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Entry version 144 (18 Sep 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Adiponectin receptor protein 1

Gene

ADIPOR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi191Zinc1 Publication1
Metal bindingi337Zinc1 Publication1
Metal bindingi341Zinc1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processFatty acid metabolism, Lipid metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96A54

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.113.1.9 the hly iii (hly iii) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adiponectin receptor protein 11 Publication
Alternative name(s):
Progestin and adipoQ receptor family member 11 Publication
Progestin and adipoQ receptor family member I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADIPOR1Imported
Synonyms:PAQR11 Publication, TESBP1A
ORF Names:CGI-45
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24040 ADIPOR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607945 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96A54

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 136Cytoplasmic1 PublicationAdd BLAST136
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei137 – 157Helical; Name=11 PublicationAdd BLAST21
Topological domaini158 – 170Extracellular1 PublicationAdd BLAST13
Transmembranei171 – 191Helical; Name=21 PublicationAdd BLAST21
Topological domaini192 – 203Cytoplasmic1 PublicationAdd BLAST12
Transmembranei204 – 224Helical; Name=31 PublicationAdd BLAST21
Topological domaini225 – 234Extracellular1 Publication10
Transmembranei235 – 255Helical; Name=41 PublicationAdd BLAST21
Topological domaini256 – 264Cytoplasmic1 Publication9
Transmembranei265 – 285Helical; Name=51 PublicationAdd BLAST21
Topological domaini286 – 298Extracellular1 PublicationAdd BLAST13
Transmembranei299 – 319Helical; Name=61 PublicationAdd BLAST21
Topological domaini320 – 337Cytoplasmic1 PublicationAdd BLAST18
Transmembranei338 – 358Helical; Name=71 PublicationAdd BLAST21
Topological domaini359 – 375Extracellular1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi161 – 167MYFMAPL → SGSSGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 229-G--G-231 and 291-S--S-297. 1 Publication7
Mutagenesisi191H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-208; A-337 and A-341. 1 Publication1
Mutagenesisi208D → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-337 and A-341. 1 Publication1
Mutagenesisi229 – 231YCS → GGG: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 291-S--S-297. 1 Publication3
Mutagenesisi291 – 297FVKATTV → SSSGGGS: Decreases activation of AMPK in response to ADIPOQ binding; when associated with 161-S--S-167 and 229-G--G-231. 1 Publication7
Mutagenesisi337H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-341. 1 Publication1
Mutagenesisi341H → A: Decreases activation of AMPK in response to ADIPOQ binding; when associated with A-191; A-208 and A-337. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51094

Open Targets

More...
OpenTargetsi
ENSG00000159346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134861801

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3392946

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADIPOR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38372248

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002188271 – 375Adiponectin receptor protein 1Add BLAST375

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96A54

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96A54

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96A54

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96A54

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96A54

PeptideAtlas

More...
PeptideAtlasi
Q96A54

PRoteomics IDEntifications database

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PRIDEi
Q96A54

ProteomicsDB human proteome resource

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ProteomicsDBi
75913

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96A54

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96A54

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337). Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337). Weakly expressed in colon, thymus and small intestine (PubMed:12802337).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159346 Expressed in 226 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96A54 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96A54 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homooligomers and heterooligomers with ADIPOR2 (PubMed:12802337).

Interacts with APPL2 (via BAR domain); hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1.

Interacts with APPL1; ADIPOQ enhances this interaction; inhibites adiponectin-stimulated binding of APPL2 to ADIPOR1 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119283, 25 interactors

Database of interacting proteins

More...
DIPi
DIP-48622N

Protein interaction database and analysis system

More...
IntActi
Q96A54, 24 interactors

Molecular INTeraction database

More...
MINTi
Q96A54

STRING: functional protein association networks

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STRINGi
9606.ENSP00000341785

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q96A54

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96A54

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0748 Eukaryota
COG1272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154563

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000197115

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96A54

KEGG Orthology (KO)

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KOi
K07297

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYCGIAM

Database of Orthologous Groups

More...
OrthoDBi
1524940at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96A54

TreeFam database of animal gene trees

More...
TreeFami
TF313640

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004254 AdipoR/HlyIII-related

