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Entry version 172 (16 Oct 2019)
Sequence version 4 (30 Nov 2010)
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Protein

Rho GTPase-activating protein 7

Gene

DLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96QB1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 7
Alternative name(s):
Deleted in liver cancer 1 protein
Short name:
DLC-1
HP protein
Rho-type GTPase-activating protein 7
START domain-containing protein 12
Short name:
StARD12
StAR-related lipid transfer protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DLC1
Synonyms:ARHGAP7, KIAA1723, STARD12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2897 DLC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604258 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96QB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi475F → G: Abolishes interaction with EF1A1. 1 Publication1
Mutagenesisi476L → G: Abolishes interaction with EF1A1. 1 Publication1
Mutagenesisi879Y → F: Unable to displace endogenous DLC1 from focal adhesions. 1 Publication1
Mutagenesisi1114R → E: No catalytic activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
10395

MalaCards human disease database

More...
MalaCardsi
DLC1

Open Targets

More...
OpenTargetsi
ENSG00000164741

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27351

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q96QB1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DLC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104315

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567071 – 1528Rho GTPase-activating protein 7Add BLAST1528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei523PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei566PhosphoserineBy similarity1
Modified residuei757PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q96QB1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q96QB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q96QB1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q96QB1

PeptideAtlas

More...
PeptideAtlasi
Q96QB1

PRoteomics IDEntifications database

More...
PRIDEi
Q96QB1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19782
20045
20421
77848 [Q96QB1-2]
77849 [Q96QB1-1]
77850 [Q96QB1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96QB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q96QB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164741 Expressed in 241 organ(s), highest expression level in upper lobe of lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q96QB1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96QB1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017753

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115667, 20 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q96QB1

Database of interacting proteins

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DIPi
DIP-56928N

Protein interaction database and analysis system

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IntActi
Q96QB1, 39 interactors

Molecular INTeraction database

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MINTi
Q96QB1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276297

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11528
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96QB1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q96QB1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini448 – 515SAMAdd BLAST68
Domaini1078 – 1284Rho-GAPPROSITE-ProRule annotationAdd BLAST207
Domaini1314 – 1521STARTPROSITE-ProRule annotationAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni710 – 884Focal adhesion-targeting (FAT)Add BLAST175
Regioni1051 – 1073Polybasic cluster (PBR)Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi741 – 747Poly-Ser7
Compositional biasi868 – 874Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity.1 Publication
The polybasic cluster is required for activation and mediates binding to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) containing membranes.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2200 Eukaryota
ENOG410XQ10 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039960

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q96QB1

KEGG Orthology (KO)

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KOi
K20632

Identification of Orthologs from Complete Genome Data

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OMAi
DSQTDIY

Database of Orthologous Groups

More...
OrthoDBi
218349at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96QB1

