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Entry version 192 (31 Jul 2019)
Sequence version 2 (30 May 2000)
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Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

DVL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the signal transduction pathway mediated by multiple Wnt genes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201688 WNT mediated activation of DVL
R-HSA-4086400 PCP/CE pathway
R-HSA-4641258 Degradation of DVL
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins
R-HSA-5663220 RHO GTPases Activate Formins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q92997

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q92997

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q92997 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3
Short name:
Dishevelled-3
Alternative name(s):
DSH homolog 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DVL3
Synonyms:KIAA0208
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3087 DVL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601368 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q92997

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Robinow syndrome, autosomal dominant 3 (DRS3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Robinow syndrome, a rare skeletal dysplasia syndrome characterized by dysmorphic features resembling a fetal face, mesomelic limb shortening, genital hypoplasia, renal anomalies, and costovertebral segmentation defects.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi271R → K: Localizes to plasma membranes. 1 Publication1
Mutagenesisi342R → K: No effect on subcellular location. 1 Publication1
Mutagenesisi614R → K: Localizes to plasma membranes. 1 Publication1

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
1857

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DVL3

MalaCards human disease database

More...
MalaCardsi
DVL3
MIMi616894 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000161202

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3107 Autosomal dominant Robinow syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27543

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6028

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DVL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6919875

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001457491 – 716Segment polarity protein dishevelled homolog DVL-3Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27Omega-N-methylarginine1 Publication1
Modified residuei48PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1 Publication1
Modified residuei212Omega-N-methylarginine1 Publication1
Modified residuei271Asymmetric dimethylarginine; by PRMT1; alternate1 Publication1
Modified residuei271Symmetric dimethylarginine; by PRMT7; alternate1 Publication1
Modified residuei342Omega-N-methylarginine; alternate2 Publications1
Modified residuei342Symmetric dimethylarginine; by PRMT7; alternate2 Publications1
Modified residuei346Phosphothreonine1 Publication1
Modified residuei614Symmetric dimethylarginine; by PRMT71 Publication1
Modified residuei697PhosphoserineCombined sources1
Modified residuei698Dimethylated arginine; alternate1 Publication1
Modified residuei698Omega-N-methylarginine; alternate1 Publication1
Modified residuei700Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.1 Publication
Phosphorylated by CSNK1D.2 Publications
Arginine methylation may function as a switch in regulation of function in Wnt signaling.2 Publications

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q92997

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q92997

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q92997

PeptideAtlas

More...
PeptideAtlasi
Q92997

PRoteomics IDEntifications database

More...
PRIDEi
Q92997

ProteomicsDB human proteome resource

More...
ProteomicsDBi
5895
75666 [Q92997-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q92997

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q92997

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161202 Expressed in 231 organ(s), highest expression level in lower esophagus muscularis layer

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q92997 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q92997 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB046486
HPA058265

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity).

Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction.

Interacts with CYLD, CEP164 and DAB2.

Interacts with DCDC2.

Interacts with FOXK1 and FOXK2 (PubMed:25805136).

Interacts with DAAM2 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108190, 103 interactors

Database of interacting proteins

More...
DIPi
DIP-34509N

Protein interaction database and analysis system

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IntActi
Q92997, 189 interactors

Molecular INTeraction database

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MINTi
Q92997

STRING: functional protein association networks

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STRINGi
9606.ENSP00000316054

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q92997

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q92997

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 82DIXPROSITE-ProRule annotationAdd BLAST82
Domaini249 – 321PDZPROSITE-ProRule annotationAdd BLAST73
Domaini422 – 496DEPPROSITE-ProRule annotationAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DSH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3571 Eukaryota
ENOG410Y5G4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182903

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000017084

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q92997

KEGG Orthology (KO)

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KOi
K02353

Identification of Orthologs from Complete Genome Data

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OMAi
TNQSDNC

Database of Orthologous Groups

More...
OrthoDBi
474724at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q92997

TreeFam database of animal gene trees

More...
TreeFami
TF318198

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit
3.10.20.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008342 DVL3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

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PANTHERi
PTHR10878 PTHR10878, 1 hit
PTHR10878:SF6 PTHR10878:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01760 DISHEVELLED
PR01763 DISHEVELLED3

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q92997-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD
60 70 80 90 100
DDFGVVKEEI SDDNAKLPCF NGRVVSWLVS AEGSHPDPAP FCADNPSELP
110 120 130 140 150
PPMERTGGIG DSRPPSFHPH AGGGSQENLD NDTETDSLVS AQRERPRRRD
160 170 180 190 200
GPEHATRLNG TAKGERRREP GGYDSSSTLM SSELETTSFF DSDEDDSTSR
210 220 230 240 250
FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD STMSLNIITV
260 270 280 290 300
TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL
310 320 330 340 350
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS
360 370 380 390 400
EPIRPIDPAA WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER
410 420 430 440 450
LDDFHLSIHS DMAAIVKAMA SPESGLEVRD RMWLKITIPN AFIGSDVVDW
460 470 480 490 500
LYHNVEGFTD RREARKYASN LLKAGFIRHT VNKITFSEQC YYIFGDLCGN
510 520 530 540 550
MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY PPPPHPYNPH
560 570 580 590 600
PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG
610 620 630 640 650
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL ASSLRSHHTH
660 670 680 690 700
PSYGPPGVPP LYGPPMLMMP PPPAAMGPPG APPGRDLASV PPELTASRQS
710
FRMAMGNPSE FFVDVM
Length:716
Mass (Da):78,055
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1A55EBF9507D06E
GO
Isoform 2 (identifier: Q92997-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     350-367: SEPIRPIDPAAWVSHTAA → T

