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Entry version 179 (18 Sep 2019)
Sequence version 2 (28 Mar 2003)
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Protein

Probable ATP-dependent RNA helicase DDX27

Gene

DDX27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154).1 Publication

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi262 – 269ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX27 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX27
Synonyms:cPERP-F1 Publication, RHLP
ORF Names:HSPC259, PP3241
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15837 DDX27

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616621 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96GQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86 – 88Missing : No interaction with PEBOW complex. 1 Publication3

Organism-specific databases

DisGeNET

More...
DisGeNETi
55661

Open Targets

More...
OpenTargetsi
ENSG00000124228

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27213

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDX27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
29427946

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000550311 – 796Probable ATP-dependent RNA helicase DDX27Add BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei54PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96GQ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96GQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q96GQ7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96GQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96GQ7

PeptideAtlas

More...
PeptideAtlasi
Q96GQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q96GQ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
76655

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q96GQ7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96GQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96GQ7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96GQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124228 Expressed in 234 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96GQ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96GQ7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047087

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:25825154).

Interacts directly with BOP1 and PES1 (PubMed:25825154).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120793, 127 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96GQ7

Protein interaction database and analysis system

More...
IntActi
Q96GQ7, 53 interactors

Molecular INTeraction database

More...
MINTi
Q96GQ7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483495

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q96GQ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini249 – 423Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini457 – 603Helicase C-terminalPROSITE-ProRule annotationAdd BLAST147

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi86 – 88Required for interaction with the PEBOW complex1 Publication3
Motifi195 – 200Nuclear localization signalSequence analysis6
Motifi218 – 246Q motifAdd BLAST29
Motifi371 – 374DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi44 – 200Asp/Glu/Lys-richAdd BLAST157

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain regulates nucleolar localization (PubMed:25825154).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0338 Eukaryota
COG0513 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074997

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96GQ7

KEGG Orthology (KO)

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KOi
K13181

Database of Orthologous Groups

More...
OrthoDBi
268859at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96GQ7

TreeFam database of animal gene trees

More...
TreeFami
TF314780

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q96GQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLAQRRRGG CEKLRAGPQA VLASGSGFCD NMLADLGLIG TIGEDDEVPV
60 70 80 90 100
EPESDSGDEE EEGPIVLGRR QKALGKNRSA DFNPDFVFTE KEGTYDGSWA
110 120 130 140 150
LADVMSQLKK KRAATTLDEK IEKVRKKRKT EDKEAKSGKL EKEKEAKEGS
160 170 180 190 200
EPKEQEDLQE NDEEGSEDEA SETDYSSADE NILTKADTLK VKDRKKKKKK
210 220 230 240 250
GQEAGGFFED ASQYDENLSF QDMNLSRPLL KAITAMGFKQ PTPIQKACIP
260 270 280 290 300
VGLLGKDICA CAATGTGKTA AFALPVLERL IYKPRQAPVT RVLVLVPTRE
310 320 330 340 350
LGIQVHSVTR QLAQFCNITT CLAVGGLDVK SQEAALRAAP DILIATPGRL
360 370 380 390 400
IDHLHNCPSF HLSSIEVLIL DEADRMLDEY FEEQMKEIIR MCSHHRQTML
410 420 430 440 450
FSATMTDEVK DLASVSLKNP VRIFVNSNTD VAPFLRQEFI RIRPNREGDR
460 470 480 490 500
EAIVAALLTR TFTDHVMLFT QTKKQAHRMH ILLGLMGLQV GELHGNLSQT
510 520 530 540 550
QRLEALRRFK DEQIDILVAT DVAARGLDIE GVKTVINFTM PNTIKHYVHR
560 570 580 590 600
VGRTARAGRA GRSVSLVGED ERKMLKEIVK AAKAPVKARI LPQDVILKFR
610 620 630 640 650
DKIEKMEKDV YAVLQLEAEE KEMQQSEAQI NTAKRLLEKG KEAVVQEPER
660 670 680 690 700
SWFQTKEERK KEKIAKALQE FDLALRGKKK RKKFMKDAKK KGEMTAEERS
710 720 730 740 750
QFEILKAQMF AERLAKRNRR AKRARAMPEE EPVRGPAKKQ KQGKKSVFDE
760 770 780 790
ELTNTSKKAL KQYRAGPSFE ERKQLGLPHQ RRGGNFKSKS RYKRRK
Length:796
Mass (Da):89,835
Last modified:March 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9282C712B8F8B84A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z6D5B7Z6D5_HUMAN
Probable ATP-dependent RNA helicase...
DDX27
765Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X059A0A087X059_HUMAN
Probable ATP-dependent RNA helicase...
DDX27
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYH5A0A087WYH5_HUMAN
Probable ATP-dependent RNA helicase...
DDX27
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF28937 differs from that shown. Sequencing errors.Curated
The sequence AAF28937 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAG22482 differs from that shown. Reason: Frameshift at positions 208, 427, 434 and 532.Curated
The sequence AAH16060 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91284 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14343 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti482L → F in AAK21271 (Ref. 1) Curated1
Sequence conflicti542N → S in BAA91284 (PubMed:14702039).Curated1
Sequence conflicti548V → D in AAK95821 (Ref. 1) Curated1
Sequence conflicti548V → D in BAB14343 (PubMed:14702039).Curated1
Sequence conflicti674A → T in AAK21271 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022849766G → S2 PublicationsCorresponds to variant dbSNP:rs1130146Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY044431 mRNA Translation: AAK95821.1
AF336851 mRNA Translation: AAK21271.1
AL049766 Genomic DNA No translation available.
AL357560 Genomic DNA No translation available.
BC009304 mRNA Translation: AAH09304.2
BC011927 mRNA Translation: AAH11927.2
BC016060 mRNA Translation: AAH16060.2 Different initiation.
BC126287 mRNA Translation: AAI26288.1
BC130275 mRNA Translation: AAI30276.1
BC144125 mRNA Translation: AAI44126.1
AK022979 mRNA Translation: BAB14343.1 Different initiation.
AK000603 mRNA Translation: BAA91284.1 Different initiation.
AF193054 mRNA Translation: AAG22482.1 Frameshift.
AF161377 mRNA Translation: AAF28937.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13416.1