TreeFam database of animal gene trees

More...
TreeFami
TF314044

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028854 DLC1
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12659:SF2 PTHR12659:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q96QB1-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVAIRKRSW EEHVTHWMGQ PFNSDDRNTA CHHGLVADSL QASMEKDATL
60 70 80 90 100
NVDRKEKCVS LPDCCHGSEL RDFPGRPMGH LSKDVDENDS HEGEDQFLSL
110 120 130 140 150
EASTETLVHV SDEDNNADLC LTDDKQVLNT QGQKTSGQHM IQGAGSLEKA
160 170 180 190 200
LPIIQSNQVS SNSWGIAGET ELALVKESGE RKVTDSISKS LELCNEISLS
210 220 230 240 250
EIKDAPKVNA VDTLNVKDIA PEKQLLNSAV IAQQRRKPDP PKDENERSTC
260 270 280 290 300
NVVQNEFLDT PCTNRGLPLL KTDFGSCLLQ PPSCPNGMSA ENGLEKSGFS
310 320 330 340 350
QHQNKSPPKV KAEDGMQCLQ LKETLATQEP TDNQVRLRKR KEIREDRDRA
360 370 380 390 400
RLDSMVLLIM KLDQLDQDIE NALSTSSSPS GTPTNLRRHV PDLESGSESG
410 420 430 440 450
ADTISVNQTR VNLSSDTEST DLPSSTPVAN SGTKPKTTAI QGISEKEKAE
460 470 480 490 500
IEAKEACDWL RATGFPQYAQ LYEDFLFPID ISLVKREHDF LDRDAIEALC
510 520 530 540 550
RRLNTLNKCA VMKLEISPHR KRSDDSDEDE PCAISGKWTF QRDSKRWSRL
560 570 580 590 600
EEFDVFSPKQ DLVPGSPDDS HPKDGPSPGG TLMDLSERQE VSSVRSLSST
610 620 630 640 650
GSLPSHAPPS EDAATPRTNS VISVCSSSNL AGNDDSFGSL PSPKELSSFS
660 670 680 690 700
FSMKGHEKTA KSKTRSLLKR MESLKLKSSH HSKHKAPSKL GLIISGPILQ
710 720 730 740 750
EGMDEEKLKQ LNCVEISALN GNRINVPMVR KRSVSNSTQT SSSSSQSETS
760 770 780 790 800
SAVSTPSPVT RTRSLSACNK RVGMYLEGFD PFNQSTFNNV VEQNFKNRES
810 820 830 840 850
YPEDTVFYIP EDHKPGTFPK ALTNGSFSPS GNNGSVNWRT GSFHGPGHIS
860 870 880 890 900
LRRENSSDSP KELKRRNSSS SMSSRLSIYD NVPGSILYSS SGDLADLENE
910 920 930 940 950
DIFPELDDIL YHVKGMQRIV NQWSEKFSDE GDSDSALDSV SPCPSSPKQI
960 970 980 990 1000
HLDVDNDRTT PSDLDSTGNS LNEPEEPSEI PERRDSGVGA SLTRSNRHRL
1010 1020 1030 1040 1050
RWHSFQSSHR PSLNSVSLQI NCQSVAQMNL LQKYSLLKLT ALLEKYTPSN
1060 1070 1080 1090 1100
KHGFSWAVPK FMKRIKVPDY KDRSVFGVPL TVNVQRTGQP LPQSIQQAMR
1110 1120 1130 1140 1150
YLRNHCLDQV GLFRKSGVKS RIQALRQMNE GAIDCVNYEG QSAYDVADML
1160 1170 1180 1190 1200
KQYFRDLPEP LMTNKLSETF LQIYQYVPKD QRLQAIKAAI MLLPDENREV
1210 1220 1230 1240 1250
LQTLLYFLSD VTAAVKENQM TPTNLAVCLA PSLFHLNTLK RENSSPRVMQ
1260 1270 1280 1290 1300
RKQSLGKPDQ KDLNENLAAT QGLAHMIAEC KKLFQVPEEM SRCRNSYTEQ
1310 1320 1330 1340 1350
ELKPLTLEAL GHLGNDDSAD YQHFLQDCVD GLFKEVKEKF KGWVSYSTSE
1360 1370 1380 1390 1400
QAELSYKKVS EGPPLRLWRS VIEVPAVPEE ILKRLLKEQH LWDVDLLDSK
1410 1420 1430 1440 1450
VIEILDSQTE IYQYVQNSMA PHPARDYVVL RTWRTNLPKG ACALLLTSVD
1460 1470 1480 1490 1500
HDRAPVVGVR VNVLLSRYLI EPCGPGKSKL TYMCRVDLRG HMPEWYTKSF
1510 1520
GHLCAAEVVK IRDSFSNQNT ETKDTKSR
Length:1,528
Mass (Da):170,591
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D20F29CC606302E
GO
Isoform 1 (identifier: Q96QB1-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-437: Missing.
     438-450: TAIQGISEKEKAE → MCRKKPDTMILTQ

Show »
Length:1,091
Mass (Da):122,827
Checksum:i422B9D58B528E26C
GO
Isoform 3 (identifier: Q96QB1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-498: EIEAKEACDW...DFLDRDAIEA → AVKSVKLEVD...FHVAGEENIT
     499-1528: Missing.