Note: No experimental confirmation available.
Show »
Length:699
Mass (Da):76,256
Checksum:iAD4CB18FDB88AA63
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITC6A0A3B3ITC6_HUMAN
Segment polarity protein dishevelle...
DVL3
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCF1F8WCF1_HUMAN
Segment polarity protein dishevelle...
DVL3
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISG4A0A3B3ISG4_HUMAN
Segment polarity protein dishevelle...
DVL3
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13199 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2G → D in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti76S → Y in AAB84228 (PubMed:9344861).Curated1
Sequence conflicti102P → S in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti151G → W in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti182S → R in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti218K → N in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti222R → W in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti230E → D in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti233S → C in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti236S → T in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti239T → S in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti242T → A in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti303N → K in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti431R → C in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti450W → C in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti465R → P in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti472L → V in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti543P → R in AAB65244 (PubMed:9192851).Curated1
Sequence conflicti553 – 554FP → LG in AAB65244 (PubMed:9192851).Curated2
Sequence conflicti629A → T in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti633S → I in AAB47447 (PubMed:8817329).Curated1
Sequence conflicti682 – 716PPGRD…FVDVM → LRAATWPQCPRN in BAA13199 (PubMed:9039502).CuratedAdd BLAST35

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036116216R → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_025519433W → L1 PublicationCorresponds to variant dbSNP:rs17853048Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053371350 – 367SEPIR…SHTAA → T in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U49262 mRNA Translation: AAB47447.1
U75651 mRNA Translation: AAB84228.1
AF006013 mRNA Translation: AAB65244.1
D86963 mRNA Translation: BAA13199.2 Different initiation.
AK304686 mRNA Translation: BAG65457.1
AC131235 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78295.1
CH471052 Genomic DNA Translation: EAW78296.1
BC032459 mRNA Translation: AAH32459.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3253.1 [Q92997-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC5763

NCBI Reference Sequences

More...
RefSeqi
NP_004414.3, NM_004423.3 [Q92997-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313143; ENSP00000316054; ENSG00000161202 [Q92997-1]
ENST00000431765; ENSP00000405885; ENSG00000161202 [Q92997-2]
ENST00000649964; ENSP00000497134; ENSG00000161202 [Q92997-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1857

UCSC genome browser

More...
UCSCi
uc003fms.4 human [Q92997-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49262 mRNA Translation: AAB47447.1
U75651 mRNA Translation: AAB84228.1
AF006013 mRNA Translation: AAB65244.1
D86963 mRNA Translation: BAA13199.2 Different initiation.
AK304686 mRNA Translation: BAG65457.1
AC131235 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78295.1
CH471052 Genomic DNA Translation: EAW78296.1
BC032459 mRNA Translation: AAH32459.1
CCDSiCCDS3253.1 [Q92997-1]
PIRiJC5763
RefSeqiNP_004414.3, NM_004423.3 [Q92997-1]

3D structure databases

SMRiQ92997
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108190, 103 interactors
DIPiDIP-34509N
IntActiQ92997, 189 interactors
MINTiQ92997
STRINGi9606.ENSP00000316054

Chemistry databases

BindingDBiQ92997
ChEMBLiCHEMBL6028

Protein family/group databases

MoonDBiQ92997 Predicted

PTM databases

iPTMnetiQ92997
PhosphoSitePlusiQ92997

Polymorphism and mutation databases

BioMutaiDVL3
DMDMi6919875

Proteomic databases

jPOSTiQ92997
MaxQBiQ92997
PaxDbiQ92997
PeptideAtlasiQ92997
PRIDEiQ92997
ProteomicsDBi5895
75666 [Q92997-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1857
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313143; ENSP00000316054; ENSG00000161202 [Q92997-1]
ENST00000431765; ENSP00000405885; ENSG00000161202 [Q92997-2]
ENST00000649964; ENSP00000497134; ENSG00000161202 [Q92997-1]
GeneIDi1857
KEGGihsa:1857
UCSCiuc003fms.4 human [Q92997-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1857
DisGeNETi1857

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DVL3
GeneReviewsiDVL3
HGNCiHGNC:3087 DVL3
HPAiCAB046486
HPA058265
MalaCardsiDVL3
MIMi601368 gene
616894 phenotype
neXtProtiNX_Q92997
OpenTargetsiENSG00000161202
Orphaneti3107 Autosomal dominant Robinow syndrome
PharmGKBiPA27543

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
GeneTreeiENSGT00950000182903
HOGENOMiHOG000017084
InParanoidiQ92997
KOiK02353
OMAiTNQSDNC
OrthoDBi474724at2759
PhylomeDBiQ92997
TreeFamiTF318198

Enzyme and pathway databases

ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201688 WNT mediated activation of DVL
R-HSA-4086400 PCP/CE pathway
R-HSA-4641258 Degradation of DVL
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins
R-HSA-5663220 RHO GTPases Activate Formins
SignaLinkiQ92997
SIGNORiQ92997

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DVL3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DVL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1857

Protein Ontology

More...
PROi
PR:Q92997

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161202 Expressed in 231 organ(s), highest expression level in lower esophagus muscularis layer
ExpressionAtlasiQ92997 baseline and differential
GenevisibleiQ92997 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008342 DVL3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF6 PTHR10878:SF6, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
PR01763 DISHEVELLED3
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDVL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q92997
Secondary accession number(s): B4E3E5
, D3DNT0, O14642, Q13531, Q8N5E9, Q92607
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 31, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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