Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (13 Nov 2019)
Sequence version 4 (03 Oct 2012)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

E3 SUMO-protein ligase gei-17

Gene

gei-17

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as an E3-type smo-1 ligase (PubMed:15654100, PubMed:16701625, PubMed:16549501, PubMed:25475837). Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment (PubMed:25475837). In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation (PubMed:15654100). In embryos, plays a role in determining telomere localization in the nucleus (PubMed:24297748).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri400 – 477SP-RING-typePROSITE-ProRule annotationAdd BLAST78

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232118 SUMOylation of transcription factors
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3899300 SUMOylation of transcription cofactors
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4090294 SUMOylation of intracellular receptors
R-CEL-4551638 SUMOylation of chromatin organization proteins
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-5696395 Formation of Incision Complex in GG-NER
R-CEL-877312 Regulation of IFNG signaling

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00886

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 SUMO-protein ligase gei-17 (EC:2.3.2.-)
Alternative name(s):
E3 SUMO-protein transferase gei-17Curated
Gex-3-interacting protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gei-17Imported
ORF Names:W10D5.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
W10D5.3a ; CE46915 ; WBGene00001574 ; gei-17
W10D5.3c ; CE46906 ; WBGene00001574 ; gei-17
W10D5.3d ; CE46859 ; WBGene00001574 ; gei-17
W10D5.3e ; CE47019 ; WBGene00001574 ; gei-17
W10D5.3f ; CE46965 ; WBGene00001574 ; gei-17
W10D5.3g ; CE46934 ; WBGene00001574 ; gei-17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown abolishes metaphase and spindle midzone-specific smo-1 conjugation during the first embryonic mitotic division. RNAi-mediated knockdown disrupts the anchoring of telomeres to the nuclear envelope in embryos, but not in muscle nuclei (PubMed:24297748).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi417L → A: Greatly reduces E3 ligase activity and decreases smo-1 chain formation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002701911 – 780E3 SUMO-protein ligase gei-17Add BLAST780

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q94361

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q94361

PeptideAtlas

More...
PeptideAtlasi
Q94361

PRoteomics IDEntifications database

More...
PRIDEi
Q94361

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001574 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with gex-3.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
38164, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-24916N

Protein interaction database and analysis system

More...
IntActi
Q94361, 9 interactors

STRING: functional protein association networks

More...
STRINGi
6239.W10D5.3c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q94361

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini203 – 367PINITPROSITE-ProRule annotationAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 146Gln-richAdd BLAST29
Compositional biasi172 – 178Poly-Ala7
Compositional biasi506 – 511Poly-Asp6
Compositional biasi550 – 553Poly-Asp4
Compositional biasi711 – 779Gln-richAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIAS family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri400 – 477SP-RING-typePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2169 Eukaryota
ENOG410XQ2E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182717

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019659

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q94361

KEGG Orthology (KO)

More...
KOi
K04706

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTTTWLC

Database of Orthologous Groups

More...
OrthoDBi
1131748at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.780, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023321 PINIT
IPR038654 PINIT_sf
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14324 PINIT, 1 hit
PF02891 zf-MIZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51466 PINIT, 1 hit
PS51044 ZF_SP_RING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q94361-1) [UniParc]FASTAAdd to basket
Also known as: c