Show »
Length:498
Mass (Da):54,552
Checksum:iAA2A500A52492F1F
GO
Isoform 4 (identifier: Q96QB1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-437: Missing.
     438-511: Missing.

Note: No experimental confirmation available.
Show »
Length:1,017
Mass (Da):114,152
Checksum:iA001B182EDE65398
GO
Isoform 5 (identifier: Q96QB1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     450-463: EIEAKEACDWLRAT → GKLTFWFCFLANLF
     464-1528: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):50,890
Checksum:i299AF4E12B29EEB1
GO
Isoform 6 (identifier: Q96QB1-6) [UniParc]FASTAAdd to basket
Also known as: i-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: MSVAIRKRSW...VADSLQASME → MGDPKAHVMA...IWKNTRDRRL
     46-448: Missing.

Note: Produced by alternative promoter usage. ubiquitously expressed, significantly down-regulated in multiple carcinoma cell lines. PubMed:21217778 (ABX83661/ABX83662) sequences are in conflict in positions: 49-50:EA->KP.
Show »
Length:1,125
Mass (Da):126,746
Checksum:iA93D84FF40E9B92A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YWS8A0A0J9YWS8_HUMAN
Rho GTPase-activating protein 7
DLC1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMP5R4GMP5_HUMAN
Rho GTPase-activating protein 7
DLC1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI70E5RI70_HUMAN
Rho GTPase-activating protein 7
DLC1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB81637 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB21814 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43S → C in BAB14996 (PubMed:14702039).Curated1
Sequence conflicti130T → I in BAB14996 (PubMed:14702039).Curated1
Sequence conflicti571H → L in BAB21814 (PubMed:11214970).Curated1
Sequence conflicti1114R → K in AAB87700 (PubMed:9605766).Curated1
Sequence conflicti1364P → R in AAB87700 (PubMed:9605766).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05929327R → C. Corresponds to variant dbSNP:rs34575560Ensembl.1
Natural variantiVAR_05929481L → V. Corresponds to variant dbSNP:rs3816748Ensembl.1
Natural variantiVAR_059295254Q → H2 PublicationsCorresponds to variant dbSNP:rs11203495Ensembl.1
Natural variantiVAR_059296255N → D3 PublicationsCorresponds to variant dbSNP:rs11203494Ensembl.1
Natural variantiVAR_059297260T → I2 PublicationsCorresponds to variant dbSNP:rs3816747Ensembl.1
Natural variantiVAR_059298320Q → H. Corresponds to variant dbSNP:rs34591797Ensembl.1
Natural variantiVAR_014229712N → S2 PublicationsCorresponds to variant dbSNP:rs1044092Ensembl.1
Natural variantiVAR_014230791V → M5 PublicationsCorresponds to variant dbSNP:rs532841Ensembl.1
Natural variantiVAR_014231959T → A1 PublicationCorresponds to variant dbSNP:rs121908500EnsemblClinVar.1
Natural variantiVAR_014232998H → Q1 PublicationCorresponds to variant dbSNP:rs149295187Ensembl.1
Natural variantiVAR_0142331025V → A1 Publication1
Natural variantiVAR_0142341199E → V2 PublicationsCorresponds to variant dbSNP:rs1044093Ensembl.1
Natural variantiVAR_0142351209S → C2 PublicationsCorresponds to variant dbSNP:rs1044094Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0378711 – 437Missing in isoform 1 and isoform 4. 3 PublicationsAdd BLAST437
Alternative sequenceiVSP_0538361 – 45MSVAI…QASME → MGDPKAHVMARPLRAPLRRS FSDHIRDSTARALDVIWKNT RDRRL in isoform 6. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_05383746 – 448Missing in isoform 6. 1 PublicationAdd BLAST403
Alternative sequenceiVSP_044651438 – 511Missing in isoform 4. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_037872438 – 450TAIQG…KEKAE → MCRKKPDTMILTQ in isoform 1. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_037873450 – 498EIEAK…DAIEA → AVKSVKLEVDEDKSTKGSNF SNSEVAIGLSPYTFPQKRLF HVAGEENIT in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_046331450 – 463EIEAK…WLRAT → GKLTFWFCFLANLF in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_046332464 – 1528Missing in isoform 5. 1 PublicationAdd BLAST1065
Alternative sequenceiVSP_037874499 – 1528Missing in isoform 3. 1 PublicationAdd BLAST1030

