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Entry version 172 (08 May 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Myocardin-related transcription factor A

Gene

MRTFA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-5663220 RHO GTPases Activate Formins

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q969V6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myocardin-related transcription factor ACurated
Short name:
MRTF-ACurated
Alternative name(s):
MKL/myocardin-like protein 11 Publication
Megakaryoblastic leukemia 1 protein1 Publication
Megakaryocytic acute leukemia proteinBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRTFAImported
Synonyms:KIAA14381 Publication, MALBy similarity, MKL11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14334 MRTFA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606078 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q969V6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MRTFA may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with RBM15 (PubMed:11431691, PubMed:11344311). Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MRTFA chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene (PubMed:11431691, PubMed:11344311).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3 – 4Breakpoint for translocation to form RBM15-MRTFA1 Publication2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
57591

MalaCards human disease database

More...
MalaCardsi
MKL1

Open Targets

More...
OpenTargetsi
ENSG00000196588

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
402023 Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30827

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB08080 LATRUNCULIN B

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MKL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32363202

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001266251 – 931Myocardin-related transcription factor AAdd BLAST931

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
Modified residuei124PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei156PhosphoserineCombined sources1
Modified residuei305PhosphothreonineCombined sources1
Modified residuei310PhosphoserineBy similarity1
Modified residuei312PhosphoserineBy similarity1
Modified residuei313PhosphothreonineBy similarity1
Modified residuei317PhosphoserineBy similarity1
Modified residuei320PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei446PhosphoserineBy similarity1
Modified residuei447PhosphothreonineBy similarity1
Modified residuei449PhosphoserineBy similarity1
Modified residuei450PhosphothreonineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei456PhosphothreonineBy similarity1
Modified residuei458PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei492PhosphoserineBy similarity1
Modified residuei507PhosphoserineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei685PhosphoserineBy similarity1
Modified residuei691PhosphoserineBy similarity1
Modified residuei695PhosphoserineBy similarity1
Modified residuei792PhosphoserineBy similarity1
Modified residuei807PhosphoserineBy similarity1
Modified residuei859PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-6 by Erk inhibits binding of globular actin (G-actin), unmasking the nuclear localization signal (NLS) and promoting nuclear import.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q969V6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q969V6

MaxQB - The MaxQuant DataBase

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MaxQBi
Q969V6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q969V6

PeptideAtlas

More...
PeptideAtlasi
Q969V6

PRoteomics IDEntifications database

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PRIDEi
Q969V6

ProteomicsDB human proteome resource

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ProteomicsDBi
75854

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q969V6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q969V6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196588 Expressed in 205 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q969V6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q969V6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030782

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SRF, forming the SRF-MRTFA nuclear complex which binds the 5'-CArG-3' consensus motif (CArG box) on DNA via SRF (PubMed:14565952, PubMed:19350017). Interacts (via RPEL repeats) with globular actin (G-actin), thereby regulating its subcellular location and activity of the complex formed with SRF (PubMed:19350017). Either forms a trivalent (by binding three G-actin monomers) or pentavalent (by binding five G-actin monomers) complex with G-actin (By similarity). Forms a nuclear ternary complex with SCAI and SRF, leading to suppress MRTFA-induced SRF transcriptional activity (PubMed:19350017). Interacts with beta-actin (ACTB); interaction with ACTB prevents interaction with SCAI (By similarity). Interacts with MRTFB (PubMed:14565952).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SRFP118312EBI-493122,EBI-493034

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121642, 24 interactors

Protein interaction database and analysis system

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IntActi
Q969V6, 13 interactors

Molecular INTeraction database

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MINTi
Q969V6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347847

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1931
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KVUNMR-A336-396[»]
2KW9NMR-A336-396[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q969V6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q969V6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati24 – 49RPEL 1Add BLAST26
Repeati68 – 93RPEL 2Add BLAST26
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini347 – 381SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 256Mediates interaction with SCAI and ACTBBy similarityAdd BLAST256
Regioni6 – 23Intervening spacer sequence 1By similarityAdd BLAST18
Regioni50 – 67Intervening spacer sequence 2By similarityAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili515 – 563Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi264 – 286Gln-richAdd BLAST23
Compositional biasi564 – 811Pro-richAdd BLAST248

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity.By similarity
The RPEL repeats mediate binding to globular actin (G-actin); each RPEL repeat-binding to one G-actin monomer. In addition, each intervening spacer sequence region can bind one G-actin monomer, to reach a pentavalent complex.By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFJX Eukaryota
ENOG41101AM LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182979

