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Entry version 127 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Tumor protein p53-inducible nuclear protein 1

Gene

TP53INP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Antioxidant
Biological processApoptosis, Autophagy, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96A56

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor protein p53-inducible nuclear protein 1
Alternative name(s):
Stress-induced protein
p53-dependent damage-inducible nuclear protein 1
Short name:
p53DINP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TP53INP1
Synonyms:P53DINP1, SIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18022 TP53INP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606185 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96A56

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
94241

Open Targets

More...
OpenTargetsi
ENSG00000164938

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38278

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96A56

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TP53INP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61216823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724061 – 240Tumor protein p53-inducible nuclear protein 1Add BLAST240

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96A56

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96A56

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96A56

PeptideAtlas

More...
PeptideAtlasi
Q96A56

PRoteomics IDEntifications database

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PRIDEi
Q96A56

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
75914 [Q96A56-1]
75915 [Q96A56-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96A56

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96A56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By adriamycin, gamma irradiation and H2O2, in a p53/TP53-dependent way. At lower levels by UV irradiation. By TP73.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164938 Expressed in 202 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96A56 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96A56 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005856

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with p53/TP53 and HIPK2.

Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B AND MAP1LC3C.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125152, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q96A56, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344215

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi25 – 37LIRAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 17Poly-Ser4
Compositional biasi20 – 61Glu-richAdd BLAST42

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9V Eukaryota
ENOG4111S9D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063829

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010288

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96A56

KEGG Orthology (KO)

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KOi
K15310

Identification of Orthologs from Complete Genome Data

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OMAi
DCHSRQI

Database of Orthologous Groups

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OrthoDBi
616989at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96A56

TreeFam database of animal gene trees

More...
TreeFami
TF333017

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029431 TP53INP
IPR029556 TP53INP1

The PANTHER Classification System

More...
PANTHERi
PTHR31671 PTHR31671, 1 hit
PTHR31671:SF0 PTHR31671:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14839 DOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q96A56-1) [UniParc]FASTAAdd to basket
Also known as: p53DINP1a, alpha, SIP27, TEAP

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQRLNKMFV GEVSSSSNQE PEFNEKEDDE WILVDFIDTC TGFSAEEEEE
60 70 80 90 100
EEDISEESPT EHPSVFSCLP ASLECLADTS DSCFLQFESC PMEESWFITP
110 120 130 140 150
PPCFTAGGLT TIKVETSPME NLLIEHPSMS VYAVHNSCPG LSEATRGTDE
160 170 180 190 200
LHSPSSPRVE AQNEMGQHIH CYVAALAAHT TFLEQPKSFR PSQWIKEHSE
210 220 230 240
RQPLNRNSLR RQNLTRDCHP RQVKHNGWVV HQPCPRQYNY
Length:240
Mass (Da):27,366
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1950D66EDDB4A186
GO
Isoform 2 (identifier: Q96A56-2) [UniParc]FASTAAdd to basket
Also known as: p53DINP1b, beta, SIP18

The sequence of this isoform differs from the canonical sequence as follows:
     159-240: VEAQNEMGQH...HQPCPRQYNY → ARKSCL

Show »
Length:164
Mass (Da):18,244
Checksum:i8C5B27F2CFB47B8E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05140475C → R. Corresponds to variant dbSNP:rs11991800Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013176159 – 240VEAQN…RQYNY → ARKSCL in isoform 2. 2 PublicationsAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017926 mRNA Translation: BAB62149.1
AB017927 mRNA Translation: BAB62150.1
AB062056 Genomic DNA Translation: BAB62151.1
AB062056 Genomic DNA Translation: BAB62152.1
AF409114 mRNA Translation: AAL04513.1
AF409115 mRNA Translation: AAL04514.1
AK315071 mRNA Translation: BAG37542.1
CH471060 Genomic DNA Translation: EAW91740.1
BC074813 mRNA Translation: AAH74813.1
BC074868 mRNA Translation: AAH74868.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47899.1 [Q96A56-2]
CCDS6265.1 [Q96A56-1]

NCBI Reference Sequences

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RefSeqi
NP_001129205.1, NM_001135733.1 [Q96A56-2]
NP_150601.1, NM_033285.3 [Q96A56-1]
XP_011515688.1, XM_011517386.2 [Q96A56-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342697; ENSP00000344215; ENSG00000164938 [Q96A56-1]
ENST00000448464; ENSP00000390063; ENSG00000164938 [Q96A56-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
94241

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:94241

UCSC genome browser

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UCSCi
uc003yhg.4 human [Q96A56-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017926 mRNA Translation: BAB62149.1
AB017927 mRNA Translation: BAB62150.1
AB062056 Genomic DNA Translation: BAB62151.1
AB062056 Genomic DNA Translation: BAB62152.1
AF409114 mRNA Translation: AAL04513.1
AF409115 mRNA Translation: AAL04514.1
AK315071 mRNA Translation: BAG37542.1
CH471060 Genomic DNA Translation: EAW91740.1
BC074813 mRNA Translation: AAH74813.1
BC074868 mRNA Translation: AAH74868.1
CCDSiCCDS47899.1 [Q96A56-2]
CCDS6265.1 [Q96A56-1]
RefSeqiNP_001129205.1, NM_001135733.1 [Q96A56-2]
NP_150601.1, NM_033285.3 [Q96A56-1]
XP_011515688.1, XM_011517386.2 [Q96A56-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125152, 13 interactors
IntActiQ96A56, 12 interactors
STRINGi9606.ENSP00000344215

PTM databases

iPTMnetiQ96A56
PhosphoSitePlusiQ96A56

Polymorphism and mutation databases

BioMutaiTP53INP1
DMDMi61216823

Proteomic databases

jPOSTiQ96A56
MassIVEiQ96A56
PaxDbiQ96A56
PeptideAtlasiQ96A56
PRIDEiQ96A56
ProteomicsDBi75914 [Q96A56-1]
75915 [Q96A56-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
94241

Genome annotation databases

EnsembliENST00000342697; ENSP00000344215; ENSG00000164938 [Q96A56-1]
ENST00000448464; ENSP00000390063; ENSG00000164938 [Q96A56-2]
GeneIDi94241
KEGGihsa:94241
UCSCiuc003yhg.4 human [Q96A56-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94241
DisGeNETi94241

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TP53INP1
HGNCiHGNC:18022 TP53INP1
HPAiHPA005856
MIMi606185 gene
neXtProtiNX_Q96A56
OpenTargetsiENSG00000164938
PharmGKBiPA38278

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ9V Eukaryota
ENOG4111S9D LUCA
GeneTreeiENSGT00530000063829
HOGENOMiHOG000010288
InParanoidiQ96A56
KOiK15310
OMAiDCHSRQI
OrthoDBi616989at2759
PhylomeDBiQ96A56
TreeFamiTF333017

Enzyme and pathway databases

ReactomeiR-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
SIGNORiQ96A56

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TP53INP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TP53INP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
94241
PharosiQ96A56

Protein Ontology

More...
PROi
PR:Q96A56

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164938 Expressed in 202 organ(s), highest expression level in female gonad
ExpressionAtlasiQ96A56 baseline and differential
GenevisibleiQ96A56 HS

Family and domain databases

InterProiView protein in InterPro
IPR029431 TP53INP
IPR029556 TP53INP1
PANTHERiPTHR31671 PTHR31671, 1 hit
PTHR31671:SF0 PTHR31671:SF0, 1 hit
PfamiView protein in Pfam
PF14839 DOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT53I1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96A56
Secondary accession number(s): B2RCE5, Q969R9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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