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPNNQWQIP INNGLTHQEN MAAHAAVMKL RVHDLQSIIS QLSLRKPRPQ
60 70 80 90 100
KSEHQKVVVE SLRDPHHARQ IYQMASNFPN GNYEMQKRPA TTSQVRSHPY
110 120 130 140 150
VLPSRSGASN HLVNHHYQQQ QQQQPQPHNL LHQQMMASHH SHLQQQHHPS
160 170 180 190 200
TVRWLTPELL EEQLRGSMRY GAPAAAAATN APLHSSFPNH GRSSQQSLQK
210 220 230 240 250
SEKSNRPKKM YADNFEPLPL PFYDVISVLL KPVELHSSDS PTLKQTKQLQ
260 270 280 290 300
FPFLLTAEHI SKISYRADVT PLPRYELQLR FFNLTEPVQG PQKDDFPLNC
310 320 330 340 350
YARVDDSVVQ LPNVIPTNKT NAEPKRPSRP VNITSNMNRY KKEHTVAVEW
360 370 380 390 400
LADKRVWAAG VYFVHRVNSD ILFKRLNQNV SRHRSLEVTK QEVIKKLSGG
410 420 430 440 450
EDDIAMDRLN ISLLDPLCKT RMTTPSRCQD CTHLQCFDLL SYLMMNEKKP
460 470 480 490 500
TWQCPVCSSN CPYDRLIVDD YFLDMLAKVD KNTTEVELKE DGSYDVIKEE
510 520 530 540 550
AFCISDDDDD DVVPATVNGT ASCSSTNGNG LANEAAKKKP ADDDIITLSD
560 570 580 590 600
DDDEELNRGI MNSLNDSFSP GRHTASAELA AQKTPPQQKK KTKDDDIEII
610 620 630 640 650
TLDDTPPRPV AASANLPMRQ MSQQNQMPVG SSPSGMASTQ MGMNEGASKT
660 670 680 690 700
IRDALNKIGE QSANSSTQSS PLVQLHHTTH PLNFAQSSYM NPSSGSQTPT
710 720 730 740 750
SQYGYSPMIN QAPHFQMQNG LIGRNNQMVH MQQHHLQQQQ QQQQSPQIMS
760 770 780
PSFYAQQQMS NGGAFAYYPP QYPQQQYRQN
Note: No experimental confirmation available.
Length:780
Mass (Da):88,139
Last modified:October 3, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49D86A064355139D
GO
Isoform 2 (identifier: Q94361-2) [UniParc]FASTAAdd to basket
Also known as: f

The sequence of this isoform differs from the canonical sequence as follows:
     152-206: Missing.
     763-780: GAFAYYPPQYPQQQYRQN → DTNNIQPPRILSMAEIQANASRLLVNGHLMIDHSGVTMRNPRGSRN

Note: No experimental confirmation available.
Show »
Length:753
Mass (Da):84,972
Checksum:i85CCBDA2B3E9F565
GO
Isoform 3 (identifier: Q94361-3) [UniParc]FASTAAdd to basket
Also known as: g

The sequence of this isoform differs from the canonical sequence as follows:
     85-206: Missing.
     661-661: Missing.
     763-780: GAFAYYPPQYPQQQYRQN → DTNNIQPPRILSMAEIQANASRLLVNGHLMIDHSGVTMRNPRGSRN

Note: No experimental confirmation available.
Show »
Length:685
Mass (Da):77,038
Checksum:iC990B2D04BA784F6
GO
Isoform 4 (identifier: Q94361-4) [UniParc]FASTAAdd to basket
Also known as: e

The sequence of this isoform differs from the canonical sequence as follows:
     152-206: Missing.
     559-574: Missing.
     661-706: Missing.

Note: No experimental confirmation available.
Show »
Length:663
Mass (Da):75,455
Checksum:i08AC26EBFE72638D
GO
Isoform 5 (identifier: Q94361-5) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     152-206: Missing.
     661-706: Missing.

Note: No experimental confirmation available.
Show »
Length:679
Mass (Da):77,170
Checksum:i7820F23B0A04136A
GO
Isoform 6 (identifier: Q94361-6) [UniParc]FASTAAdd to basket
Also known as: d