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000038001

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q969V6

KEGG Orthology (KO)

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KOi
K22525

Database of Orthologous Groups

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OrthoDBi
190145at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q969V6

TreeFam database of animal gene trees

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TreeFami
TF326024

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029992 MRTF-A
IPR004018 RPEL_repeat
IPR003034 SAP_dom
IPR036361 SAP_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR22793:SF6 PTHR22793:SF6, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02755 RPEL, 2 hits
PF02037 SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00707 RPEL, 2 hits
SM00513 SAP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF68906 SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51073 RPEL, 2 hits
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q969V6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPLKSPAAF HEQRRSLERA RTEDYLKRKI RSRPERSELV RMHILEETSA
60 70 80 90 100
EPSLQAKQLK LKRARLADDL NEKIAQRPGP MELVEKNILP VESSLKEAII
110 120 130 140 150
VGQVNYPKVA DSSSFDEDSS DALSPEQPAS HESQGSVPSP LEARVSEPLL
160 170 180 190 200
SATSASPTQV VSQLPMGRDS REMLFLAEQP PLPPPPLLPP SLTNGTTIPT
210 220 230 240 250
AKSTPTLIKQ SQPKSASEKS QRSKKAKELK PKVKKLKYHQ YIPPDQKQDR
260 270 280 290 300
GAPPMDSSYA KILQQQQLFL QLQILNQQQQ QHHNYQAILP APPKSAGEAL
310 320 330 340 350
GSSGTPPVRS LSTTNSSSSS GAPGPCGLAR QNSTSLTGKP GALPANLDDM
360 370 380 390 400
KVAELKQELK LRSLPVSGTK TELIERLRAY QDQISPVPGA PKAPAATSIL
410 420 430 440 450
HKAGEVVVAF PAARLSTGPA LVAAGLAPAE VVVATVASSG VVKFGSTGST
460 470 480 490 500
PPVSPTPSER SLLSTGDENS TPGDTFGEMV TSPLTQLTLQ ASPLQILVKE
510 520 530 540 550
EGPRAGSCCL SPGGRAELEG RDKDQMLQEK DKQIEALTRM LRQKQQLVER
560 570 580 590 600
LKLQLEQEKR AQQPAPAPAP LGTPVKQENS FSSCQLSQQP LGPAHPFNPS
610 620 630 640 650
LAAPATNHID PCAVAPGPPS VVVKQEALQP EPEPVPAPQL LLGPQGPSLI
660 670 680 690 700
KGVAPPTLIT DSTGTHLVLT VTNKNADSPG LSSGSPQQPS SQPGSPAPAP
710 720 730 740 750
SAQMDLEHPL QPLFGTPTSL LKKEPPGYEE AMSQQPKQQE NGSSSQQMDD
760 770 780 790 800
LFDILIQSGE ISADFKEPPS LPGKEKPSPK TVCGSPLAAQ PSPSAELPQA
810 820 830 840 850
APPPPGSPSL PGRLEDFLES STGLPLLTSG HDGPEPLSLI DDLHSQMLSS
860 870 880 890 900
TAILDHPPSP MDTSELHFVP EPSSTMGLDL ADGHLDSMDW LELSSGGPVL
910 920 930
SLAPLSTTAP SLFSTDFLDG HDLQLHWDSC L
Length:931
Mass (Da):98,919
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EDE5E2C56D89609
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QY84B0QY84_HUMAN
Phosphatase and actin regulator
MRTFA MKL1, hCG_41119
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QY74B0QY74_HUMAN
Phosphatase and actin regulator
MRTFA
73Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
W0Z7M9W0Z7M9_HUMAN
Mkl1 variant 1 Mkl1_S
MRTFA mkl1
966Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER32E7ER32_HUMAN
Myocardin-related transcription fac...
MRTFA
798Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QY83B0QY83_HUMAN
Myocardin-related transcription fac...
MRTFA
881Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X287A0A087X287_HUMAN
Myocardin-related transcription fac...
MRTFA
799Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU73A0A087WU73_HUMAN
Myocardin-related transcription fac...
MRTFA
882Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q29R68Q29R68_HUMAN
MKL1 protein
MRTFA MKL1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK56920 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA92676 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC38828 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC38829 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_021409648S → G2 PublicationsCorresponds to variant dbSNP:rs878756Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ297257 mRNA Translation: CAC38826.1
AF364035 mRNA Translation: AAK56920.1 Different initiation.
CR456522 mRNA Translation: CAG30408.1
AJ297258 mRNA Translation: CAC38827.1
AF368061 mRNA Translation: AAK54721.1
AJ303089 mRNA Translation: CAC38828.1 Different initiation.
AJ303090 mRNA Translation: CAC38829.1 Different initiation.
AB037859 mRNA Translation: BAA92676.2 Different initiation.
AL022238 Genomic DNA No translation available.
AL713710 mRNA Translation: CAD28507.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14003.1

