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Entry version 119 (18 Sep 2019)
Sequence version 2 (10 Oct 2003)
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Protein

Zinc finger SWIM domain-containing protein 3

Gene

ZSWIM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri531 – 572SWIM-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q96MP5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM3
Synonyms:C20orf164
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16157 ZSWIM3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96MP5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
140831

Open Targets

More...
OpenTargetsi
ENSG00000132801

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25706

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZSWIM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41019518

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002230991 – 696Zinc finger SWIM domain-containing protein 3Add BLAST696

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96MP5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96MP5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96MP5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96MP5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96MP5

PeptideAtlas

More...
PeptideAtlasi
Q96MP5

PRoteomics IDEntifications database

More...
PRIDEi
Q96MP5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
77384

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96MP5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96MP5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132801 Expressed in 153 organ(s), highest expression level in oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q96MP5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055692
HPA060508

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126724, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q96MP5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000255152

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri531 – 572SWIM-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEGZ Eukaryota
ENOG4110N49 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017273

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230974

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96MP5

KEGG Orthology (KO)

More...
KOi
K17604

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPSFPHR

Database of Orthologous Groups

More...
OrthoDBi
338340at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96MP5

TreeFam database of animal gene trees

More...
TreeFami
TF335703

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006564 Znf_PMZ
IPR007527 Znf_SWIM
IPR040302 ZSWIM3

The PANTHER Classification System

More...
PANTHERi
PTHR31569:SF3 PTHR31569:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04434 SWIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00575 ZnF_PMZ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50966 ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q96MP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELGSCFKTY EDFKECFSAY KRENRCSFIL RDCVSVRFHN LNHGTSIRED
60 70 80 90 100
ILYVQVKFVC IRTQSNRKRT READMCPAYL LLRYNERLDR LFISELNTQH
110 120 130 140 150
IHGDSKVASP GGDTTGKSQK TMCLQRLQPV QPTTKKDLDT AEKSLVEPSF
160 170 180 190 200
CLDKVQVSSK PEQEGITPSD LAKIAKVMKN FLKVDEGSMA SFSVGDSQHL
210 220 230 240 250
DRLSFQSSKM TDLFIRFPEN LLLHRVENTQ GHILYAFLVE NKERESRVVH
260 270 280 290 300
FAVLKAETVT SVAKMLSIFT EFNSDWPKVK VVFVDPSFHY RAILQEIFPA
310 320 330 340 350
ARILLSIYHT TRLLEKKLHR SSANPSFKRL MKEALREAVF VTSEASLKNL
360 370 380 390 400
CQMSQAVLDE DLFNFLQAHW FTCELLWYMH VRKGLLACNT YMDSLDIVTS
410 420 430 440 450
KVSSLFREQQ SLLDCILCFV DYIDFFNTKG LKNLPTPPPK LKRARPASMP
460 470 480 490 500
LKSKKAFGIC GESLTSLPAE ETKPDAQQVQ VQQQSQVPPS QVGMLDTLHQ
510 520 530 540 550
SGSELAYKLC HNEWEVVQNS THLVDMAGSS VDVQLLEDSH QVSKDGCSCS
560 570 580 590 600
CSFQQWYHLP CRHILALLHT SQQPVGEAMV CRRWQKKYQY LLGPNGELQD
610 620 630 640 650
RGMVPNTGQP EKQGRNDMIQ DLSRELANLL MQTEGPELEE RYSTLRKIVD
660 670 680 690
IWAGPSQPSE LFQQPGDFKD VGRLPFLWGK QEEGEGFPPA TAVMHY
Length:696
Mass (Da):79,454
Last modified:October 10, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30C91C23ACB1AF23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti329R → S in BAB71239 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053769259V → A1 PublicationCorresponds to variant dbSNP:rs2903808Ensembl.1
Natural variantiVAR_062161291R → W. Corresponds to variant dbSNP:rs35928298Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056641 mRNA Translation: BAB71239.1
AL008726 Genomic DNA No translation available.
BC027611 mRNA Translation: AAH27611.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13381.1

NCBI Reference Sequences

More...
RefSeqi
NP_542790.2, NM_080752.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000255152; ENSP00000255152; ENSG00000132801

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140831

UCSC genome browser

More...
UCSCi
uc002xqd.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056641 mRNA Translation: BAB71239.1
AL008726 Genomic DNA No translation available.
BC027611 mRNA Translation: AAH27611.1
CCDSiCCDS13381.1
RefSeqiNP_542790.2, NM_080752.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126724, 1 interactor
IntActiQ96MP5, 3 interactors
STRINGi9606.ENSP00000255152

PTM databases

iPTMnetiQ96MP5
PhosphoSitePlusiQ96MP5

Polymorphism and mutation databases

BioMutaiZSWIM3
DMDMi41019518

Proteomic databases

EPDiQ96MP5
jPOSTiQ96MP5
MassIVEiQ96MP5
MaxQBiQ96MP5
PaxDbiQ96MP5
PeptideAtlasiQ96MP5
PRIDEiQ96MP5
ProteomicsDBi77384

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255152; ENSP00000255152; ENSG00000132801
GeneIDi140831
KEGGihsa:140831
UCSCiuc002xqd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140831
DisGeNETi140831

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZSWIM3
HGNCiHGNC:16157 ZSWIM3
HPAiHPA055692
HPA060508
neXtProtiNX_Q96MP5
OpenTargetsiENSG00000132801
PharmGKBiPA25706

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEGZ Eukaryota
ENOG4110N49 LUCA
GeneTreeiENSGT00390000017273
HOGENOMiHOG000230974
InParanoidiQ96MP5
KOiK17604
OMAiDPSFPHR
OrthoDBi338340at2759
PhylomeDBiQ96MP5
TreeFamiTF335703

Enzyme and pathway databases

SignaLinkiQ96MP5

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140831

Pharos

More...
Pharosi
Q96MP5

Protein Ontology

More...
PROi
PR:Q96MP5

Gene expression databases

BgeeiENSG00000132801 Expressed in 153 organ(s), highest expression level in oocyte
GenevisibleiQ96MP5 HS

Family and domain databases

InterProiView protein in InterPro
IPR006564 Znf_PMZ
IPR007527 Znf_SWIM
IPR040302 ZSWIM3
PANTHERiPTHR31569:SF3 PTHR31569:SF3, 1 hit
PfamiView protein in Pfam
PF04434 SWIM, 1 hit
SMARTiView protein in SMART
SM00575 ZnF_PMZ, 1 hit
PROSITEiView protein in PROSITE
PS50966 ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSWM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96MP5
Secondary accession number(s): Q9BR13
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: September 18, 2019
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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