The sequence of this isoform differs from the canonical sequence as follows:
     85-86: Missing.
     152-206: Missing.
     661-706: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):76,911
Checksum:i24B32E5E747C815E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02218585 – 206Missing in isoform 3. CuratedAdd BLAST122
Alternative sequenceiVSP_02218685 – 86Missing in isoform 6. Curated2
Alternative sequenceiVSP_022187152 – 206Missing in isoform 2, isoform 4, isoform 5 and isoform 6. CuratedAdd BLAST55
Alternative sequenceiVSP_022188559 – 574Missing in isoform 4. CuratedAdd BLAST16
Alternative sequenceiVSP_022189661 – 706Missing in isoform 4, isoform 5 and isoform 6. CuratedAdd BLAST46
Alternative sequenceiVSP_022190661Missing in isoform 3. Curated1
Alternative sequenceiVSP_022191763 – 780GAFAY…QYRQN → DTNNIQPPRILSMAEIQANA SRLLVNGHLMIDHSGVTMRN PRGSRN in isoform 2 and isoform 3. CuratedAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z79758 Genomic DNA Translation: CAB02133.4
Z79758 Genomic DNA Translation: CAB02134.3
Z79758 Genomic DNA Translation: CAB54321.3
Z79758 Genomic DNA Translation: CAD98729.3
Z79758 Genomic DNA Translation: CAD98730.3
Z79758 Genomic DNA Translation: CAI79179.3

Protein sequence database of the Protein Information Resource

More...
PIRi
T26330
T26331
T26332

NCBI Reference Sequences

More...
RefSeqi
NP_001021677.3, NM_001026506.3 [Q94361-4]
NP_001021678.3, NM_001026507.3 [Q94361-2]
NP_001021679.3, NM_001026508.3 [Q94361-3]
NP_492442.3, NM_060041.3 [Q94361-5]
NP_492443.3, NM_060042.3 [Q94361-6]
NP_492444.4, NM_060043.4 [Q94361-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W10D5.3a.1; W10D5.3a.1; WBGene00001574 [Q94361-5]
W10D5.3a.2; W10D5.3a.2; WBGene00001574 [Q94361-5]
W10D5.3a.3; W10D5.3a.3; WBGene00001574 [Q94361-5]
W10D5.3a.4; W10D5.3a.4; WBGene00001574 [Q94361-5]
W10D5.3c.1; W10D5.3c.1; WBGene00001574 [Q94361-1]
W10D5.3c.2; W10D5.3c.2; WBGene00001574 [Q94361-1]
W10D5.3c.3; W10D5.3c.3; WBGene00001574 [Q94361-1]
W10D5.3d.1; W10D5.3d.1; WBGene00001574 [Q94361-6]
W10D5.3e.1; W10D5.3e.1; WBGene00001574 [Q94361-4]
W10D5.3e.2; W10D5.3e.2; WBGene00001574 [Q94361-4]
W10D5.3e.3; W10D5.3e.3; WBGene00001574 [Q94361-4]
W10D5.3e.4; W10D5.3e.4; WBGene00001574 [Q94361-4]
W10D5.3f.1; W10D5.3f.1; WBGene00001574 [Q94361-2]
W10D5.3f.2; W10D5.3f.2; WBGene00001574 [Q94361-2]
W10D5.3f.3; W10D5.3f.3; WBGene00001574 [Q94361-2]
W10D5.3f.4; W10D5.3f.4; WBGene00001574 [Q94361-2]
W10D5.3g.1; W10D5.3g.1; WBGene00001574 [Q94361-3]
W10D5.3g.2; W10D5.3g.2; WBGene00001574 [Q94361-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172733

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W10D5.3

UCSC genome browser

More...
UCSCi
W10D5.3f c. elegans [Q94361-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79758 Genomic DNA Translation: CAB02133.4
Z79758 Genomic DNA Translation: CAB02134.3
Z79758 Genomic DNA Translation: CAB54321.3
Z79758 Genomic DNA Translation: CAD98729.3
Z79758 Genomic DNA Translation: CAD98730.3
Z79758 Genomic DNA Translation: CAI79179.3
PIRiT26330
T26331
T26332
RefSeqiNP_001021677.3, NM_001026506.3 [Q94361-4]
NP_001021678.3, NM_001026507.3 [Q94361-2]
NP_001021679.3, NM_001026508.3 [Q94361-3]
NP_492442.3, NM_060041.3 [Q94361-5]
NP_492443.3, NM_060042.3 [Q94361-6]
NP_492444.4, NM_060043.4 [Q94361-1]

3D structure databases

SMRiQ94361
ModBaseiSearch...