NCBI Reference Sequences

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RefSeqi
NP_060365.7, NM_017895.7

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371764; ENSP00000360828; ENSG00000124228
ENST00000622530; ENSP00000483495; ENSG00000124228

Database of genes from NCBI RefSeq genomes

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GeneIDi
55661

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55661

UCSC genome browser

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UCSCi
uc002xuh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY044431 mRNA Translation: AAK95821.1
AF336851 mRNA Translation: AAK21271.1
AL049766 Genomic DNA No translation available.
AL357560 Genomic DNA No translation available.
BC009304 mRNA Translation: AAH09304.2
BC011927 mRNA Translation: AAH11927.2
BC016060 mRNA Translation: AAH16060.2 Different initiation.
BC126287 mRNA Translation: AAI26288.1
BC130275 mRNA Translation: AAI30276.1
BC144125 mRNA Translation: AAI44126.1
AK022979 mRNA Translation: BAB14343.1 Different initiation.
AK000603 mRNA Translation: BAA91284.1 Different initiation.
AF193054 mRNA Translation: AAG22482.1 Frameshift.
AF161377 mRNA Translation: AAF28937.1 Sequence problems.
CCDSiCCDS13416.1
RefSeqiNP_060365.7, NM_017895.7

3D structure databases

SMRiQ96GQ7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120793, 127 interactors
CORUMiQ96GQ7
IntActiQ96GQ7, 53 interactors
MINTiQ96GQ7
STRINGi9606.ENSP00000483495

PTM databases

iPTMnetiQ96GQ7
PhosphoSitePlusiQ96GQ7
SwissPalmiQ96GQ7

Polymorphism and mutation databases

BioMutaiDDX27
DMDMi29427946

2D gel databases

SWISS-2DPAGEiQ96GQ7

Proteomic databases

EPDiQ96GQ7
jPOSTiQ96GQ7
MassIVEiQ96GQ7
MaxQBiQ96GQ7
PaxDbiQ96GQ7
PeptideAtlasiQ96GQ7
PRIDEiQ96GQ7
ProteomicsDBi76655

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55661
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371764; ENSP00000360828; ENSG00000124228
ENST00000622530; ENSP00000483495; ENSG00000124228
GeneIDi55661
KEGGihsa:55661
UCSCiuc002xuh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55661
DisGeNETi55661

GeneCards: human genes, protein and diseases

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GeneCardsi
DDX27
HGNCiHGNC:15837 DDX27
HPAiHPA047087
MIMi616621 gene
neXtProtiNX_Q96GQ7
OpenTargetsiENSG00000124228
PharmGKBiPA27213

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0338 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00550000074997
InParanoidiQ96GQ7
KOiK13181
OrthoDBi268859at2759
PhylomeDBiQ96GQ7
TreeFamiTF314780

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DDX27 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DDX27

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55661

Pharos

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Pharosi
Q96GQ7

Protein Ontology

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PROi
PR:Q96GQ7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000124228 Expressed in 234 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiQ96GQ7 baseline and differential
GenevisibleiQ96GQ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96GQ7
Secondary accession number(s): A0AVB6
, B7ZLY1, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: September 18, 2019
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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