

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPKOW
HGNCiHGNC:30677 GPKOW
HPAiHPA000287
HPA001894
MIMi301003 gene
neXtProtiNX_Q92917
OpenTargetsiENSG00000068394
Orphaneti2570 Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome
PharmGKBiPA134956055

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4315 Eukaryota
ENOG410YYBE LUCA
GeneTreeiENSGT00390000015154
HOGENOMiHOG000231362
InParanoidiQ92917
KOiK13101
OMAiCTPSGEG
OrthoDBi1427830at2759
PhylomeDBiQ92917
TreeFamiTF316786

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GPKOW human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27238
PMAP-CutDBiQ92917

Protein Ontology

More...
PROi
PR:Q92917

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000068394 Expressed in 218 organ(s), highest expression level in muscle of leg
GenevisibleiQ92917 HS

Family and domain databases

CDDicd13152 KOW_GPKOW_A, 1 hit
cd13153 KOW_GPKOW_B, 1 hit
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR041993 GPKOW_KOW1
IPR041994 GPKOW_KOW2
IPR005824 KOW
IPR026822 Spp2/MOS2_G-patch
PfamiView protein in Pfam
PF12656 G-patch_2, 1 hit
PF00467 KOW, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00739 KOW, 2 hits
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPKOW_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92917
Secondary accession number(s): Q59EK5, Q9BQA8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 6, 2007
Last modified: May 8, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again