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF035119 mRNA Translation: AAB87700.1
AF026219 mRNA Translation: AAB81637.1 Different initiation.
AF408781
, AF408768, AF408769, AF408770, AF408771, AF408772, AF408773, AF408774, AF408775, AF408776, AF408777, AF408778, AF408779, AF408780 Genomic DNA Translation: AAK97501.1
AB051510 mRNA Translation: BAB21814.1 Different initiation.
AK024774 mRNA Translation: BAB14996.1
AK299049 mRNA Translation: BAG61122.1
AC015641 Genomic DNA No translation available.
AC019270 Genomic DNA No translation available.
AC022844 Genomic DNA No translation available.
AC106845 Genomic DNA No translation available.
BC049842 mRNA Translation: AAH49842.1
BC054511 mRNA Translation: AAH54511.1
EU159199 mRNA Translation: ABX83661.1
EU159200 mRNA Translation: ABX83662.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55201.1 [Q96QB1-4]
CCDS5989.1 [Q96QB1-2]
CCDS5990.1 [Q96QB1-1]
CCDS5991.2 [Q96QB1-5]
CCDS83253.1 [Q96QB1-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001157743.1, NM_001164271.1 [Q96QB1-4]
NP_001303597.1, NM_001316668.1 [Q96QB1-6]
NP_001335010.1, NM_001348081.1 [Q96QB1-2]
NP_001335011.1, NM_001348082.1 [Q96QB1-4]
NP_001335012.1, NM_001348083.1 [Q96QB1-4]
NP_001335013.1, NM_001348084.1 [Q96QB1-4]
NP_006085.2, NM_006094.4 [Q96QB1-1]
NP_079043.3, NM_024767.3 [Q96QB1-5]
NP_872584.2, NM_182643.2 [Q96QB1-2]
XP_005273431.1, XM_005273374.1 [Q96QB1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276297; ENSP00000276297; ENSG00000164741 [Q96QB1-2]
ENST00000316609; ENSP00000321034; ENSG00000164741 [Q96QB1-3]
ENST00000358919; ENSP00000351797; ENSG00000164741 [Q96QB1-1]
ENST00000511869; ENSP00000425878; ENSG00000164741 [Q96QB1-5]
ENST00000512044; ENSP00000422595; ENSG00000164741 [Q96QB1-6]
ENST00000520226; ENSP00000428028; ENSG00000164741 [Q96QB1-4]
ENST00000644385; ENSP00000495134; ENSG00000285265 [Q96QB1-5]
ENST00000645814; ENSP00000496212; ENSG00000285265 [Q96QB1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10395