Protein-protein interaction databases

BioGridi38164, 4 interactors
DIPiDIP-24916N
IntActiQ94361, 9 interactors
STRINGi6239.W10D5.3c.1

Proteomic databases

EPDiQ94361
PaxDbiQ94361
PeptideAtlasiQ94361
PRIDEiQ94361

Genome annotation databases

EnsemblMetazoaiW10D5.3a.1; W10D5.3a.1; WBGene00001574 [Q94361-5]
W10D5.3a.2; W10D5.3a.2; WBGene00001574 [Q94361-5]
W10D5.3a.3; W10D5.3a.3; WBGene00001574 [Q94361-5]
W10D5.3a.4; W10D5.3a.4; WBGene00001574 [Q94361-5]
W10D5.3c.1; W10D5.3c.1; WBGene00001574 [Q94361-1]
W10D5.3c.2; W10D5.3c.2; WBGene00001574 [Q94361-1]
W10D5.3c.3; W10D5.3c.3; WBGene00001574 [Q94361-1]
W10D5.3d.1; W10D5.3d.1; WBGene00001574 [Q94361-6]
W10D5.3e.1; W10D5.3e.1; WBGene00001574 [Q94361-4]
W10D5.3e.2; W10D5.3e.2; WBGene00001574 [Q94361-4]
W10D5.3e.3; W10D5.3e.3; WBGene00001574 [Q94361-4]
W10D5.3e.4; W10D5.3e.4; WBGene00001574 [Q94361-4]
W10D5.3f.1; W10D5.3f.1; WBGene00001574 [Q94361-2]
W10D5.3f.2; W10D5.3f.2; WBGene00001574 [Q94361-2]
W10D5.3f.3; W10D5.3f.3; WBGene00001574 [Q94361-2]
W10D5.3f.4; W10D5.3f.4; WBGene00001574 [Q94361-2]
W10D5.3g.1; W10D5.3g.1; WBGene00001574 [Q94361-3]
W10D5.3g.2; W10D5.3g.2; WBGene00001574 [Q94361-3]
GeneIDi172733
KEGGicel:CELE_W10D5.3
UCSCiW10D5.3f c. elegans [Q94361-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172733
WormBaseiW10D5.3a ; CE46915 ; WBGene00001574 ; gei-17
W10D5.3c ; CE46906 ; WBGene00001574 ; gei-17
W10D5.3d ; CE46859 ; WBGene00001574 ; gei-17
W10D5.3e ; CE47019 ; WBGene00001574 ; gei-17
W10D5.3f ; CE46965 ; WBGene00001574 ; gei-17
W10D5.3g ; CE46934 ; WBGene00001574 ; gei-17

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00950000182717
HOGENOMiHOG000019659
InParanoidiQ94361
KOiK04706
OMAiQTTTWLC
OrthoDBi1131748at2759

Enzyme and pathway databases

UniPathwayiUPA00886
ReactomeiR-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232118 SUMOylation of transcription factors
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3899300 SUMOylation of transcription cofactors
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4090294 SUMOylation of intracellular receptors
R-CEL-4551638 SUMOylation of chromatin organization proteins
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-5696395 Formation of Incision Complex in GG-NER
R-CEL-877312 Regulation of IFNG signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q94361

Gene expression databases

BgeeiWBGene00001574 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di2.60.120.780, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR023321 PINIT
IPR038654 PINIT_sf
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF14324 PINIT, 1 hit
PF02891 zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51466 PINIT, 1 hit
PS51044 ZF_SP_RING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGEI17_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q94361
Secondary accession number(s): Q564X2
, Q7Z0X3, Q7Z0X4, Q94363, Q9U326
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 3, 2012
Last modified: November 13, 2019
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again