NCBI Reference Sequences

More...
RefSeqi
NP_001269589.1, NM_001282660.1
NP_001269590.1, NM_001282661.1
NP_065882.1, NM_020831.4
XP_005261751.1, XM_005261694.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355630; ENSP00000347847; ENSG00000196588
ENST00000407029; ENSP00000385835; ENSG00000196588

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57591

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57591

UCSC genome browser

More...
UCSCi
uc003ayv.3 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297257 mRNA Translation: CAC38826.1
AF364035 mRNA Translation: AAK56920.1 Different initiation.
CR456522 mRNA Translation: CAG30408.1
AJ297258 mRNA Translation: CAC38827.1
AF368061 mRNA Translation: AAK54721.1
AJ303089 mRNA Translation: CAC38828.1 Different initiation.
AJ303090 mRNA Translation: CAC38829.1 Different initiation.
AB037859 mRNA Translation: BAA92676.2 Different initiation.
AL022238 Genomic DNA No translation available.
AL713710 mRNA Translation: CAD28507.2
CCDSiCCDS14003.1
RefSeqiNP_001269589.1, NM_001282660.1
NP_001269590.1, NM_001282661.1
NP_065882.1, NM_020831.4
XP_005261751.1, XM_005261694.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KVUNMR-A336-396[»]
2KW9NMR-A336-396[»]
SMRiQ969V6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121642, 24 interactors
IntActiQ969V6, 13 interactors
MINTiQ969V6
STRINGi9606.ENSP00000347847

Chemistry databases

DrugBankiDB08080 LATRUNCULIN B

PTM databases

iPTMnetiQ969V6
PhosphoSitePlusiQ969V6

Polymorphism and mutation databases

BioMutaiMKL1
DMDMi32363202

Proteomic databases

EPDiQ969V6
jPOSTiQ969V6
MaxQBiQ969V6
PaxDbiQ969V6
PeptideAtlasiQ969V6
PRIDEiQ969V6
ProteomicsDBi75854

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57591
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355630; ENSP00000347847; ENSG00000196588
ENST00000407029; ENSP00000385835; ENSG00000196588
GeneIDi57591
KEGGihsa:57591
UCSCiuc003ayv.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57591
DisGeNETi57591

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MKL1
HGNCiHGNC:14334 MRTFA
HPAiHPA030782
MalaCardsiMKL1
MIMi606078 gene
neXtProtiNX_Q969V6
OpenTargetsiENSG00000196588
Orphaneti402023 Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)
PharmGKBiPA30827

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFJX Eukaryota
ENOG41101AM LUCA
GeneTreeiENSGT00950000182979
HOGENOMiHOG000038001
InParanoidiQ969V6
KOiK22525
OrthoDBi190145at2759
PhylomeDBiQ969V6
TreeFamiTF326024

Enzyme and pathway databases

ReactomeiR-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-5663220 RHO GTPases Activate Formins
SIGNORiQ969V6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MKL1 human
EvolutionaryTraceiQ969V6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MKL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57591

Protein Ontology

More...
PROi
PR:Q969V6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196588 Expressed in 205 organ(s), highest expression level in blood
ExpressionAtlasiQ969V6 baseline and differential
GenevisibleiQ969V6 HS

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR029992 MRTF-A
IPR004018 RPEL_repeat
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PANTHERiPTHR22793:SF6 PTHR22793:SF6, 1 hit
PfamiView protein in Pfam
PF02755 RPEL, 2 hits
PF02037 SAP, 1 hit
SMARTiView protein in SMART
SM00707 RPEL, 2 hits
SM00513 SAP, 1 hit
SUPFAMiSSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS51073 RPEL, 2 hits
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRTFA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q969V6
Secondary accession number(s): Q8TCL1
, Q96SC5, Q96SC6, Q9P2B0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: December 1, 2001
Last modified: May 8, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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