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10395

UCSC genome browser

More...
UCSCi
uc003wwk.2 human [Q96QB1-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035119 mRNA Translation: AAB87700.1
AF026219 mRNA Translation: AAB81637.1 Different initiation.
AF408781
, AF408768, AF408769, AF408770, AF408771, AF408772, AF408773, AF408774, AF408775, AF408776, AF408777, AF408778, AF408779, AF408780 Genomic DNA Translation: AAK97501.1
AB051510 mRNA Translation: BAB21814.1 Different initiation.
AK024774 mRNA Translation: BAB14996.1
AK299049 mRNA Translation: BAG61122.1
AC015641 Genomic DNA No translation available.
AC019270 Genomic DNA No translation available.
AC022844 Genomic DNA No translation available.
AC106845 Genomic DNA No translation available.
BC049842 mRNA Translation: AAH49842.1
BC054511 mRNA Translation: AAH54511.1
EU159199 mRNA Translation: ABX83661.1
EU159200 mRNA Translation: ABX83662.1
CCDSiCCDS55201.1 [Q96QB1-4]
CCDS5989.1 [Q96QB1-2]
CCDS5990.1 [Q96QB1-1]
CCDS5991.2 [Q96QB1-5]
CCDS83253.1 [Q96QB1-6]
RefSeqiNP_001157743.1, NM_001164271.1 [Q96QB1-4]
NP_001303597.1, NM_001316668.1 [Q96QB1-6]
NP_001335010.1, NM_001348081.1 [Q96QB1-2]
NP_001335011.1, NM_001348082.1 [Q96QB1-4]
NP_001335012.1, NM_001348083.1 [Q96QB1-4]
NP_001335013.1, NM_001348084.1 [Q96QB1-4]
NP_006085.2, NM_006094.4 [Q96QB1-1]
NP_079043.3, NM_024767.3 [Q96QB1-5]
NP_872584.2, NM_182643.2 [Q96QB1-2]
XP_005273431.1, XM_005273374.1 [Q96QB1-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKYNMR-A451-515[»]
2GYTNMR-A451-513[»]
2KAPNMR-A454-513[»]
2LOZNMR-B811-824[»]
3KUQX-ray2.30A1074-1283[»]
5FZTX-ray2.10B904-926[»]
SMRiQ96QB1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115667, 20 interactors
CORUMiQ96QB1
DIPiDIP-56928N
IntActiQ96QB1, 39 interactors
MINTiQ96QB1
STRINGi9606.ENSP00000276297

PTM databases

iPTMnetiQ96QB1
PhosphoSitePlusiQ96QB1

Polymorphism and mutation databases

BioMutaiDLC1
DMDMi313104315

Proteomic databases

EPDiQ96QB1
jPOSTiQ96QB1
MassIVEiQ96QB1
PaxDbiQ96QB1
PeptideAtlasiQ96QB1
PRIDEiQ96QB1
ProteomicsDBi19782
20045
20421
77848 [Q96QB1-2]
77849 [Q96QB1-1]
77850 [Q96QB1-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10395

Genome annotation databases

EnsembliENST00000276297; ENSP00000276297; ENSG00000164741 [Q96QB1-2]
ENST00000316609; ENSP00000321034; ENSG00000164741 [Q96QB1-3]
ENST00000358919; ENSP00000351797; ENSG00000164741 [Q96QB1-1]
ENST00000511869; ENSP00000425878; ENSG00000164741 [Q96QB1-5]
ENST00000512044; ENSP00000422595; ENSG00000164741 [Q96QB1-6]
ENST00000520226; ENSP00000428028; ENSG00000164741 [Q96QB1-4]
ENST00000644385; ENSP00000495134; ENSG00000285265 [Q96QB1-5]
ENST00000645814; ENSP00000496212; ENSG00000285265 [Q96QB1-3]
GeneIDi10395
KEGGihsa:10395
UCSCiuc003wwk.2 human [Q96QB1-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10395
DisGeNETi10395

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DLC1
HGNCiHGNC:2897 DLC1
HPAiHPA017753
MalaCardsiDLC1
MIMi604258 gene
neXtProtiNX_Q96QB1
OpenTargetsiENSG00000164741
PharmGKBiPA27351

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2200 Eukaryota
ENOG410XQ10 LUCA
GeneTreeiENSGT00950000183061
HOGENOMiHOG000039960
InParanoidiQ96QB1
KOiK20632
OMAiDSQTDIY
OrthoDBi218349at2759
PhylomeDBiQ96QB1
TreeFamiTF314044

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SIGNORiQ96QB1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DLC1 human
EvolutionaryTraceiQ96QB1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DLC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10395
PharosiQ96QB1

Protein Ontology

More...
PROi
PR:Q96QB1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164741 Expressed in 241 organ(s), highest expression level in upper lobe of lung
ExpressionAtlasiQ96QB1 baseline and differential
GenevisibleiQ96QB1 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR028854 DLC1
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PANTHERiPTHR12659:SF2 PTHR12659:SF2, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG07_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96QB1
Secondary accession number(s): B4DR10
, B8PTI0, E9PDZ8, E9PF76, E9PGY9, O14868, O43199, Q7Z5R8, Q86UC6, Q9C0E0, Q9H7A2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 30, 2010
Last modified: October 16, 2019
This is version 172 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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