The PANTHER Classification System

More...
PANTHERi
PTHR20855 PTHR20855, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03006 HlyIII, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96A54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE
60 70 80 90 100
EQTCPVPQEE EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL
110 120 130 140 150
PDWLKDNDYL LHGHRPPMPS FRACFKSIFR IHTETGNIWT HLLGFVLFLF
160 170 180 190 200
LGILTMLRPN MYFMAPLQEK VVFGMFFLGA VLCLSFSWLF HTVYCHSEKV
210 220 230 240 250
SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS IVCVLGISAI
260 270 280 290 300
IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM
310 320 330 340 350
GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV
360 370
HFYGVSNLQE FRYGLEGGCT DDTLL
Length:375
Mass (Da):42,616
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CC0300A7D178EB0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0W7C9J0W7_HUMAN
Adiponectin receptor protein 1
ADIPOR1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNM5C9JNM5_HUMAN
Adiponectin receptor protein 1
ADIPOR1
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W782F8W782_HUMAN
Adiponectin receptor protein 1
ADIPOR1
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34040 differs from that shown. Reason: Frameshift at position 369.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti183C → W in BAG50922 (PubMed:14702039).Curated1
Sequence conflicti340F → Y in BAD96223 (Ref. 5) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY424279 mRNA Translation: AAR08367.1
AF125179 mRNA Translation: AAQ13552.1
AF151803 mRNA Translation: AAD34040.1 Frameshift.
AK001484 mRNA Translation: BAG50922.1
AK222503 mRNA Translation: BAD96223.1
CH471067 Genomic DNA Translation: EAW91450.1
BC001594 mRNA Translation: AAH01594.1
BC010743 mRNA Translation: AAH10743.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1430.1

NCBI Reference Sequences

More...
RefSeqi
NP_001277482.1, NM_001290553.1
NP_001277486.1, NM_001290557.1
NP_001277558.1, NM_001290629.1
NP_057083.2, NM_015999.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340990; ENSP00000341785; ENSG00000159346

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51094

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51094

UCSC genome browser

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UCSCi
uc001gyq.7 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424279 mRNA Translation: AAR08367.1
AF125179 mRNA Translation: AAQ13552.1
AF151803 mRNA Translation: AAD34040.1 Frameshift.
AK001484 mRNA Translation: BAG50922.1
AK222503 mRNA Translation: BAD96223.1
CH471067 Genomic DNA Translation: EAW91450.1
BC001594 mRNA Translation: AAH01594.1
BC010743 mRNA Translation: AAH10743.1
CCDSiCCDS1430.1
RefSeqiNP_001277482.1, NM_001290553.1
NP_001277486.1, NM_001290557.1
NP_001277558.1, NM_001290629.1
NP_057083.2, NM_015999.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXVX-ray2.90A89-375[»]
5LXGX-ray2.73A89-375[»]
SMRiQ96A54
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119283, 25 interactors
DIPiDIP-48622N
IntActiQ96A54, 24 interactors
MINTiQ96A54
STRINGi9606.ENSP00000341785

Chemistry databases

BindingDBiQ96A54
ChEMBLiCHEMBL3392946

Protein family/group databases

TCDBi1.C.113.1.9 the hly iii (hly iii) family

PTM databases

iPTMnetiQ96A54
PhosphoSitePlusiQ96A54

Polymorphism and mutation databases

BioMutaiADIPOR1
DMDMi38372248

Proteomic databases

EPDiQ96A54
jPOSTiQ96A54
MassIVEiQ96A54
MaxQBiQ96A54
PaxDbiQ96A54
PeptideAtlasiQ96A54
PRIDEiQ96A54
ProteomicsDBi75913

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q96A54

The DNASU plasmid repository

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DNASUi
51094
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340990; ENSP00000341785; ENSG00000159346
GeneIDi51094
KEGGihsa:51094
UCSCiuc001gyq.7 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51094
DisGeNETi51094

GeneCards: human genes, protein and diseases

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GeneCardsi
ADIPOR1
HGNCiHGNC:24040 ADIPOR1
MIMi607945 gene
neXtProtiNX_Q96A54
OpenTargetsiENSG00000159346
PharmGKBiPA134861801

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00940000154563
HOGENOMiHOG000197115
InParanoidiQ96A54
KOiK07297
OMAiDYCGIAM
OrthoDBi1524940at2759
PhylomeDBiQ96A54
TreeFamiTF313640

Enzyme and pathway databases

ReactomeiR-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
SIGNORiQ96A54

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADIPOR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ADIPOR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51094

Pharos

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Pharosi
Q96A54

Protein Ontology

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PROi
PR:Q96A54

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000159346 Expressed in 226 organ(s), highest expression level in blood
ExpressionAtlasiQ96A54 baseline and differential
GenevisibleiQ96A54 HS

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAQR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96A54
Secondary accession number(s): B3KMB0
, Q53HS7, Q53YY6, Q9Y360
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: December 1, 2001
Last modified: September 18, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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